Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)

 AT1B1_MOUSE             Reviewed;         304 AA.
P14094;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
20-JUN-2018, entry version 172.
RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1;
AltName: Full=Sodium/potassium-dependent ATPase subunit beta-1;
Name=Atp1b1; Synonyms=Atp4b;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=2557580;
Gloor S.;
"Cloning and nucleotide sequence of the mouse Na,K-ATPase beta-
subunit.";
Nucleic Acids Res. 17:10117-10117(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=129; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 15-21; 72-107; 171-179; 205-217; 225-249 AND
279-291, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=C57BL/6J; TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-304.
STRAIN=BALB/cJ; TISSUE=Brain;
PubMed=12106288; DOI=10.1111/j.1460-9568.1990.tb00460.x;
Kato K.;
"A collection of cDNA clones with specific expression patterns in
mouse brain.";
Eur. J. Neurosci. 2:704-711(1990).
[5]
INTERACTION WITH FXYD3.
PubMed=15743908; DOI=10.1091/mbc.E04-10-0878;
Crambert G., Li C., Claeys D., Geering K.;
"FXYD3 (Mat-8), a new regulator of Na,K-ATPase.";
Mol. Biol. Cell 16:2363-2371(2005).
[6]
INTERACTION WITH NKAIN1; NKAIN2 AND NKAIN4.
STRAIN=C57BL/6J;
PubMed=17606467; DOI=10.1093/hmg/ddm167;
Gorokhova S., Bibert S., Geering K., Heintz N.;
"A novel family of transmembrane proteins interacting with beta
subunits of the Na,K-ATPase.";
Hum. Mol. Genet. 16:2394-2410(2007).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-101, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=18034455; DOI=10.1021/pr0701254;
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine
phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
[8]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-158; ASN-163 AND ASN-266.
PubMed=19349973; DOI=10.1038/nbt.1532;
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
Schiess R., Aebersold R., Watts J.D.;
"Mass-spectrometric identification and relative quantification of N-
linked cell surface glycoproteins.";
Nat. Biotechnol. 27:378-386(2009).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[10]
INTERACTION WITH OBSCN, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=23392350; DOI=10.1096/fj.12-221317;
Hu L.Y., Kontrogianni-Konstantopoulos A.;
"The kinase domains of obscurin interact with intercellular adhesion
proteins.";
FASEB J. 27:2001-2012(2013).
[11]
GLUTATHIONYLATION.
PubMed=21454534; DOI=10.1074/jbc.M110.184101;
Bibert S., Liu C.C., Figtree G.A., Garcia A., Hamilton E.J.,
Marassi F.M., Sweadner K.J., Cornelius F., Geering K., Rasmussen H.H.;
"FXYD proteins reverse inhibition of the Na+-K+ pump mediated by
glutathionylation of its beta1 subunit.";
J. Biol. Chem. 286:18562-18572(2011).
-!- FUNCTION: This is the non-catalytic component of the active
enzyme, which catalyzes the hydrolysis of ATP coupled with the
exchange of Na(+) and K(+) ions across the plasma membrane. The
beta subunit regulates, through assembly of alpha/beta
heterodimers, the number of sodium pumps transported to the plasma
membrane.
-!- FUNCTION: Involved in cell adhesion and establishing epithelial
cell polarity. {ECO:0000250}.
-!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
catalytic alpha subunit, an auxiliary non-catalytic beta subunit
and an additional regulatory subunit. Interacts with regulatory
subunit FXYD1 (By similarity). Interacts with regulatory subunit
FXYD3 (PubMed:15743908). Interacts with NKAIN1, NKAIN2 and NKAIN4
(PubMed:17606467). Interacts with MLC1 (By similarity). Part of a
complex containing MLC1, TRPV4, AQP4 and HEPACAM (By similarity).
Interacts with KIRREL3 (By similarity). Interacts with OBSCN (via
protein kinase domain 1) (PubMed:23392350).
