Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)

 SCNAA_HUMAN             Reviewed;        1956 AA.
Q9Y5Y9; A6NDQ1;
21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
02-SEP-2008, sequence version 2.
28-FEB-2018, entry version 147.
RecName: Full=Sodium channel protein type 10 subunit alpha;
AltName: Full=Peripheral nerve sodium channel 3;
Short=PN3;
Short=hPN3;
AltName: Full=Sodium channel protein type X subunit alpha;
AltName: Full=Voltage-gated sodium channel subunit alpha Nav1.8;
Name=SCN10A;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN VOLTAGE-EVOKED DEPOLARIZATION,
TISSUE SPECIFICITY, AND VARIANTS ALA-1073 AND VAL-1713.
TISSUE=Spinal ganglion;
PubMed=9839820; DOI=10.1016/S0304-3959(98)00120-1;
Rabert D.K., Koch B.D., Ilnicka M., Obernolte R.A., Naylor S.L.,
Herman R.C., Eglen R.M., Hunter J.C., Sangameswaran L.;
"A tetrodotoxin-resistant voltage-gated sodium channel from human
dorsal root ganglia, hPN3/SCN10A.";
Pain 78:107-114(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16641997; DOI=10.1038/nature04728;
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
[3]
VARIANT TRP-916.
PubMed=21248752; DOI=10.1038/nature09639;
Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P.,
Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A.,
Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C.,
Jia M., Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A.,
Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S.,
Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A.,
Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C.,
Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R.,
Futreal P.A.;
"Exome sequencing identifies frequent mutation of the SWI/SNF complex
gene PBRM1 in renal carcinoma.";
Nature 469:539-542(2011).
[4]
VARIANTS FEPS2 PRO-554 AND THR-1304, CHARACTERIZATION OF VARIANTS
FEPS2 PRO-554 AND THR-1304, VARIANTS LEU-939; LEU-940; ASN-1056;
TYR-1523 AND SER-1662, AND CHARACTERIZATION OF VARIANT TYR-1523.
PubMed=23115331; DOI=10.1073/pnas.1216080109;
Faber C.G., Lauria G., Merkies I.S., Cheng X., Han C., Ahn H.S.,
Persson A.K., Hoeijmakers J.G., Gerrits M.M., Pierro T., Lombardi R.,
Kapetis D., Dib-Hajj S.D., Waxman S.G.;
"Gain-of-function Nav1.8 mutations in painful neuropathy.";
Proc. Natl. Acad. Sci. U.S.A. 109:19444-19449(2012).
-!- FUNCTION: Tetrodotoxin-resistant channel that mediates the
voltage-dependent sodium ion permeability of excitable membranes.
Assuming opened or closed conformations in response to the voltage
difference across the membrane, the protein forms a sodium-
selective channel through which sodium ions may pass in accordance
with their electrochemical gradient. Plays a role in neuropathic
pain mechanisms. {ECO:0000269|PubMed:9839820}.
-!- SUBUNIT: The channel consists of an ion conducting pore forming
alpha-subunit regulated by one or more associated auxiliary
subunits SCN1B, SCN2B and SCN3B; electrophysiological properties
may vary depending on the type of the associated beta subunits.
Found in a number of complexes with PRX, DYNLT1 and PDZD2.
Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10
and many others (By similarity). Interacts with NEDD4 and NEDD4L.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:D0E0C2}; Multi-pass membrane protein
{ECO:0000250|UniProtKB:D0E0C2}. Note=It can be translocated to the
cell membrane through association with S100A10. {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in the dorsal root ganglia and
sciatic nerve. {ECO:0000269|PubMed:9839820}.
-!- DOMAIN: The sequence contains 4 internal repeats, each with 5
hydrophobic segments (S1, S2, S3, S5, S6) and one positively
charged segment (S4). Segments S4 are probably the voltage-sensors
and are characterized by a series of positively charged amino
acids at every third position. {ECO:0000305}.
-!- PTM: Ubiquitinated by NEDD4L; which promotes its endocytosis.
{ECO:0000250}.
-!- PTM: Phosphorylation at Ser-1451 by PKC in a highly conserved
cytoplasmic loop slows inactivation of the sodium channel and
reduces peak sodium currents. {ECO:0000250}.
