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Small nuclear protein PRAC1 (Prostate cancer susceptibility candidate protein 1) (Prostate, rectum and colon expressed gene protein)

 PRAC1_HUMAN             Reviewed;          57 AA.
04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
16-JAN-2019, entry version 95.
RecName: Full=Small nuclear protein PRAC1;
AltName: Full=Prostate cancer susceptibility candidate protein 1;
AltName: Full=Prostate, rectum and colon expressed gene protein;
Name=PRAC1; Synonyms=C17orf92, PRAC;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
PubMed=11340635; DOI=10.1002/pros.1055;
Liu X.F., Olsson P., Wolfgang C.D., Bera T.K., Duray P., Lee B.,
Pastan I.;
"PRAC: a novel small nuclear protein that is specifically expressed in
human prostate and colon.";
Prostate 47:125-131(2001).
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11340635}.
-!- TISSUE SPECIFICITY: Highly expressed in prostate, rectum, and
distal colon, and weakly expressed in bladder. Expressed in
prostate cancer cell lines. {ECO:0000269|PubMed:11340635}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AF331165; AAK38837.1; -; mRNA.
EMBL; AC091179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471109; EAW94717.1; -; Genomic_DNA.
EMBL; BC030950; AAH30950.1; -; mRNA.
CCDS; CCDS11535.1; -.
RefSeq; NP_115767.1; NM_032391.2.
UniGene; Hs.116467; -.
ProteinModelPortal; Q96KF2; -.
STRING; 9606.ENSP00000290294; -.
iPTMnet; Q96KF2; -.
PhosphoSitePlus; Q96KF2; -.
BioMuta; PRAC1; -.
PaxDb; Q96KF2; -.
PRIDE; Q96KF2; -.
ProteomicsDB; 77065; -.
Ensembl; ENST00000290294; ENSP00000290294; ENSG00000159182.
GeneID; 84366; -.
KEGG; hsa:84366; -.
UCSC; uc002iny.4; human.
CTD; 84366; -.
DisGeNET; 84366; -.
EuPathDB; HostDB:ENSG00000159182.4; -.
GeneCards; PRAC1; -.
HGNC; HGNC:30591; PRAC1.
HPA; HPA047871; -.
MIM; 609819; gene.
neXtProt; NX_Q96KF2; -.
OpenTargets; ENSG00000159182; -.
PharmGKB; PA164725009; -.
eggNOG; ENOG410IV1Y; Eukaryota.
GeneTree; ENSGT00940000165611; -.
HOGENOM; HOG000115683; -.
InParanoid; Q96KF2; -.
OrthoDB; 1422494at2759; -.
PhylomeDB; Q96KF2; -.
TreeFam; TF341666; -.
GenomeRNAi; 84366; -.
PRO; PR:Q96KF2; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000159182; Expressed in 41 organ(s), highest expression level in mucosa of sigmoid colon.
CleanEx; HS_PRAC; -.
Genevisible; Q96KF2; HS.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
2: Evidence at transcript level;
Complete proteome; Nucleus; Polymorphism; Reference proteome.
CHAIN 1 57 Small nuclear protein PRAC1.
VARIANT 4 4 A -> V (in dbSNP:rs34734055).
SEQUENCE 57 AA; 5959 MW; A460DC3FDAB1A49D CRC64;

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