{ECO:0000250|UniProtKB:P05026, ECO:0000250|UniProtKB:P07340,
ECO:0000269|PubMed:15743908, ECO:0000269|PubMed:17606467,
ECO:0000269|PubMed:23392350}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Single-pass
type II membrane protein {ECO:0000255}. Cell membrane, sarcolemma
{ECO:0000269|PubMed:23392350}. Note=Colocalizes with OBSCN at the
intercalated disk and sarcolemma in cardiomyocytes. Localizes in
long striations at the level of Z and M lines.
{ECO:0000269|PubMed:23392350}.
-!- TISSUE SPECIFICITY: Expressed in cardiac muscle and in flexor
digitorum brevis (FDB) muscle (at protein level).
{ECO:0000269|PubMed:23392350}.
-!- DOMAIN: The C-terminal lobe folds into an immunoglobulin-like
domain and mediates cell adhesion properties. {ECO:0000250}.
-!- PTM: Glutathionylated. {ECO:0000269|PubMed:21454534}.
-!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta
family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X16646; CAA34639.1; -; mRNA.
EMBL; BC027319; AAH27319.1; -; mRNA.
EMBL; X61433; CAA43675.1; -; mRNA.
CCDS; CCDS35755.1; -.
PIR; S09601; S09601.
RefSeq; NP_033851.1; NM_009721.6.
UniGene; Mm.4550; -.
ProteinModelPortal; P14094; -.
BioGrid; 198244; 5.
ComplexPortal; CPX-126; Sodium:potassium-exchanging ATPase complex.
IntAct; P14094; 12.
MINT; P14094; -.
STRING; 10090.ENSMUSP00000027863; -.
iPTMnet; P14094; -.
PhosphoSitePlus; P14094; -.
SwissPalm; P14094; -.
PaxDb; P14094; -.
PeptideAtlas; P14094; -.
PRIDE; P14094; -.
Ensembl; ENSMUST00000027863; ENSMUSP00000027863; ENSMUSG00000026576.
GeneID; 11931; -.
KEGG; mmu:11931; -.
UCSC; uc007dip.2; mouse.
CTD; 481; -.
MGI; MGI:88108; Atp1b1.
eggNOG; KOG3927; Eukaryota.
eggNOG; ENOG411150A; LUCA.
GeneTree; ENSGT00550000074530; -.
HOGENOM; HOG000039248; -.
HOVERGEN; HBG050603; -.
InParanoid; P14094; -.
KO; K01540; -.
OMA; QVPQIQK; -.
OrthoDB; EOG091G0DJ4; -.
PhylomeDB; P14094; -.
TreeFam; TF314618; -.
Reactome; R-MMU-210991; Basigin interactions.
Reactome; R-MMU-5578775; Ion homeostasis.
Reactome; R-MMU-936837; Ion transport by P-type ATPases.
ChiTaRS; Atp1b1; mouse.
PRO; PR:P14094; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026576; -.
CleanEx; MM_ATP1B1; -.
CleanEx; MM_ATP4B; -.
ExpressionAtlas; P14094; baseline and differential.
Genevisible; P14094; MM.
GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
GO; GO:0016323; C:basolateral plasma membrane; IDA:MGI.
GO; GO:0005901; C:caveola; ISO:MGI.
GO; GO:0014704; C:intercalated disc; IMP:BHF-UCL.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0043209; C:myelin sheath; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0042383; C:sarcolemma; IMP:BHF-UCL.
GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IMP:BHF-UCL.
GO; GO:0005524; F:ATP binding; IEA:Ensembl.
GO; GO:0001671; F:ATPase activator activity; ISO:MGI.
GO; GO:0051117; F:ATPase binding; ISO:MGI.
GO; GO:0030955; F:potassium ion binding; IEA:Ensembl.
GO; GO:0008022; F:protein C-terminus binding; IPI:MGI.
GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO; GO:0031402; F:sodium ion binding; IEA:Ensembl.
GO; GO:0005391; F:sodium:potassium-exchanging ATPase activity; ISO:MGI.
GO; GO:0046034; P:ATP metabolic process; ISO:MGI.
GO; GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0006874; P:cellular calcium ion homeostasis; IMP:BHF-UCL.
GO; GO:0030007; P:cellular potassium ion homeostasis; ISO:MGI.
GO; GO:0006883; P:cellular sodium ion homeostasis; ISO:MGI.
GO; GO:0086009; P:membrane repolarization; ISO:MGI.
GO; GO:0030001; P:metal ion transport; ISO:MGI.
GO; GO:0032781; P:positive regulation of ATPase activity; ISO:MGI.
GO; GO:1903281; P:positive regulation of calcium:sodium antiporter activity; IMP:BHF-UCL.
GO; GO:1903288; P:positive regulation of potassium ion import; ISO:MGI.
GO; GO:1901018; P:positive regulation of potassium ion transmembrane transporter activity; ISO:MGI.
GO; GO:1903278; P:positive regulation of sodium ion export across plasma membrane; ISO:MGI.
GO; GO:0010107; P:potassium ion import; ISO:MGI.
GO; GO:0006813; P:potassium ion transport; ISO:MGI.
GO; GO:0072659; P:protein localization to plasma membrane; ISO:MGI.
GO; GO:0050821; P:protein stabilization; IMP:BHF-UCL.
GO; GO:1903169; P:regulation of calcium ion transmembrane transport; IMP:BHF-UCL.
GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IMP:BHF-UCL.
GO; GO:0010468; P:regulation of gene expression; IMP:BHF-UCL.
GO; GO:0055119; P:relaxation of cardiac muscle; IMP:BHF-UCL.
GO; GO:0001666; P:response to hypoxia; ISO:MGI.
GO; GO:0036376; P:sodium ion export across plasma membrane; ISO:MGI.
GO; GO:0006814; P:sodium ion transport; ISO:MGI.
Gene3D; 2.60.40.1660; -; 1.
InterPro; IPR000402; Na/K_ATPase_sub_beta.
InterPro; IPR015565; Na/K_ATPase_sub_beta_chordates.
InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
PANTHER; PTHR11523; PTHR11523; 1.
PANTHER; PTHR11523:SF10; PTHR11523:SF10; 1.
Pfam; PF00287; Na_K-ATPase; 1.
TIGRFAMs; TIGR01107; Na_K_ATPase_bet; 1.
PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
PROSITE; PS00391; ATPASE_NA_K_BETA_2; 1.
1: Evidence at protein level;
Cell adhesion; Cell membrane; Complete proteome;
Direct protein sequencing; Disulfide bond; Glutathionylation;
Glycoprotein; Ion transport; Membrane; Phosphoprotein; Potassium;
Potassium transport; Reference proteome; Signal-anchor; Sodium;
Sodium transport; Sodium/potassium transport; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 304 Sodium/potassium-transporting ATPase
subunit beta-1.
/FTId=PRO_0000219098.
TOPO_DOM 1 34 Cytoplasmic. {ECO:0000255}.
TRANSMEM 35 62 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 63 304 Extracellular. {ECO:0000255}.
REGION 191 304 immunoglobulin-like. {ECO:0000250}.
MOD_RES 11 11 Phosphoserine.
{ECO:0000250|UniProtKB:P07340}.
MOD_RES 101 101 Phosphotyrosine.
{ECO:0000244|PubMed:18034455}.
CARBOHYD 158 158 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19349973}.
CARBOHYD 163 163 N-linked (GlcNAc...) asparagine;
atypical. {ECO:0000269|PubMed:19349973}.
CARBOHYD 193 193 N-linked (GlcNAc...) asparagine.
{ECO:0000250}.
CARBOHYD 266 266 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19349973}.
DISULFID 126 149 {ECO:0000250}.
DISULFID 159 175 {ECO:0000250}.