-!- PTM: Lacks the cysteine which covalently binds the conotoxin
GVIIJ. This cysteine (position 816) is speculated in other sodium
channel subunits alpha to be implied in covalent binding with the
sodium channel subunit beta-2 or beta-4.
{ECO:0000250|UniProtKB:P15389}.
-!- DISEASE: Episodic pain syndrome, familial, 2 (FEPS2) [MIM:615551]:
An autosomal dominant neurologic disorder characterized by adult-
onset of paroxysmal pain mainly affecting the distal lower
extremities. {ECO:0000269|PubMed:23115331}. Note=The disease is
caused by mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
Nav1.8/SCN10A subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF117907; AAD30863.1; -; mRNA.
EMBL; AC116038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC137625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS33736.1; -.
RefSeq; NP_001280235.2; NM_001293306.2.
RefSeq; NP_001280236.2; NM_001293307.2.
RefSeq; NP_006505.3; NM_006514.3.
UniGene; Hs.250443; -.
ProteinModelPortal; Q9Y5Y9; -.
SMR; Q9Y5Y9; -.
STRING; 9606.ENSP00000390600; -.
BindingDB; Q9Y5Y9; -.
ChEMBL; CHEMBL5451; -.
DrugBank; DB01086; Benzocaine.
DrugBank; DB00297; Bupivacaine.
DrugBank; DB01161; Chloroprocaine.
DrugBank; DB00527; Cinchocaine.
DrugBank; DB00907; Cocaine.
DrugBank; DB00645; Dyclonine.
DrugBank; DB00473; Hexylcaine.
DrugBank; DB06218; Lacosamide.
DrugBank; DB01002; Levobupivacaine.
DrugBank; DB00281; Lidocaine.
DrugBank; DB00961; Mepivacaine.
DrugBank; DB01173; Orphenadrine.
DrugBank; DB00892; Oxybuprocaine.
DrugBank; DB00721; Procaine.
DrugBank; DB00807; Proparacaine.
DrugBank; DB00296; Ropivacaine.
DrugBank; DB00313; Valproic Acid.
GuidetoPHARMACOLOGY; 585; -.
iPTMnet; Q9Y5Y9; -.
PhosphoSitePlus; Q9Y5Y9; -.
BioMuta; SCN10A; -.
DMDM; 205371821; -.
PaxDb; Q9Y5Y9; -.
PeptideAtlas; Q9Y5Y9; -.
PRIDE; Q9Y5Y9; -.
Ensembl; ENST00000449082; ENSP00000390600; ENSG00000185313.
GeneID; 6336; -.
KEGG; hsa:6336; -.
UCSC; uc003ciq.4; human.
CTD; 6336; -.
DisGeNET; 6336; -.
EuPathDB; HostDB:ENSG00000185313.6; -.
GeneCards; SCN10A; -.
H-InvDB; HIX0030722; -.
HGNC; HGNC:10582; SCN10A.
MalaCards; SCN10A; -.
MIM; 604427; gene.
MIM; 615551; phenotype.
neXtProt; NX_Q9Y5Y9; -.
OpenTargets; ENSG00000185313; -.
Orphanet; 88642; Channelopathy-associated congenital insensitivity to pain.
Orphanet; 46348; Paroxysmal extreme pain disorder.
Orphanet; 90026; Primary erythermalgia.
Orphanet; 306577; Sodium channelopathy-related small fiber neuropathy.
PharmGKB; PA35000; -.
eggNOG; KOG2301; Eukaryota.
eggNOG; ENOG410XNP6; LUCA.
GeneTree; ENSGT00830000128242; -.
HOGENOM; HOG000231755; -.
HOVERGEN; HBG053100; -.
InParanoid; Q9Y5Y9; -.
KO; K04842; -.
OMA; WNIFDCI; -.
OrthoDB; EOG091G00FK; -.
PhylomeDB; Q9Y5Y9; -.
TreeFam; TF323985; -.
Reactome; R-HSA-445095; Interaction between L1 and Ankyrins.
Reactome; R-HSA-5576892; Phase 0 - rapid depolarisation.
SIGNOR; Q9Y5Y9; -.
GeneWiki; SCN10A; -.
GenomeRNAi; 6336; -.
PRO; PR:Q9Y5Y9; -.
Proteomes; UP000005640; Chromosome 3.
Bgee; ENSG00000185313; -.
CleanEx; HS_SCN10A; -.
