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Siroheme synthase [Includes: Uroporphyrinogen-III C-methyltransferase (Urogen III methylase) (EC 2.1.1.107) (Uroporphyrinogen III methylase) (UROM) (SUMT); Sirohydrochlorin ferrochelatase (EC 4.99.1.4); Precorrin-2 dehydrogenase (EC 1.3.1.76)]

 C3SQE2_ECOLX            Unreviewed;       457 AA.
C3SQE2; A0A0J3YL55;
16-JUN-2009, integrated into UniProtKB/TrEMBL.
16-JUN-2009, sequence version 1.
22-NOV-2017, entry version 73.
RecName: Full=Siroheme synthase {ECO:0000256|HAMAP-Rule:MF_01646};
Includes:
RecName: Full=Uroporphyrinogen-III C-methyltransferase {ECO:0000256|HAMAP-Rule:MF_01646};
Short=Urogen III methylase {ECO:0000256|HAMAP-Rule:MF_01646};
EC=2.1.1.107 {ECO:0000256|HAMAP-Rule:MF_01646};
AltName: Full=Uroporphyrinogen III methylase {ECO:0000256|HAMAP-Rule:MF_01646};
Short=UROM {ECO:0000256|HAMAP-Rule:MF_01646};
AltName: Full=SUMT {ECO:0000256|HAMAP-Rule:MF_01646};
Includes:
RecName: Full=Sirohydrochlorin ferrochelatase {ECO:0000256|HAMAP-Rule:MF_01646};
EC=4.99.1.4 {ECO:0000256|HAMAP-Rule:MF_01646};
Includes:
RecName: Full=Precorrin-2 dehydrogenase {ECO:0000256|HAMAP-Rule:MF_01646};
EC=1.3.1.76 {ECO:0000256|HAMAP-Rule:MF_01646};
Name=cysG {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000313|EMBL:AIZ84401.1};
Synonyms=cobA {ECO:0000313|EMBL:ASG47886.1};
ORFNames=A4T40_22495 {ECO:0000313|EMBL:ORD27060.1},
A5958_12255 {ECO:0000313|EMBL:OAJ87409.1},
A8C65_03385 {ECO:0000313|EMBL:OWD58496.1},
A8M44_14180 {ECO:0000313|EMBL:OWE07287.1},
A8M71_19400 {ECO:0000313|EMBL:OWF13013.1},
A8M72_04275 {ECO:0000313|EMBL:OWE87792.1},
A9R57_01550 {ECO:0000313|EMBL:OEI62143.1},
AC789_1c37370 {ECO:0000313|EMBL:AJE57930.1},
ACN002_3449 {ECO:0000313|EMBL:ALY14907.1},
ACU57_16475 {ECO:0000313|EMBL:KPO09619.1},
ACU90_16060 {ECO:0000313|EMBL:KPO51901.1},
AKN40_0395 {ECO:0000313|EMBL:ASO77231.1},
AM266_07320 {ECO:0000313|EMBL:KQJ17067.1},
AMK83_08135 {ECO:0000313|EMBL:KYV71892.1},
AML35_23680 {ECO:0000313|EMBL:KYS88702.1},
APU18_01725 {ECO:0000313|EMBL:KSZ18093.1},
ARC77_13220 {ECO:0000313|EMBL:AMW43129.1},
AU473_04920 {ECO:0000313|EMBL:APA40281.1},
AW059_21670 {ECO:0000313|EMBL:OTB36597.1},
B1K96_23660 {ECO:0000313|EMBL:OTE90678.1},
B7C53_02900 {ECO:0000313|EMBL:OWS87264.1},
BHS80_18530 {ECO:0000313|EMBL:OWX89874.1},
BHS81_20170 {ECO:0000313|EMBL:ORJ74540.1},
BHS87_18900 {ECO:0000313|EMBL:ORS99860.1},
BJJ90_01855 {ECO:0000313|EMBL:APT00850.1},
BK248_06075 {ECO:0000313|EMBL:OJK76454.1},
BK292_07805 {ECO:0000313|EMBL:OJM96950.1},
BK334_22810 {ECO:0000313|EMBL:OJP11240.1},
BK383_21245 {ECO:0000313|EMBL:OJR53036.1},
BK400_00735 {ECO:0000313|EMBL:OJS91557.1},
BMT53_17355 {ECO:0000313|EMBL:OKB91145.1},
BMT91_03480 {ECO:0000313|EMBL:OOK30968.1},
BMT94_13825 {ECO:0000313|EMBL:OOJ06770.1},
BN17_33031 {ECO:0000313|EMBL:CCJ45986.1},
BUE81_05565 {ECO:0000313|EMBL:OLR88355.1},
BUE82_00790 {ECO:0000313|EMBL:APT60609.1},
BW690_17970 {ECO:0000313|EMBL:ONG27170.1},
BWP17_00170 {ECO:0000313|EMBL:OOC85775.1},
BXT93_04970 {ECO:0000313|EMBL:ONG36048.1},
BZL33_00310 {ECO:0000313|EMBL:OUK56503.1},
CA268_00620 {ECO:0000313|EMBL:ARR58061.1},
CA593_09385 {ECO:0000313|EMBL:ARR33299.1},
CDL37_28050 {ECO:0000313|EMBL:OXK45488.1},
CDL44_10895 {ECO:0000313|EMBL:OXK11718.1},
CDL49_15075 {ECO:0000313|EMBL:OXJ80489.1},
CES94_02150 {ECO:0000313|EMBL:ASG47886.1},
EC3234A_57c00300 {ECO:0000313|EMBL:OAC42288.1},
ECs4219 {ECO:0000313|EMBL:ACI76681.1},
EL75_0328 {ECO:0000313|EMBL:KGM71720.1},
EL79_0346 {ECO:0000313|EMBL:KGM85267.1},
EL80_0339 {ECO:0000313|EMBL:KGM83912.1},
ERS085365_00955 {ECO:0000313|EMBL:CTS09653.1},
ERS085366_00167 {ECO:0000313|EMBL:CTS02055.1},
ERS085374_01455 {ECO:0000313|EMBL:CTR54887.1},
ERS085379_03723 {ECO:0000313|EMBL:CTT86346.1},
ERS085416_02860 {ECO:0000313|EMBL:CTW22455.1},
ERS139211_00061 {ECO:0000313|EMBL:CTU91130.1},
ERS150873_03036 {ECO:0000313|EMBL:CTZ57890.1},
HW42_21600 {ECO:0000313|EMBL:AIZ84401.1},
JD73_02710 {ECO:0000313|EMBL:KFD78067.1},
PGD_00517 {ECO:0000313|EMBL:CDU37482.1},
RG28_21890 {ECO:0000313|EMBL:APJ78748.1},
RX35_03135 {ECO:0000313|EMBL:OYC68381.1},
SK85_03684 {ECO:0000313|EMBL:KLX94303.1},
SM09_03621 {ECO:0000313|EMBL:KME66890.1},
UN86_22590 {ECO:0000313|EMBL:KJW26287.1},
WQ89_11825 {ECO:0000313|EMBL:KNF79892.1},
WR15_02785 {ECO:0000313|EMBL:KNF71568.1};
Escherichia coli.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=562 {ECO:0000313|EMBL:ACI76681.1};
[1] {ECO:0000313|EMBL:ACI76681.1}
NUCLEOTIDE SEQUENCE.
STRAIN=493/89 {ECO:0000313|EMBL:ACI76681.1},
86-24 {ECO:0000313|EMBL:ACI76682.1},
87-14 {ECO:0000313|EMBL:ACI76683.1},
TB182A {ECO:0000313|EMBL:ACI76684.1}, and
TW14359 {ECO:0000313|EMBL:ACI76685.1};
PubMed=19439656; DOI=10.1073/pnas.0812949106;
Leopold S.R., Magrini V., Holt N.J., Shaikh N., Mardis E.R., Cagno J.,
Ogura Y., Iguchi A., Hayashi T., Mellmann A., Karch H., Besser T.E.,
Sawyer S.A., Whittam T.S., Tarr P.I.;
"A precise reconstruction of the emergence and constrained radiations
of Escherichia coli O157 portrayed by backbone concatenomic
analysis.";
Proc. Natl. Acad. Sci. U.S.A. 106:8713-8718(2009).
[2] {ECO:0000313|EMBL:CCJ45986.1}
NUCLEOTIDE SEQUENCE.
STRAIN=IMT2125 {ECO:0000313|EMBL:CCJ45986.1};
Lim C.-J.;
Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:CCJ45986.1, ECO:0000313|Proteomes:UP000094022}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=IMT2125 {ECO:0000313|EMBL:CCJ45986.1,
ECO:0000313|Proteomes:UP000094022};
PubMed=23275093; DOI=10.1128/IAI.00585-12;
Dziva F., Hauser H., Connor T.R., van Diemen P.M., Prescott G.,
Langridge G.C., Eckert S., Chaudhuri R.R., Ewers C., Mellata M.,
Mukhopadhyay S., Curtiss R., Dougan G., Wieler L.H., Thomson N.R.,
Pickard D.J., Stevens M.P.;
"Sequencing and functional annotation of avian pathogenic Escherichia
coli serogroup O78 strains reveal the evolution of E. coli lineages
pathogenic for poultry via distinct mechanisms.";
Infect. Immun. 81:838-849(2013).
[4] {ECO:0000313|EMBL:ALY14907.1, ECO:0000313|Proteomes:UP000066343}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ACN002 {ECO:0000313|EMBL:ALY14907.1,
ECO:0000313|Proteomes:UP000066343};
Wei L., Wang X., Wang B.;
"Complete genome sequence of Avian pathogenic Escherichia coli strain
ACN002.";
Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:CDU37482.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=D6-117_07.11 {ECO:0000313|EMBL:CDU37482.1};
Kempf F., Loux V., Germon P.;
"Genome sequence of four bovine mastitis-causing Escherichia coli
strains.";
Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|EMBL:KGM83912.1, ECO:0000313|Proteomes:UP000030018}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=G8 {ECO:0000313|EMBL:KGM83912.1,
ECO:0000313|Proteomes:UP000030018};
Zschuettig A., Auerbach C., Meltke S., Eichhorn C., Brandt M.,
Blom J., Goesmann A., Jarek M., Scharfe M., Zimmermann K.,
Wassenaar T.M., Gunzer F.;
"Complete sequence of probiotic Symbioflor2 E. coli G3/10 and draft
sequences of Symbioflor2 strains G1/2, G4/9, G5, G6/7 and G8.";
Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|EMBL:KGM71720.1, ECO:0000313|Proteomes:UP000029988, ECO:0000313|Proteomes:UP000030000}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=G1/2 {ECO:0000313|EMBL:KGM71720.1,
ECO:0000313|Proteomes:UP000030000}, and
G6/7 {ECO:0000313|EMBL:KGM85267.1, ECO:0000313|Proteomes:UP000029988};
Zschuettig A., Auerbach C., Meltke S., Eichhorn C., Brandt M.,
Blom J., Goesmann A., Jarek M., Scharfe M., Zimmermann K.,
Wassenaar T.M., Gunzer F.;
"Complete sequence of probiotic Symbioflor2 E. coli strain G3/10 and
draft sequences of Symbioflor2 strains G1/2, G4/9, G5, G6/7 and G8.";
Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:KFD78067.1, ECO:0000313|Proteomes:UP000028651}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=48 {ECO:0000313|EMBL:KFD78067.1,
ECO:0000313|Proteomes:UP000028651};
Nuesch-Inderbinen M.T., Funk J., Cernela N., Tasara T., Klumpp J.,
Schmidt H., Stephan R.;
"Prevalence of subtilase cytotoxin-encoding subAB variants among Shiga
toxin-producing Escherichia coli strains isolated from wild ruminants
and sheep differs from that of cattle and pigs and is predominated by
the new allelic variant subAB2-2.";
Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
[9] {ECO:0000313|EMBL:APJ78748.1, ECO:0000313|Proteomes:UP000184379}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C5 {ECO:0000313|EMBL:APJ78748.1,
ECO:0000313|Proteomes:UP000184379};
Jiang J., Xu Z., Zhou Y., Zhao H., Leung F.C.C.;
"Vertical and Horizontal Evolutionary Story implied from E. coli
complete genomes.";
Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:AIZ84401.1, ECO:0000313|Proteomes:UP000030790}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=RM9387 {ECO:0000313|EMBL:AIZ84401.1,
ECO:0000313|Proteomes:UP000030790};
PubMed=25887577; DOI=10.1186/s12866-015-0413-9;
Yan X., Fratamico P.M., Bono J.L., Baranzoni G.M., Chen C.Y.;
"Genome sequencing and comparative genomics provides insights on the
evolutionary dynamics and pathogenic potential of different H-
serotypes of Shiga toxin-producing Escherichia coli O104.";
BMC Microbiol. 15:83-83(2015).
[11] {ECO:0000313|EMBL:KPO09619.1, ECO:0000313|Proteomes:UP000050307, ECO:0000313|Proteomes:UP000050556}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=09-0523 {ECO:0000313|EMBL:KPO51901.1,
ECO:0000313|Proteomes:UP000050307}, and
AW1.3 {ECO:0000313|EMBL:KPO09619.1,
ECO:0000313|Proteomes:UP000050556};
PubMed=26441869; DOI=10.3389/fmicb.2015.00932;
Mercer R.G., Zheng J., Garcia-Hernandez R., Ruan L., Ganzle M.G.,
McMullen L.M.;
"Genetic determinants of heat resistance in Escherichia coli.";
Front. Microbiol. 6:932-932(2015).
[12] {ECO:0000313|Proteomes:UP000031522}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=789 {ECO:0000313|Proteomes:UP000031522};
Huja S., Oren Y., Trost E., Brzuszkiewicz E., Biran D., Blom J.,
Goesmann A., Gottschalk G., Hacker J., Ron E.Z., Dobrindt U.;
"Genomic Avenue to Avian Colisepticemia.";
MBio 6:e01681-14(2015).
[13] {ECO:0000313|EMBL:AJE57930.1}
NUCLEOTIDE SEQUENCE.
STRAIN=789 {ECO:0000313|EMBL:AJE57930.1};
PubMed=25587010;
Huja S., Oren Y., Trost E., Brzuszkiewicz E., Biran D., Blom J.,
Goesmann A., Gottschalk G., Hacker J., Ron E.Z., Dobrindt U.;
"Genomic avenue to avian colisepticemia.";
MBio 6:0-0(2015).
[14] {ECO:0000313|EMBL:OAC42288.1, ECO:0000313|Proteomes:UP000077380}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=3234/A {ECO:0000313|EMBL:OAC42288.1,
ECO:0000313|Proteomes:UP000077380};
Leimbach A., Poehlein A., Daniel R., Dobrindt U.;
"Comparative genomics of E. coli bovine mastitis and fecal commensal
isolates.";
Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
[15] {ECO:0000313|EMBL:KJW26287.1, ECO:0000313|Proteomes:UP000033592}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=St. Olav39 {ECO:0000313|EMBL:KJW26287.1,
ECO:0000313|Proteomes:UP000033592};
Gabrielsen C., Afset J.E., Drablos F.;
"Genome sequences of 11 non-O157 Shiga Toxin-Producing Escherichia
coli strains.";
Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
[16] {ECO:0000313|EMBL:OYC68381.1, ECO:0000313|Proteomes:UP000215493}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=224-2931 {ECO:0000313|EMBL:OYC68381.1,
ECO:0000313|Proteomes:UP000215493};
The Broad Institute Genomics Platform;
The Broad Institute Genome Sequencing Center for Infectious Disease;
Earl A.M., Hultgren S., Shreiber H., Conover M., Hibbing M.,
Stapleton A., Roberts P., Hooton T.M., Manson-McGuire A., Young S.,
Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M., Shea T.,
Wortman J., Nusbaum C., Birren B.;
"The Genome Sequence of Escherichia coli 224-2931.";
Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
[17] {ECO:0000313|EMBL:KLX94303.1, ECO:0000313|Proteomes:UP000036012, ECO:0000313|Proteomes:UP000036405}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=BIDMC112 {ECO:0000313|EMBL:KLX94303.1,
ECO:0000313|Proteomes:UP000036012}, and
CHS199 {ECO:0000313|EMBL:KME66890.1,
ECO:0000313|Proteomes:UP000036405};
The Broad Institute Genomics Platform;
The Broad Institute Genome Sequencing Center for Infectious Disease;
Earl A.M., Onderdonk A.B., Kirby J., Ferraro M.J., Huang S.,
Spencer M., Fodor A., Hooper D., Dekker J., O'Brien T., Quan V.,
Gombosev A., Delaney M., DuBois A., Ernst C., Kim D.S., Rossman W.,
Gohs F., Petruso H., Nozar T., Mougeot F., Manson-McGuire A.,
Young S., Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M.,
Shea T., Wortman I., Wortman J.R., Nusbaum C., Birren B.;
"The Genome Sequence of None.";
Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
[18] {ECO:0000313|EMBL:KNF71568.1, ECO:0000313|Proteomes:UP000036812, ECO:0000313|Proteomes:UP000037564}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CFSAN026817 {ECO:0000313|EMBL:KNF79892.1,
ECO:0000313|Proteomes:UP000036812}, and
CFSAN026843 {ECO:0000313|EMBL:KNF71568.1,
ECO:0000313|Proteomes:UP000037564};
Gonzalez-Escalona N., Toro M., Timme R., Payne J.;
"Genome sequences of 64 non-O157:H7 Shiga toxin-producing Escherichia
coli strains.";
Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
[19] {ECO:0000313|EMBL:KQJ17067.1, ECO:0000313|Proteomes:UP000051850}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=221 {ECO:0000313|EMBL:KQJ17067.1,
ECO:0000313|Proteomes:UP000051850};
Kudirkiene E., Olsen J.E.;
"Characterization of Escherichia coli strains isolated from cattle and
human in Tanzania.";
Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
[20] {ECO:0000313|EMBL:CTR54887.1}
NUCLEOTIDE SEQUENCE.
STRAIN=201589_aEPEC {ECO:0000313|EMBL:CTW22455.1},
403728 {ECO:0000313|EMBL:CTU91130.1},
503028_aEPEC {ECO:0000313|EMBL:CTS09653.1},
503225_aEPEC {ECO:0000313|EMBL:CTS02055.1},
504888_aEPEC {ECO:0000313|EMBL:CTR54887.1},
702161 {ECO:0000313|EMBL:CTT86346.1}, and
G500830 {ECO:0000313|EMBL:CTZ57890.1};
Rikkerink E.H.A., Fineran P.C.;
"Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the
Causal Agent of Kiwifruit Canker Disease.";
Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
[21] {ECO:0000313|EMBL:ASO77231.1, ECO:0000313|Proteomes:UP000203621}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MEM {ECO:0000313|EMBL:ASO77231.1,
ECO:0000313|Proteomes:UP000203621};
Liu B.;
"Domestication mutations in four distinct E. coli isolates are strain-
specific and environment dependent.";
Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
[22] {ECO:0000313|Proteomes:UP000038112, ECO:0000313|Proteomes:UP000040589, ECO:0000313|Proteomes:UP000040934}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=201589_aEPEC {ECO:0000313|Proteomes:UP000040934},
403728 {ECO:0000313|Proteomes:UP000044893},
503028_aEPEC {ECO:0000313|Proteomes:UP000041959},
503225_aEPEC {ECO:0000313|Proteomes:UP000045242},
504888_aEPEC {ECO:0000313|Proteomes:UP000038112},
702161 {ECO:0000313|Proteomes:UP000040589}, and
G500830 {ECO:0000313|Proteomes:UP000042305};
Pathogen Informatics;
Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
[23] {ECO:0000313|EMBL:KSZ18093.1, ECO:0000313|Proteomes:UP000053450}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=50870281 {ECO:0000313|EMBL:KSZ18093.1,
ECO:0000313|Proteomes:UP000053450};
Millard Andrew;
Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
[24] {ECO:0000313|EMBL:KYS88702.1, ECO:0000313|Proteomes:UP000076106, ECO:0000313|Proteomes:UP000076304}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=STEC 1686 {ECO:0000313|EMBL:KYS88702.1,
ECO:0000313|Proteomes:UP000076106}, and
STEC 309 {ECO:0000313|EMBL:KYV71892.1,
ECO:0000313|Proteomes:UP000076304};
Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
[25] {ECO:0000313|EMBL:ARR58061.1, ECO:0000313|Proteomes:UP000194331}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Z1002 {ECO:0000313|EMBL:ARR58061.1};
PubMed=27506685; DOI=.1093/cid/ciw553;
Zheng B., Dong H., Xu H., Lv J., Zhang J., Jiang X., Du Y., Xiao Y.,
Li L.;
"Coexistence of MCR-1 and NDM-1 in Clinical Escherichia coli
Isolates.";
Clin. Infect. Dis. 63:1393-1395(2016).
[26] {ECO:0000313|EMBL:OEI62143.1, ECO:0000313|Proteomes:UP000095183}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=EPEC 2827 {ECO:0000313|EMBL:OEI62143.1,
ECO:0000313|Proteomes:UP000095183};
Ferdous M., Kooistra-Smid A.M., Rossen J.W., Friedrich A.W.;
"Virulence, Antimicrobial resistance properties and Phylogenetic
background of E. coli O157 isolates that do not carry the H7 flagellar
antigen.";
Front. Microbiol. 0:0-0(2016).
[27] {ECO:0000313|EMBL:AMW43129.1, ECO:0000313|Proteomes:UP000076266}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=28RC1 {ECO:0000313|EMBL:AMW43129.1,
ECO:0000313|Proteomes:UP000076266};
Baranzoni G.M., Fratamico P., Reichenberger E., Kim G.-H., Breidt F.,
Kay K.;
"Complete Genome Sequences of Escherichia coli O157:H7 strains SRCC
1675 and 28RC.";
Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
[28] {ECO:0000313|EMBL:OAJ87409.1, ECO:0000313|Proteomes:UP000077539}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2011C-4315 {ECO:0000313|EMBL:OAJ87409.1,
ECO:0000313|Proteomes:UP000077539};
Lindsey R.L., Rowe L., Garcia-Toledo L., Loparev V., Knipe K.,
Stripling D., Martin H., Trees E., Juieng P., Batra D., Strockbine N.;
"High Quality Draft Genomes for Six Non-O157 Shiga Toxin-producing
Escherichia coli Strains Generated with PacBio Sequencing and Optical
Maps.";
Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
[29] {ECO:0000313|Proteomes:UP000196647, ECO:0000313|Proteomes:UP000196745, ECO:0000313|Proteomes:UP000196822}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ECOR04 {ECO:0000313|EMBL:OWD58496.1,
ECO:0000313|Proteomes:UP000196822},
ECOR47 {ECO:0000313|EMBL:OWE07287.1,
ECO:0000313|Proteomes:UP000196647},
ECOR65 {ECO:0000313|EMBL:OWE87792.1,
ECO:0000313|Proteomes:UP000196745}, and
ECOR70 {ECO:0000313|EMBL:OWF13013.1,
ECO:0000313|Proteomes:UP000196823};
Fischer W., Schubert S., Messerer M.;
"Investigation of Horizontal Gene Transfer of Pathogenicity Islands in
Escherichia coli using Next-Generation Sequencing.";
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[30] {ECO:0000313|EMBL:APT00850.1, ECO:0000313|Proteomes:UP000185422}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SLK172 {ECO:0000313|EMBL:APT00850.1,
ECO:0000313|Proteomes:UP000185422};
Bai L., Wang J., Hurley D., Yu Z., Wang L., Chen Q., Li J., Li F.,
Fanning S.;
"Characterisation of two large plasmids containing ESBL genes; a novel
disrupted mcr-1 gene and a lysogenized phage P-1 like sequence,
cultured from a human atypical enteropathogenic Escherichia coli
(aEPEC) recovered in China.";
Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
[31] {ECO:0000313|Proteomes:UP000184168, ECO:0000313|Proteomes:UP000184277, ECO:0000313|Proteomes:UP000184336}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=452 {ECO:0000313|EMBL:OJK76454.1,
ECO:0000313|Proteomes:UP000184168}, 559 {ECO:0000313|EMBL:OJP11240.1,
ECO:0000313|Proteomes:UP000184459}, 570 {ECO:0000313|EMBL:OJR53036.1,
ECO:0000313|Proteomes:UP000184277}, 634 {ECO:0000313|EMBL:OJM96950.1,
ECO:0000313|Proteomes:UP000184369}, and
726 {ECO:0000313|EMBL:OJS91557.1, ECO:0000313|Proteomes:UP000184336};
Wang Y., Zhang R., Li J., Wu Z., Wenjuan Y., Schwarz S., Tyrrell J.,
Zheng Y., Wang S., Shen Z., Liu Z., Lei L., Li M., Zhang Q., Wu C.,
Zhang Q., Wu Y., Walsh T., Shen J.;
"Comprehensive resistome analysis reveals the prevalence of NDM and
MCR-1 in Chinese poultry production.";
Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
[32] {ECO:0000313|EMBL:APA40281.1, ECO:0000313|Proteomes:UP000177471}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PA20 {ECO:0000313|EMBL:APA40281.1,
ECO:0000313|Proteomes:UP000177471};
Uhlich G.A., Chen C.-Y., Paoli G.;
"E. coli O157:H7 PA20.";
Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
[33] {ECO:0000313|EMBL:OOJ06770.1, ECO:0000313|Proteomes:UP000188758, ECO:0000313|Proteomes:UP000188855}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2.3-R4 {ECO:0000313|EMBL:OOK30968.1,
ECO:0000313|Proteomes:UP000188855}, and
4-R1 {ECO:0000313|EMBL:OOJ06770.1, ECO:0000313|Proteomes:UP000188758};
Moran R.A., Anantham S., Nigro S.J., Holt K.E., Hall R.M.;
"Whole genome sequences of antibiotic resistant commensal Escherichia
coli from healthy Australian adults.";
Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
[34] {ECO:0000313|EMBL:OKB91145.1, ECO:0000313|Proteomes:UP000185961}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=256 {ECO:0000313|EMBL:OKB91145.1,
ECO:0000313|Proteomes:UP000185961};
Tasara T., Fierz L., Klumpp J., Schmidt H., Stephan R.;
"Draft genome sequences of five Shigatoxin-producing Escherichia coli
isolates harboring the new recently described Subtilase cytotoxin
allelic variant subAB2-3.";
Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
[35] {ECO:0000313|EMBL:OLR88355.1, ECO:0000313|Proteomes:UP000186204}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=204965 {ECO:0000313|EMBL:OLR88355.1,
ECO:0000313|Proteomes:UP000186204};
Hartl R., Kerschner H., Lepuschitz S., Ruppitsch W., Allerberger F.,
Apfalter P.;
"First detection of the mcr-1 gene in a multidrug-resistant
Escherichia coli isolate from an Austrian patient.";
Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
[36] {ECO:0000313|EMBL:APT60609.1, ECO:0000313|Proteomes:UP000185501}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2016C-3936C1 {ECO:0000313|EMBL:APT60609.1,
ECO:0000313|Proteomes:UP000185501};
Lindsey R.L., Batra D., Rowe L., Loparev V.N., Stripling D.,
Garcia-Toledo L., Knipe K., Juieng P., Sheth M., Martin H.,
Laufer Halpin A.;
"High Quality Genome Sequence of an Escherichia coli O157 carrying a
mcr-1 Resistance Gene Isolated from a Patient in the United States.";
Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
[37] {ECO:0000313|Proteomes:UP000214591, ECO:0000313|Proteomes:UP000214661, ECO:0000313|Proteomes:UP000214667}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FC10225 {ECO:0000313|EMBL:OXK45488.1,
ECO:0000313|Proteomes:UP000214591},
FC10255 {ECO:0000313|EMBL:OXK11718.1,
ECO:0000313|Proteomes:UP000214667}, and
FC10274 {ECO:0000313|EMBL:OXJ80489.1,
ECO:0000313|Proteomes:UP000214661};
PubMed=28686503;
Luo Y., Luo R., Ding H., Ren X., Luo H., Zhang Y., Ye L., Cui S.;
"Characterization of Carbapenem-Resistant Escherichia coli Isolates
Through the Whole-Genome Sequencing Analysis.";
Microb. Drug Resist. 0:0-0(2017).
[38] {ECO:0000313|EMBL:ONG36048.1, ECO:0000313|Proteomes:UP000188967}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ICBEcBL-II-13 {ECO:0000313|EMBL:ONG36048.1,
ECO:0000313|Proteomes:UP000188967};
Moura Q., Fernandes M.R., Cerdeira L., Vianello M., Souza T.A.,
Ienne S., Lincopan N.;
"Draft genome sequence of an E. coli strain isolated from human, in
Amazon, Brazil.";
Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
[39] {ECO:0000313|EMBL:ONG27170.1, ECO:0000313|Proteomes:UP000188724}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ICBEC13AM {ECO:0000313|EMBL:ONG27170.1,
ECO:0000313|Proteomes:UP000188724};
Fernandes M.R., Sellera F.P., Esposito F., Cerdeira L., Lincopan N.;
"Draft genome sequence of Escherichia coli (ICBEC13AM) encoding mcr-1
gene in marine environment.";
Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
[40] {ECO:0000313|EMBL:OUK56503.1, ECO:0000313|Proteomes:UP000195107}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SJRP/Ec42687 {ECO:0000313|EMBL:OUK56503.1};
Casella T., Cerdeira L., Lincopan N., Nogueira M.C.;
"Draft genome sequence of Escherichia coli strain SJRP/Ec42687.";
Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
[41] {ECO:0000313|EMBL:OOC85775.1, ECO:0000313|Proteomes:UP000188999}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=EDL 933 {ECO:0000313|EMBL:OOC85775.1,
ECO:0000313|Proteomes:UP000188999};
Kozyreva V.K., Truong C.-L., Greninger A.L., Mukhopadhyay R.,
Crandall J., Chaturvedi V.;
"Validation and Implementation of CLIA-Compliant Whole Genome
Sequencing (WGS) in Public Health Laboratory.";
Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
[42] {ECO:0000313|EMBL:OTB36597.1, ECO:0000313|Proteomes:UP000194247}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=OLC1000 {ECO:0000313|EMBL:OTB36597.1,
ECO:0000313|Proteomes:UP000194247};
Carrillo C.D., Koziol A.G., Mathews A., Goji N., Lambert D.,
Huszczynski G., Deschenes M., Gauthier M., Amoako K., Blais B.;
"Application of genomics in the determination of verotoxigenic
Escherichia coli toxin subtypes.";
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
[43] {ECO:0000313|EMBL:OWS87264.1, ECO:0000313|Proteomes:UP000197917}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Ec39590 {ECO:0000313|EMBL:OWS87264.1,
ECO:0000313|Proteomes:UP000197917};
Melo L.C., Boisson M.N., Cerdeira L., Saras E., Medaille C.,
Boulois H.-J., Madec J.-Y., Haenni M., Lincopan N.;
"Draft Genome Sequence of Escherichia coli Isolated from Cat Harboring
blaTEM-52b.";
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
[44] {ECO:0000313|EMBL:OTE90678.1, ECO:0000313|Proteomes:UP000194285}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=34VL {ECO:0000313|EMBL:OTE90678.1,
ECO:0000313|Proteomes:UP000194285};
Sartori L., Cerdeira L., Lincopan N.;
"Escherichia coli sequence carrying blaCTX-M-15 recovered from dairy
cow.";
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
[45] {ECO:0000313|EMBL:ORD27060.1, ECO:0000313|Proteomes:UP000192295}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=OS_01_020_10 {ECO:0000313|EMBL:ORD27060.1,
ECO:0000313|Proteomes:UP000192295};
The Broad Institute Genomics Platform;
The Broad Institute Genomic Center for Infectious Diseases;
Earl A., Manson-Mcguire A., Hultgren S., Schreiber H., Chapman S.,
Conover M., Hibbing M., Stapleton A., Roberts P., Hooton T., Young S.,
Abouelleil A., Cao P., Cusick C., Shea T., Nusbaum C., Birren B.;
"The Genome Sequence of Escherichia coli OS_01_020_10.";
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
[46] {ECO:0000313|Proteomes:UP000193168, ECO:0000313|Proteomes:UP000193530, ECO:0000313|Proteomes:UP000197700}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=KCJK1866 {ECO:0000313|EMBL:ORJ74540.1,
ECO:0000313|Proteomes:UP000193168},
KCJK1886 {ECO:0000313|EMBL:OWX89874.1,
ECO:0000313|Proteomes:UP000197700}, and
KCJK2140 {ECO:0000313|EMBL:ORS99860.1,
ECO:0000313|Proteomes:UP000193530};
Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
Dimitrov K.M., Suarez D.L., Swayne D.E.;
Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
[47] {ECO:0000313|EMBL:ARR33299.1, ECO:0000313|Proteomes:UP000194199}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=5CRE51 {ECO:0000313|EMBL:ARR33299.1,
ECO:0000313|Proteomes:UP000194199};
Mu J.-J., Lin Y.-C.;
"Coexistence of MCR-1 and NDM-9 in Escherichia coli clinical isolate
in Taiwan.";
Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
[48] {ECO:0000313|EMBL:ARR58061.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Z1002 {ECO:0000313|EMBL:ARR58061.1};
Song R., Chenine A.L., Ruprecht R.M.;
Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
[49] {ECO:0000313|EMBL:ASG47886.1, ECO:0000313|Proteomes:UP000197584}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ABWA45 {ECO:0000313|EMBL:ASG47886.1,
ECO:0000313|Proteomes:UP000197584};
Zurfluh K., Stephan R., Klumpp J., Hummerjohann J., Bagutti C.,
Marti R.;
"Genome of Escherichia coli isolate ABWA45, an rmtB encoding
wastewater isolate.";
Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Multifunctional enzyme that catalyzes the SAM-dependent
methylations of uroporphyrinogen III at position C-2 and C-7 to
form precorrin-2 via precorrin-1. Then it catalyzes the NAD-
dependent ring dehydrogenation of precorrin-2 to yield
sirohydrochlorin. Finally, it catalyzes the ferrochelation of
sirohydrochlorin to yield siroheme. {ECO:0000256|HAMAP-
Rule:MF_01646, ECO:0000256|SAAS:SAAS00350950}.
-!- CATALYTIC ACTIVITY: Precorrin-2 + NAD(+) = sirohydrochlorin +
NADH. {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000256|SAAS:SAAS00916503}.
-!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + precorrin-1 = S-
adenosyl-L-homocysteine + precorrin-2. {ECO:0000256|HAMAP-
Rule:MF_01646, ECO:0000256|SAAS:SAAS00825977}.
-!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + uroporphyrinogen III
= S-adenosyl-L-homocysteine + precorrin-1. {ECO:0000256|HAMAP-
Rule:MF_01646, ECO:0000256|SAAS:SAAS00825997}.
-!- CATALYTIC ACTIVITY: Siroheme + 2 H(+) = sirohydrochlorin + Fe(2+).
{ECO:0000256|HAMAP-Rule:MF_01646, ECO:0000256|SAAS:SAAS00350854}.
-!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
sirohydrochlorin from precorrin-2: step 1/1. {ECO:0000256|HAMAP-
Rule:MF_01646, ECO:0000256|SAAS:SAAS00350842}.
-!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.
{ECO:0000256|HAMAP-Rule:MF_01646, ECO:0000256|SAAS:SAAS00350909}.
-!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
biosynthesis; siroheme from sirohydrochlorin: step 1/1.
{ECO:0000256|HAMAP-Rule:MF_01646, ECO:0000256|SAAS:SAAS00350918}.
-!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
{ECO:0000256|HAMAP-Rule:MF_01646, ECO:0000256|SAAS:SAAS00916549}.
-!- SIMILARITY: Belongs to the precorrin methyltransferase family.
{ECO:0000256|RuleBase:RU003960}.
-!- SIMILARITY: In the C-terminal section; belongs to the precorrin
methyltransferase family. {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000256|SAAS:SAAS00545078}.
-!- SIMILARITY: In the N-terminal section; belongs to the precorrin-2
dehydrogenase / sirohydrochlorin ferrochelatase family.
{ECO:0000256|HAMAP-Rule:MF_01646, ECO:0000256|SAAS:SAAS00545089}.
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EMBL; EU894120; ACI76681.1; -; Genomic_DNA.
EMBL; EU894121; ACI76682.1; -; Genomic_DNA.
EMBL; EU894122; ACI76683.1; -; Genomic_DNA.
EMBL; EU894123; ACI76684.1; -; Genomic_DNA.
EMBL; EU894124; ACI76685.1; -; Genomic_DNA.
EMBL; CP009104; AIZ84401.1; -; Genomic_DNA.
EMBL; CP010315; AJE57930.1; -; Genomic_DNA.
EMBL; CP007491; ALY14907.1; -; Genomic_DNA.
EMBL; CP015020; AMW43129.1; -; Genomic_DNA.
EMBL; CP017669; APA40281.1; -; Genomic_DNA.
EMBL; CP010122; APJ78748.1; -; Genomic_DNA.
EMBL; CP017631; APT00850.1; -; Genomic_DNA.
EMBL; CP018770; APT60609.1; -; Genomic_DNA.
EMBL; CP021175; ARR33299.1; -; Genomic_DNA.
EMBL; CP021202; ARR58061.1; -; Genomic_DNA.
EMBL; CP022154; ASG47886.1; -; Genomic_DNA.
EMBL; CP012378; ASO77231.1; -; Genomic_DNA.
EMBL; HE964769; CCJ45986.1; -; Genomic_DNA.
EMBL; HG976950; CDU37482.1; -; Genomic_DNA.
EMBL; CXZU01000006; CTR54887.1; -; Genomic_DNA.
EMBL; CYAV01000001; CTS02055.1; -; Genomic_DNA.
EMBL; CYAQ01000005; CTS09653.1; -; Genomic_DNA.
EMBL; CYBF01000028; CTT86346.1; -; Genomic_DNA.
EMBL; CYDH01000001; CTU91130.1; -; Genomic_DNA.
EMBL; CYCX01000021; CTW22455.1; -; Genomic_DNA.
EMBL; CYFX01000020; CTZ57890.1; -; Genomic_DNA.
EMBL; JPQG01000001; KFD78067.1; -; Genomic_DNA.
EMBL; JPKH01000003; KGM71720.1; -; Genomic_DNA.
EMBL; JPKL01000008; KGM83912.1; -; Genomic_DNA.
EMBL; JPMZ01000002; KGM85267.1; -; Genomic_DNA.
EMBL; JZDU01000118; KJW26287.1; -; Genomic_DNA.
EMBL; LEUM01000020; KLX94303.1; -; Genomic_DNA.
EMBL; LEYN01000026; KME66890.1; -; Genomic_DNA.
EMBL; LGZN01000010; KNF71568.1; -; Genomic_DNA.
EMBL; LGZP01000022; KNF79892.1; -; Genomic_DNA.
EMBL; LDYI01000115; KPO09619.1; -; Genomic_DNA.
EMBL; LECN01000109; KPO51901.1; -; Genomic_DNA.
EMBL; LIVE01000009; KQJ17067.1; -; Genomic_DNA.
EMBL; LNIP01000023; KSZ18093.1; -; Genomic_DNA.
EMBL; LOGT01000158; KYS88702.1; -; Genomic_DNA.
EMBL; LOCS01000113; KYV71892.1; -; Genomic_DNA.
EMBL; LCVH01000057; OAC42288.1; -; Genomic_DNA.
EMBL; LXPG01000002; OAJ87409.1; -; Genomic_DNA.
EMBL; LZEH01000223; OEI62143.1; -; Genomic_DNA.
EMBL; MOFD01000008; OJK76454.1; -; Genomic_DNA.
EMBL; MOGU01000011; OJM96950.1; -; Genomic_DNA.
EMBL; MOIL01000027; OJP11240.1; -; Genomic_DNA.
EMBL; MOKI01000044; OJR53036.1; -; Genomic_DNA.
EMBL; MOKZ01000001; OJS91557.1; -; Genomic_DNA.
EMBL; MPGT01000001; OKB91145.1; -; Genomic_DNA.
EMBL; MSEK01000039; OLR88355.1; -; Genomic_DNA.
EMBL; MTKH01000147; ONG27170.1; -; Genomic_DNA.
EMBL; MTPS01000066; ONG36048.1; -; Genomic_DNA.
EMBL; MTFS01000001; OOC85775.1; -; Genomic_DNA.
EMBL; MOZG01000017; OOJ06770.1; -; Genomic_DNA.
EMBL; MPAF01000004; OOK30968.1; -; Genomic_DNA.
EMBL; NCRV01000002; ORD27060.1; -; Genomic_DNA.
EMBL; NAHY01000290; ORJ74540.1; -; Genomic_DNA.
EMBL; NAFT01000070; ORS99860.1; -; Genomic_DNA.
EMBL; NEME01000019; OTB36597.1; -; Genomic_DNA.
EMBL; NBCM01000034; OTE90678.1; -; Genomic_DNA.
EMBL; MUAC01000001; OUK56503.1; -; Genomic_DNA.
EMBL; LYBG01001148; OWD58496.1; -; Genomic_DNA.
EMBL; LYCB01000329; OWE07287.1; -; Genomic_DNA.
EMBL; LYDD01000151; OWE87792.1; -; Genomic_DNA.
EMBL; LYDH01000335; OWF13013.1; -; Genomic_DNA.
EMBL; NBSF01000003; OWS87264.1; -; Genomic_DNA.
EMBL; NACI01000037; OWX89874.1; -; Genomic_DNA.
EMBL; NIIE01000015; OXJ80489.1; -; Genomic_DNA.
EMBL; NIIK01000011; OXK11718.1; -; Genomic_DNA.
EMBL; NIIS01000121; OXK45488.1; -; Genomic_DNA.
EMBL; LEOO01000016; OYC68381.1; -; Genomic_DNA.
RefSeq; WP_000349855.1; NZ_NQEA01000115.1.
STRING; 469008.ECD_03219; -.
EnsemblBacteria; AIZ84401; AIZ84401; HW42_21600.
EnsemblBacteria; AJE57930; AJE57930; AC789_1c37370.
EnsemblBacteria; ALY14907; ALY14907; ACN002_3449.
EnsemblBacteria; ALZ68535; ALZ68535; AWH59_21430.
EnsemblBacteria; AMW43129; AMW43129; ARC77_13220.
EnsemblBacteria; ANM84129; ANM84129; A8V37_17110.
EnsemblBacteria; AOT30916; AOT30916; FORC31_0447.
EnsemblBacteria; CDU37482; CDU37482; PGD_00517.
EnsemblBacteria; CTR54887; CTR54887; ERS085374_01455.
EnsemblBacteria; CTS02055; CTS02055; ERS085366_00167.
EnsemblBacteria; CTS09653; CTS09653; ERS085365_00955.
EnsemblBacteria; CTT86346; CTT86346; ERS085379_03723.
EnsemblBacteria; CTU91130; CTU91130; ERS139211_00061.
EnsemblBacteria; CTW22455; CTW22455; ERS085416_02860.
EnsemblBacteria; CTX82304; CTX82304; ERS139235_03572.
EnsemblBacteria; CTY20685; CTY20685; ERS139269_01308.
EnsemblBacteria; CTY24419; CTY24419; ERS139266_02783.
EnsemblBacteria; CTZ57890; CTZ57890; ERS150873_03036.
EnsemblBacteria; KFD78067; KFD78067; JD73_02710.
EnsemblBacteria; KGM71720; KGM71720; EL75_0328.
EnsemblBacteria; KGM83912; KGM83912; EL80_0339.
EnsemblBacteria; KGM85267; KGM85267; EL79_0346.
EnsemblBacteria; KHH11575; KHH11575; PU69_02050.
EnsemblBacteria; KHI28958; KHI28958; PU33_18820.
EnsemblBacteria; KIG80196; KIG80196; PU38_15855.
EnsemblBacteria; KIH00952; KIH00952; PU21_23035.
EnsemblBacteria; KIH37516; KIH37516; PD07_03460.
EnsemblBacteria; KIQ47587; KIQ47587; IY32_05255.
EnsemblBacteria; KJW26287; KJW26287; UN86_22590.
EnsemblBacteria; KLG76302; KLG76302; WR12_16310.
EnsemblBacteria; KLX91893; KLX91893; SK83_00806.
EnsemblBacteria; KLX94303; KLX94303; SK85_03684.
EnsemblBacteria; KME66890; KME66890; SM09_03621.
EnsemblBacteria; KNF71568; KNF71568; WR15_02785.
EnsemblBacteria; KNF79892; KNF79892; WQ89_11825.
EnsemblBacteria; KPO09619; KPO09619; ACU57_16475.
EnsemblBacteria; KPO51901; KPO51901; ACU90_16060.
EnsemblBacteria; KQJ17067; KQJ17067; AM266_07320.
EnsemblBacteria; KSZ18093; KSZ18093; APU18_01725.
EnsemblBacteria; KXQ42187; KXQ42187; AUQ01_02325.
EnsemblBacteria; KYS88702; KYS88702; AML35_23680.
EnsemblBacteria; KYV71892; KYV71892; AMK83_08135.
EnsemblBacteria; OAC42288; OAC42288; EC3234A_57c00300.
EnsemblBacteria; OAF39104; OAF39104; AXK33_18755.
EnsemblBacteria; OAJ87409; OAJ87409; A5958_12255.
EnsemblBacteria; OCO28937; OCO28937; AN669_0222835.
EnsemblBacteria; ODA85740; ODA85740; A9D65_06600.
EnsemblBacteria; ODH23315; ODH23315; A6804_10975.
EnsemblBacteria; ODH31125; ODH31125; A6803_08835.
EnsemblBacteria; OEG68087; OEG68087; A7H95_05410.
EnsemblBacteria; OEI62143; OEI62143; A9R57_01550.
PATRIC; fig|562.10472.peg.2968; -.
eggNOG; ENOG4105CB8; Bacteria.
eggNOG; COG0007; LUCA.
eggNOG; COG1648; LUCA.
HOGENOM; HOG000290518; -.
UniPathway; UPA00148; UER00222.
UniPathway; UPA00262; UER00211.
UniPathway; UPA00262; UER00222.
UniPathway; UPA00262; UER00376.
Proteomes; UP000028651; Unassembled WGS sequence.
Proteomes; UP000029988; Unassembled WGS sequence.
Proteomes; UP000030000; Unassembled WGS sequence.
Proteomes; UP000030018; Unassembled WGS sequence.
Proteomes; UP000030790; Chromosome.
Proteomes; UP000031522; Chromosome.
Proteomes; UP000033592; Unassembled WGS sequence.
Proteomes; UP000036012; Unassembled WGS sequence.
Proteomes; UP000036405; Unassembled WGS sequence.
Proteomes; UP000036812; Unassembled WGS sequence.
Proteomes; UP000037564; Unassembled WGS sequence.
Proteomes; UP000038112; Unassembled WGS sequence.
Proteomes; UP000040589; Unassembled WGS sequence.
Proteomes; UP000040934; Unassembled WGS sequence.
Proteomes; UP000041959; Unassembled WGS sequence.
Proteomes; UP000042305; Unassembled WGS sequence.
Proteomes; UP000044893; Unassembled WGS sequence.
Proteomes; UP000045242; Unassembled WGS sequence.
Proteomes; UP000050307; Unassembled WGS sequence.
Proteomes; UP000050556; Unassembled WGS sequence.
Proteomes; UP000051850; Unassembled WGS sequence.
Proteomes; UP000053450; Unassembled WGS sequence.
Proteomes; UP000066343; Chromosome.
Proteomes; UP000076106; Unassembled WGS sequence.
Proteomes; UP000076266; Chromosome.
Proteomes; UP000076304; Unassembled WGS sequence.
Proteomes; UP000077380; Unassembled WGS sequence.
Proteomes; UP000077539; Unassembled WGS sequence.
Proteomes; UP000094022; Unassembled WGS sequence.
Proteomes; UP000095183; Unassembled WGS sequence.
Proteomes; UP000177471; Chromosome.
Proteomes; UP000184168; Unassembled WGS sequence.
Proteomes; UP000184277; Unassembled WGS sequence.
Proteomes; UP000184336; Unassembled WGS sequence.
Proteomes; UP000184369; Unassembled WGS sequence.
Proteomes; UP000184379; Chromosome.
Proteomes; UP000184459; Unassembled WGS sequence.
Proteomes; UP000185422; Chromosome.
Proteomes; UP000185501; Chromosome.
Proteomes; UP000185961; Unassembled WGS sequence.
Proteomes; UP000186204; Unassembled WGS sequence.
Proteomes; UP000188724; Unassembled WGS sequence.
Proteomes; UP000188758; Unassembled WGS sequence.
Proteomes; UP000188855; Unassembled WGS sequence.
Proteomes; UP000188967; Unassembled WGS sequence.
Proteomes; UP000188999; Unassembled WGS sequence.
Proteomes; UP000192295; Unassembled WGS sequence.
Proteomes; UP000193168; Unassembled WGS sequence.
Proteomes; UP000193530; Unassembled WGS sequence.
Proteomes; UP000194199; Chromosome.
Proteomes; UP000194247; Unassembled WGS sequence.
Proteomes; UP000194285; Unassembled WGS sequence.
Proteomes; UP000194331; Chromosome.
Proteomes; UP000195107; Unassembled WGS sequence.
Proteomes; UP000196647; Unassembled WGS sequence.
Proteomes; UP000196745; Unassembled WGS sequence.
Proteomes; UP000196822; Unassembled WGS sequence.
Proteomes; UP000196823; Unassembled WGS sequence.
Proteomes; UP000197584; Chromosome.
Proteomes; UP000197700; Unassembled WGS sequence.
Proteomes; UP000197917; Unassembled WGS sequence.
Proteomes; UP000203621; Chromosome.
Proteomes; UP000214591; Unassembled WGS sequence.
Proteomes; UP000214661; Unassembled WGS sequence.
Proteomes; UP000214667; Unassembled WGS sequence.
Proteomes; UP000215493; Unassembled WGS sequence.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-UniRule.
GO; GO:0051266; F:sirohydrochlorin ferrochelatase activity; IEA:UniProtKB-EC.
GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-UniRule.
GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniRule.
GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniRule.
Gene3D; 1.10.8.210; -; 1.
Gene3D; 3.30.950.10; -; 1.
Gene3D; 3.40.1010.10; -; 1.
HAMAP; MF_01646; Siroheme_synth; 1.
InterPro; IPR000878; 4pyrrol_Mease.
InterPro; IPR035996; 4pyrrol_Methylase_sf.
InterPro; IPR014777; 4pyrrole_Mease_sub1.
InterPro; IPR014776; 4pyrrole_Mease_sub2.
InterPro; IPR006366; CobA/CysG_C.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR037115; Sirohaem_synt_dimer_dom_sf.
InterPro; IPR012409; Sirohaem_synth.
InterPro; IPR028281; Sirohaem_synthase_central.
InterPro; IPR019478; Sirohaem_synthase_dimer_dom.
InterPro; IPR006367; Sirohaem_synthase_N.
InterPro; IPR003043; Uropor_MeTrfase_CS.
Pfam; PF10414; CysG_dimeriser; 1.
Pfam; PF13241; NAD_binding_7; 1.
Pfam; PF14824; Sirohm_synth_M; 1.
Pfam; PF00590; TP_methylase; 1.
PIRSF; PIRSF036426; Sirohaem_synth; 1.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF53790; SSF53790; 1.
TIGRFAMs; TIGR01469; cobA_cysG_Cterm; 1.
TIGRFAMs; TIGR01470; cysG_Nterm; 1.
PROSITE; PS00839; SUMT_1; 1.
PROSITE; PS00840; SUMT_2; 1.
3: Inferred from homology;
Cobalamin biosynthesis {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000256|SAAS:SAAS00025873};
Complete proteome {ECO:0000313|Proteomes:UP000028651,
ECO:0000313|Proteomes:UP000029988, ECO:0000313|Proteomes:UP000030000,
ECO:0000313|Proteomes:UP000030018};
Lyase {ECO:0000256|HAMAP-Rule:MF_01646, ECO:0000256|SAAS:SAAS00025919,
ECO:0000313|EMBL:AIZ84401.1};
Methyltransferase {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000256|RuleBase:RU003960, ECO:0000256|SAAS:SAAS00099290,
ECO:0000313|EMBL:ACI76681.1};
Multifunctional enzyme {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000256|SAAS:SAAS00428961};
NAD {ECO:0000256|HAMAP-Rule:MF_01646, ECO:0000256|SAAS:SAAS00916507};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000256|SAAS:SAAS00916534, ECO:0000313|EMBL:AIZ84401.1};
Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_01646};
Porphyrin biosynthesis {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000256|SAAS:SAAS00916529};
S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000256|SAAS:SAAS00099242};
Transferase {ECO:0000256|HAMAP-Rule:MF_01646,
ECO:0000256|RuleBase:RU003960, ECO:0000256|SAAS:SAAS00099290,
ECO:0000313|EMBL:ACI76681.1}.
DOMAIN 6 115 NAD_binding_7.
{ECO:0000259|Pfam:PF13241}.
DOMAIN 119 145 Sirohm_synth_M.
{ECO:0000259|Pfam:PF14824}.
DOMAIN 150 207 CysG_dimeriser.
{ECO:0000259|Pfam:PF10414}.
DOMAIN 218 426 TP_methylase. {ECO:0000259|Pfam:PF00590}.
NP_BIND 22 23 NAD. {ECO:0000256|HAMAP-Rule:MF_01646}.
NP_BIND 43 44 NAD. {ECO:0000256|HAMAP-Rule:MF_01646}.
REGION 1 203 precorrin-2 dehydrogenase /
sirohydrochlorin ferrochelatase.
{ECO:0000256|HAMAP-Rule:MF_01646}.
REGION 216 457 Uroporphyrinogen-III C-methyltransferase.
{ECO:0000256|HAMAP-Rule:MF_01646}.
REGION 301 303 S-adenosyl-L-methionine binding.
{ECO:0000256|HAMAP-Rule:MF_01646}.
REGION 331 332 S-adenosyl-L-methionine binding.
{ECO:0000256|HAMAP-Rule:MF_01646}.
ACT_SITE 248 248 Proton acceptor. {ECO:0000256|HAMAP-
Rule:MF_01646,
ECO:0000256|PIRSR:PIRSR036426-1}.
ACT_SITE 270 270 Proton donor. {ECO:0000256|HAMAP-
Rule:MF_01646,
ECO:0000256|PIRSR:PIRSR036426-1}.
BINDING 225 225 S-adenosyl-L-methionine; via carbonyl
oxygen. {ECO:0000256|HAMAP-
Rule:MF_01646}.
BINDING 306 306 S-adenosyl-L-methionine; via carbonyl
oxygen. {ECO:0000256|HAMAP-
Rule:MF_01646}.
BINDING 382 382 S-adenosyl-L-methionine; via amide
nitrogen. {ECO:0000256|HAMAP-
Rule:MF_01646}.
BINDING 411 411 S-adenosyl-L-methionine; via amide
nitrogen and carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_01646}.
MOD_RES 128 128 Phosphoserine. {ECO:0000256|HAMAP-
Rule:MF_01646}.
SEQUENCE 457 AA; 49951 MW; DDDE0DC90C5CF2F4 CRC64;
MDHLPIFCQL RDRDCLIVGG GDVAERKARL LLDAGARLTV NALAFIPQFT AWADAGMLTL
VEGPFDESLL DTCWLAIAAT DDDALNQRVS EAAEARRIFC NVVDAPKAAS FIMPSIIDRS
PLMVAVSSGG TSPVLARLLR EKLESLLPLH LGQVAKYAGQ LRGRVKQQFA TMGERRRFWE
KLFVNDRLAQ SLANNDQKAI TETTEQLINE PLDHRGEVVL VGAGPGDAGL LTLKGLQQIQ
QADVVVYDRL VSDDIMNLVR RDADRVFVGK RAGYHCVPQE EINQILLREA QKGKRVVRLK
GGDPFIFGRG GEELETLCNA GIPFSVVPGI TAASGCSAYS GIPLTHRDYA QSVRLITGHL
KTGGELDWEN LAAEKQTLVF YMGLNQAATI QQKLIEHGMP GEMPVAIVEN GTAVTQRVID
GTLTQLGELA QQMNSPSLII IGRVVGLRDK LNWFSNH


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