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Sodium/potassium-transporting ATPase subunit alpha-1 (Na( )/K( ) ATPase alpha-1 subunit) (EC 3.6.3.9) (Sodium pump subunit alpha-1)

 AT1A1_SHEEP             Reviewed;        1021 AA.
P04074;
01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
01-NOV-1986, sequence version 1.
30-AUG-2017, entry version 145.
RecName: Full=Sodium/potassium-transporting ATPase subunit alpha-1;
Short=Na(+)/K(+) ATPase alpha-1 subunit;
EC=3.6.3.9;
AltName: Full=Sodium pump subunit alpha-1;
Flags: Precursor;
Name=ATP1A1;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=2993903; DOI=10.1038/316691a0;
Shull G.E., Schwartz A., Lingrel J.B.;
"Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase
deduced from a complementary DNA.";
Nature 316:691-695(1985).
[2]
PROTEIN SEQUENCE OF 475-492.
PubMed=2162343;
Hinz H.R., Kirley T.L.;
"Lysine 480 is an essential residue in the putative ATP site of lamb
kidney (Na,K)-ATPase. Identification of the pyridoxal 5'-diphospho-5'-
adenosine and pyridoxal phosphate reactive residue.";
J. Biol. Chem. 265:10260-10265(1990).
-!- FUNCTION: This is the catalytic component of the active enzyme,
which catalyzes the hydrolysis of ATP coupled with the exchange of
sodium and potassium ions across the plasma membrane. This action
creates the electrochemical gradient of sodium and potassium ions,
providing the energy for active transport of various nutrients.
-!- CATALYTIC ACTIVITY: ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP +
phosphate + Na(+)(Out) + K(+)(In).
-!- ENZYME REGULATION: Specifically inhibited by cardiac glycosides
such as digoxin or ouabain.
-!- SUBUNIT: Interacts with SIK1 (By similarity). Interacts with
SLC35G1 and STIM1 (By similarity). Composed of three subunits:
alpha (catalytic), beta and gamma. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P05023}; Multi-pass membrane protein
{ECO:0000255}.
-!- PTM: Phosphorylation on Tyr-10 modulates pumping activity.
Phosphorylation of Ser-941 by PKA modulates the response of ATP1A1
to PKC (By similarity). Dephosphorylation by protein phosphatase
2A (PP2A) following increases in intracellular sodium, leading to
increase catalytic activity (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC
3.A.3) family. Type IIC subfamily. {ECO:0000305}.
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EMBL; X02813; CAA26581.1; -; mRNA.
EMBL; X02813; CAA26582.1; -; mRNA.
PIR; A01074; PWSHNA.
RefSeq; NP_001009360.1; NM_001009360.1.
UniGene; Oar.424; -.
ProteinModelPortal; P04074; -.
SMR; P04074; -.
PRIDE; P04074; -.
Ensembl; ENSOART00000022009; ENSOARP00000021706; ENSOARG00000020213.
GeneID; 443381; -.
KEGG; oas:443381; -.
CTD; 476; -.
GeneTree; ENSGT00890000139334; -.
HOVERGEN; HBG004298; -.
KO; K01539; -.
OMA; ARIMPEQ; -.
OrthoDB; EOG091G01BB; -.
Proteomes; UP000002356; Chromosome 1.
ExpressionAtlas; P04074; baseline.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
GO; GO:0043234; C:protein complex; IEA:Ensembl.
GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:Ensembl.
GO; GO:0030315; C:T-tubule; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0051087; F:chaperone binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0016791; F:phosphatase activity; IEA:Ensembl.
GO; GO:0005391; F:sodium:potassium-exchanging ATPase activity; ISS:UniProtKB.
GO; GO:1990239; F:steroid hormone binding; IEA:Ensembl.
GO; GO:0030007; P:cellular potassium ion homeostasis; IEA:Ensembl.
GO; GO:0071383; P:cellular response to steroid hormone stimulus; IEA:Ensembl.
GO; GO:0006883; P:cellular sodium ion homeostasis; IEA:Ensembl.
GO; GO:0086009; P:membrane repolarization; IEA:Ensembl.
GO; GO:0031947; P:negative regulation of glucocorticoid biosynthetic process; IEA:Ensembl.
GO; GO:0045822; P:negative regulation of heart contraction; IEA:Ensembl.
GO; GO:0045823; P:positive regulation of heart contraction; IEA:Ensembl.
GO; GO:0045989; P:positive regulation of striated muscle contraction; IEA:Ensembl.
GO; GO:0010107; P:potassium ion import; IEA:Ensembl.
GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
GO; GO:0002028; P:regulation of sodium ion transport; ISS:UniProtKB.
GO; GO:0002026; P:regulation of the force of heart contraction; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:1903416; P:response to glycoside; IEA:Ensembl.
GO; GO:0036376; P:sodium ion export from cell; IEA:Ensembl.
CDD; cd02608; P-type_ATPase_Na-K_like; 1.
Gene3D; 3.40.1110.10; -; 2.
InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
InterPro; IPR023299; ATPase_P-typ_cyto_domN.
InterPro; IPR018303; ATPase_P-typ_P_site.
InterPro; IPR023298; ATPase_P-typ_TM_dom.
InterPro; IPR008250; ATPase_P-typ_transduc_dom_A.
InterPro; IPR023214; HAD-like_dom.
InterPro; IPR005775; P-type_ATPase_IIC.
InterPro; IPR001757; P_typ_ATPase.
Pfam; PF00689; Cation_ATPase_C; 1.
Pfam; PF00690; Cation_ATPase_N; 1.
SMART; SM00831; Cation_ATPase_N; 1.
SUPFAM; SSF56784; SSF56784; 3.
SUPFAM; SSF81653; SSF81653; 1.
SUPFAM; SSF81660; SSF81660; 1.
SUPFAM; SSF81665; SSF81665; 3.
TIGRFAMs; TIGR01106; ATPase-IIC_X-K; 1.
TIGRFAMs; TIGR01494; ATPase_P-type; 2.
PROSITE; PS00154; ATPASE_E1_E2; 1.
1: Evidence at protein level;
Acetylation; ATP-binding; Cell membrane; Complete proteome;
Direct protein sequencing; Hydrolase; Ion transport; Magnesium;
Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein;
Potassium; Potassium transport; Reference proteome; Sodium;
Sodium transport; Sodium/potassium transport; Transmembrane;
Transmembrane helix; Transport.
PROPEP 1 5 {ECO:0000250}.
/FTId=PRO_0000002491.
CHAIN 6 1021 Sodium/potassium-transporting ATPase
subunit alpha-1.
/FTId=PRO_0000002492.
TOPO_DOM 6 85 Cytoplasmic. {ECO:0000255}.
TRANSMEM 86 106 Helical. {ECO:0000255}.
TOPO_DOM 107 129 Extracellular. {ECO:0000255}.
TRANSMEM 130 150 Helical. {ECO:0000255}.
TOPO_DOM 151 286 Cytoplasmic. {ECO:0000255}.
TRANSMEM 287 306 Helical. {ECO:0000255}.
TOPO_DOM 307 318 Extracellular. {ECO:0000255}.
TRANSMEM 319 336 Helical. {ECO:0000255}.
TOPO_DOM 337 770 Cytoplasmic. {ECO:0000255}.
TRANSMEM 771 790 Helical. {ECO:0000255}.
TOPO_DOM 791 800 Extracellular. {ECO:0000255}.
TRANSMEM 801 821 Helical. {ECO:0000255}.
TOPO_DOM 822 841 Cytoplasmic. {ECO:0000255}.
TRANSMEM 842 864 Helical. {ECO:0000255}.
TOPO_DOM 865 916 Extracellular. {ECO:0000255}.
TRANSMEM 917 936 Helical. {ECO:0000255}.
TOPO_DOM 937 949 Cytoplasmic. {ECO:0000255}.
TRANSMEM 950 968 Helical. {ECO:0000255}.
TOPO_DOM 969 983 Extracellular. {ECO:0000255}.
TRANSMEM 984 1004 Helical. {ECO:0000255}.
TOPO_DOM 1005 1021 Cytoplasmic. {ECO:0000255}.
REGION 80 82 Phosphoinositide-3 kinase binding.
{ECO:0000250}.
ACT_SITE 374 374 4-aspartylphosphate intermediate.
{ECO:0000250}.
METAL 715 715 Magnesium. {ECO:0000250}.
METAL 719 719 Magnesium. {ECO:0000250}.
BINDING 485 485 ATP. {ECO:0000250}.
MOD_RES 9 9 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q8VDN2}.
MOD_RES 10 10 Phosphotyrosine.
{ECO:0000250|UniProtKB:P06685}.
MOD_RES 16 16 Phosphoserine; by PKC.
{ECO:0000250|UniProtKB:P06685}.
MOD_RES 21 21 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q8VDN2}.
MOD_RES 38 38 Phosphoserine.
{ECO:0000250|UniProtKB:P06685}.
MOD_RES 45 45 Phosphoserine.
{ECO:0000250|UniProtKB:P06685}.
MOD_RES 226 226 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VDN2}.
MOD_RES 258 258 Phosphotyrosine.
{ECO:0000250|UniProtKB:Q8VDN2}.
MOD_RES 450 450 Phosphoserine.
{ECO:0000250|UniProtKB:P06685}.
MOD_RES 482 482 Phosphoserine.
{ECO:0000250|UniProtKB:P06685}.
MOD_RES 540 540 Phosphotyrosine.
{ECO:0000250|UniProtKB:P05023}.
MOD_RES 666 666 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VDN2}.
MOD_RES 941 941 Phosphoserine; by PKA.
{ECO:0000250|UniProtKB:P06685}.
SEQUENCE 1021 AA; 112658 MW; 0D493D95BD9D4312 CRC64;
MGKGVGRDKY EPAAVSEHGD KKKAKKERDM DELKKEVSMD DHKLSLDELH RKYGTDLNRG
LTTARAAEIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSM LLWIGAVLCF LAYGIQAATE
EEPQNDNLYL GVVLSAVVII TGCFSYYQEA KSSKIMESFK NMVPQQALVI RNGEKMSINA
EEVVVGDLVE VKGGDRIPAD LRIISANGCK VDNSSLTGES EPQTRSPDFT NENPLETRNI
AFFSTNCVEG TARGIVVYTG DRTVMGRIAT LASGLEGGQT PIAAEIEHFI HIITGVAVFL
GVSFFILSLI LEYTWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA RKNCLVKNLE
AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT TENQSGVSFD KTSATWLALS
RIAGLCNRAV FQANQDNLPI LKRAVAGDAS ESALLKCIEV CCGSVKEMRE RYAKIVEIPF
NSTNKYQLSI HKNANAGEPR HLLVMKGAPE RILDRCSSIL IHGKEQPLDE ELKDAFQNAY
LELGGLGERV LGFCHLMLPD EQFPEGFQFD TDDVNFPVDN LCFVGLISMI DPPRAAVPDA
VGKCRSAGIK VIMVTGDHPI TAKAIAKGVG IISEGNETVE DIAARLNIPV SQVNPRDARA
CVVHGSDLKD MTPEQLDDIL KYHTEIVFAR TSPQQKLIIV EGCQRQGAIV AVTGDGVNDS
PALKKADIGV AMGIAGSDVS KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIAYTLTS
NIPEITPFLI FIIANIPLPL GTVTILCIDL GTDMVPAISL AYEQAESDIM KRQPRNPQTD
KLVNERLISM AYGQIGMIQA LGGFFTYFVI MAENGFLPNH LLGIRVTWDD RWINDVEDSY
GQQWTYEQRK IVEFTCHTAF FVSIVVVQWA DLVICKTRRN SVFQQGMKNK ILIFGLFEET
ALAAFLSYCP GMGVALRMYP LKPTWWFCAF PYSLLIFVYD EVRKLIIRRR PGGWVEKETY
Y


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