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Sodium/glucose cotransporter 1 (Na( )/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)

 SC5A1_RAT               Reviewed;         665 AA.
P53790; P97787;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
23-MAY-2018, entry version 131.
RecName: Full=Sodium/glucose cotransporter 1;
Short=Na(+)/glucose cotransporter 1;
AltName: Full=High affinity sodium-glucose cotransporter;
AltName: Full=Solute carrier family 5 member 1;
Name=Slc5a1; Synonyms=Sglt1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Kidney;
PubMed=8163506;
Lee W.S., Kanai Y., Wells R.G., Hediger M.A.;
"The high affinity Na+/glucose cotransporter. Re-evaluation of
function and distribution of expression.";
J. Biol. Chem. 269:12032-12039(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Kasahara M., Mori K.;
Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Jejunum;
PubMed=9214758; DOI=10.1271/bbb.61.979;
Aoshima H., Yokoyama T., Tanizaki J., Izu H., Yamada M.;
"The sugar specificity of Na+/glucose cotransporter from rat
jejunum.";
Biosci. Biotechnol. Biochem. 61:979-983(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Actively transports glucose into cells by Na(+)
cotransport with a Na(+) to glucose coupling ratio of 2:1.
Efficient substrate transport in mammalian kidney is provided by
the concerted action of a low affinity high capacity and a high
affinity low capacity Na(+)/glucose cotransporter arranged in
series along kidney proximal tubules.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- DEVELOPMENTAL STAGE: Appears on embryonic day 18 and gradually
increases until birth.
-!- PTM: N-glycosylation is not necessary for the cotransporter
function. {ECO:0000250}.
-!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC
2.A.21) family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; U03120; AAA19015.1; -; mRNA.
EMBL; D16101; BAA03676.1; -; mRNA.
EMBL; AB000729; BAA19172.1; -; mRNA.
EMBL; BC081827; AAH81827.1; -; mRNA.
PIR; A53582; A53582.
RefSeq; NP_037165.1; NM_013033.2.
UniGene; Rn.10224; -.
STRING; 10116.ENSRNOP00000024165; -.
BindingDB; P53790; -.
ChEMBL; CHEMBL5374; -.
GuidetoPHARMACOLOGY; 915; -.
iPTMnet; P53790; -.
PhosphoSitePlus; P53790; -.
PaxDb; P53790; -.
PRIDE; P53790; -.
Ensembl; ENSRNOT00000024165; ENSRNOP00000024165; ENSRNOG00000017775.
GeneID; 25552; -.
KEGG; rno:25552; -.
UCSC; RGD:3713; rat.
CTD; 6523; -.
RGD; 3713; Slc5a1.
eggNOG; ENOG410IP49; Eukaryota.
eggNOG; COG4146; LUCA.
GeneTree; ENSGT00760000118955; -.
HOGENOM; HOG000025422; -.
HOVERGEN; HBG052859; -.
InParanoid; P53790; -.
KO; K14158; -.
OMA; VEGWILA; -.
OrthoDB; EOG091G077U; -.
PhylomeDB; P53790; -.
Reactome; R-RNO-189200; Cellular hexose transport.
Reactome; R-RNO-8981373; Intestinal hexose absorption.
PRO; PR:P53790; -.
Proteomes; UP000002494; Chromosome 14.
Bgee; ENSRNOG00000017775; -.
Genevisible; P53790; RN.
GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
GO; GO:0031526; C:brush border membrane; IDA:RGD.
GO; GO:0005911; C:cell-cell junction; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005412; F:glucose:sodium symporter activity; IDA:RGD.
GO; GO:1904659; P:glucose transmembrane transport; TAS:RGD.
GO; GO:0050892; P:intestinal absorption; TAS:RGD.
GO; GO:0001951; P:intestinal D-glucose absorption; TAS:RGD.
Gene3D; 1.20.1730.10; -; 1.
InterPro; IPR038377; Na/Glc_symporter_sf.
InterPro; IPR001734; Na/solute_symporter.
InterPro; IPR018212; Na/solute_symporter_CS.
Pfam; PF00474; SSF; 1.
TIGRFAMs; TIGR00813; sss; 1.
PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Ion transport;
Membrane; Phosphoprotein; Reference proteome; Sodium;
Sodium transport; Sugar transport; Symport; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 665 Sodium/glucose cotransporter 1.
/FTId=PRO_0000105370.
TOPO_DOM 1 28 Extracellular. {ECO:0000255}.
TRANSMEM 29 49 Helical. {ECO:0000255}.
TOPO_DOM 50 64 Cytoplasmic. {ECO:0000255}.
TRANSMEM 65 85 Helical. {ECO:0000255}.
TOPO_DOM 86 105 Extracellular. {ECO:0000255}.
TRANSMEM 106 126 Helical. {ECO:0000255}.
TOPO_DOM 127 142 Cytoplasmic. {ECO:0000255}.
TRANSMEM 143 163 Helical. {ECO:0000255}.
TOPO_DOM 164 178 Extracellular. {ECO:0000255}.
TRANSMEM 179 201 Helical. {ECO:0000255}.
TOPO_DOM 202 208 Cytoplasmic. {ECO:0000255}.
TRANSMEM 209 229 Helical. {ECO:0000255}.
TOPO_DOM 230 277 Extracellular. {ECO:0000255}.
TRANSMEM 278 298 Helical. {ECO:0000255}.
TOPO_DOM 299 313 Cytoplasmic. {ECO:0000255}.
TRANSMEM 314 334 Helical. {ECO:0000255}.
TOPO_DOM 335 380 Extracellular. {ECO:0000255}.
TRANSMEM 381 401 Helical. {ECO:0000255}.
TOPO_DOM 402 423 Cytoplasmic. {ECO:0000255}.
TRANSMEM 424 444 Helical. {ECO:0000255}.
TOPO_DOM 445 455 Extracellular. {ECO:0000255}.
TRANSMEM 456 476 Helical. {ECO:0000255}.
TOPO_DOM 477 484 Cytoplasmic. {ECO:0000255}.
TRANSMEM 485 505 Helical. {ECO:0000255}.
TOPO_DOM 506 526 Extracellular. {ECO:0000255}.
INTRAMEM 527 563 Helical. {ECO:0000255}.
TOPO_DOM 564 644 Extracellular. {ECO:0000255}.
TRANSMEM 645 665 Helical. {ECO:0000255}.
BINDING 457 457 Glucose. {ECO:0000250}.
SITE 43 43 Implicated in sodium coupling.
{ECO:0000250}.
SITE 300 300 Implicated in sodium coupling.
{ECO:0000250}.
SITE 460 460 Involved in sugar-binding/transport and
inhibitor binding. {ECO:0000250}.
MOD_RES 588 588 Phosphothreonine.
{ECO:0000250|UniProtKB:Q8C3K6}.
CARBOHYD 248 248 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 255 611 {ECO:0000250}.
CONFLICT 354 354 Y -> H (in Ref. 3; BAA19172).
{ECO:0000305}.
SEQUENCE 665 AA; 73066 MW; A92038D964BFF061 CRC64;
MDSSTLSPAV TATDAPIQSY ERIRNAADIS VIVIYFVVVM AVGLWAMFST NRGTVGGFFL
AGRSMVWWPI GASLFASNIG SGHFVGLAGT GAAAGIAMGG FEWNALVFVV VLGWLFVPIY
IKAGVVTMPE YLRKRFGGKR IQIYLSVLSL LLYIFTKISA DIFSGAIFIN LALGLDIYLA
IFILLAITAL YTITGGLAAV IYTDTLQTAI MLVGSFILTG FAFREVGGYE AFMDKYMKAI
PTLVSDGNIT VKEECYTPRA DSFHIFRDPI TGDMPWPGLI FGLSILALWY WCTDQVIVQR
CLSAKNMSHV KAGCTLCGYL KLLPMFLMVM PGMISRILYT DKIACVLPSE CKKYCGTPVG
CTNIAYPTLV VELMPNGLRG LMLSVMMASL MSSLTSIFNS ASTLFTMDIY TKIRKGASEK
ELMIAGRLFI LVLIGISIAW VPIVQSAQSG QLFDYIQSIT SYLGPPIAAV FLLAIFCKRV
NEPGAFWGLI LGFLIGISRM ITEFAYGTGS CMEPSNCPKI ICGVHYLYFA IILFAISVVT
VLVISLLTKP IPDVHLYRLC WSLRNSTEER IDLDAGEEEP VEEDPKDTIE IDAEAPQKEK
GCFRKAYDLF CGLDQDKGPK MTKEEEEAMK LKMTDTSEKP LWRTVVNING IILLAVAVFC
HAYFA


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