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Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel) (Transient receptor protein 6) (TRP-6)

 TRPC6_MOUSE             Reviewed;         930 AA.
Q61143; B9EIW2; Q9Z2J1;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 3.
05-DEC-2018, entry version 167.
RecName: Full=Short transient receptor potential channel 6 {ECO:0000250|UniProtKB:Q9Y210};
Short=TrpC6 {ECO:0000303|PubMed:14761972};
AltName: Full=Calcium entry channel;
AltName: Full=Transient receptor protein 6;
Short=TRP-6;
Name=Trpc6 {ECO:0000303|PubMed:14761972, ECO:0000312|MGI:MGI:109523};
Synonyms=Trp6, Trrp6;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=9368034; DOI=10.1074/jbc.272.47.29672;
Boulay G., Zhu X., Peyton M., Jiang M., Hurst R., Stefani E.,
Birnbaumer L.;
"Cloning and expression of a novel mammalian homolog of Drosophila
transient receptor potential (Trp) involved in calcium entry secondary
to activation of receptors coupled by the Gq class of G protein.";
J. Biol. Chem. 272:29672-29680(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=DBA/2J;
PubMed=10050885; DOI=10.1038/sj.onc.1202445;
Buess M., Engler O., Hirsch H.H., Moroni C.;
"Search for oncogenic regulators in an autocrine tumor model using
differential display PCR: identification of novel candidate genes
including the calcium channel mtrp6.";
Oncogene 18:1487-1494(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 631-739.
TISSUE=Brain;
PubMed=8646775; DOI=10.1016/S0092-8674(00)81233-7;
Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E.,
Birnbaumer L.;
"trp, a novel mammalian gene family essential for agonist-activated
capacitative Ca2+ entry.";
Cell 85:661-671(1996).
[6]
PHOSPHORYLATION BY FYN.
PubMed=14761972; DOI=10.1074/jbc.M311274200;
Hisatsune C., Kuroda Y., Nakamura K., Inoue T., Nakamura T.,
Michikawa T., Mizutani A., Mikoshiba K.;
"Regulation of TRPC6 channel activity by tyrosine phosphorylation.";
J. Biol. Chem. 279:18887-18894(2004).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-814, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Lung;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Thought to form a receptor-activated non-selective
calcium permeant cation channel. Probably is operated by a
phosphatidylinositol second messenger system activated by receptor
tyrosine kinases or G-protein coupled receptors. Activated by
diacylglycerol (DAG) in a membrane-delimited fashion,
independently of protein kinase C. Seems not to be activated by
intracellular calcium store depletion.
{ECO:0000250|UniProtKB:Q9Y210}.
-!- SUBUNIT: Homodimer; forms channel complex. Interacts with MX1 and
RNF24. {ECO:0000250|UniProtKB:Q9Y210}.
-!- INTERACTION:
Q96D31:ORAI1 (xeno); NbExp=2; IntAct=EBI-15563578, EBI-2291476;
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:Q9Y210}; Multi-pass membrane protein
{ECO:0000250|UniProtKB:Q9Y210}.
-!- TISSUE SPECIFICITY: Lung and brain.
-!- PTM: Phosphorylated by FYN, leading to an increase of TRPC6
channel activity. {ECO:0000269|PubMed:14761972}.
-!- PTM: N-glycosylated.
-!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
STrpC subfamily. TRPC6 sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U49069; AAC06146.1; -; mRNA.
EMBL; AF057748; AAC64394.1; -; mRNA.
EMBL; CH466522; EDL24958.1; -; Genomic_DNA.
EMBL; BC141131; AAI41132.1; -; mRNA.
CCDS; CCDS22815.1; -.
RefSeq; NP_038866.2; NM_013838.2.
RefSeq; XP_006509913.1; XM_006509850.3.
UniGene; Mm.325086; -.
PDB; 6CV9; EM; 3.80 A; A/B/C/D=94-930.
PDBsum; 6CV9; -.
ProteinModelPortal; Q61143; -.
SMR; Q61143; -.
BioGrid; 204332; 1.
DIP; DIP-60893N; -.
IntAct; Q61143; 3.
STRING; 10090.ENSMUSP00000057965; -.
ChEMBL; CHEMBL1795081; -.
GuidetoPHARMACOLOGY; 491; -.
iPTMnet; Q61143; -.
PhosphoSitePlus; Q61143; -.
MaxQB; Q61143; -.
PaxDb; Q61143; -.
PRIDE; Q61143; -.
Ensembl; ENSMUST00000050433; ENSMUSP00000057965; ENSMUSG00000031997.
GeneID; 22068; -.
KEGG; mmu:22068; -.
UCSC; uc009odl.1; mouse.
CTD; 7225; -.
MGI; MGI:109523; Trpc6.
eggNOG; KOG3609; Eukaryota.
eggNOG; ENOG410XQ0Y; LUCA.
GeneTree; ENSGT00940000156121; -.
HOGENOM; HOG000020590; -.
HOVERGEN; HBG068337; -.
InParanoid; Q61143; -.
KO; K04969; -.
OMA; SECNQKQ; -.
OrthoDB; EOG091G01FB; -.
TreeFam; TF313147; -.
Reactome; R-MMU-114508; Effects of PIP2 hydrolysis.
Reactome; R-MMU-139853; Elevation of cytosolic Ca2+ levels.
Reactome; R-MMU-3295583; TRP channels.
PRO; PR:Q61143; -.
Proteomes; UP000000589; Chromosome 9.
Bgee; ENSMUSG00000031997; Expressed in 110 organ(s), highest expression level in cumulus cell.
ExpressionAtlas; Q61143; baseline and differential.
Genevisible; Q61143; MM.
GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; ISA:MGI.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0036057; C:slit diaphragm; IDA:MGI.
GO; GO:0003779; F:actin binding; ISO:MGI.
GO; GO:0042805; F:actinin binding; ISO:MGI.
GO; GO:0051117; F:ATPase binding; ISO:MGI.
GO; GO:0005262; F:calcium channel activity; ISO:MGI.
GO; GO:0005261; F:cation channel activity; ISO:MGI.
GO; GO:0030276; F:clathrin binding; ISO:MGI.
GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; ISO:MGI.
GO; GO:0005216; F:ion channel activity; IDA:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0015279; F:store-operated calcium channel activity; IDA:MGI.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
GO; GO:0070301; P:cellular response to hydrogen peroxide; ISO:MGI.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
GO; GO:0050774; P:negative regulation of dendrite morphogenesis; ISO:MGI.
GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
GO; GO:0051928; P:positive regulation of calcium ion transport; ISO:MGI.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:MGI.
GO; GO:0032414; P:positive regulation of ion transmembrane transporter activity; ISO:MGI.
GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:MGI.
GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; ISO:MGI.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
GO; GO:0007338; P:single fertilization; IBA:GO_Central.
CDD; cd00204; ANK; 1.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR013555; TRP_dom.
InterPro; IPR005462; TRPC6_channel.
InterPro; IPR002153; TRPC_channel.
PANTHER; PTHR10117; PTHR10117; 1.
PANTHER; PTHR10117:SF7; PTHR10117:SF7; 1.
Pfam; PF12796; Ank_2; 1.
Pfam; PF00520; Ion_trans; 1.
Pfam; PF08344; TRP_2; 1.
PRINTS; PR01097; TRNSRECEPTRP.
PRINTS; PR01647; TRPCHANNEL6.
SMART; SM00248; ANK; 3.
SUPFAM; SSF48403; SSF48403; 1.
PROSITE; PS50297; ANK_REP_REGION; 2.
PROSITE; PS50088; ANK_REPEAT; 1.
1: Evidence at protein level;
3D-structure; ANK repeat; Calcium; Calcium channel; Calcium transport;
Cell membrane; Complete proteome; Glycoprotein; Ion channel;
Ion transport; Membrane; Phosphoprotein; Reference proteome; Repeat;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 930 Short transient receptor potential
channel 6.
/FTId=PRO_0000215323.
TOPO_DOM 1 437 Cytoplasmic. {ECO:0000255}.
TRANSMEM 438 458 Helical. {ECO:0000255}.
TOPO_DOM 459 486 Extracellular. {ECO:0000255}.
TRANSMEM 487 507 Helical. {ECO:0000255}.
TOPO_DOM 508 520 Cytoplasmic. {ECO:0000255}.
TRANSMEM 521 541 Helical. {ECO:0000255}.
TOPO_DOM 542 591 Extracellular. {ECO:0000255}.
TRANSMEM 592 612 Helical. {ECO:0000255}.
TOPO_DOM 613 635 Cytoplasmic. {ECO:0000255}.
TRANSMEM 636 656 Helical. {ECO:0000255}.
TOPO_DOM 657 705 Extracellular. {ECO:0000255}.
TRANSMEM 706 726 Helical. {ECO:0000255}.
TOPO_DOM 727 930 Cytoplasmic. {ECO:0000255}.
REPEAT 96 125 ANK 1.
REPEAT 131 160 ANK 2.
REPEAT 162 188 ANK 3.
REPEAT 217 246 ANK 4.
MOD_RES 814 814 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CARBOHYD 560 560 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CONFLICT 3 56 Missing (in Ref. 2). {ECO:0000305}.
CONFLICT 105 105 A -> V (in Ref. 1; AAC06146).
{ECO:0000305}.
CONFLICT 114 114 R -> W (in Ref. 1; AAC06146).
{ECO:0000305}.
CONFLICT 134 134 N -> D (in Ref. 2; AAC64394).
{ECO:0000305}.
CONFLICT 184 184 A -> S (in Ref. 1; AAC06146).
{ECO:0000305}.
CONFLICT 371 371 Y -> D (in Ref. 1; AAC06146).
{ECO:0000305}.
CONFLICT 436 437 RG -> PR (in Ref. 1; AAC06146).
{ECO:0000305}.
CONFLICT 905 905 T -> S (in Ref. 1; AAC06146).
{ECO:0000305}.
SEQUENCE 930 AA; 106681 MW; 9501C8D50FF33430 CRC64;
MSQSPRFVTR RGGSLKAAPG AGTRRNESQD YLLMDELGDD GYPQLPLPPY GYYPSFRGNE
NRLTHRRQTI LREKGRRLAN RGPAYMFNDH STSLSIEEER FLDAAEYGNI PVVRKMLEEC
HSLNVNCVDY MGQNALQLAV ANEHLEITEL LLKKENLSRV GDALLLAISK GYVRIVEAIL
NHPAFAEGKR LATSPSQSEL QQDDFYAYDE DGTRFSHDVT PIILAAHCQE YEIVHTLLRK
GARIERPHDY FCKCTECSQK QKHDSFSHSR SRINAYKGLA SPAYLSLSSE DPVMTALELS
NELAVLANIE KEFKNDYRKL SMQCKDFVVG LLDLCRNTEE VEAILNGDAE TRQPGDFGRP
NLSRLKLAIK YEVKKFVAHP NCQQQLLSIW YENLSGLRQQ TMAVKFLVVL AVAIGLPFLA
LIYWCAPCSK MGKILRGPFM KFVAHAASFT IFLGLLVMNA ADRFEGTKLL PNETSTDNAR
QLFRMKTSCF SWMEMLIISW VIGMIWAECK EIWTQGPKEY LFELWNMLDF GMLAIFAASF
IARFMAFWHA SKAQSIIDAN DTLKDLTKVT LGDNVKYYNL ARIKWDPTDP QIISEGLYAI
AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG MFNLYSYYIG
AKQNEAFTTV EESFKTLFWA IFGLSEVKSV VINYNHKFIE NIGYVLYGVY NVTMVIVLLN
MLIAMINSSF QEIEDDADVE WKFARAKLWF SYFEEGRTLP VPFNLVPSPK SLLYLLLKFK
KWMCELIQGQ KQGFQEDAEM NKRNEEKKFG ISGSHEDLSK FSLDKNQLAH NKQSSTRSSE
DYHLNSFSNP PRQYQKIMKR LIKRYVLQAQ IDKESDEVNE GELKEIKQDI SSLRYELLEE
KSQNTEDLAE LIRKLGERLS LEPKLEESRR


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