Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Sodium/hydrogen exchanger 3 (Na( )/H( ) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)

 SL9A3_RAT               Reviewed;         831 AA.
P26433;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 1.
23-MAY-2018, entry version 138.
RecName: Full=Sodium/hydrogen exchanger 3;
AltName: Full=Na(+)/H(+) exchanger 3;
Short=NHE-3;
AltName: Full=Solute carrier family 9 member 3;
Name=Slc9a3; Synonyms=Nhe3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Kidney;
PubMed=1577762;
Orlowski J., Kandasamy R.A., Shull G.E.;
"Molecular cloning of putative members of the Na/H exchanger gene
family. cDNA cloning, deduced amino acid sequence, and mRNA tissue
expression of the rat Na/H exchanger NHE-1 and two structurally
related proteins.";
J. Biol. Chem. 267:9331-9339(1992).
[2]
PHOSPHORYLATION AT SER-552 AND SER-605.
PubMed=9933588; DOI=10.1074/jbc.274.7.3978;
Zhao H., Wiederkehr M.R., Fan L., Collazo R.L., Crowder L.A.,
Moe O.W.;
"Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein
kinase a and NHE-3 phosphoserines 552 and 605.";
J. Biol. Chem. 274:3978-3987(1999).
[3]
INTERACTION WITH CHP1 AND CHP2.
PubMed=12576672; DOI=10.1248/bpb.26.148;
Inoue H., Nakamura Y., Nagita M., Takai T., Masuda M., Nakamura N.,
Kanazawa H.;
"Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-
binding protein, is expressed in intestinal epithelium.";
Biol. Pharm. Bull. 26:148-155(2003).
[4]
INTERACTION WITH SHANK2.
PubMed=16293618; DOI=10.1074/jbc.M509786200;
Han W., Kim K.H., Jo M.J., Lee J.H., Yang J., Doctor R.B., Moe O.W.,
Lee J., Kim E., Lee M.G.;
"Shank2 associates with and regulates Na+/H+ exchanger 3.";
J. Biol. Chem. 281:1461-1469(2006).
[5]
TISSUE SPECIFICITY, INTERACTION WITH AHCYL1, AND SUBCELLULAR LOCATION.
PubMed=20584908; DOI=10.1074/jbc.M110.133066;
He P., Klein J., Yun C.C.;
"Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by
inositol 1,4,5-triphosphate (IP3) receptor-binding protein released
with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.";
J. Biol. Chem. 285:27869-27878(2010).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552; SER-560 AND
SER-807, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Involved in pH regulation to eliminate acids generated
by active metabolism or to counter adverse environmental
conditions. Major proton extruding system driven by the inward
sodium ion chemical gradient. Plays an important role in signal
transduction. {ECO:0000250|UniProtKB:P48764}.
-!- SUBUNIT: Binds SLC9A3R1 and SLC9A3R2. Interacts with PDZD3 and
interactions decrease in response to elevated calcium ion levels.
Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity).
Interacts with CHP1, CHP2 and SHANK2 (PubMed:12576672,
PubMed:16293618). Interacts with AHCYL1; the interaction is
required for SLC9A3 activity (PubMed:20584908).
{ECO:0000250|UniProtKB:P48764, ECO:0000250|UniProtKB:Q28362,
ECO:0000269|PubMed:12576672, ECO:0000269|PubMed:16293618,
ECO:0000269|PubMed:20584908}.
-!- INTERACTION:
Q810D1:Chp2; NbExp=3; IntAct=EBI-961694, EBI-6146708;
Q9QX74:Shank2; NbExp=2; IntAct=EBI-961694, EBI-397902;
-!- SUBCELLULAR LOCATION: Apical cell membrane
{ECO:0000269|PubMed:20584908}; Multi-pass membrane protein.
Note=In intestinal epithelial cells, localizes to the ileal brush
border. Phosphorylation at Ser-661 by SGK1 is associated with
increased abundance at the cell membrane. Angiotensin-2 enhances
apical expression (By similarity). {ECO:0000250|UniProtKB:P48764,
ECO:0000250|UniProtKB:Q28362}.
-!- TISSUE SPECIFICITY: Most abundant in colon and small intestine,
followed by kidney and stomach. In kidney, expressed in proximal
tubules and outer medulla (at protein level) (PubMed:20584908).
{ECO:0000269|PubMed:20584908}.
-!- PTM: Phosphorylated by PKA, which inhibits activity.
Phosphorylation at Ser-661 by SGK1 is associated with increased
abundance at the cell membrane (By similarity).
{ECO:0000250|UniProtKB:P26432, ECO:0000250|UniProtKB:P26433}.
-!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1
(CPA1) transporter (TC 2.A.36) family. {ECO:0000305}.
-!- CAUTION: The number, localization and denomination of hydrophobic
domains in the Na(+)/H(+) exchangers vary among authors.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M85300; AAA41702.1; -; mRNA.
PIR; B40204; B40204.
RefSeq; NP_036786.1; NM_012654.1.
UniGene; Rn.9706; -.
ProteinModelPortal; P26433; -.
SMR; P26433; -.
BioGrid; 246908; 1.
IntAct; P26433; 5.
MINT; P26433; -.
STRING; 10116.ENSRNOP00000020711; -.
GuidetoPHARMACOLOGY; 950; -.
TCDB; 2.A.36.1.2; the monovalent cation:proton antiporter-1 (cpa1) family.
iPTMnet; P26433; -.
PhosphoSitePlus; P26433; -.
PaxDb; P26433; -.
PRIDE; P26433; -.
DNASU; 24784; -.
GeneID; 24784; -.
KEGG; rno:24784; -.
UCSC; RGD:3720; rat.
CTD; 6550; -.
RGD; 3720; Slc9a3.
eggNOG; KOG1966; Eukaryota.
eggNOG; COG0025; LUCA.
HOGENOM; HOG000247044; -.
HOVERGEN; HBG052615; -.
InParanoid; P26433; -.
KO; K12040; -.
PhylomeDB; P26433; -.
PRO; PR:P26433; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
GO; GO:0005903; C:brush border; IDA:RGD.
GO; GO:0031526; C:brush border membrane; IDA:RGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0030165; F:PDZ domain binding; ISS:UniProtKB.
GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
GO; GO:0015385; F:sodium:proton antiporter activity; IDA:RGD.
GO; GO:0007623; P:circadian rhythm; IEP:RGD.
GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
GO; GO:0006898; P:receptor-mediated endocytosis; IMP:RGD.
GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
GO; GO:0006885; P:regulation of pH; IDA:RGD.
GO; GO:0002028; P:regulation of sodium ion transport; IMP:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:0098719; P:sodium ion import across plasma membrane; ISS:UniProtKB.
GO; GO:0006814; P:sodium ion transport; IDA:RGD.
InterPro; IPR006153; Cation/H_exchanger.
InterPro; IPR018422; Cation/H_exchanger_CPA1.
InterPro; IPR018410; Na/H_exchanger_3/5.
InterPro; IPR004709; NaH_exchanger.
PANTHER; PTHR10110; PTHR10110; 1.
Pfam; PF00999; Na_H_Exchanger; 1.
PRINTS; PR01084; NAHEXCHNGR.
PRINTS; PR01087; NAHEXCHNGR3.
TIGRFAMs; TIGR00840; b_cpa1; 1.
1: Evidence at protein level;
Antiport; Cell membrane; Complete proteome; Glycoprotein;
Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium;
Sodium transport; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 831 Sodium/hydrogen exchanger 3.
/FTId=PRO_0000052358.
TOPO_DOM 1 11 Cytoplasmic. {ECO:0000255}.
INTRAMEM 12 25 Name=A/M1. {ECO:0000255}.
TOPO_DOM 26 51 Cytoplasmic. {ECO:0000255}.
INTRAMEM 52 70 Name=B/M2. {ECO:0000255}.
TOPO_DOM 71 76 Cytoplasmic. {ECO:0000255}.
TRANSMEM 77 96 Helical; Name=C/M3. {ECO:0000255}.
TOPO_DOM 97 109 Extracellular. {ECO:0000255}.
TRANSMEM 110 130 Helical; Name=D/M4. {ECO:0000255}.
TOPO_DOM 131 136 Cytoplasmic. {ECO:0000255}.
TRANSMEM 137 157 Helical; Name=E/M5. {ECO:0000255}.
TOPO_DOM 158 177 Extracellular. {ECO:0000255}.
TRANSMEM 178 199 Helical; Name=F/M5A. {ECO:0000255}.
TOPO_DOM 200 207 Cytoplasmic. {ECO:0000255}.
TRANSMEM 208 229 Helical; Name=G/M5B. {ECO:0000255}.
TOPO_DOM 230 249 Extracellular. {ECO:0000255}.
TRANSMEM 250 271 Helical; Name=H/M6. {ECO:0000255}.
TOPO_DOM 272 287 Cytoplasmic. {ECO:0000255}.
TRANSMEM 288 306 Helical; Name=I/M7. {ECO:0000255}.
TOPO_DOM 307 337 Extracellular. {ECO:0000255}.
TRANSMEM 338 359 Helical; Name=J/M8. {ECO:0000255}.
TOPO_DOM 360 366 Cytoplasmic. {ECO:0000255}.
TRANSMEM 367 387 Helical; Name=K/M9. {ECO:0000255}.
TOPO_DOM 388 402 Extracellular. {ECO:0000255}.
INTRAMEM 403 423 Name=L. {ECO:0000255}.
TOPO_DOM 424 432 Extracellular. {ECO:0000255}.
TRANSMEM 433 453 Helical; Name=M/M10. {ECO:0000255}.
TOPO_DOM 454 831 Cytoplasmic. {ECO:0000255}.
REGION 588 665 Interaction with PDZD3. {ECO:0000250}.
MOD_RES 552 552 Phosphoserine.
{ECO:0000244|PubMed:22673903,
ECO:0000269|PubMed:9933588}.
MOD_RES 560 560 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 590 590 Phosphoserine.
{ECO:0000250|UniProtKB:G3X939}.
MOD_RES 605 605 Phosphoserine.
{ECO:0000269|PubMed:9933588}.
MOD_RES 661 661 Phosphoserine; by SGK1.
{ECO:0000250|UniProtKB:P26432}.
MOD_RES 807 807 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 810 810 Phosphoserine.
{ECO:0000250|UniProtKB:G3X939}.
CARBOHYD 323 323 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 831 AA; 93105 MW; 77A4BF10DFF99E3F CRC64;
MWHPALGPGW KPLLALAVAV TSLRGVRGIE EEPNSGGSFQ IVTFKWHHVQ DPYIIALWIL
VASLAKIVFH LSHKVTSVVP ESALLIVLGL VLGGIVWAAD HIASFTLTPT LFFFYLLPPI
VLDAGYFMPN RLFFGNLGTI LLYAVIGTIW NAATTGLSLY GVFLSGLMGE LKIGLLDFLL
FGSLIAAVDP VAVLAVFEEV HVNEVLFIIV FGESLLNDAV TVVLYNVFES FVTLGGDAVT
GVDCVKGIVS FFVVSLGGTL VGVIFAFLLS LVTRFTKHVR IIEPGFVFVI SYLSYLTSEM
LSLSAILAIT FCGICCQKYV KANISEQSAT TVRYTMKMLA SGAETIIFMF LGISAVDPVI
WTWNTAFVLL TLVFISVYRA IGVVLQTWIL NRYRMVQLET IDQVVMSYGG LRGAVAYALV
VLLDEKKVKE KNLFVSTTLI VVFFTVIFQG LTIKPLVQWL KVKRSEQREP KLNEKLHGRA
FDHILSAIED ISGQIGHNYL RDKWSNFDRK FLSKVLMRRS AQKSRDRILN VFHELNLKDA
ISYVAEGERR GSLAFIRSPS TDNMVNVDFS TPRPSTVEAS VSYFLRENVS AVCLDMQSLE
QRRRSIRDTE DMVTHHTLQQ YLYKPRQEYK HLYSRHELTP NEDEKQDKEI FHRTMRKRLE
SFKSAKLGIN QNKKAAKLYK RERAQKRRNS SIPNGKLPME NLAHNFTIKE KDLELSEPEE
ATNYEEISGG IEFLASVTKD VASDSGAGID NPVFSPDEDL DPSILSRVPP WLSPGETVVP
SQRARVQIPN SPSNFRRLTP FRLSNKSVDS FLQADGPEEQ LQPASPESTH M


Related products :

Catalog number Product name Quantity
GWB-FEFC12 Anti- SLC9A9 (solute carrier family 9 (sodium hydrogen exchanger). member 9) Antibody
EIAAB37166 Homo sapiens,Human,Na(+)_H(+) exchanger 10,NHE-10,SLC9A10,sNHE,Sodium_hydrogen exchanger 10,Solute carrier family 9 member 10,Sperm-specific Na(+)_H(+) exchanger
EIAAB37165 Gm610,Mouse,Mus musculus,Na(+)_H(+) exchanger 10,NHE-10,Slc9a10,sNHE,Sodium_hydrogen exchanger 10,Solute carrier family 10 member 10,Sperm-specific Na(+)_H(+) exchanger
GWB-AED125 Solute Carrier Family 9 (Sodium Hydrogen Exchanger) Member 9 (SLC9A9) Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
GWB-C757EC Solute Carrier Family 9 (Sodium Hydrogen Exchanger) Member 3 Regulator 1 (SLC9A3R1) Mouse anti-Human Monoclonal (EBP-10) Antibo
EIAAB37102 Electroneutral Na+-driven Cl-HCO3 exchanger,Electroneutral sodium bicarbonate exchanger 1,Kiaa0739,k-NBC3,Mouse,Mus musculus,Slc4a8,Solute carrier family 4 member 8
EIAAB37103 Electroneutral Na+-driven Cl-HCO3 exchanger,Electroneutral sodium bicarbonate exchanger 1,k-NBC3,Ndcbe1,Rat,Rattus norvegicus,Slc4a8,Solute carrier family 4 member 8
EIAAB38595 Na(+)_H(+) exchanger 1,NHE1,NHE-1,Pig,SLC9A1,Sodium_hydrogen exchanger 1,Solute carrier family 9 member 1,Sus scrofa
EIAAB38607 Na(+)_H(+) exchanger 5,Nhe5,NHE-5,Rat,Rattus norvegicus,Slc9a5,Sodium_hydrogen exchanger 5,Solute carrier family 9 member 5
EIAAB38606 Na(+)_H(+) exchanger 4,Nhe4,NHE-4,Rat,Rattus norvegicus,Slc9a4,Sodium_hydrogen exchanger 4,Solute carrier family 9 member 4
EIAAB38596 Na(+)_H(+) exchanger 1,Nhe1,NHE-1,Rat,Rattus norvegicus,Slc9a1,Sodium_hydrogen exchanger 1,Solute carrier family 9 member 1
EIAAB38605 Mouse,Mus musculus,Na(+)_H(+) exchanger 4,Nhe4,NHE-4,Slc9a4,Sodium_hydrogen exchanger 4,Solute carrier family 9 member 4
EIAAB38594 Bos taurus,Bovine,Na(+)_H(+) exchanger 1,NHE1,NHE-1,SLC9A1,Sodium_hydrogen exchanger 1,Solute carrier family 9 member 1
EIAAB37167 Homo sapiens,Human,Na(+)_H(+) exchanger 11,NHE-11,SLC9A11,Sodium_hydrogen exchanger 11,Solute carrier family 9 member 11
EIAAB38593 Mouse,Mus musculus,Na(+)_H(+) exchanger 1,Nhe1,NHE-1,Slc9a1,Sodium_hydrogen exchanger 1,Solute carrier family 9 member 1
EIAAB38614 Na(+)_H(+) exchanger 8,Nhe8,NHE-8,Rat,Rattus norvegicus,Slc9a8,Sodium_hydrogen exchanger 8,Solute carrier family 9 member 8
EIAAB38612 Mouse,Mus musculus,Na(+)_H(+) exchanger 8,Nhe8,NHE-8,Slc9a8,Sodium_hydrogen exchanger 8,Solute carrier family 9 member 8
EIAAB38600 H7,Na(+)_H(+) exchanger 2,Nhe2,NHE-2,Rat,Rattus norvegicus,Slc9a2,Sodium_hydrogen exchanger 2,Solute carrier family 9 member 2
EIAAB38603 Na(+)_H(+) exchanger 3,Nhe3,NHE-3,Rat,Rattus norvegicus,Slc9a3,Sodium_hydrogen exchanger 3,Solute carrier family 9 member 3
EIAAB38615 Mouse,Mus musculus,Na(+)_H(+) exchanger 9,Nhe9,NHE-9,Slc9a9,Sodium_hydrogen exchanger 9,Solute carrier family 9 member 9
EIAAB38610 Mouse,Mus musculus,Na(+)_H(+) exchanger 7,Nhe7,NHE-7,Slc9a7,Sodium_hydrogen exchanger 7,Solute carrier family 9 member 7
EIAAB38611 Homo sapiens,Human,Na(+)_H(+) exchanger 7,NHE7,NHE-7,SLC9A7,Sodium_hydrogen exchanger 7,Solute carrier family 9 member 7
EIAAB38592 Na(+)_H(+) exchanger 1,NHE1,NHE-1,Oryctolagus cuniculus,Rabbit,SLC9A1,Sodium_hydrogen exchanger 1,Solute carrier family 9 member 1
EIAAB38608 Homo sapiens,Human,Na(+)_H(+) exchanger 5,NHE5,NHE-5,SLC9A5,Sodium_hydrogen exchanger 5,Solute carrier family 9 member 5
EIAAB38602 Na(+)_H(+) exchanger 3,NHE3,NHE-3,Oryctolagus cuniculus,Rabbit,SLC9A3,Sodium_hydrogen exchanger 3,Solute carrier family 9 member 3


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur