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Sirtuin 1

 H2Q1Z0_PANTR            Unreviewed;       751 AA.
H2Q1Z0; A0A2J8NV92;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
20-JUN-2018, entry version 48.
SubName: Full=SIRT1 isoform 2 {ECO:0000313|EMBL:PNI75678.1};
SubName: Full=Sirtuin 1 {ECO:0000313|Ensembl:ENSPTRP00000004394};
Name=SIRT1 {ECO:0000313|Ensembl:ENSPTRP00000004394,
ECO:0000313|VGNC:VGNC:12502};
ORFNames=CK820_G0008014 {ECO:0000313|EMBL:PNI75678.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000004394, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000004394, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000004394}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:PNI75678.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI75678.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI75678.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSPTRP00000093057}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2018) to UniProtKB.
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EMBL; AC191768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; NBAG03000223; PNI75678.1; -; Genomic_DNA.
RefSeq; XP_003312628.1; XM_003312580.4.
RefSeq; XP_016773875.1; XM_016918386.1.
STRING; 9598.ENSPTRP00000004394; -.
PaxDb; H2Q1Z0; -.
Ensembl; ENSPTRT00000004767; ENSPTRP00000004394; ENSPTRG00000002548.
Ensembl; ENSPTRT00000084295; ENSPTRP00000093057; ENSPTRG00000051532.
GeneID; 107966703; -.
KEGG; ptr:107966703; -.
CTD; 23411; -.
VGNC; VGNC:12502; SIRT1.
eggNOG; KOG2684; Eukaryota.
eggNOG; COG0846; LUCA.
GeneTree; ENSGT00870000136443; -.
InParanoid; H2Q1Z0; -.
KO; K11411; -.
OMA; SDSGTCQ; -.
OrthoDB; EOG091G07CT; -.
TreeFam; TF105896; -.
Proteomes; UP000002277; Chromosome 10.
Bgee; ENSPTRG00000002548; -.
GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
Gene3D; 3.30.1600.10; -; 2.
InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
InterPro; IPR003000; Sirtuin.
InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
InterPro; IPR026590; Ssirtuin_cat_dom.
Pfam; PF02146; SIR2; 1.
SUPFAM; SSF52467; SSF52467; 1.
PROSITE; PS50305; SIRTUIN; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Reference proteome {ECO:0000313|Proteomes:UP000002277}.
DOMAIN 248 502 Deacetylase sirtuin-type.
{ECO:0000259|PROSITE:PS50305}.
SEQUENCE 751 AA; 82031 MW; 4725F7FC4D2937D8 CRC64;
MADEAALALQ PGGSPSAAGA DREAASSPAG EPLRKRPRRD GPGLERSPGE PGGAAPEREV
PAAARGCPGA AAAALWREAE AETAATAAAA GGEQEAQATA AAGEGDNGPG LQGPSREPPL
ADNFYDEDDD DEGEEEEEAA AAAIGYRDNL LFGDEIITNG FHSCESDEED RASHASSSDW
TPRPRIGPYT FVQQHLMIGT DPRTILKDLL PETIPPPELD DMTLWQIVIN ILSEPPKRKK
RKDINTIEDA VKLLQECKKI IVLTGAGVSV SCGIPDFRSR DGIYARLAVD FPDLPDPQAM
FDIEYFRKDP RPFFKFAKEI YPGQFQPSLC HKFIALSDKE GKLLRNYTQN IDTLEQVAGI
QRIIQCHGSF ATASCLICKY KVDCEAVRGD IFNQVVPRCP RCPADEPLAI MKPEIVFFGE
NLPEQFHRAM KYDKDEVDLL IVIGSSLKVR PVALIPSSIP HEVPQILINR EPLPHLHFDV
ELLGDCDVII NELCHRLGGE YAKLCCNPVK LSEITEKPPR TQKELAYLSE LPPTPLHVSE
DSSSPERTSP PDSSVIVTLL DQAAKSNDDL DVSESKGCME EKPQEVQTSR NVESIAEQME
NPDLKNVGSS TGEKNERTSV AGTVRKCWPN RVAKEQISKR LDGNQYLFLP PNRYIFHGAE
VYSDSEDDVL SSSSCGSNSD SGTCQSPSLE EPMEDESEIE EFYNGLEDEP DVPERAGGAG
FGTDGDDQEA INEAISVKQE VTDMNYPSNK S


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