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Sodium/potassium-transporting ATPase subunit alpha (Na( )/K( ) ATPase alpha subunit) (EC 3.6.3.9) (Sodium pump subunit alpha)

 AT1A_TETCF              Reviewed;        1022 AA.
P05025;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
13-AUG-1987, sequence version 1.
25-OCT-2017, entry version 120.
RecName: Full=Sodium/potassium-transporting ATPase subunit alpha;
Short=Na(+)/K(+) ATPase alpha subunit;
EC=3.6.3.9;
AltName: Full=Sodium pump subunit alpha;
Flags: Precursor;
Tetronarce californica (Pacific electric ray) (Torpedo californica).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
Elasmobranchii; Batoidea; Torpediniformes; Torpedinidae; Tetronarce.
NCBI_TaxID=7787;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=2993905; DOI=10.1038/316733a0;
Kawakami K., Noguchi S., Noda M., Takahashi H., Ohta T., Kawamura M.,
Nojima H., Nagano K., Hirose T., Inayama S., Hayashida H., Miyata T.,
Numa S.;
"Primary structure of the alpha-subunit of Torpedo californica (Na+ +
K+)ATPase deduced from cDNA sequence.";
Nature 316:733-736(1985).
[2]
PROTEIN SEQUENCE OF 386-402; 502-512; 671-689 AND 887-906.
PubMed=3008150; DOI=10.1073/pnas.83.7.2071;
Ohta T., Nagano K., Yoshida M.;
"The active site structure of Na+/K+-transporting ATPase: location of
the 5'-(p-fluorosulfonyl)benzoyladenosine binding site and soluble
peptides released by trypsin.";
Proc. Natl. Acad. Sci. U.S.A. 83:2071-2075(1986).
-!- FUNCTION: This is the catalytic component of the active enzyme,
which catalyzes the hydrolysis of ATP coupled with the exchange of
sodium and potassium ions across the plasma membrane. This action
creates the electrochemical gradient of sodium and potassium ions,
providing the energy for active transport of various nutrients.
-!- CATALYTIC ACTIVITY: ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP +
phosphate + Na(+)(Out) + K(+)(In).
-!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
catalytic alpha subunit, an auxiliary non-catalytic beta subunit
and an additional regulatory subunit. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
membrane protein.
-!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC
3.A.3) family. Type IIC subfamily. {ECO:0000305}.
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EMBL; X02810; CAA26578.1; -; mRNA.
PIR; S00503; S00503.
ProteinModelPortal; P05025; -.
SMR; P05025; -.
PRIDE; P05025; -.
HOVERGEN; HBG004298; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0005391; F:sodium:potassium-exchanging ATPase activity; IEA:UniProtKB-EC.
CDD; cd02608; P-type_ATPase_Na-K_like; 1.
Gene3D; 3.40.1110.10; -; 2.
InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
InterPro; IPR023299; ATPase_P-typ_cyto_domN.
InterPro; IPR018303; ATPase_P-typ_P_site.
InterPro; IPR023298; ATPase_P-typ_TM_dom.
InterPro; IPR008250; ATPase_P-typ_transduc_dom_A.
InterPro; IPR036412; HAD-like_sf.
InterPro; IPR005775; P-type_ATPase_IIC.
InterPro; IPR001757; P_typ_ATPase.
Pfam; PF00689; Cation_ATPase_C; 1.
Pfam; PF00690; Cation_ATPase_N; 1.
SMART; SM00831; Cation_ATPase_N; 1.
SUPFAM; SSF56784; SSF56784; 1.
SUPFAM; SSF81653; SSF81653; 1.
SUPFAM; SSF81660; SSF81660; 1.
SUPFAM; SSF81665; SSF81665; 3.
TIGRFAMs; TIGR01106; ATPase-IIC_X-K; 1.
TIGRFAMs; TIGR01494; ATPase_P-type; 2.
PROSITE; PS00154; ATPASE_E1_E2; 1.
1: Evidence at protein level;
ATP-binding; Cell membrane; Direct protein sequencing; Hydrolase;
Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding;
Phosphoprotein; Potassium; Potassium transport; Sodium;
Sodium transport; Sodium/potassium transport; Transmembrane;
Transmembrane helix; Transport.
PROPEP 1 5
/FTId=PRO_0000002509.
CHAIN 6 1022 Sodium/potassium-transporting ATPase
subunit alpha.
/FTId=PRO_0000002510.
TOPO_DOM 6 87 Cytoplasmic. {ECO:0000255}.
TRANSMEM 88 108 Helical. {ECO:0000255}.
TOPO_DOM 109 131 Lumenal. {ECO:0000255}.
TRANSMEM 132 152 Helical. {ECO:0000255}.
TOPO_DOM 153 288 Cytoplasmic. {ECO:0000255}.
TRANSMEM 289 308 Helical. {ECO:0000255}.
TOPO_DOM 309 320 Lumenal. {ECO:0000255}.
TRANSMEM 321 338 Helical. {ECO:0000255}.
TOPO_DOM 339 771 Cytoplasmic. {ECO:0000255}.
TRANSMEM 772 791 Helical. {ECO:0000255}.
TOPO_DOM 792 801 Lumenal. {ECO:0000255}.
TRANSMEM 802 822 Helical. {ECO:0000255}.
TOPO_DOM 823 842 Cytoplasmic. {ECO:0000255}.
TRANSMEM 843 865 Helical. {ECO:0000255}.
TOPO_DOM 866 917 Lumenal. {ECO:0000255}.
TRANSMEM 918 937 Helical. {ECO:0000255}.
TOPO_DOM 938 950 Cytoplasmic. {ECO:0000255}.
TRANSMEM 951 969 Helical. {ECO:0000255}.
TOPO_DOM 970 984 Lumenal. {ECO:0000255}.
TRANSMEM 985 1005 Helical. {ECO:0000255}.
TOPO_DOM 1006 1022 Cytoplasmic. {ECO:0000255}.
REGION 82 84 Interaction with phosphoinositide-3
kinase. {ECO:0000250}.
ACT_SITE 376 376 4-aspartylphosphate intermediate.
{ECO:0000250}.
METAL 716 716 Magnesium. {ECO:0000250}.
METAL 720 720 Magnesium. {ECO:0000250}.
MOD_RES 16 16 Phosphoserine; by PKC. {ECO:0000250}.
MOD_RES 942 942 Phosphoserine; by PKA. {ECO:0000250}.
SEQUENCE 1022 AA; 112430 MW; D92FE737847D73C2 CRC64;
MGKGAASEKY QPAATSENAK NSKKSKSKTT DLDELKKEVS LDDHKLNLDE LHQKYGTDLT
QGLTPARAKE ILARDGPNAL TPPPTTPEWI KFCRQLFGGF SILLWTGAIL CFLAYGIQVA
TVDNPANDNL YLGVVLSTVV IITGCFSYYQ EAKSSKIMDS FKNMVPQQAL VIRDGEKSSI
NAEQVVVGDL VEVKGGDRIP ADLRIISACS CKVDNSSLTG ESEPQSRSPE YSSENPLETK
NIAFFSTNCV EGTARGIVIN IGDHTVMGRI ATLASGLEVG QTPIAAEIEH FIHIITGVAV
FLGVSFFILS LILGYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN
LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTENQSGIS FDKTSLSWNA
LSRIAALCNR AVFQAGQDSV PILKRSVAGD ASESALLKCI ELCCGSVSQM RDRNPKIVEI
PFNSTNKYQL SIHENDKADS RYLLVMKGAP ERILDRCSTI LLNGEDKPLN EEMKEAFQNA
YLELGGLGER VLGFCHLKLS TSKFPEGYPF DVEEPNFPIT DLCFVGLMSM IDPPRAAVPD
AVGKCRSAGI KVIMVTGDHP ITAKAIAKGV GIISEGNETV EDIAARLNIP VNQVNPRDAK
ACVVHGTDLK DLSHENLDDI LHYHTEIVFA RTSPQQKLII VEGCQRQGAI VAVTGDGVND
SPALKKADIG VAMGIAGSDV SKQAADMILL DDNFASIVTG VEEGRLIFDN LKKSIAYTLT
SNIPEITPFL VFIIANVPLP LGTVTILCID LGTDMVPAIS LAYERAESDI MKRQPRNPKT
DKLVNERLIS MAYGQIGMIQ ALGGFFSYFV ILAENGFLPI DLIGIREKWD ELWTQDLEDS
YGQQWTYEQR KIVEYTCHTS FFVSIVIVQW ADLIICKTRR NSIFQQGMKN KILIFGLFEE
TALAAFLSYT PGTDIALRMY PLKPSWWFCA FPYSLIIFLY DEARRFILRR NPGGWVEQET
YY


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