Genevisible; Q9Y5Y9; HS.
GO; GO:0071439; C:clathrin complex; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0001518; C:voltage-gated sodium channel complex; IDA:BHF-UCL.
GO; GO:0044325; F:ion channel binding; IPI:BHF-UCL.
GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
GO; GO:0005248; F:voltage-gated sodium channel activity; IDA:BHF-UCL.
GO; GO:0086016; P:AV node cell action potential; IMP:BHF-UCL.
GO; GO:0086043; P:bundle of His cell action potential; IMP:BHF-UCL.
GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IMP:BHF-UCL.
GO; GO:0055117; P:regulation of cardiac muscle contraction; IMP:BHF-UCL.
GO; GO:0002027; P:regulation of heart rate; IMP:BHF-UCL.
GO; GO:0034765; P:regulation of ion transmembrane transport; IDA:BHF-UCL.
GO; GO:0007600; P:sensory perception; TAS:ProtInc.
GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO; GO:0035725; P:sodium ion transmembrane transport; IDA:BHF-UCL.
Gene3D; 1.20.120.350; -; 4.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR028809; Na_channel_a10su.
InterPro; IPR001696; Na_channel_asu.
InterPro; IPR010526; Na_trans_assoc.
InterPro; IPR027359; Volt_channel_dom_sf.
PANTHER; PTHR10037:SF208; PTHR10037:SF208; 1.
Pfam; PF00520; Ion_trans; 4.
Pfam; PF06512; Na_trans_assoc; 1.
PRINTS; PR00170; NACHANNEL.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disease mutation; Disulfide bond;
Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein;
Polymorphism; Reference proteome; Repeat; Sodium; Sodium channel;
Sodium transport; Transmembrane; Transmembrane helix; Transport;
Ubl conjugation; Voltage-gated channel.
CHAIN 1 1956 Sodium channel protein type 10 subunit
alpha.
/FTId=PRO_0000048507.
TOPO_DOM 1 125 Cytoplasmic. {ECO:0000305}.
TRANSMEM 126 149 Helical; Name=S1 of repeat I.
{ECO:0000255}.
TOPO_DOM 150 154 Extracellular. {ECO:0000305}.
TRANSMEM 155 174 Helical; Name=S2 of repeat I.
{ECO:0000255}.
TOPO_DOM 175 187 Cytoplasmic. {ECO:0000305}.
TRANSMEM 188 206 Helical; Name=S3 of repeat I.
{ECO:0000255}.
TOPO_DOM 207 212 Extracellular. {ECO:0000305}.
TRANSMEM 213 232 Helical; Voltage-sensor; Name=S4 of
repeat I. {ECO:0000255}.
TOPO_DOM 233 248 Cytoplasmic. {ECO:0000305}.
TRANSMEM 249 272 Helical; Name=S5 of repeat I.
{ECO:0000255}.
TOPO_DOM 273 341 Extracellular. {ECO:0000305}.
INTRAMEM 342 366 Pore-forming.
{ECO:0000250|UniProtKB:D0E0C2}.
TOPO_DOM 367 373 Extracellular. {ECO:0000305}.
TRANSMEM 374 399 Helical; Name=S6 of repeat I.
{ECO:0000255}.
TOPO_DOM 400 659 Cytoplasmic. {ECO:0000305}.
TRANSMEM 660 684 Helical; Name=S1 of repeat II.
{ECO:0000255}.
TOPO_DOM 685 695 Extracellular. {ECO:0000305}.
TRANSMEM 696 719 Helical; Name=S2 of repeat II.
{ECO:0000255}.
TOPO_DOM 720 727 Cytoplasmic. {ECO:0000305}.
TRANSMEM 728 747 Helical; Name=S3 of repeat II.
{ECO:0000255}.
TOPO_DOM 748 753 Extracellular. {ECO:0000305}.
TRANSMEM 754 773 Helical; Voltage-sensor; Name=S4 of
repeat II. {ECO:0000255}.
TOPO_DOM 774 789 Cytoplasmic. {ECO:0000305}.
TRANSMEM 790 810 Helical; Name=S5 of repeat II.
{ECO:0000255}.
TOPO_DOM 811 834 Extracellular. {ECO:0000305}.
INTRAMEM 835 855 Pore-forming.
{ECO:0000250|UniProtKB:D0E0C2}.
TOPO_DOM 856 864 Extracellular. {ECO:0000305}.
TRANSMEM 865 890 Helical; Name=S6 of repeat II.
{ECO:0000255}.
TOPO_DOM 891 1147 Cytoplasmic. {ECO:0000305}.
TRANSMEM 1148 1171 Helical; Name=S1 of repeat III.
{ECO:0000255}.
TOPO_DOM 1172 1184 Extracellular. {ECO:0000305}.
TRANSMEM 1185 1210 Helical; Name=S2 of repeat III.
{ECO:0000255}.
TOPO_DOM 1211 1216 Cytoplasmic. {ECO:0000305}.
TRANSMEM 1217 1238 Helical; Name=S3 of repeat III.
{ECO:0000255}.
TOPO_DOM 1239 1242 Extracellular. {ECO:0000305}.
TRANSMEM 1243 1264 Helical; Voltage-sensor; Name=S4 of
repeat III. {ECO:0000255}.
TOPO_DOM 1265 1283 Cytoplasmic. {ECO:0000305}.
TRANSMEM 1284 1311 Helical; Name=S5 of repeat III.
{ECO:0000255}.
TOPO_DOM 1312 1353 Extracellular. {ECO:0000305}.
INTRAMEM 1354 1375 Pore-forming.
{ECO:0000250|UniProtKB:D0E0C2}.
TOPO_DOM 1376 1391 Extracellular. {ECO:0000305}.
TRANSMEM 1392 1418 Helical; Name=S6 of repeat III.
{ECO:0000255}.
TOPO_DOM 1419 1471 Cytoplasmic. {ECO:0000305}.
TRANSMEM 1472 1495 Helical; Name=S1 of repeat IV.
{ECO:0000255}.
TOPO_DOM 1496 1506 Extracellular. {ECO:0000305}.
TRANSMEM 1507 1530 Helical; Name=S2 of repeat IV.
{ECO:0000255}.
TOPO_DOM 1531 1536 Cytoplasmic. {ECO:0000305}.
TRANSMEM 1537 1560 Helical; Name=S3 of repeat IV.
{ECO:0000255}.
TOPO_DOM 1561 1572 Extracellular. {ECO:0000305}.
TRANSMEM 1573 1594 Helical; Voltage-sensor; Name=S4 of
repeat IV. {ECO:0000255}.
TOPO_DOM 1595 1609 Cytoplasmic. {ECO:0000305}.
TRANSMEM 1610 1632 Helical; Name=S5 of repeat IV.
{ECO:0000255}.
TOPO_DOM 1633 1646 Extracellular. {ECO:0000305}.
INTRAMEM 1647 1669 Pore-forming.
{ECO:0000250|UniProtKB:D0E0C2}.
TOPO_DOM 1670 1697 Extracellular. {ECO:0000305}.
TRANSMEM 1698 1722 Helical; Name=S6 of repeat IV.
{ECO:0000255}.
TOPO_DOM 1723 1956 Cytoplasmic. {ECO:0000305}.
REPEAT 116 405 I. {ECO:0000305}.
REPEAT 647 911 II. {ECO:0000305}.
REPEAT 1140 1449 III. {ECO:0000305}.
REPEAT 1458 1757 IV. {ECO:0000305}.
DOMAIN 1851 1880 IQ.
MOD_RES 441 441 Phosphoserine.
{ECO:0000250|UniProtKB:Q14524}.
MOD_RES 444 444 Phosphoserine.
{ECO:0000250|UniProtKB:Q14524}.
MOD_RES 467 467 Phosphoserine.
{ECO:0000250|UniProtKB:Q14524}.
MOD_RES 479 479 Phosphoserine.
{ECO:0000250|UniProtKB:Q14524}.
MOD_RES 612 612 Phosphoserine.
{ECO:0000250|UniProtKB:Q14524}.
MOD_RES 615 615 Phosphoserine.
{ECO:0000250|UniProtKB:Q14524}.
MOD_RES 1451 1451 Phosphoserine; by PKC.
{ECO:0000250|UniProtKB:Q14524}.
CARBOHYD 284 284 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 288 288 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 312 312 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 335 335 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 819 819 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1312 1312 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1328 1328 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1336 1336 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1686 1686 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 276 319 {ECO:0000250|UniProtKB:D0E0C2}.
