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Signal transducer and activator of transcription

 F6ZBH0_HORSE            Unreviewed;       749 AA.
F6ZBH0;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
28-MAR-2018, entry version 46.
RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
Name=STAT1 {ECO:0000313|Ensembl:ENSECAP00000007853,
ECO:0000313|VGNC:VGNC:23663};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000007853, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000007853, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007853,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000007853}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007853};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
Nucleus {ECO:0000256|RuleBase:RU046415}.
-!- SIMILARITY: Belongs to the transcription factor STAT family.
{ECO:0000256|RuleBase:RU046415}.
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STRING; 9796.ENSECAP00000007853; -.
PaxDb; F6ZBH0; -.
Ensembl; ENSECAT00000010206; ENSECAP00000007853; ENSECAG00000009039.
VGNC; VGNC:23663; STAT1.
eggNOG; KOG3667; Eukaryota.
eggNOG; ENOG410XPN8; LUCA.
GeneTree; ENSGT00760000119236; -.
InParanoid; F6ZBH0; -.
OMA; WYNMLTT; -.
OrthoDB; EOG091G03O3; -.
TreeFam; TF318648; -.
Proteomes; UP000002281; Chromosome 18.
Bgee; ENSECAG00000009039; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0043234; C:protein complex; IEA:Ensembl.
GO; GO:0045296; F:cadherin binding; IEA:Ensembl.
GO; GO:0035035; F:histone acetyltransferase binding; IEA:Ensembl.
GO; GO:0042393; F:histone binding; IEA:Ensembl.
GO; GO:0035257; F:nuclear hormone receptor binding; IEA:Ensembl.
GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0070491; F:repressing transcription factor binding; IEA:Ensembl.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0004871; F:signal transducer activity; IEA:UniProtKB-UniRule.
GO; GO:0000983; F:transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:Ensembl.
GO; GO:0044389; F:ubiquitin-like protein ligase binding; IEA:Ensembl.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0008015; P:blood circulation; ISS:UniProtKB.
GO; GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB.
GO; GO:0035458; P:cellular response to interferon-beta; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0007259; P:JAK-STAT cascade; ISS:UniProtKB.
GO; GO:0010742; P:macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0072162; P:metanephric mesenchymal cell differentiation; ISS:UniProtKB.
GO; GO:0072136; P:metanephric mesenchymal cell proliferation involved in metanephros development; ISS:UniProtKB.
GO; GO:0046725; P:negative regulation by virus of viral protein levels in host cell; IEA:Ensembl.
GO; GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; ISS:UniProtKB.
GO; GO:0072308; P:negative regulation of metanephric nephron tubule epithelial cell differentiation; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0061326; P:renal tubule development; IEA:Ensembl.
GO; GO:0051591; P:response to cAMP; ISS:UniProtKB.
GO; GO:0034097; P:response to cytokine; ISS:UniProtKB.
GO; GO:0007584; P:response to nutrient; ISS:UniProtKB.
GO; GO:0043434; P:response to peptide hormone; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0060337; P:type I interferon signaling pathway; IEA:Ensembl.
CDD; cd10372; SH2_STAT1; 1.
Gene3D; 1.10.532.10; -; 1.
Gene3D; 1.10.8.1200; -; 1.
Gene3D; 2.60.40.630; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR001217; STAT.
InterPro; IPR038295; STAT1_C_sf.
InterPro; IPR035859; STAT1_SH2.
InterPro; IPR022752; STAT1_TAZ2-bd_C.
InterPro; IPR036535; STAT_N_sf.
InterPro; IPR013800; STAT_TF_alpha.
InterPro; IPR015988; STAT_TF_coiled-coil.
InterPro; IPR013801; STAT_TF_DNA-bd.
InterPro; IPR012345; STAT_TF_DNA-bd_N.
InterPro; IPR013799; STAT_TF_prot_interaction.
PANTHER; PTHR11801; PTHR11801; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF12162; STAT1_TAZ2bind; 1.
Pfam; PF01017; STAT_alpha; 1.
Pfam; PF02864; STAT_bind; 1.
Pfam; PF02865; STAT_int; 1.
SMART; SM00964; STAT_int; 1.
SUPFAM; SSF47655; SSF47655; 1.
SUPFAM; SSF48092; SSF48092; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
3: Inferred from homology;
Activator {ECO:0000256|RuleBase:RU046415};
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Cytoplasm {ECO:0000256|RuleBase:RU046415};
DNA-binding {ECO:0000256|RuleBase:RU046415};
Nucleus {ECO:0000256|RuleBase:RU046415};
Phosphoprotein {ECO:0000256|RuleBase:RU046415};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
ECO:0000256|RuleBase:RU046415};
Transcription {ECO:0000256|RuleBase:RU046415};
Transcription regulation {ECO:0000256|RuleBase:RU046415}.
DOMAIN 573 670 SH2. {ECO:0000259|PROSITE:PS50001}.
COILED 139 166 {ECO:0000256|SAM:Coils}.
COILED 266 290 {ECO:0000256|SAM:Coils}.
SEQUENCE 749 AA; 87231 MW; 32B7F3A1E666E852 CRC64;
MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAANDV SFATIRFHDL
LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPIQ MSMIICSCLK EERKILENAQ
RFNQAQSGNI QSTVMLDKQK ELDSRVRNVK DKVMCIEQEI KTLEDLQDEY DFKCKTSQNR
EHEANGVAKN DQKQEQMLLQ KMYLMLDNKR KEVVHKIIEL LNVTELTQKA LINDELVEWK
RRQQSACIGG PPNACLDQLQ NWFTIVAESL QQVRQQLKKL EELEQKYTYE HDPITKNKQG
LWDRTFSLFQ QLIQNSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK LQELNYNLKV
KVLFDKDVNE RNTVKGFRKF NILGTHTKVM NMEESTNGSL AAEFRHLQLK EQKNAGTRTN
EGPLIVTEEL HSLSFETQLC QPGLVIDLET TSLPVVVISN VSQLPSGWAS ILWYNMLVAE
PRNLSFFLNP PCARWSQLSE VLSWQFSSVT KRGLSVDQLN MLGEKLLGPN AGPDGLIPWT
RFCKENINDK NFPFWLWIES ILELIKKHLL SLWNDGCIVG FISKERERAL LKDQQPGTFL
LRFSESCREG AITFTWVERS QNGGEPYFHA VEPYTKKELS AVTFPDIIRN YKVMAAENIP
ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDGPKGTG YIKTELISVS EVHPSRLQTT
DNLLPMSPEE FDEVSRIVGS VEFDMVSTW


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