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Small nuclear protein PRAC1 (Prostate cancer susceptibility candidate protein 1) (Prostate, rectum and colon expressed gene protein)

 PRAC1_HUMAN             Reviewed;          57 AA.
Q96KF2;
04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
20-JUN-2018, entry version 92.
RecName: Full=Small nuclear protein PRAC1;
AltName: Full=Prostate cancer susceptibility candidate protein 1;
AltName: Full=Prostate, rectum and colon expressed gene protein;
Name=PRAC1; Synonyms=C17orf92, PRAC;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
TISSUE=Prostate;
PubMed=11340635; DOI=10.1002/pros.1055;
Liu X.F., Olsson P., Wolfgang C.D., Bera T.K., Duray P., Lee B.,
Pastan I.;
"PRAC: a novel small nuclear protein that is specifically expressed in
human prostate and colon.";
Prostate 47:125-131(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11340635}.
-!- TISSUE SPECIFICITY: Highly expressed in prostate, rectum, and
distal colon, and weakly expressed in bladder. Expressed in
prostate cancer cell lines. {ECO:0000269|PubMed:11340635}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF331165; AAK38837.1; -; mRNA.
EMBL; AC091179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471109; EAW94717.1; -; Genomic_DNA.
EMBL; BC030950; AAH30950.1; -; mRNA.
CCDS; CCDS11535.1; -.
RefSeq; NP_115767.1; NM_032391.2.
UniGene; Hs.116467; -.
ProteinModelPortal; Q96KF2; -.
STRING; 9606.ENSP00000290294; -.
iPTMnet; Q96KF2; -.
PhosphoSitePlus; Q96KF2; -.
BioMuta; PRAC1; -.
PaxDb; Q96KF2; -.
PRIDE; Q96KF2; -.
ProteomicsDB; 77065; -.
Ensembl; ENST00000290294; ENSP00000290294; ENSG00000159182.
GeneID; 84366; -.
KEGG; hsa:84366; -.
UCSC; uc002iny.4; human.
CTD; 84366; -.
DisGeNET; 84366; -.
EuPathDB; HostDB:ENSG00000159182.4; -.
GeneCards; PRAC1; -.
HGNC; HGNC:30591; PRAC1.
HPA; HPA047871; -.
MIM; 609819; gene.
neXtProt; NX_Q96KF2; -.
OpenTargets; ENSG00000159182; -.
PharmGKB; PA164725009; -.
eggNOG; ENOG410IV1Y; Eukaryota.
eggNOG; ENOG4110PPZ; LUCA.
GeneTree; ENSGT00390000010034; -.
HOGENOM; HOG000115683; -.
InParanoid; Q96KF2; -.
OMA; CNSRILG; -.
OrthoDB; EOG091G17TI; -.
PhylomeDB; Q96KF2; -.
TreeFam; TF341666; -.
GenomeRNAi; 84366; -.
PRO; PR:Q96KF2; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000159182; -.
CleanEx; HS_PRAC; -.
Genevisible; Q96KF2; HS.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
2: Evidence at transcript level;
Complete proteome; Nucleus; Polymorphism; Reference proteome.
CHAIN 1 57 Small nuclear protein PRAC1.
/FTId=PRO_0000312417.
VARIANT 4 4 A -> V (in dbSNP:rs34734055).
/FTId=VAR_051285.
SEQUENCE 57 AA; 5959 MW; A460DC3FDAB1A49D CRC64;
MLCAHFSDQG PAHLTTSKSA FLSNKKTSTL KHLLGETRSD GSACNSGISG GRGRKIP


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