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Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)

 AT1B1_SHEEP             Reviewed;         303 AA.
P05028;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
13-AUG-1987, sequence version 1.
23-MAY-2018, entry version 117.
RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1;
AltName: Full=Sodium/potassium-dependent ATPase subunit beta-1;
Name=ATP1B1;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3012356; DOI=10.1038/321429a0;
Shull G.E., Lane L.K., Lingrel J.B.;
"Amino-acid sequence of the beta-subunit of the (Na+ + K+)ATPase
deduced from a cDNA.";
Nature 321:429-431(1986).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7521214; DOI=10.1016/0167-4838(94)00074-3;
Sun Y., Ball W.J. Jr.;
"Identification of antigenic sites on the Na+/K(+)-ATPase beta-
subunit: their sequences and the effects of thiol reduction upon their
structure.";
Biochim. Biophys. Acta 1207:236-248(1994).
-!- FUNCTION: This is the non-catalytic component of the active
enzyme, which catalyzes the hydrolysis of ATP coupled with the
exchange of Na(+) and K(+) ions across the plasma membrane. The
beta subunit regulates, through assembly of alpha/beta
heterodimers, the number of sodium pumps transported to the plasma
membrane.
-!- FUNCTION: Involved in cell adhesion and establishing epithelial
cell polarity. {ECO:0000250}.
-!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
catalytic alpha subunit, an auxiliary non-catalytic beta subunit
and an additional regulatory subunit. Interacts with regulatory
subunit FXYD1. Interacts with regulatory subunit FXYD3. Interacts
with NKAIN1, NKAIN2 and NKAIN4. Interacts with MLC1. Part of a
complex containing MLC1, TRPV4, AQP4 and HEPACAM. Interacts with
KIRREL3. Interacts with OBSCN (via protein kinase domain 1).
{ECO:0000250|UniProtKB:P05026, ECO:0000250|UniProtKB:P07340,
ECO:0000250|UniProtKB:P14094}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass
type II membrane protein {ECO:0000255}. Cell membrane, sarcolemma
{ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the
intercalated disk and sarcolemma in cardiomyocytes. Localizes in
long striations at the level of Z and M lines.
{ECO:0000250|UniProtKB:P14094}.
-!- DOMAIN: The C-terminal lobe folds into an immunoglobulin-like
domain and mediates cell adhesion properties. {ECO:0000250}.
-!- PTM: Glutathionylated. {ECO:0000250|UniProtKB:P14094}.
-!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta
family. {ECO:0000305}.
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EMBL; X03883; CAA27515.1; -; mRNA.
PIR; A25768; A25768.
RefSeq; NP_001009796.1; NM_001009796.1.
UniGene; Oar.421; -.
ProteinModelPortal; P05028; -.
Ensembl; ENSOART00000010200; ENSOARP00000010054; ENSOARG00000009371.
GeneID; 443384; -.
KEGG; oas:443384; -.
CTD; 481; -.
GeneTree; ENSGT00550000074530; -.
HOVERGEN; HBG050603; -.
KO; K01540; -.
OMA; QVPQIQK; -.
OrthoDB; EOG091G0DJ4; -.
Proteomes; UP000002356; Chromosome 12.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0043209; C:myelin sheath; IEA:Ensembl.
GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:Ensembl.
GO; GO:0001671; F:ATPase activator activity; IEA:Ensembl.
GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
GO; GO:0030955; F:potassium ion binding; IEA:Ensembl.
GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0031402; F:sodium ion binding; IEA:Ensembl.
GO; GO:0005391; F:sodium:potassium-exchanging ATPase activity; IEA:Ensembl.
GO; GO:0046034; P:ATP metabolic process; IEA:Ensembl.
GO; GO:0060048; P:cardiac muscle contraction; IEA:Ensembl.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0030007; P:cellular potassium ion homeostasis; IEA:Ensembl.
GO; GO:0006883; P:cellular sodium ion homeostasis; IEA:Ensembl.
GO; GO:0086009; P:membrane repolarization; IEA:Ensembl.
GO; GO:1903281; P:positive regulation of calcium:sodium antiporter activity; IEA:Ensembl.
GO; GO:1903288; P:positive regulation of potassium ion import; IEA:Ensembl.
GO; GO:1901018; P:positive regulation of potassium ion transmembrane transporter activity; IEA:Ensembl.
GO; GO:1903278; P:positive regulation of sodium ion export across plasma membrane; IEA:Ensembl.
GO; GO:0010107; P:potassium ion import; IEA:Ensembl.
GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IEA:Ensembl.
GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
GO; GO:0055119; P:relaxation of cardiac muscle; IEA:Ensembl.
GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:Ensembl.
Gene3D; 2.60.40.1660; -; 1.
InterPro; IPR000402; Na/K_ATPase_sub_beta.
InterPro; IPR015565; Na/K_ATPase_sub_beta_chordates.
InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
PANTHER; PTHR11523; PTHR11523; 1.
PANTHER; PTHR11523:SF10; PTHR11523:SF10; 1.
Pfam; PF00287; Na_K-ATPase; 1.
TIGRFAMs; TIGR01107; Na_K_ATPase_bet; 1.
PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
2: Evidence at transcript level;
Cell adhesion; Cell membrane; Complete proteome; Disulfide bond;
Glutathionylation; Glycoprotein; Ion transport; Membrane;
Phosphoprotein; Potassium; Potassium transport; Reference proteome;
Signal-anchor; Sodium; Sodium transport; Sodium/potassium transport;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 303 Sodium/potassium-transporting ATPase
subunit beta-1.
/FTId=PRO_0000219101.
TOPO_DOM 1 34 Cytoplasmic. {ECO:0000255}.
TRANSMEM 35 62 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 63 303 Extracellular. {ECO:0000255}.
REGION 191 303 immunoglobulin-like. {ECO:0000250}.
MOD_RES 11 11 Phosphoserine.
{ECO:0000250|UniProtKB:P07340}.
MOD_RES 101 101 Phosphotyrosine.
{ECO:0000250|UniProtKB:P14094}.
CARBOHYD 158 158 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 193 193 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 265 265 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
DISULFID 126 149 {ECO:0000250}.
DISULFID 159 175 {ECO:0000250}.
DISULFID 213 276 {ECO:0000250}.
SEQUENCE 303 AA; 35071 MW; 0038B8EA355A3540 CRC64;
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF IGTIQVMLLT
ISEFKPTYQD RVAPPGLTQI PQIQKTEIAF RPNDPKSYMT YVDNIDNFLK KYRDSAQKDD
MIFEDCGNVP SELKDRGEFN NEQGERKVCR FKLEWLGNCS GINDETYGYK EGKPCVIIKL
NRVLGFKPKP PKNESLETYP VMKYNPYVLP VQCTGKRDED KEKVGSIEYF GLGGYPGFPL
QYYPYYGKLL QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE
VKS


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