DISULFID 857 866 {ECO:0000250|UniProtKB:D0E0C2}.
VARIANT 509 509 S -> P (in dbSNP:rs7630989).
/FTId=VAR_020605.
VARIANT 554 554 L -> P (in FEPS2; increases the
excitability of small DRG neurons;
dbSNP:rs138404783).
{ECO:0000269|PubMed:23115331}.
/FTId=VAR_070878.
VARIANT 590 590 G -> R (in dbSNP:rs35332705).
/FTId=VAR_048696.
VARIANT 916 916 R -> W (found in a renal cell carcinoma
sample; somatic mutation;
dbSNP:rs370208223).
{ECO:0000269|PubMed:21248752}.
/FTId=VAR_064748.
VARIANT 939 939 P -> L (in dbSNP:rs202174472).
{ECO:0000269|PubMed:23115331}.
/FTId=VAR_070879.
VARIANT 940 940 Q -> L. {ECO:0000269|PubMed:23115331}.
/FTId=VAR_070880.
VARIANT 1056 1056 D -> N (in dbSNP:rs751574392).
{ECO:0000269|PubMed:23115331}.
/FTId=VAR_070881.
VARIANT 1073 1073 V -> A (in dbSNP:rs6795970).
{ECO:0000269|PubMed:9839820}.
/FTId=VAR_020606.
VARIANT 1092 1092 L -> P (in dbSNP:rs12632942).
/FTId=VAR_020607.
VARIANT 1304 1304 A -> T (in FEPS2; increases the
excitability of small DRG neurons;
dbSNP:rs142173735).
{ECO:0000269|PubMed:23115331}.
/FTId=VAR_070882.
VARIANT 1523 1523 C -> Y (no gain in function in response
to depolarization; dbSNP:rs142217269).
{ECO:0000269|PubMed:23115331}.
/FTId=VAR_070883.
VARIANT 1662 1662 G -> S (in dbSNP:rs151090729).
{ECO:0000269|PubMed:23115331}.
/FTId=VAR_070884.
VARIANT 1713 1713 M -> V (in dbSNP:rs6599241).
{ECO:0000269|PubMed:9839820}.
/FTId=VAR_020608.
SEQUENCE 1956 AA; 220626 MW; 4A4A2C5E135B6685 CRC64;
MEFPIGSLET NNFRRFTPES LVEIEKQIAA KQGTKKAREK HREQKDQEEK PRPQLDLKAC
NQLPKFYGEL PAELIGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR
RTAIKVSVHS WFSLFITVTI LVNCVCMTRT DLPEKIEYVF TVIYTFEALI KILARGFCLN
EFTYLRDPWN WLDFSVITLA YVGTAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI
HSVKKLADVT ILTIFCLSVF ALVGLQLFKG NLKNKCVKND MAVNETTNYS SHRKPDIYIN
KRGTSDPLLC GNGSDSGHCP DGYICLKTSD NPDFNYTSFD SFAWAFLSLF RLMTQDSWER
LYQQTLRTSG KIYMIFFVLV IFLGSFYLVN LILAVVTMAY EEQNQATTDE IEAKEKKFQE
ALEMLRKEQE VLAALGIDTT SLHSHNGSPL TSKNASERRH RIKPRVSEGS TEDNKSPRSD
PYNQRRMSFL GLASGKRRAS HGSVFHFRSP GRDISLPEGV TDDGVFPGDH ESHRGSLLLG
GGAGQQGPLP RSPLPQPSNP DSRHGEDEHQ PPPTSELAPG AVDVSAFDAG QKKTFLSAEY
LDEPFRAQRA MSVVSIITSV LEELEESEQK CPPCLTSLSQ KYLIWDCCPM WVKLKTILFG
LVTDPFAELT ITLCIVVNTI FMAMEHHGMS PTFEAMLQIG NIVFTIFFTA EMVFKIIAFD
PYYYFQKKWN IFDCIIVTVS LLELGVAKKG SLSVLRSFRL LRVFKLAKSW PTLNTLIKII
GNSVGALGNL TIILAIIVFV FALVGKQLLG ENYRNNRKNI SAPHEDWPRW HMHDFFHSFL
IVFRILCGEW IENMWACMEV GQKSICLILF LTVMVLGNLV VLNLFIALLL NSFSADNLTA
PEDDGEVNNL QVALARIQVF GHRTKQALCS FFSRSCPFPQ PKAEPELVVK LPLSSSKAEN
HIAANTARGS SGGLQAPRGP RDEHSDFIAN PTVWVSVPIA EGESDLDDLE DDGGEDAQSF
QQEVIPKGQQ EQLQQVERCG DHLTPRSPGT GTSSEDLAPS LGETWKDESV PQVPAEGVDD
TSSSEGSTVD CLDPEEILRK IPELADDLEE PDDCFTEGCI RHCPCCKLDT TKSPWDVGWQ
VRKTCYRIVE HSWFESFIIF MILLSSGSLA FEDYYLDQKP TVKALLEYTD RVFTFIFVFE
MLLKWVAYGF KKYFTNAWCW LDFLIVNISL ISLTAKILEY SEVAPIKALR TLRALRPLRA
LSRFEGMRVV VDALVGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFWRC INYTDGEFSL
