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Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (mTRP7)

 TRPC7_MOUSE             Reviewed;         862 AA.
Q9WVC5;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
12-SEP-2018, entry version 157.
RecName: Full=Short transient receptor potential channel 7;
Short=TrpC7;
AltName: Full=Transient receptor protein 7;
Short=TRP-7;
Short=mTRP7;
Name=Trpc7; Synonyms=Trp7, Trrp8;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10488066; DOI=10.1074/jbc.274.39.27359;
Okada T., Inoue R., Yamazaki K., Maeda A., Kurosaki T., Yamakuni T.,
Tanaka I., Shimizu S., Ikenaka K., Imoto K., Mori Y.;
"Molecular and functional characterization of a novel mouse transient
receptor potential protein homologue TRP7. Ca(2+)-permeable cation
channel that is constitutively activated and enhanced by stimulation
of G protein-coupled receptor.";
J. Biol. Chem. 274:27359-27370(1999).
-!- FUNCTION: Thought to form a receptor-activated non-selective
calcium permeant cation channel. Probably is operated by a
phosphatidylinositol second messenger system activated by receptor
tyrosine kinases or G-protein coupled receptors. Activated by
diacylglycerol (DAG). May also be activated by intracellular
calcium store depletion.
-!- SUBUNIT: Interacts with MX1 and RNF24. Interacts (via ANK-repeat
domains) with PRKG1. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}.
-!- PTM: Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7
activity. {ECO:0000250}.
-!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
STrpC subfamily. TRPC7 sub-subfamily. {ECO:0000305}.
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EMBL; AF139923; AAD42069.1; -; mRNA.
CCDS; CCDS26566.1; -.
RefSeq; NP_036165.1; NM_012035.3.
UniGene; Mm.62409; -.
ProteinModelPortal; Q9WVC5; -.
SMR; Q9WVC5; -.
STRING; 10090.ENSMUSP00000022023; -.
GuidetoPHARMACOLOGY; 492; -.
TCDB; 1.A.4.1.2; the transient receptor potential ca(2+) channel (trp-cc) family.
iPTMnet; Q9WVC5; -.
PhosphoSitePlus; Q9WVC5; -.
MaxQB; Q9WVC5; -.
PaxDb; Q9WVC5; -.
PRIDE; Q9WVC5; -.
Ensembl; ENSMUST00000022023; ENSMUSP00000022023; ENSMUSG00000021541.
GeneID; 26946; -.
KEGG; mmu:26946; -.
UCSC; uc007qtb.2; mouse.
CTD; 57113; -.
MGI; MGI:1349470; Trpc7.
eggNOG; KOG3609; Eukaryota.
eggNOG; ENOG410XQ0Y; LUCA.
GeneTree; ENSGT00760000119180; -.
HOGENOM; HOG000020590; -.
HOVERGEN; HBG068337; -.
InParanoid; Q9WVC5; -.
KO; K04970; -.
OMA; SEQCKQY; -.
OrthoDB; EOG091G01FB; -.
PhylomeDB; Q9WVC5; -.
TreeFam; TF313147; -.
Reactome; R-MMU-114508; Effects of PIP2 hydrolysis.
Reactome; R-MMU-139853; Elevation of cytosolic Ca2+ levels.
Reactome; R-MMU-3295583; TRP channels.
PRO; PR:Q9WVC5; -.
Proteomes; UP000000589; Chromosome 13.
Bgee; ENSMUSG00000021541; Expressed in 150 organ(s), highest expression level in female gonad.
ExpressionAtlas; Q9WVC5; baseline and differential.
Genevisible; Q9WVC5; MM.
GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IC:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
GO; GO:0005262; F:calcium channel activity; IDA:MGI.
GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
GO; GO:0006816; P:calcium ion transport; IDA:MGI.
GO; GO:0006828; P:manganese ion transport; IDA:MGI.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
GO; GO:0007338; P:single fertilization; IBA:GO_Central.
CDD; cd00204; ANK; 1.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR004729; TRP_channel.
InterPro; IPR013555; TRP_dom.
InterPro; IPR005463; TRPC7_channel.
InterPro; IPR002153; TRPC_channel.
PANTHER; PTHR10117; PTHR10117; 1.
PANTHER; PTHR10117:SF9; PTHR10117:SF9; 1.
Pfam; PF12796; Ank_2; 1.
Pfam; PF00520; Ion_trans; 1.
Pfam; PF08344; TRP_2; 1.
PRINTS; PR01097; TRNSRECEPTRP.
PRINTS; PR01648; TRPCHANNEL7.
SMART; SM00248; ANK; 3.
SUPFAM; SSF48403; SSF48403; 1.
TIGRFAMs; TIGR00870; trp; 1.
2: Evidence at transcript level;
ANK repeat; Calcium; Calcium channel; Calcium transport;
Cell membrane; Complete proteome; Glycoprotein; Ion channel;
Ion transport; Membrane; Nucleus; Phosphoprotein; Reference proteome;
Repeat; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 862 Short transient receptor potential
channel 7.
/FTId=PRO_0000215325.
TOPO_DOM 1 351 Cytoplasmic. {ECO:0000255}.
TRANSMEM 352 372 Helical. {ECO:0000255}.
TOPO_DOM 373 383 Extracellular. {ECO:0000255}.
TRANSMEM 384 404 Helical. {ECO:0000255}.
TOPO_DOM 405 465 Cytoplasmic. {ECO:0000255}.
TRANSMEM 466 486 Helical. {ECO:0000255}.
TOPO_DOM 487 537 Extracellular. {ECO:0000255}.
TRANSMEM 538 558 Helical. {ECO:0000255}.
TOPO_DOM 559 581 Cytoplasmic. {ECO:0000255}.
TRANSMEM 582 602 Helical. {ECO:0000255}.
TOPO_DOM 603 651 Extracellular. {ECO:0000255}.
TRANSMEM 652 672 Helical. {ECO:0000255}.
TOPO_DOM 673 862 Cytoplasmic. {ECO:0000255}.
REPEAT 42 71 ANK 1.
REPEAT 77 106 ANK 2.
REPEAT 108 134 ANK 3.
REPEAT 163 192 ANK 4.
MOD_RES 15 15 Phosphothreonine; by PKG/PRKG1.
{ECO:0000250|UniProtKB:Q9HCX4}.
CARBOHYD 514 514 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 862 AA; 99475 MW; C2EB2CE1A6AF9C3D CRC64;
MLGSNTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS AEYGNIPVVR
KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK ENLARVGDAL LLAISKGYVR
IVEAILSHPA FAQGQRLTLS PLEQELRDDD FYAYDEDGTR FSHDITPIIL AAHCQEYEIV
HILLLKGARI ERPHDYFCKC NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL
TALELSNELA RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNLQVW
SDHHRPSLSR IKLAIKYEVK KFVAHPNCQQ QLLTMWYENL SGLRQQSIAV KFLAVFGVSI
GLPFLAIAYW IAPCSKLGQT LRSPFMKFVA HAVSFTIFLG LLVVNASDRF EGVKTLPNET
FTDYPKQIFR VKTTQFSWTE MLIMKWVLGM IWSECKEIWE EGPREYVLHL WNLLDFGMLS
IFVASFTARF MAFLKASEAQ LYVDQYVQDV TLHNVSLPPE VAYFTYARDK WWPSDPQIIS
EGLYAIAVVL SFSRIAYILP ANESFGPLQI SLGRTVKDIF KFMVIFIMVF VAFMIGMFNL
YSYYRGAKYN PAFTTVEESF KTLFWSIFGL SEVISVVLKY DHKFIENIGY VLYGVYNVTM
VVVLLNMLIA MINNSYQEIE EDADVEWKFA RAKLWLSYFD EGRTLPAPFN LVPSPKSFYY
LIMRIKMCLI ELCQSKAKRC ENDLEMGMLN SKFRKTRYQA GMRNSENLTA NSTFSKPTRY
QKIMKRLIKR YVLKAQVDRE NDEVNEGELK EIKQDISSLR YELLEEKSQA TGELADLIQQ
LSEKFGKNLN KDHLRVNQGK DI


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