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Small cell adhesion glycoprotein (Small transmembrane and glycosylated protein)

 SMAGP_HUMAN             Reviewed;          97 AA.
Q0VAQ4; A6NIL5;
08-APR-2008, integrated into UniProtKB/Swiss-Prot.
05-SEP-2006, sequence version 1.
23-MAY-2018, entry version 94.
RecName: Full=Small cell adhesion glycoprotein;
AltName: Full=Small transmembrane and glycosylated protein;
Name=SMAGP;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
IDENTIFICATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
GLYCOSYLATION.
PubMed=15021913; DOI=10.1038/sj.onc.1207469;
Tarbe N.G., Rio M.-C., Weidle U.H.;
"SMAGP, a new small trans-membrane glycoprotein altered in cancer.";
Oncogene 23:3395-3403(2004).
[5]
SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=15986429; DOI=10.1002/ijc.21275;
Tarbe N.G., Rio M.-C., Hummel S., Weidle U.H., Zoeller M.;
"Overexpression of the small transmembrane and glycosylated protein
SMAGP supports metastasis formation of a rat pancreatic adenocarcinoma
line.";
Int. J. Cancer 117:913-922(2005).
-!- FUNCTION: May play a role in epithelial cell-cell contacts. May
play a role in tumor invasiveness and metastasis formation.
{ECO:0000269|PubMed:15986429}.
-!- INTERACTION:
O43765:SGTA; NbExp=3; IntAct=EBI-10226799, EBI-347996;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15021913};
Single-pass type III membrane protein {ECO:0000255}. Cytoplasmic
vesicle membrane {ECO:0000269|PubMed:15986429}; Single-pass type
III membrane protein {ECO:0000255}. Note=Predominantly on lateral
parts of the membrane, at cell-cell epithelial junctions
(PubMed:15021913). Detected on cytoplasmic membranes in
undifferentiated tumors (PubMed:15986429).
{ECO:0000269|PubMed:15021913, ECO:0000269|PubMed:15986429}.
-!- TISSUE SPECIFICITY: Detected in breast, endometrium, colon and
biliary tract. Detected in polarized epithelial structures
characterized by cell-cell adhesion (at protein level).
{ECO:0000269|PubMed:15021913}.
-!- PTM: O-glycosylated. The O-glycan is modified with sialic acid
residues. {ECO:0000269|PubMed:15021913}.
-!- SIMILARITY: Belongs to the SMAGP family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AC046135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC139768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471111; EAW58184.1; -; Genomic_DNA.
EMBL; BC008712; AAH08712.2; -; mRNA.
EMBL; BC120965; AAI20966.1; -; mRNA.
EMBL; BC120966; AAI20967.1; -; mRNA.
CCDS; CCDS44889.1; -.
RefSeq; NP_001026798.1; NM_001031628.1.
RefSeq; NP_001029045.1; NM_001033873.1.
UniGene; Hs.652389; -.
ProteinModelPortal; Q0VAQ4; -.
SMR; Q0VAQ4; -.
BioGrid; 121462; 3.
IntAct; Q0VAQ4; 5.
iPTMnet; Q0VAQ4; -.
PhosphoSitePlus; Q0VAQ4; -.
BioMuta; SMAGP; -.
DMDM; 121940462; -.
EPD; Q0VAQ4; -.
MaxQB; Q0VAQ4; -.
PaxDb; Q0VAQ4; -.
PeptideAtlas; Q0VAQ4; -.
PRIDE; Q0VAQ4; -.
TopDownProteomics; Q0VAQ4; -.
Ensembl; ENST00000398453; ENSP00000381471; ENSG00000170545.
Ensembl; ENST00000603798; ENSP00000475068; ENSG00000170545.
Ensembl; ENST00000603864; ENSP00000474892; ENSG00000170545.
GeneID; 57228; -.
KEGG; hsa:57228; -.
UCSC; uc001ryd.2; human.
CTD; 57228; -.
DisGeNET; 57228; -.
EuPathDB; HostDB:ENSG00000170545.16; -.
GeneCards; SMAGP; -.
HGNC; HGNC:26918; SMAGP.
HPA; HPA039711; -.
neXtProt; NX_Q0VAQ4; -.
OpenTargets; ENSG00000170545; -.
PharmGKB; PA165513352; -.
eggNOG; ENOG410J3FG; Eukaryota.
eggNOG; ENOG410ZCM8; LUCA.
GeneTree; ENSGT00390000010077; -.
HOGENOM; HOG000154341; -.
HOVERGEN; HBG100579; -.
InParanoid; Q0VAQ4; -.
OMA; DREKEEY; -.
OrthoDB; EOG091G16WO; -.
PhylomeDB; Q0VAQ4; -.
TreeFam; TF337016; -.
ChiTaRS; SMAGP; human.
GenomeRNAi; 57228; -.
PRO; PR:Q0VAQ4; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000170545; -.
ExpressionAtlas; Q0VAQ4; baseline and differential.
Genevisible; Q0VAQ4; HS.
GO; GO:0030054; C:cell junction; IDA:HPA.
GO; GO:0005913; C:cell-cell adherens junction; IBA:GO_Central.
GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005886; C:plasma membrane; IDA:HPA.
GO; GO:0050839; F:cell adhesion molecule binding; IBA:GO_Central.
GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
GO; GO:0008037; P:cell recognition; IBA:GO_Central.
GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
1: Evidence at protein level;
Cell membrane; Complete proteome; Cytoplasmic vesicle; Glycoprotein;
Membrane; Reference proteome; Sialic acid; Transmembrane;
Transmembrane helix.
CHAIN 1 97 Small cell adhesion glycoprotein.
/FTId=PRO_0000328795.
TOPO_DOM 1 36 Extracellular. {ECO:0000255}.
TRANSMEM 37 57 Helical; Signal-anchor for type III
membrane protein. {ECO:0000255}.
TOPO_DOM 58 97 Cytoplasmic. {ECO:0000255}.
CARBOHYD 2 2 O-linked (GalNAc...) threonine.
{ECO:0000255}.
CARBOHYD 3 3 O-linked (GalNAc...) serine.
{ECO:0000255}.
CARBOHYD 6 6 O-linked (GalNAc...) threonine.
{ECO:0000255}.
CARBOHYD 7 7 O-linked (GalNAc...) threonine.
{ECO:0000255}.
CARBOHYD 9 9 O-linked (GalNAc...) serine.
{ECO:0000255}.
CARBOHYD 16 16 O-linked (GalNAc...) threonine.
{ECO:0000255}.
CARBOHYD 17 17 O-linked (GalNAc...) threonine.
{ECO:0000255}.
CARBOHYD 23 23 O-linked (GalNAc...) threonine.
{ECO:0000255}.
SEQUENCE 97 AA; 10679 MW; 90BC88F950B94904 CRC64;
MTSLLTTPSP REELMTTPIL QPTEALSPED GASTALIAVV ITVVFLTLLS VVILIFFYLY
KNKGSYVTYE PTEGEPSAIV QMESDLAKGS EKEEYFI


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