DISULFID 214 277 {ECO:0000250}.
SEQUENCE 304 AA; 35195 MW; 8E15D8F860932680 CRC64;
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF IGTIQVMLLT
ISELKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA YVLNIIRFLE KYKDSAQKDD
MIFEDCGNVP SEPKERGDIN HERGERKVCR FKLDWLGNCS GLNDDSYGYR EGKPCIIIKL
NRVLGFKPKP PKNESLETYP LMMKYNPNVL PVQCTGKRDE DKDKVGNIEY FGMGGYYGFP
LQYYPYYGKL LQPKYLQPLL AVQFTNLTVD TEIRVECKAY GENIGYSEKD RFQGRFDVKI
EIKS


Related products :

Catalog number Product name Quantity
H1775 Sodium potassium-transporting ATPase subunit beta-2 (ATP1B2), Rat, ELISA Kit 96T
AT1B1_HUMAN Human ELISA Kit FOR Sodium per potassium-transporting ATPase subunit beta-1 96T
H1781 Sodium potassium-transporting ATPase subunit beta-3 (ATP1B3), Rat, ELISA Kit 96T
E1119m Bovine ELISA Kit FOR Sodium per potassium-transporting ATPase subunit beta-3 96T
H1760 Sodium potassium-transporting ATPase subunit beta-1 (ATP1B1), Rat, ELISA Kit 96T
H1758 Sodium potassium-transporting ATPase subunit beta-1 (ATP1B1), Pig, ELISA Kit 96T
AT1B3_HUMAN Human ELISA Kit FOR Sodium per potassium-transporting ATPase subunit beta-3 96T
E1083m Rabbit ELISA Kit FOR Sodium per potassium-transporting ATPase subunit beta-1 96T
AT1B3_MOUSE Mouse ELISA Kit FOR Sodium per potassium-transporting ATPase subunit beta-3 96T
H1754 Sodium potassium-transporting ATPase subunit beta-1 (ATP1B1), Dog, ELISA Kit 96T
H1761 Sodium potassium-transporting ATPase subunit beta-1 (ATP1B1), Sheep, ELISA Kit 96T
AE55115SH Sheep Sodium per potassium-transporting ATPase subunit beta-1 (ATP1B1) ELISA Kit 48T
H1774 Sodium potassium-transporting ATPase subunit beta-2 (ATP1B2), Rabbit, ELISA Kit 96T
H1755 Sodium potassium-transporting ATPase subunit beta-1 (ATP1B1), Guinea pig, ELISA Kit 96T
H1780 Sodium potassium-transporting ATPase subunit beta-3 (ATP1B3), Rabbit, ELISA Kit 96T
H1757 Sodium potassium-transporting ATPase subunit beta-1 (ATP1B1), Mouse, ELISA Kit 96T
H1756 Sodium potassium-transporting ATPase subunit beta-1 (ATP1B1), Human, ELISA Kit 96T
H1773 Sodium potassium-transporting ATPase subunit beta-2 (ATP1B2), Mouse, ELISA Kit 96T
H1771 Sodium potassium-transporting ATPase subunit beta-2 (ATP1B2), Bovine, ELISA Kit 96T
H1778 Sodium potassium-transporting ATPase subunit beta-3 (ATP1B3), Guinea pig, ELISA Kit 96T
H1753 Sodium potassium-transporting ATPase subunit beta-1 (ATP1B1), Chicken, ELISA Kit 96T
H1779 Sodium potassium-transporting ATPase subunit beta-3 (ATP1B3), Human, ELISA Kit 96T
H1759 Sodium potassium-transporting ATPase subunit beta-1 (ATP1B1), Rabbit, ELISA Kit 96T
H1772 Sodium potassium-transporting ATPase subunit beta-2 (ATP1B2), Human, ELISA Kit 96T
H1777 Sodium potassium-transporting ATPase subunit beta-3 (ATP1B3), Chicken, ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur