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Signal transducer and activator of transcription 5A (Mammary gland factor)

 STA5A_SHEEP             Reviewed;         794 AA.
P42231;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 2.
28-MAR-2018, entry version 124.
RecName: Full=Signal transducer and activator of transcription 5A;
AltName: Full=Mammary gland factor;
Name=STAT5A; Synonyms=MGF, STAT5;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
PubMed=7514531;
Wakao H., Gouilleux F., Groner B.;
"Mammary gland factor (MGF) is a novel member of the cytokine
regulated transcription factor gene family and confers the prolactin
response.";
EMBO J. 13:2182-2191(1994).
[2]
ERRATUM, AND SEQUENCE REVISION.
PubMed=7882987;
Wakao H., Gouilleux F., Groner B.;
EMBO J. 14:854-855(1995).
[3]
PARTIAL PROTEIN SEQUENCE.
TISSUE=Mammary gland;
PubMed=7537213;
Azam M., Erdjument-Bromage H., Kreider B.L., Xia M., Quelle F.,
Basu R., Saris C., Tempst P., Ihle J.N., Schindler C.;
"Interleukin-3 signals through multiple isoforms of Stat5.";
EMBO J. 14:1402-1411(1995).
-!- FUNCTION: Carries out a dual function: signal transduction and
activation of transcription. Mediates cellular responses to the
cytokine KITLG/SCF and other growth factors. May mediate cellular
responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the
GAS element and activates PRL-induced transcription. Regulates the
expression of milk proteins during lactation.
-!- SUBUNIT: Forms a homodimer or a heterodimer with a related family
member. Binds NR3C1. Interacts with NCOA1 and SOCS7. Interacts
with ERBB4 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into
the nucleus in response to phosphorylation.
-!- TISSUE SPECIFICITY: Found in mammary gland and, in lesser extent,
in ovary, thymus, spleen, kidney, lung, muscle and adrenal gland.
-!- INDUCTION: By prolactin.
-!- PTM: ISGylated. {ECO:0000250|UniProtKB:P42230}.
-!- PTM: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3,
IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity).
Activated KIT promotes phosphorylation on tyrosine residues and
subsequent translocation to the nucleus (By similarity). Tyrosine
phosphorylated in response to constitutively activated FGFR1,
FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation
is required for DNA-binding activity and dimerization. Serine
phosphorylation is also required for maximal transcriptional
activity (By similarity). Tyrosine phosphorylated in response to
signaling via activated FLT3; wild-type FLT3 results in much
weaker phosphorylation than constitutively activated mutant FLT3.
Alternatively, can be phosphorylated by JAK2 at Tyr-694 (By
similarity). {ECO:0000250|UniProtKB:P40763,
ECO:0000250|UniProtKB:P42229, ECO:0000250|UniProtKB:P42230,
ECO:0000250|UniProtKB:Q62771}.
-!- SIMILARITY: Belongs to the transcription factor STAT family.
{ECO:0000305}.
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EMBL; X78428; CAA55191.1; -; mRNA.
PIR; S55527; S55527.
RefSeq; NP_001009402.1; NM_001009402.1.
UniGene; Oar.13291; -.
ProteinModelPortal; P42231; -.
SMR; P42231; -.
iPTMnet; P42231; -.
GeneID; 443419; -.
KEGG; oas:443419; -.
CTD; 6776; -.
HOVERGEN; HBG107486; -.
KO; K11223; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:AgBase.
GO; GO:0005634; C:nucleus; ISS:AgBase.
GO; GO:0003677; F:DNA binding; ISS:AgBase.
GO; GO:0003700; F:DNA binding transcription factor activity; IEA:InterPro.
GO; GO:0004871; F:signal transducer activity; ISS:AgBase.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISS:AgBase.
GO; GO:0046543; P:development of secondary female sexual characteristics; ISS:AgBase.
GO; GO:0007565; P:female pregnancy; ISS:AgBase.
GO; GO:0007259; P:JAK-STAT cascade; ISS:AgBase.
GO; GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; IEA:InterPro.
GO; GO:0007595; P:lactation; ISS:AgBase.
GO; GO:0019915; P:lipid storage; ISS:AgBase.
GO; GO:0001553; P:luteinization; ISS:AgBase.
GO; GO:0030879; P:mammary gland development; ISS:AgBase.
GO; GO:0001779; P:natural killer cell differentiation; ISS:AgBase.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:AgBase.
GO; GO:0045647; P:negative regulation of erythrocyte differentiation; ISS:AgBase.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:AgBase.
GO; GO:0045579; P:positive regulation of B cell differentiation; ISS:AgBase.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:AgBase.
GO; GO:0050729; P:positive regulation of inflammatory response; ISS:AgBase.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; ISS:AgBase.
GO; GO:0045931; P:positive regulation of mitotic cell cycle; ISS:AgBase.
GO; GO:0040018; P:positive regulation of multicellular organism growth; ISS:AgBase.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:AgBase.
GO; GO:0030155; P:regulation of cell adhesion; ISS:AgBase.
GO; GO:0030856; P:regulation of epithelial cell differentiation; ISS:AgBase.
GO; GO:0019218; P:regulation of steroid metabolic process; ISS:AgBase.
GO; GO:0043029; P:T cell homeostasis; ISS:AgBase.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.532.10; -; 1.
Gene3D; 2.60.40.630; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR001217; STAT.
InterPro; IPR035858; STAT5a/5b.
InterPro; IPR036535; STAT_N_sf.
InterPro; IPR013800; STAT_TF_alpha.
InterPro; IPR015988; STAT_TF_coiled-coil.
InterPro; IPR013801; STAT_TF_DNA-bd.
InterPro; IPR012345; STAT_TF_DNA-bd_N.
InterPro; IPR013799; STAT_TF_prot_interaction.
PANTHER; PTHR11801; PTHR11801; 1.
PANTHER; PTHR11801:SF47; PTHR11801:SF47; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF01017; STAT_alpha; 1.
Pfam; PF02864; STAT_bind; 1.
Pfam; PF02865; STAT_int; 1.
SMART; SM00252; SH2; 1.
SMART; SM00964; STAT_int; 1.
SUPFAM; SSF47655; SSF47655; 1.
SUPFAM; SSF48092; SSF48092; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
1: Evidence at protein level;
Activator; Complete proteome; Cytoplasm; Direct protein sequencing;
DNA-binding; Lactation; Nucleus; Phosphoprotein; Reference proteome;
SH2 domain; Transcription; Transcription regulation; Ubl conjugation.
CHAIN 1 794 Signal transducer and activator of
transcription 5A.
/FTId=PRO_0000182427.
DOMAIN 589 686 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
MOD_RES 90 90 Phosphotyrosine.
{ECO:0000250|UniProtKB:P42229}.
MOD_RES 129 129 Phosphoserine.
{ECO:0000250|UniProtKB:P42229}.
MOD_RES 682 682 Phosphotyrosine.
{ECO:0000250|UniProtKB:P42229}.
MOD_RES 694 694 Phosphotyrosine; by JAK2.
{ECO:0000250|UniProtKB:P42229}.
SEQUENCE 794 AA; 90917 MW; E69A4EC826AF60BE CRC64;
MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQVTQL
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY VHVSSRTRTT AAPWSWLRCI RHILYNEQRL
VREATNGNSS AGILVDAMSQ KHLQINQTFE ELRLVTQDTE NELKKLQQTQ EYFIIQYQES
LRIQAQFAQL AQLNPQERLS RETALQQKQV SLEAWLQREA QTLQQYRVEL AEKHQKTLQL
LRKQQTIILD DELIQWKRRH DWRGMEAPPR SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQRTG TLSAHFRNMS
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL LFLAQKLFNN
SSSHLEDYNG MSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPDRNL WNLKPFTTRE GSIRSLADRL
GDLNYLIYVF PDRPKDEVFS KYYTPVLAKA VDGYVKPQIK QVVPEFVSAS ADSAGSSATY
MDQAPSPAVC PQPHYNMYPQ NPDPVLDQDG EFDLDETMDV ARHVEELLRR PNGQSGPLSP
PPAGLFTPAR GSLS


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