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Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18)

 SC11A_CANLF             Reviewed;         179 AA.
P67811; O75957; P21378;
11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
12-SEP-2018, entry version 101.
RecName: Full=Signal peptidase complex catalytic subunit SEC11A;
EC=3.4.21.89;
AltName: Full=Endopeptidase SP18;
AltName: Full=Microsomal signal peptidase 18 kDa subunit;
Short=SPase 18 kDa subunit;
AltName: Full=SEC11 homolog A;
AltName: Full=SEC11-like protein 1;
AltName: Full=SPC18;
Name=SEC11A; Synonyms=SEC11L1, SPC18;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 1-34.
TISSUE=Liver;
PubMed=2188978;
Shelness G.S., Blobel G.;
"Two subunits of the canine signal peptidase complex are homologous to
yeast SEC11 protein.";
J. Biol. Chem. 265:9512-9519(1990).
[2]
IDENTIFICATION OF SIGNAL PEPTIDASE COMPLEX.
PubMed=3511473; DOI=10.1073/pnas.83.3.581;
Evans E.A., Gilmore R., Blobel G.;
"Purification of microsomal signal peptidase as a complex.";
Proc. Natl. Acad. Sci. U.S.A. 83:581-585(1986).
[3]
TOPOLOGY.
PubMed=8444896;
Shelness G.S., Lin L., Nicchitta C.V.;
"Membrane topology and biogenesis of eukaryotic signal peptidase.";
J. Biol. Chem. 268:5201-5208(1993).
[4]
FUNCTION.
PubMed=14559916; DOI=10.1074/jbc.M307542200;
Liang H., VanValkenburgh C., Chen X., Mullins C., Van Kaer L.,
Green N., Fang H.;
"Genetic complementation in yeast reveals functional similarities
between the catalytic subunits of mammalian signal peptidase
complex.";
J. Biol. Chem. 278:50932-50939(2003).
-!- FUNCTION: Component of the microsomal signal peptidase complex
which removes signal peptides from nascent proteins as they are
translocated into the lumen of the endoplasmic reticulum.
{ECO:0000269|PubMed:14559916}.
-!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
leader sequences from secreted and periplasmic proteins.
-!- SUBUNIT: Component of the microsomal signal peptidase complex
which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and
SPCS3.
-!- SUBCELLULAR LOCATION: Microsome membrane; Single-pass type II
membrane protein. Endoplasmic reticulum membrane; Single-pass type
II membrane protein.
-!- SIMILARITY: Belongs to the peptidase S26B family. {ECO:0000305}.
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EMBL; J05466; AAA30895.1; -; mRNA.
PIR; A35309; A35309.
RefSeq; NP_001003313.1; NM_001003313.1.
UniGene; Cfa.3874; -.
ProteinModelPortal; P67811; -.
SMR; P67811; -.
CORUM; P67811; -.
STRING; 9615.ENSCAFP00000018993; -.
MEROPS; S26.009; -.
PaxDb; P67811; -.
PRIDE; P67811; -.
Ensembl; ENSCAFT00000020466; ENSCAFP00000018993; ENSCAFG00000012889.
GeneID; 404004; -.
KEGG; cfa:404004; -.
CTD; 23478; -.
VGNC; VGNC:53239; SEC11A.
eggNOG; KOG3342; Eukaryota.
eggNOG; COG0681; LUCA.
GeneTree; ENSGT00390000015600; -.
HOGENOM; HOG000111516; -.
HOVERGEN; HBG057279; -.
InParanoid; P67811; -.
KO; K13280; -.
OMA; YIPFVGY; -.
OrthoDB; EOG091G0X3D; -.
TreeFam; TF313648; -.
Reactome; R-CFA-422085; Synthesis, secretion, and deacylation of Ghrelin.
Proteomes; UP000002254; Chromosome 3.
Bgee; ENSCAFG00000012889; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO; GO:0005787; C:signal peptidase complex; IBA:GO_Central.
GO; GO:0008233; F:peptidase activity; IBA:GO_Central.
GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
GO; GO:0006465; P:signal peptide processing; IBA:GO_Central.
InterPro; IPR036286; LexA/Signal_pep-like_sf.
InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
InterPro; IPR015927; Peptidase_S24_S26A/B/C.
InterPro; IPR001733; Peptidase_S26B.
InterPro; IPR037712; SEC11A/SEC11B.
PANTHER; PTHR10806; PTHR10806; 1.
PANTHER; PTHR10806:SF8; PTHR10806:SF8; 1.
Pfam; PF00717; Peptidase_S24; 1.
PRINTS; PR00728; SIGNALPTASE.
SUPFAM; SSF51306; SSF51306; 1.
TIGRFAMs; TIGR02228; sigpep_I_arch; 1.
PROSITE; PS00501; SPASE_I_1; 1.
PROSITE; PS00761; SPASE_I_3; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Endoplasmic reticulum;
Hydrolase; Membrane; Microsome; Protease; Reference proteome;
Signal-anchor; Transmembrane; Transmembrane helix.
CHAIN 1 179 Signal peptidase complex catalytic
subunit SEC11A.
/FTId=PRO_0000109542.
TOPO_DOM 1 16 Cytoplasmic. {ECO:0000255}.
TRANSMEM 17 36 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 37 179 Lumenal. {ECO:0000255}.
ACT_SITE 56 56 {ECO:0000250}.
SEQUENCE 179 AA; 20625 MW; DFD245A17BA3B47F CRC64;
MLSLDFLDDV RRMNKRQLYY QVLNFGMIVS SALMIWKGLM VITGSESPIV VVLSGSMEPA
FHRGDLLFLT NRVEDPIRVG EIVVFRIEGR EIPIVHRVLK IHEKQNGHIK FLTKGDNNAV
DDRGLYKQGQ HWLEKKDVVG RARGFVPYIG IVTILMNDYP KFKYAVLFLL GLFVLVHRE


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