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Snake venom metalloproteinase HT-1 (SVMP) (EC 3.4.24.-) (Hemorrhagic metalloproteinase HT-1) (Hemorrhagic toxin I) (Fragment)

 VM3H1_CRORU             Reviewed;         216 AA.
Q9PSN7;
13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
22-NOV-2017, entry version 79.
RecName: Full=Snake venom metalloproteinase HT-1;
Short=SVMP;
EC=3.4.24.-;
AltName: Full=Hemorrhagic metalloproteinase HT-1;
AltName: Full=Hemorrhagic toxin I;
Flags: Fragment;
Crotalus ruber ruber (Red diamond rattlesnake).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
NCBI_TaxID=8736 {ECO:0000305};
[1] {ECO:0000305}
PROTEIN SEQUENCE.
TISSUE=Venom {ECO:0000269|PubMed:8514736};
PubMed=8514736;
Takeya H., Nishida S., Nishino N., Makinose Y., Omori-Satoh T.,
Nikai T., Sugihara H., Iwanaga S.;
"Primary structures of platelet aggregation inhibitors (disintegrins)
autoproteolytically released from snake venom hemorrhagic
metalloproteinases and new fluorogenic peptide substrates for these
enzymes.";
J. Biochem. 113:473-483(1993).
-!- FUNCTION: Zinc protease from snake venom that induces hemorrhage.
{ECO:0000250}.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Binds 1 zinc ion per subunit. {ECO:0000250};
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- SIMILARITY: Belongs to the venom metalloproteinase (M12B) family.
P-III subfamily. P-IIIa sub-subfamily. {ECO:0000305}.
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PIR; JX0265; JX0265.
ProteinModelPortal; Q9PSN7; -.
SMR; Q9PSN7; -.
HOVERGEN; HBG006978; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0008237; F:metallopeptidase activity; IDA:UniProtKB.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0007596; P:blood coagulation; TAS:UniProtKB.
Gene3D; 4.10.70.10; -; 1.
InterPro; IPR006586; ADAM_Cys-rich.
InterPro; IPR018358; Disintegrin_CS.
InterPro; IPR001762; Disintegrin_dom.
InterPro; IPR036436; Disintegrin_dom_sf.
Pfam; PF08516; ADAM_CR; 1.
Pfam; PF00200; Disintegrin; 1.
PRINTS; PR00289; DISINTEGRIN.
SMART; SM00608; ACR; 1.
SMART; SM00050; DISIN; 1.
SUPFAM; SSF57552; SSF57552; 1.
PROSITE; PS00427; DISINTEGRIN_1; 1.
PROSITE; PS50214; DISINTEGRIN_2; 1.
1: Evidence at protein level;
Calcium; Direct protein sequencing; Disulfide bond; Glycoprotein;
Hemorrhagic toxin; Hemostasis impairing toxin; Hydrolase;
Metal-binding; Metalloprotease; Protease; Secreted; Toxin; Zinc.
CHAIN <1 216 Snake venom metalloproteinase HT-1.
/FTId=PRO_0000078190.
DOMAIN 8 94 Disintegrin. {ECO:0000255|PROSITE-
ProRule:PRU00068}.
MOTIF 72 74 D/ECD-tripeptide.
COMPBIAS 95 216 Cys-rich.
METAL 10 10 Calcium; via carbonyl oxygen.
{ECO:0000250}.
METAL 13 13 Calcium. {ECO:0000250}.
METAL 15 15 Calcium; via carbonyl oxygen.
{ECO:0000250}.
METAL 17 17 Calcium. {ECO:0000250}.
METAL 20 20 Calcium. {ECO:0000250}.
METAL 23 23 Calcium. {ECO:0000250}.
CARBOHYD 175 175 N-linked (GlcNAc...) asparagine.
{ECO:0000305}.
DISULFID 11 40 {ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 22 35 {ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 24 30 {ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 34 57 {ECO:0000250|UniProtKB:P20164,
ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 48 54 {ECO:0000250|UniProtKB:P20164,
ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 53 79 {ECO:0000250|UniProtKB:P20164,
ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 66 86 {ECO:0000250|UniProtKB:P20164,
ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 73 105 {ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 98 110 {ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 117 167 {ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 132 178 {ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 145 155 {ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 162 204 {ECO:0000255|PROSITE-ProRule:PRU00068}.
DISULFID 198 209 {ECO:0000255|PROSITE-ProRule:PRU00068}.
NON_TER 1 1
SEQUENCE 216 AA; 23601 MW; 5149F3453E87CE10 CRC64;
LGTDIISPPV CGNELLEVGE ECDCGFPRNC RDPCCDATTC KLHSWVECES GECCGQCKFT
SAGNECRPAR SECDIAESCT GQSADCPMDD FHRNGQPCLN NFGYCYNGNC PILYHQCYAL
FGSNVYEAED SCFERNQKGD DDGYCRKENG EKIPCAPEDV KCGRLYCKDN SPGPNDSCKT
FNSNEDDHKE MVLPGTKCAD GKVCSNGHCV DVASAY


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