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Sodium/hydrogen exchanger 2 (H7) (Na( )/H( ) exchanger 2) (NHE-2) (Solute carrier family 9 member 2)

 SL9A2_RAT               Reviewed;         813 AA.
P48763; Q16434;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
23-MAY-2018, entry version 137.
RecName: Full=Sodium/hydrogen exchanger 2;
AltName: Full=H7;
AltName: Full=Na(+)/H(+) exchanger 2;
Short=NHE-2;
AltName: Full=Solute carrier family 9 member 2;
Name=Slc9a2; Synonyms=Nhe2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
TISSUE=Stomach;
PubMed=7685026;
Wang Z., Orlowski J., Shull G.E.;
"Primary structure and functional expression of a novel
gastrointestinal isoform of the rat Na/H exchanger.";
J. Biol. Chem. 268:11925-11928(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
STRAIN=Sprague-Dawley; TISSUE=Small intestine;
PubMed=7683411; DOI=10.1073/pnas.90.9.3938;
Collins J.F., Honda T., Knobel S., Bulus N.M., Conary J., Dubois R.,
Ghishan F.K.;
"Molecular cloning, sequencing, tissue distribution, and functional
expression of a Na+/H+ exchanger (NHE-2).";
Proc. Natl. Acad. Sci. U.S.A. 90:3938-3942(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
TISSUE=Liver;
PubMed=8595899; DOI=10.1006/geno.1995.0004;
Ghishan F.K., Knobel S.M., Summar M.;
"Molecular cloning, sequencing, chromosomal localization, and tissue
distribution of the human Na+/H+ exchanger (SLC9A2).";
Genomics 30:25-30(1995).
[4]
INTERACTION WITH CHP1 AND CHP2.
PubMed=12576672; DOI=10.1248/bpb.26.148;
Inoue H., Nakamura Y., Nagita M., Takai T., Masuda M., Nakamura N.,
Kanazawa H.;
"Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-
binding protein, is expressed in intestinal epithelium.";
Biol. Pharm. Bull. 26:148-155(2003).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Involved in pH regulation to eliminate acids generated
by active metabolism or to counter adverse environmental
conditions. Major proton extruding system driven by the inward
sodium ion chemical gradient. Seems to play an important role in
colonic sodium absorption.
-!- SUBUNIT: Interacts with CHP1 and CHP2.
{ECO:0000269|PubMed:12576672}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Long;
IsoId=P48763-1; Sequence=Displayed;
Name=Short;
IsoId=P48763-2; Sequence=VSP_003394;
-!- TISSUE SPECIFICITY: Predominantly in small intestine, colon, and
stomach, with much lower levels in skeletal muscle, kidney, brain,
testis, uterus, heart and lung.
-!- PTM: Phosphorylated (Possible).
-!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1
(CPA1) transporter (TC 2.A.36) family. {ECO:0000305}.
-!- CAUTION: The number, localization and denomination of hydrophobic
domains in the Na(+)/H(+) exchangers vary among authors.
{ECO:0000305}.
-!- CAUTION: PubMed:8595899 sequence was originally thought to
originate from human. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L11236; AAA72350.1; -; mRNA.
EMBL; L11004; AAA75406.1; -; mRNA.
EMBL; S81591; AAB36180.1; -; mRNA.
PIR; A46748; A46748.
PIR; A57644; A57644.
RefSeq; NP_001106806.1; NM_001113335.1. [P48763-1]
RefSeq; NP_036785.2; NM_012653.2. [P48763-2]
UniGene; Rn.11047; -.
ProteinModelPortal; P48763; -.
SMR; P48763; -.
IntAct; P48763; 2.
STRING; 10116.ENSRNOP00000021270; -.
iPTMnet; P48763; -.
PhosphoSitePlus; P48763; -.
PaxDb; P48763; -.
PRIDE; P48763; -.
Ensembl; ENSRNOT00000021270; ENSRNOP00000021270; ENSRNOG00000015567. [P48763-1]
GeneID; 24783; -.
KEGG; rno:24783; -.
UCSC; RGD:3719; rat. [P48763-1]
CTD; 6549; -.
RGD; 3719; Slc9a2.
eggNOG; KOG1966; Eukaryota.
eggNOG; COG0025; LUCA.
GeneTree; ENSGT00760000119074; -.
HOGENOM; HOG000247044; -.
HOVERGEN; HBG052615; -.
InParanoid; P48763; -.
KO; K14722; -.
OMA; AYKMEWK; -.
OrthoDB; EOG091G02Q0; -.
PhylomeDB; P48763; -.
TreeFam; TF317212; -.
Reactome; R-RNO-425986; Sodium/Proton exchangers.
PRO; PR:P48763; -.
Proteomes; UP000002494; Chromosome 9.
Bgee; ENSRNOG00000015567; -.
Genevisible; P48763; RN.
GO; GO:0016324; C:apical plasma membrane; TAS:RGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
GO; GO:0015385; F:sodium:proton antiporter activity; IDA:RGD.
GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
GO; GO:0008104; P:protein localization; IEA:Ensembl.
GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
GO; GO:0098719; P:sodium ion import across plasma membrane; IBA:GO_Central.
InterPro; IPR006153; Cation/H_exchanger.
InterPro; IPR018422; Cation/H_exchanger_CPA1.
InterPro; IPR001953; Na/H_exchanger_2.
InterPro; IPR004709; NaH_exchanger.
InterPro; IPR032103; NHE_CaM-bd.
PANTHER; PTHR10110; PTHR10110; 1.
Pfam; PF00999; Na_H_Exchanger; 1.
Pfam; PF16644; NEXCaM_BD; 1.
PRINTS; PR01084; NAHEXCHNGR.
PRINTS; PR01086; NAHEXCHNGR2.
TIGRFAMs; TIGR00840; b_cpa1; 1.
1: Evidence at protein level;
Alternative splicing; Antiport; Complete proteome; Glycoprotein;
Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium;
Sodium transport; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 813 Sodium/hydrogen exchanger 2.
/FTId=PRO_0000052354.
TOPO_DOM 1 13 Cytoplasmic. {ECO:0000255}.
INTRAMEM 14 34 Name=A/M1. {ECO:0000255}.
TOPO_DOM 35 80 Cytoplasmic. {ECO:0000255}.
INTRAMEM 81 101 Name=B/M2. {ECO:0000255}.
TOPO_DOM 102 107 Cytoplasmic. {ECO:0000255}.
TRANSMEM 108 128 Helical; Name=C/M3. {ECO:0000255}.
TOPO_DOM 129 139 Extracellular. {ECO:0000255}.
TRANSMEM 140 160 Helical; Name=D/M4. {ECO:0000255}.
TOPO_DOM 161 169 Cytoplasmic. {ECO:0000255}.
TRANSMEM 170 190 Helical; Name=E/M5. {ECO:0000255}.
TOPO_DOM 191 209 Extracellular. {ECO:0000255}.
TRANSMEM 210 230 Helical; Name=F/M5A. {ECO:0000255}.
TOPO_DOM 231 237 Cytoplasmic. {ECO:0000255}.
TRANSMEM 238 258 Helical; Name=G/M5B. {ECO:0000255}.
TOPO_DOM 259 278 Extracellular. {ECO:0000255}.
TRANSMEM 279 299 Helical; Name=H/M6. {ECO:0000255}.
TOPO_DOM 300 308 Cytoplasmic. {ECO:0000255}.
TRANSMEM 309 329 Helical; Name=I/M7. {ECO:0000255}.
TOPO_DOM 330 361 Extracellular. {ECO:0000255}.
TRANSMEM 362 382 Helical; Name=J/M8. {ECO:0000255}.
TOPO_DOM 383 392 Cytoplasmic. {ECO:0000255}.
TRANSMEM 393 413 Helical; Name=K/M9. {ECO:0000255}.
TOPO_DOM 414 430 Extracellular. {ECO:0000255}.
INTRAMEM 431 451 Name=L. {ECO:0000255}.
TOPO_DOM 452 459 Extracellular. {ECO:0000255}.
TRANSMEM 460 480 Helical; Name=M13. {ECO:0000255}.
TOPO_DOM 481 813 Cytoplasmic. {ECO:0000255}.
CARBOHYD 351 351 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 1 116 Missing (in isoform Short).
{ECO:0000303|PubMed:7683411,
ECO:0000303|PubMed:8595899}.
/FTId=VSP_003394.
CONFLICT 504 504 H -> HW (in Ref. 3; AAB36180).
{ECO:0000305}.
CONFLICT 610 616 LYQIRQR -> SLSNPPA (in Ref. 3; AAB36180).
{ECO:0000305}.
CONFLICT 742 742 A -> P (in Ref. 3; AAB36180).
{ECO:0000305}.
CONFLICT 786 786 V -> G (in Ref. 2; AAA75406).
{ECO:0000305}.
SEQUENCE 813 AA; 91403 MW; 29727267D7085845 CRC64;
MGPSGTAHRM RAPLSWLLLL LLSLQVAVPA GALAETLLDA PGARGASSNP PSPASVVAPG
TTPFEESRLP VFTLDYPHVQ IPFEITLWIL LASLAKIGFH LYHKLPTIVP ESCLLIMVGL
LLGGIIFGVD EKSPPAMKTD VFFLYLLPPI VLDAGYFMPT RPFFENLGTI FWYAVVGTLW
NSIGIGLSLF GICQIEAFGL SDITLLQNLL FGSLISAVDP VAVLAVFENI HVNEQLYILV
FGESLLNDAV TVVLYNLFKS FCQMKTIQTV DVFAGIANFF VVGIGGVLIG ILLGFIAAFT
TRFTHNIRVI EPLFVFLYSY LSYITAEMFH LSGIMAITAC AMTMNKYVEE NVSQKSYTTI
KYFMKMLSSV SETLIFIFMG VSTVGKNHEW NWAFVCFTLA FCLIWRALGV FVLTQVINWF
RTIPLTFKDQ FIIAYGGLRG AICFALVFLL PATVFPRKKL FITAAIVVIF FTVFILGITI
RPLVEFLDVK RSNKKQQAVS EEIHCRFFDH VKTGIEDVCG HWGHNFWRDK FKKFDDKYLR
KLLIRENQPK SSIVSLYKKL EIKHAIEMAE TGMISTVPSF ASLNDCREEK IRKLTPGEMD
EIREILSRNL YQIRQRTLSY NRHNLTADTS ERQAKEILIR RRHSLRESLR KDNSLNRERR
ASTSTSRYLS LPKNTKLPEK LQKKNKVSNA DGNSSDSDMD GTTVLNLQPR ARRFLPDQFS
KKASPAYKME WKNEVDVGSA RAPPSVTPAP RSKEGGTQTP GVLRQPLLSK DQRFGRGRED
SLTEDVPPKP PPRLVRRASE PGNRKGRLGN EKP


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