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Small rubber particle protein (HbSRPP) (22 kDa rubber particle protein) (22 kDa RPP) (27 kDa natural rubber allergen) (Latex allergen Hev b 3) (allergen Hev b 3)

 SRPP_HEVBR              Reviewed;         204 AA.
O82803; Q9S8I3; Q9S8I4; Q9S8I5; Q9S9G7;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
12-APR-2017, entry version 77.
RecName: Full=Small rubber particle protein {ECO:0000303|PubMed:10358068};
Short=HbSRPP {ECO:0000303|PubMed:10358068};
AltName: Full=22 kDa rubber particle protein;
Short=22 kDa RPP;
AltName: Full=27 kDa natural rubber allergen;
AltName: Full=Latex allergen Hev b 3 {ECO:0000303|PubMed:8828541};
AltName: Allergen=Hev b 3 {ECO:0000303|PubMed:8828541};
Name=SRPP {ECO:0000303|PubMed:10358068};
Synonyms=HEVB3 {ECO:0000303|PubMed:8828541};
Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae;
Crotonoideae; Micrandreae; Hevea.
NCBI_TaxID=3981;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND FUNCTION.
STRAIN=cv. RRIM 600; TISSUE=Latex;
PubMed=10358068; DOI=10.1074/jbc.274.24.17132;
Oh S.K., Kang H., Shin D.H., Yang J., Chow K.-S., Yeang H.Y.,
Wagner B., Breiteneder H., Han K.-H.;
"Isolation, characterization, and functional analysis of a novel cDNA
clone encoding a small rubber particle protein from Hevea
brasiliensis.";
J. Biol. Chem. 274:17132-17138(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. RRIM 600; TISSUE=Latex;
PubMed=10550757; DOI=10.1016/S0091-6749(99)70093-X;
Wagner B., Krebitz M., Buck D., Niggemann B., Yeang H.Y., Han K.-H.,
Scheiner O., Breiteneder H.;
"Cloning, expression, and characterization of recombinant Hev b 3, a
Hevea brasiliensis protein associated with latex allergy in patients
with spina bifida.";
J. Allergy Clin. Immunol. 104:1084-1092(1999).
[3]
PROTEIN SEQUENCE OF 12-17; 23-31; 36-50; 54-68; 73-86; 91-104;
106-123; 125-143 AND 175-192.
TISSUE=Latex;
PubMed=7888787;
Alenius H., Kalkkinen N., Lukka M., Turjanmaa K., Reunala T.,
Maekinen-Kiljunen S., Palosuo T.;
"Purification and partial amino acid sequencing of a 27-kD natural
rubber allergen recognized by latex-allergic children with spina
bifida.";
Int. Arch. Allergy Immunol. 106:258-262(1995).
[4]
PROTEIN SEQUENCE OF 8-33; 36-49; 54-68; 73-90 AND 178-194.
TISSUE=Latex;
PubMed=7650400;
Lu L.-J., Kurup V.P., Hoffman D.R., Kelly K.J., Murali P.S.,
Fink J.N.;
"Characterization of a major latex allergen associated with
hypersensitivity in spina bifida patients.";
J. Immunol. 155:2721-2728(1995).
[5]
PROTEIN SEQUENCE OF 18-35; 54-68; 73-90; 106-122 AND 183-194, AND MASS
SPECTROMETRY.
STRAIN=cv. Costa Rica, and cv. RRIM 600; TISSUE=Latex;
PubMed=9636811; DOI=10.1111/j.1398-9995.1998.tb04089.x;
Yeang H.Y., Ward M.A., Zamri A.S.M., Dennis M.S., Light D.R.;
"Amino acid sequence similarity of Hev b 3 to two previously reported
27- and 23-kDa latex proteins allergenic to spina bifida patients.";
Allergy 53:513-519(1998).
[6]
ALLERGEN.
PubMed=8828541; DOI=10.1016/S0091-6749(96)70097-0;
Yeang H.Y., Cheong K.F., Sunderasan E., Hamzah S., Chew N.P.,
Hamid S., Hamilton R.G., Cardosa M.J.;
"The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3)
rubber particle proteins are recognized by IgE from patients with
spina bifida and latex allergy.";
J. Allergy Clin. Immunol. 98:628-639(1996).
[7]
EPITOPE MAPPING.
PubMed=11275264; DOI=10.1016/S0161-5890(00)00095-X;
Banerjee B., Kanitpong K., Fink J.N., Zussman M., Sussman G.L.,
Kelly K.J., Kurup V.P.;
"Unique and shared IgE epitopes of Hev b 1 and Hev b 3 in latex
allergy.";
Mol. Immunol. 37:789-798(2000).
[8]
INDUCTION.
PubMed=12461132; DOI=10.1093/pcp/pcf161;
Sookmark U., Pujade-Renaud V., Chrestin H., Lacote R., Naiyanetr C.,
Seguin M., Romruensukharom P., Narangajavana J.;
"Characterization of polypeptides accumulated in the latex cytosol of
rubber trees affected by the tapping panel dryness syndrome.";
Plant Cell Physiol. 43:1323-1333(2002).
[9]
TISSUE SPECIFICITY.
PubMed=19415323; DOI=10.1007/s00425-009-0936-0;
Sando T., Hayashi T., Takeda T., Akiyama Y., Nakazawa Y., Fukusaki E.,
Kobayashi A.;
"Histochemical study of detailed laticifer structure and rubber
biosynthesis-related protein localization in Hevea brasiliensis using
spectral confocal laser scanning microscopy.";
Planta 230:215-225(2009).
[10]
INDUCTION BY ETHYLENE.
PubMed=22162870; DOI=10.1093/jxb/err363;
Chow K.S., Mat-Isa M.N., Bahari A., Ghazali A.K., Alias H.,
Mohd-Zainuddin Z., Hoh C.C., Wan K.L.;
"Metabolic routes affecting rubber biosynthesis in Hevea brasiliensis
latex.";
J. Exp. Bot. 63:1863-1871(2012).
[11]
SUBCELLULAR LOCATION.
PubMed=24036080; DOI=10.1016/j.bbamem.2013.08.025;
Berthelot K., Lecomte S., Estevez Y., Zhendre V., Henry S.,
Thevenot J., Dufourc E.J., Alves I.D., Peruch F.;
"Rubber particle proteins, HbREF and HbSRPP, show different
interactions with model membranes.";
Biochim. Biophys. Acta 1838:287-299(2014).
[12]
SUBUNIT, AND LACK OF GLYCOSYLATION.
PubMed=24239687; DOI=10.1016/j.bbapap.2013.10.017;
Berthelot K., Lecomte S., Estevez Y., Coulary-Salin B., Peruch F.;
"Homologous Hevea brasiliensis REF (Hevb1) and SRPP (Hevb3) present
different auto-assembling.";
Biochim. Biophys. Acta 1844:473-485(2014).
[13]
REVIEW.
PubMed=25019490; DOI=10.1016/j.biochi.2014.07.002;
Berthelot K., Lecomte S., Estevez Y., Peruch F.;
"Hevea brasiliensis REF (Hev b 1) and SRPP (Hev b 3): An overview on
rubber particle proteins.";
Biochimie 106:1-9(2014).
-!- FUNCTION: Involved in the biosynthesis of rubber, an isoprenoid
polymer (cis-1,4-polyisoprene). {ECO:0000269|PubMed:10358068}.
-!- SUBUNIT: Auto-assembles in solution into stable nanomultimers of a
globular nature. {ECO:0000269|PubMed:24239687}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24036080}.
Note=Found in latex, the cytoplasm of laticifer cells. Tightly
bound to small rubber particles, where it displays a covering
effect on the lipid headgroups of the membrane without disturbing
its integrity. {ECO:0000269|PubMed:24036080}.
-!- TISSUE SPECIFICITY: Highly expressed in the specialized vessel
laticifers, but localized only in the laticifer layers in the
conducting phloem (PubMed:10358068, PubMed:19415323). Also
detected in leaves (PubMed:10358068).
{ECO:0000269|PubMed:10358068, ECO:0000269|PubMed:19415323}.
-!- INDUCTION: Induced by tapping (PubMed:12461132). Not induced by
wounding, ethephon or abscisic acid treatment (PubMed:12461132).
Induced by ethylene (PubMed:22162870).
{ECO:0000269|PubMed:12461132, ECO:0000269|PubMed:22162870}.
-!- PTM: Not glycosylated. {ECO:0000269|PubMed:24239687}.
-!- PTM: The N-terminus is blocked. {ECO:0000269|PubMed:7888787}.
-!- PTM: Consistent shifts of about 266 Da observed by MS in various
forms of the intact protein suggest the addition of stearolyl
groups. {ECO:0000305|PubMed:9636811}.
-!- MASS SPECTROMETRY: Mass=22258; Method=Electrospray; Range=1-204;
Evidence={ECO:0000269|PubMed:9636811};
-!- MASS SPECTROMETRY: Mass=22524; Method=Electrospray; Range=1-204;
Evidence={ECO:0000269|PubMed:9636811};
-!- MASS SPECTROMETRY: Mass=22791; Method=Electrospray; Range=1-204;
Evidence={ECO:0000269|PubMed:9636811};
-!- MASS SPECTROMETRY: Mass=23058; Method=Electrospray; Range=1-204;
Evidence={ECO:0000269|PubMed:9636811};
-!- ALLERGEN: Causes an allergic reaction in human. Involved in latex
allergic reactions. Major spina bifida (SB) associated latex
allergen. Patients with SB are especially sensitive to specific
allergens that do not usually affect adult patients without SB who
are otherwise sensitive to latex. These patients are multioperated
patients, whose mucosal membranes have been frequently in contact
with latex products. Many patients with SB are sensitized to low
molecular weight polypeptides derived from the fragmentation of
Hev b 3. {ECO:0000269|PubMed:8828541}.
-!- SIMILARITY: Belongs to the REF/SRPP family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=Gloves, condoms and
bouncy balls - Issue 13 of August 2001;
URL="http://web.expasy.org/spotlight/back_issues/013";
-----------------------------------------------------------------------
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EMBL; AF051317; AAC82355.1; -; mRNA.
EMBL; AJ223388; CAA11303.1; -; mRNA.
EMBL; AJ223389; CAA11304.1; -; mRNA.
EMBL; AJ223390; CAA11305.1; -; mRNA.
PIR; T10766; T10766.
ProteinModelPortal; O82803; -.
Allergome; 3314; Hev b 3.0101.
Allergome; 387; Hev b 3.
PRIDE; O82803; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
InterPro; IPR008802; REF.
PANTHER; PTHR33732; PTHR33732; 1.
Pfam; PF05755; REF; 1.
1: Evidence at protein level;
Allergen; Cytoplasm; Direct protein sequencing.
CHAIN 1 204 Small rubber particle protein.
/FTId=PRO_0000221061.
CONFLICT 39 39 G -> Y (in Ref. 4; AA sequence).
{ECO:0000305}.
CONFLICT 44 44 G -> P (in Ref. 4; AA sequence).
{ECO:0000305}.
CONFLICT 49 49 E -> K (in Ref. 4; AA sequence).
{ECO:0000305}.
CONFLICT 78 78 V -> P (in Ref. 5; AA sequence).
{ECO:0000305}.
CONFLICT 78 78 V -> T (in Ref. 5; AA sequence).
{ECO:0000305}.
CONFLICT 118 122 GVQEG -> RKEKK (in Ref. 5; AA sequence).
{ECO:0000305}.
CONFLICT 192 192 T -> G (in Ref. 3; AA sequence).
{ECO:0000305}.
SEQUENCE 204 AA; 22345 MW; 2A3BAE7D8325D833 CRC64;
MAEEVEEERL KYLDFVRAAG VYAVDSFSTL YLYAKDISGP LKPGVDTIEN VVKTVVTPVY
YIPLEAVKFV DKTVDVSVTS LDGVVPPVIK QVSAQTYSVA QDAPRIVLDV ASSVFNTGVQ
EGAKALYANL EPKAEQYAVI TWRALNKLPL VPQVANVVVP TAVYFSEKYN DVVRGTTEQG
YRVSSYLPLL PTEKITKVFG DEAS


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