GENTAUR Molecular Products.
Monoclonal Antibody, ELISA Kit, Polyclonal Antibody, Recombinant/Purified Protein.Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery
Snaclec jerdonibitin subunit alpha (TJ-GPIb-bp subunit alpha)
SLA_PROJR Reviewed; 156 AA.
D1MGU0;
29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
19-JAN-2010, sequence version 1.
20-DEC-2017, entry version 29.
RecName: Full=Snaclec jerdonibitin subunit alpha;
AltName: Full=TJ-GPIb-bp subunit alpha;
Flags: Precursor;
Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae;
Protobothrops.
NCBI_TaxID=242841;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-44, FUNCTION, AND
SUBUNIT.
TISSUE=Venom, and Venom gland;
PubMed=21256857; DOI=10.1016/j.toxicon.2011.01.010;
Chen Z., Wu J., Zhang Y., Yang X., Yu G., Zhu S., Lee W., Lu Q.,
Zhang Y.;
"A novel platelet glycoprotein Ib-binding protein with human platelet
aggregation-inhibiting activity from Trimeresurus jerdonii venom.";
Toxicon 57:672-679(2011).
-!- FUNCTION: Snaclec that dose-dependently inhibits platelet
aggregation induced by ristocetin or low-dose thrombin, but not by
high-dose thrombin. Binds to GPIbalpha (GP1BA). In vivo, also
dose-dependently induces thrombocytopenia of mice and platelet
counts remains at very low level even after 18 hours intravenous
injection. {ECO:0000269|PubMed:21256857}.
-!- SUBUNIT: Heterodimer of subunits alpha and beta; disulfide-linked.
{ECO:0000269|PubMed:21256857}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- MISCELLANEOUS: Does not induce platelet aggregation in either
platelet rich plasma or washed platelets under high-dose
conditions. Does not inhibit platelet aggregation induced by high-
dose thrombin. Does not react with polyclonal anti-GPVI and anti-
GPIIb antibodies (PubMed:21256857). {ECO:0000305|PubMed:21256857}.
-!- SIMILARITY: Belongs to the snaclec family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; GU146049; ACZ34293.1; -; mRNA.
ProteinModelPortal; D1MGU0; -.
SMR; D1MGU0; -.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0044218; C:other organism cell membrane; IDA:UniProtKB.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0044477; P:envenomation resulting in negative regulation of platelet aggregation in other organism; IDA:UniProtKB.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR018378; C-type_lectin_CS.
InterPro; IPR016187; CTDL_fold.
Pfam; PF00059; Lectin_C; 1.
SMART; SM00034; CLECT; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Hemostasis impairing toxin;
Platelet aggregation inhibiting toxin; Secreted; Signal; Toxin.
SIGNAL 1 23 {ECO:0000269|PubMed:21256857}.
CHAIN 24 156 Snaclec jerdonibitin subunit alpha.
/FTId=PRO_0000422430.
DOMAIN 32 151 C-type lectin. {ECO:0000255|PROSITE-
ProRule:PRU00040}.
DISULFID 25 36 {ECO:0000255|PROSITE-ProRule:PRU00040}.
DISULFID 53 150 {ECO:0000255|PROSITE-ProRule:PRU00040}.
DISULFID 102 102 Interchain (with C-98 in subunit beta).
{ECO:0000255|PROSITE-ProRule:PRU00040}.
DISULFID 125 142 {ECO:0000255|PROSITE-ProRule:PRU00040}.
SEQUENCE 156 AA; 18146 MW; 80129F2F8EEBC86E CRC64;
MGRFIFVSFG LLVVFLSLSG TGADCPFDWS SFRQYCYRVF KQLKTWEDAE RFCSEQVKGA
RLVSIESYRE AVFVAQLLSE NIKATKSHVW IGLSVENKGQ QCSSKWSDGS SVSYENLVKP
FSKKCFVLKK ESEFHKWFNV YCGQQHLFMC KFLRPR
Related products :
GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45
Fax 0032 16 50 90 45
info@gentaur.com | Gentaur
GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur
GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50
Fax 01 43 25 01 60
RCS Paris B 484 237 888
SIRET 48423788800017
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
france@gentaur.com | Gentaur
GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88
Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur
GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com
Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123
GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel: 0208-080893 Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62 SWIFT RABONL2U
GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur
ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF
GENTAUR Poland Sp. z o.o.
ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX 058 710 33 48
poland@gentaur.com | Gentaur
Other countries
Österreich +43720880899
Canada Montreal +15149077481
Ceská republika Praha +420246019719
Danmark +4569918806
Finland Helsset +358942419041
Magyarország Budapest +3619980547
Ireland Dublin+35316526556
Luxembourg+35220880274
Norge Oslo+4721031366
Sverige Stockholm+46852503438
Schweiz Züri+41435006251
US New York+17185132983
GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo
Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur
Pathways :
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP1003: Ovarian Infertility Genes
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1120: Ovarian Infertility Genes
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1340: Ovarian Infertility Genes
WP1369: TNF-alpha NF-kB Signaling Pathway
WP1434: Osteopontin Signaling
WP1487: TNF-alpha and mucus production in lung epythelium
WP1531: Vitamin D synthesis
WP1571: EBV LMP1 signaling
WP1584: Type II diabetes mellitus
WP1618: alpha-Linolenic acid metabolism
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism
WP1644: DNA replication
WP1663: Homologous recombination
WP1671: Methane metabolism
WP1672: Mismatch repair
WP1680: Oxidative phosphorylation
Related Genes :
[LC1] Snaclec coagulation factor X-activating enzyme light chain 1 (C-type lectin-like protein subunit 2) (Coagulation factor X-activating enzyme gamma-chain) (RVV-X light chain 1)
[LC2] Snaclec coagulation factor X-activating enzyme light chain 2 (C-type lectin-like protein subunit 1) (Coagulation factor X-activating enzyme beta-chain) (RVV-X light chain 2)
[] Snaclec coagulation factor IX/factor X-binding protein subunit B (IX/X-bp subunit B)
[LC1] Snaclec coagulation factor X-activating enzyme light chain 1 (VL factor X activator light chain 1) (VLFXA light chain 1) [Cleaved into: Snaclec coagulation factor X-activating enzyme light chain 1 alternate form]
[] Snaclec EMS16 subunit beta (EMS16B)
[] Snaclec bothrojaracin subunit beta (BJC subunit beta)
[] Snaclec jerdonibitin subunit beta (TJ-GPIb-bp subunit beta)
[] Snaclec jerdonibitin subunit alpha (TJ-GPIb-bp subunit alpha)
[] Snaclec bothrojaracin subunit alpha (BJC subunit alpha)
[] Snaclec coagulation factor IX/factor X-binding protein subunit A (IX/X-bp subunit A)
[] Snaclec agkisacutacin subunit A (Agk-A)
[] Snaclec mucetin subunit alpha (Trimeresurus mucrosquamatus venom activator subunit alpha) (TMVA subunit alpha)
[] Snaclec mucetin subunit beta (Trimeresurus mucrosquamatus venom activator subunit beta) (TMVA subunit beta)
[] Snaclec EMS16 subunit alpha (EMS16A)
[] Snaclec rhodocytin subunit beta (Aggretin beta chain) (Rhodoaggretin subunit beta)
[] Snaclec alboluxin subunit beta (Fragment)
[] Snaclec anticoagulant protein subunit A (AaACP-A)
[] Snaclec mamushigin subunit beta
[] Snaclec mamushigin subunit alpha
[] Snaclec rhodocetin subunit alpha
[] Snaclec agglucetin subunit alpha-1 (Agkisacucetin subunit alpha)
[] Snaclec agglucetin subunit beta-2 (Antithrombin 1 chain B)
[] Snaclec anticoagulant protein subunit B (AaACP-B) (ACF 1/2 B-chain) (Agkisasin-b)
[] Snaclec coagulation factor IX-binding protein subunit A (IX-bp subunit A)
[] Snaclec lebecin subunit beta
[] Snaclec botrocetin subunit alpha (Platelet coagglutinin)
[] Snaclec botrocetin subunit beta (Platelet coagglutinin)
[] Snaclec rhodocytin subunit alpha (Aggretin alpha chain) (Rhodoaggretin subunit alpha)
[] Snaclec alboaggregin-D subunit beta
[] Snaclec rhodocetin subunit beta
Bibliography :
No related Items
Enter catalog number :
Favorites Pages:
No Favorits