VPLSIVNNKS DCKIQNSTGS FFWVNVKVNF DNVAMGYLAL LQVATFKGWM DIMYAAVDSR
EVNMQPKWED NVYMYLYFVI FIIFGGFFTL NLFVGVIIDN FNQQKKKLGG QDIFMTEEQK
KYYNAMKKLG SKKPQKPIPR PLNKFQGFVF DIVTRQAFDI TIMVLICLNM ITMMVETDDQ
SEEKTKILGK INQFFVAVFT GECVMKMFAL RQYYFTNGWN VFDFIVVVLS IASLIFSAIL
KSLQSYFSPT LFRVIRLARI GRILRLIRAA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI
YSIFGMSSFP HVRWEAGIDD MFNFQTFANS MLCLFQITTS AGWDGLLSPI LNTGPPYCDP
NLPNSNGTRG DCGSPAVGII FFTTYIIISF LIMVNMYIAV ILENFNVATE ESTEPLSEDD
FDMFYETWEK FDPEATQFIT FSALSDFADT LSGPLRIPKP NRNILIQMDL PLVPGDKIHC
LDILFAFTKN VLGESGELDS LKANMEEKFM ATNLSKSSYE PIATTLRWKQ EDISATVIQK
AYRSYVLHRS MALSNTPCVP RAEEEAASLP DEGFVAFTAN ENCVLPDKSE TASATSFPPS
YESVTRGLSD RVNMRTSSSI QNEDEATSME LIAPGP


Related products :

Catalog number Product name Quantity
EIAAB37616 Homo sapiens,hPN3,Human,Peripheral nerve sodium channel 3,PN3,SCN10A,Sodium channel protein type 10 subunit alpha,Sodium channel protein type X subunit alpha,Voltage-gated sodium channel subunit alpha
EIAAB37609 Peripheral sodium channel 1,PN1,Rat,Rattus norvegicus,Scn9a,Sodium channel protein type 9 subunit alpha,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7
EIAAB37615 Mouse,Mus musculus,Peripheral nerve sodium channel 3,PN3,Scn10a,Sensory neuron sodium channel,Sns,Sodium channel protein type 10 subunit alpha,Sodium channel protein type X subunit alpha,Voltage-gated
EIAAB37608 NaCh6,Peripheral nerve protein type 4,PN4,Rat,Rattus norvegicus,Scn8a,Sodium channel 6,Sodium channel protein type 8 subunit alpha,Sodium channel protein type VIII subunit alpha,Voltage-gated sodium c
EIAAB37612 Kiaa4197,Mouse,Mus musculus,Peripheral sodium channel 1,PN1,Scn9a,Sodium channel protein type 9 subunit alpha,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Na
EIAAB37614 Peripheral nerve sodium channel 3,PN3,Rat,Rattus norvegicus,Scn10a,Sensory neuron sodium channel,Sns,Sodium channel protein type 10 subunit alpha,Sodium channel protein type X subunit alpha,Voltage-ga
EIAAB37607 Mouse,Mus musculus,Nbna1,Scn8a,Sodium channel protein type 8 subunit alpha,Sodium channel protein type VIII subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.6
EIAAB37606 Homo sapiens,Human,MED,SCN8A,Sodium channel protein type 8 subunit alpha,Sodium channel protein type VIII subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.6
EIAAB37575 Homo sapiens,Human,NAC1,SCN1,SCN1A,Sodium channel protein brain I subunit alpha,Sodium channel protein type 1 subunit alpha,Sodium channel protein type I subunit alpha,Voltage-gated sodium channel sub
EIAAB37596 Homo sapiens,Human,SCN4A,SkM1,Sodium channel protein skeletal muscle subunit alpha,Sodium channel protein type 4 subunit alpha,Sodium channel protein type IV subunit alpha,Voltage-gated sodium channel
EIAAB37610 Nas,Oryctolagus cuniculus,Rabbit,Schwann cell sodium channel,SCN9A,Sodium channel protein type 9 subunit alpha,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha N
EIAAB37611 hNE-Na,Homo sapiens,Human,NENA,Neuroendocrine sodium channel,Peripheral sodium channel 1,PN1,SCN9A,Sodium channel protein type 9 subunit alpha,Sodium channel protein type IX subunit alpha,Voltage-gate
EIAAB37618 NaN,Nan,Rat,Rattus norvegicus,Scn11a,Sensory neuron sodium channel 2,Sns2,Sodium channel protein type 11 subunit alpha,Sodium channel protein type XI subunit alpha,Voltage-gated sodium channel subunit
EIAAB37619 hNaN,Homo sapiens,Human,Peripheral nerve sodium channel 5,PN5,SCN11A,SCN12A,Sensory neuron sodium channel 2,SNS2,Sodium channel protein type 11 subunit alpha,Sodium channel protein type XI subunit alp
EIAAB37604 HH1,Homo sapiens,Human,SCN5A,Sodium channel protein cardiac muscle subunit alpha,Sodium channel protein type 5 subunit alpha,Sodium channel protein type V subunit alpha,Voltage-gated sodium channel su
EIAAB37595 Mouse,Mus musculus,Scn4a,Sodium channel protein skeletal muscle subunit alpha,Sodium channel protein type 4 subunit alpha,Sodium channel protein type IV subunit alpha,Voltage-gated sodium channel subu
EIAAB37617 Mouse,Mus musculus,NaN,Nan,Nat,Scn11a,Sensory neuron sodium channel 2,Sns2,Sodium channel protein type 11 subunit alpha,Sodium channel protein type XI subunit alpha,Voltage-gated sodium channel subuni
EIAAB37605 Homo sapiens,Human,Putative voltage-gated sodium channel subunit alpha Nax,SCN6A,SCN7A,Sodium channel protein cardiac and skeletal muscle subunit alpha,Sodium channel protein type 7 subunit alpha,Sodi
EIAAB37603 Rat,Rattus norvegicus,Scn5a,Sodium channel protein cardiac muscle subunit alpha,Sodium channel protein type 5 subunit alpha,Sodium channel protein type V subunit alpha,Voltage-gated sodium channel sub
EIAAB37602 mH1,Mouse,Mus musculus,Scn5a,Sodium channel protein cardiac muscle subunit alpha,Sodium channel protein type 5 subunit alpha,Sodium channel protein type V subunit alpha,Voltage-gated sodium channel su
EIAAB37589 Rat,Rattus norvegicus,Scn3a,Sodium channel protein brain III subunit alpha,Sodium channel protein type 3 subunit alpha,Sodium channel protein type III subunit alpha,Voltage-gated sodium channel subtyp
EIAAB37583 Rat,Rattus norvegicus,Scn2a,Scn2a1,Sodium channel protein brain II subunit alpha,Sodium channel protein type 2 subunit alpha,Sodium channel protein type II subunit alpha,Voltage-gated sodium channel s
EIAAB37590 Homo sapiens,Human,KIAA1356,NAC3,SCN3A,Sodium channel protein brain III subunit alpha,Sodium channel protein type 3 subunit alpha,Sodium channel protein type III subunit alpha,Voltage-gated sodium cha
EIAAB37584 HBSC II,Homo sapiens,Human,NAC2,SCN2A,SCN2A1,SCN2A2,Sodium channel protein brain II subunit alpha,Sodium channel protein type 2 subunit alpha,Sodium channel protein type II subunit alpha,Voltage-gated
EIAAB37576 Rat,Rattus norvegicus,Scn1a,Sodium channel protein brain I subunit alpha,Sodium channel protein type 1 subunit alpha,Sodium channel protein type I subunit alpha,Voltage-gated sodium channel subunit al


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur