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Signal transducer and activator of transcription 3

 STAT3_CHICK             Reviewed;         771 AA.
Q6DV79; Q5F331;
02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
02-SEP-2008, sequence version 2.
12-SEP-2018, entry version 115.
RecName: Full=Signal transducer and activator of transcription 3;
Name=STAT3; ORFNames=RCJMB04_38l20;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Zhou G.Y., Leung F.C.;
"Characterization of 5' flanking sequence of chicken SOCS2 gene.";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=CB; TISSUE=Bursa of Fabricius;
PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
function analysis.";
Genome Biol. 6:R6.1-R6.9(2005).
[3]
FUNCTION, AND PHOSPHORYLATION AT TYR-706.
PubMed=15910996; DOI=10.1016/j.vetimm.2005.01.006;
Nishimichi N., Aosasa M., Kawashima T., Horiuchi H., Furusawa S.,
Matsuda H.;
"Biological activity of recombinant chicken interleukin-6 in chicken
hybridoma cells.";
Vet. Immunol. Immunopathol. 106:97-105(2005).
-!- FUNCTION: Transcription factor that binds to the interleukin-6
(IL-6)-responsive elements identified in the promoters of various
acute-phase protein genes. {ECO:0000250,
ECO:0000269|PubMed:15910996}.
-!- SUBUNIT: Forms a homodimer or a heterodimer with a related family
member, such as STAT1. Interacts with OCAD1 (By similarity).
{ECO:0000250, ECO:0000250|UniProtKB:P42227}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between
the nucleus and the cytoplasm. Constitutive nuclear presence is
independent of tyrosine phosphorylation (By similarity).
{ECO:0000250}.
-!- MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
-!- SIMILARITY: Belongs to the transcription factor STAT family.
{ECO:0000305}.
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EMBL; AY641397; AAT64887.1; -; mRNA.
EMBL; AJ851819; CAH65453.1; -; mRNA.
RefSeq; NP_001026102.1; NM_001030931.1.
RefSeq; XP_015155084.1; XM_015299598.1.
RefSeq; XP_015155085.1; XM_015299599.1.
UniGene; Gga.32114; -.
UniGene; Gga.48605; -.
SMR; Q6DV79; -.
STRING; 9031.ENSGALP00000005161; -.
iPTMnet; Q6DV79; -.
PaxDb; Q6DV79; -.
PRIDE; Q6DV79; -.
Ensembl; ENSGALT00000005170; ENSGALP00000005161; ENSGALG00000003267.
GeneID; 420027; -.
KEGG; gga:420027; -.
CTD; 6774; -.
eggNOG; KOG3667; Eukaryota.
eggNOG; ENOG410XPN8; LUCA.
GeneTree; ENSGT00760000119236; -.
HOGENOM; HOG000220792; -.
HOVERGEN; HBG055669; -.
InParanoid; Q6DV79; -.
KO; K04692; -.
OMA; ECASSPM; -.
OrthoDB; EOG091G03O3; -.
PhylomeDB; Q6DV79; -.
Reactome; R-GGA-1059683; Interleukin-6 signaling.
Reactome; R-GGA-1266695; Interleukin-7 signaling.
Reactome; R-GGA-1433557; Signaling by SCF-KIT.
Reactome; R-GGA-186763; Downstream signal transduction.
Reactome; R-GGA-6783783; Interleukin-10 signaling.
Reactome; R-GGA-6785807; Interleukin-4 and Interleukin-13 signaling.
Reactome; R-GGA-8854691; Interleukin-20 family signaling.
Reactome; R-GGA-8875791; MET activates STAT3.
Reactome; R-GGA-8983432; Interleukin-15 signaling.
Reactome; R-GGA-8984722; Interleukin-35 Signalling.
Reactome; R-GGA-8985947; Interleukin-9 signaling.
Reactome; R-GGA-9008059; Interleukin-37 signaling.
Reactome; R-GGA-9020933; Interleukin-23 signaling.
Reactome; R-GGA-9020956; Interleukin-27 signaling.
Reactome; R-GGA-9020958; Interleukin-21 signaling.
PRO; PR:Q6DV79; -.
Proteomes; UP000000539; Chromosome 27.
Bgee; ENSGALG00000003267; Expressed in 10 organ(s), highest expression level in lung.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0090575; C:RNA polymerase II transcription factor complex; IEA:Ensembl.
GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
GO; GO:0004879; F:nuclear receptor activity; IEA:Ensembl.
GO; GO:0046983; F:protein dimerization activity; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001103; F:RNA polymerase II repressing transcription factor binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; ISS:AgBase.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0048708; P:astrocyte differentiation; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
GO; GO:0042755; P:eating behavior; ISS:UniProtKB.
GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
GO; GO:0001754; P:eye photoreceptor cell differentiation; ISS:UniProtKB.
GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0070102; P:interleukin-6-mediated signaling pathway; IEA:Ensembl.
GO; GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.
GO; GO:0033210; P:leptin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0035278; P:miRNA mediated inhibition of translation; IEA:Ensembl.
GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:0045820; P:negative regulation of glycolytic process; IEA:Ensembl.
GO; GO:2001223; P:negative regulation of neuron migration; IEA:Ensembl.
GO; GO:2000737; P:negative regulation of stem cell differentiation; IEA:Ensembl.
GO; GO:0016310; P:phosphorylation; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:2000637; P:positive regulation of gene silencing by miRNA; IEA:Ensembl.
GO; GO:1904685; P:positive regulation of metalloendopeptidase activity; IEA:Ensembl.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:1905564; P:positive regulation of vascular endothelial cell proliferation; IEA:Ensembl.
GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
GO; GO:0060019; P:radial glial cell differentiation; IEA:Ensembl.
GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
GO; GO:0060259; P:regulation of feeding behavior; IEA:Ensembl.
GO; GO:0040014; P:regulation of multicellular organism growth; ISS:AgBase.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:AgBase.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0019953; P:sexual reproduction; ISS:UniProtKB.
GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:Ensembl.
GO; GO:0001659; P:temperature homeostasis; ISS:UniProtKB.
GO; GO:0006366; P:transcription by RNA polymerase II; ISS:AgBase.
CDD; cd10374; SH2_STAT3; 1.
Gene3D; 1.10.532.10; -; 1.
Gene3D; 2.60.40.630; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR001217; STAT.
InterPro; IPR035855; STAT3_SH2.
InterPro; IPR036535; STAT_N_sf.
InterPro; IPR013800; STAT_TF_alpha.
InterPro; IPR015988; STAT_TF_coiled-coil.
InterPro; IPR013801; STAT_TF_DNA-bd.
InterPro; IPR012345; STAT_TF_DNA-bd_N.
InterPro; IPR013799; STAT_TF_prot_interaction.
PANTHER; PTHR11801; PTHR11801; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF01017; STAT_alpha; 1.
Pfam; PF02864; STAT_bind; 1.
Pfam; PF02865; STAT_int; 1.
SMART; SM00964; STAT_int; 1.
SUPFAM; SSF47655; SSF47655; 1.
SUPFAM; SSF48092; SSF48092; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
1: Evidence at protein level;
Activator; Complete proteome; Cytoplasm; DNA-binding; Nucleus;
Phosphoprotein; Reference proteome; SH2 domain; Transcription;
Transcription regulation.
CHAIN 1 771 Signal transducer and activator of
transcription 3.
/FTId=PRO_0000347217.
DOMAIN 580 670 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
MOTIF 150 162 Essential for nuclear import.
{ECO:0000250}.
MOD_RES 706 706 Phosphotyrosine.
{ECO:0000269|PubMed:15910996}.
CONFLICT 23 23 S -> G (in Ref. 1; AAT64887).
{ECO:0000305}.
CONFLICT 339 339 I -> F (in Ref. 1; AAT64887).
{ECO:0000305}.
CONFLICT 542 542 Missing (in Ref. 2; CAH65453).
{ECO:0000305}.
SEQUENCE 771 AA; 88171 MW; BC4B668CE787010B CRC64;
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAANKE SHATLVFHNL
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA
TAAQQGGQAT HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK
SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRGIVSE LAGLLSAMEY VQKMLADEEL
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY
QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS
GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF AEIIMGYKIM
DATNILVSPL VYLYPDIPKE EAFGKYCRSE SQEHSEATDS GSAAPYLKTK FICVTPTSFS
NTIDLPMSPR TLDSLMQFGN SSEGAEANAG GQFESLTFDM ELTQECASSP M


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