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Sodium channel subunit beta-2

 SCN2B_CANLF             Reviewed;         215 AA.
Q864L3;
21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 2.
28-FEB-2018, entry version 87.
RecName: Full=Sodium channel subunit beta-2;
Flags: Precursor;
Name=SCN2B;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Mishra S., Sabbah H.N., Undrovinas A.I.;
"Cloning of dog cardiomyocyte sodium channel beta-2 subunit cDNA.";
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Crucial in the assembly, expression, and functional
modulation of the heterotrimeric complex of the sodium channel.
The subunit beta-2 causes an increase in the plasma membrane
surface area and in its folding into microvilli. Interacts with
TNR may play a crucial role in clustering and regulation of
activity of sodium channels at nodes of Ranvier (By similarity).
{ECO:0000250}.
-!- SUBUNIT: The voltage-sensitive sodium channel consists of an ion
conducting pore forming alpha-subunit regulated by one or more
beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3
are non-covalently associated with alpha, while beta-2 and beta-4
are covalently linked by disulfide bonds (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- SIMILARITY: Belongs to the sodium channel auxiliary subunit SCN2B
(TC 8.A.17) family. {ECO:0000305}.
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EMBL; AY263393; AAP30026.2; -; mRNA.
ProteinModelPortal; Q864L3; -.
HOGENOM; HOG000118120; -.
HOVERGEN; HBG003443; -.
InParanoid; Q864L3; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
GO; GO:0017080; F:sodium channel regulator activity; IEA:InterPro.
GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
InterPro; IPR000920; Myelin_P0-rel.
InterPro; IPR029873; SCN2B.
PANTHER; PTHR13869; PTHR13869; 1.
PANTHER; PTHR13869:SF3; PTHR13869:SF3; 1.
Pfam; PF07686; V-set; 1.
PRINTS; PR00213; MYELINP0.
SMART; SM00409; IG; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Ion channel; Ion transport; Membrane;
Phosphoprotein; Reference proteome; Signal; Sodium; Sodium channel;
Sodium transport; Transmembrane; Transmembrane helix; Transport;
Voltage-gated channel.
SIGNAL 1 29 {ECO:0000250}.
CHAIN 30 215 Sodium channel subunit beta-2.
/FTId=PRO_0000014930.
TOPO_DOM 30 159 Extracellular. {ECO:0000255}.
TRANSMEM 160 180 Helical. {ECO:0000255}.
TOPO_DOM 181 215 Cytoplasmic. {ECO:0000255}.
DOMAIN 32 154 Ig-like C2-type.
MOD_RES 192 192 Phosphoserine.
{ECO:0000250|UniProtKB:P54900}.
MOD_RES 204 204 Phosphothreonine.
{ECO:0000250|UniProtKB:P54900}.
CARBOHYD 42 42 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 66 66 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 74 74 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 50 127 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 55 55 Interchain; with alpha subunit.
{ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 215 AA; 24306 MW; D5A30A7CCF569F9F CRC64;
MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC TFNSCYTVNH
KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE FSGNPSKYDV SVMLRNVQPE
DEGIYNCYIM NPPDRHRGHG KIHLQVLXEE PPERDSTVAV IVGASVGGFL AVVILVLMVV
KCVRRKKEQK LSTDDLKTEE EGKTDGEGNP DDGAK


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