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Sodium- and chloride-dependent betaine transporter (Betaine transporter SNF-3) (Na( )/Cl(-) betaine/GABA transporter) (Sodium:neurotransmitter symporter family protein 3)

 SNF3_CAEEL              Reviewed;         600 AA.
G5EBN9;
19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
14-DEC-2011, sequence version 1.
28-FEB-2018, entry version 52.
RecName: Full=Sodium- and chloride-dependent betaine transporter {ECO:0000250|UniProtKB:P48065};
AltName: Full=Betaine transporter SNF-3 {ECO:0000303|PubMed:24212673};
AltName: Full=Na(+)/Cl(-) betaine/GABA transporter {ECO:0000250|UniProtKB:P48065};
AltName: Full=Sodium:neurotransmitter symporter family protein 3;
Name=snf-3 {ECO:0000312|EMBL:CCD63487.1,
ECO:0000312|WormBase:T13B5.1};
Synonyms=bgt-1 {ECO:0000312|EMBL:AAZ23105.1}; ORFNames=T13B5.1;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1] {ECO:0000305, ECO:0000312|EMBL:ABF20556.1}
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=16641366; DOI=10.1091/mbc.E06-02-0155;
Mullen G.P., Mathews E.A., Saxena P., Fields S.D., McManus J.R.,
Moulder G., Barstead R.J., Quick M.W., Rand J.B.;
"The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent
GABA transporter required for clearance of synaptic GABA.";
Mol. Biol. Cell 17:3021-3030(2006).
[2] {ECO:0000312|EMBL:AAZ23105.1}
NUCLEOTIDE SEQUENCE [MRNA].
Jiang G.-L., Ganapathy V., Fei Y.-J.;
"Molecular cloning and functional characteristics of a Na+/Cl--coupled
betaine transporter, BGT-1, from Caenorhabditis elegans: Localization
in hypodermis and intestine and involvement in osmo-regulation.";
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000312|EMBL:CCD63487.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2 {ECO:0000312|EMBL:CCD63487.1};
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[4] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
PHENOTYPE.
STRAIN=Bristol N2 {ECO:0000269|PubMed:24212673};
PubMed=24212673; DOI=10.1038/nn.3575;
Peden A.S., Mac P., Fei Y.J., Castro C., Jiang G., Murfitt K.J.,
Miska E.A., Griffin J.L., Ganapathy V., Jorgensen E.M.;
"Betaine acts on a ligand-gated ion channel in the nervous system of
the nematode C. elegans.";
Nat. Neurosci. 16:1794-1801(2013).
-!- FUNCTION: Betaine transporter dependent on Na(+) and Cl(-) ions
that functions primarily in the epidermis to clear betaine from
the extracellular space. Elicits current in response to betaine
but not in response to GABA, L-carnitine, sarcosine, glycine or
dimethylglycine. {ECO:0000269|PubMed:24212673}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24212673};
Multi-pass membrane protein {ECO:0000305|PubMed:24212673}.
-!- TISSUE SPECIFICITY: Highly expressed in the head, the excretory
canal, tail hypodermal cells, epidermis and vulval epithelial
cells. Expressed in the excretory canal-associated neuron and in
some non-amphidial sensory neurons in the head (at protein level).
{ECO:0000269|PubMed:16641366, ECO:0000269|PubMed:24212673}.
-!- DISRUPTION PHENOTYPE: Mutant worms are morphologically similar to
the wild-type but exhibit mild swimming defects and are lethargic
when crawling on a food-free environment with their movement being
interrupted by frequent pauses. Worms paralyze in the presence of
exogenous betaine. Simultaneous knockdown of snf-3 and egl-8
results in uncoordinated, hypercontracted and paralyzed animals.
{ECO:0000269|PubMed:24212673}.
-!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF)
family. {ECO:0000255}.
-----------------------------------------------------------------------
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EMBL; DQ482733; ABF20556.1; -; mRNA.
EMBL; DQ118731; AAZ23105.1; -; mRNA.
EMBL; FO080410; CCD63487.1; -; Genomic_DNA.
PIR; T32456; T32456.
RefSeq; NP_493910.2; NM_061509.7.
UniGene; Cel.5293; -.
ProteinModelPortal; G5EBN9; -.
STRING; 6239.T13B5.1.1; -.
EPD; G5EBN9; -.
PaxDb; G5EBN9; -.
PeptideAtlas; G5EBN9; -.
EnsemblMetazoa; T13B5.1; T13B5.1; WBGene00004902.
GeneID; 173493; -.
KEGG; cel:CELE_T13B5.1; -.
CTD; 173493; -.
WormBase; T13B5.1; CE30176; WBGene00004902; snf-3.
eggNOG; KOG3659; Eukaryota.
eggNOG; COG0733; LUCA.
GeneTree; ENSGT00760000118857; -.
InParanoid; G5EBN9; -.
KO; K05034; -.
OMA; FVYFCAL; -.
OrthoDB; EOG091G08PX; -.
PhylomeDB; G5EBN9; -.
Reactome; R-CEL-352230; Amino acid transport across the plasma membrane.
Reactome; R-CEL-442660; Na+/Cl- dependent neurotransmitter transporters.
Reactome; R-CEL-71288; Creatine metabolism.
Reactome; R-CEL-888593; Reuptake of GABA.
PRO; PR:G5EBN9; -.
Proteomes; UP000001940; Chromosome II.
Bgee; WBGene00004902; -.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0015199; F:amino-acid betaine transmembrane transporter activity; IDA:WormBase.
GO; GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
GO; GO:0015838; P:amino-acid betaine transport; IDA:WormBase.
InterPro; IPR000175; Na/ntran_symport.
InterPro; IPR037272; SNS_sf.
PANTHER; PTHR11616; PTHR11616; 1.
Pfam; PF00209; SNF; 1.
PRINTS; PR00176; NANEUSMPORT.
SUPFAM; SSF161070; SSF161070; 1.
PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Glycoprotein; Membrane;
Neurotransmitter transport; Reference proteome; Symport;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 600 Sodium- and chloride-dependent betaine
transporter.
/FTId=PRO_0000425865.
TOPO_DOM 1 38 Cytoplasmic. {ECO:0000255}.
TRANSMEM 39 59 Helical; Name=1. {ECO:0000255}.
TRANSMEM 68 88 Helical; Name=2. {ECO:0000255}.
TRANSMEM 116 136 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 137 207 Extracellular. {ECO:0000255}.
TRANSMEM 208 228 Helical; Name=4. {ECO:0000255}.
TRANSMEM 237 257 Helical; Name=5. {ECO:0000255}.
TRANSMEM 286 306 Helical; Name=6. {ECO:0000255}.
TRANSMEM 321 341 Helical; Name=7. {ECO:0000255}.
TRANSMEM 378 398 Helical; Name=8. {ECO:0000255}.
TRANSMEM 420 440 Helical; Name=9. {ECO:0000255}.
TRANSMEM 454 474 Helical; Name=10. {ECO:0000255}.
TRANSMEM 499 519 Helical; Name=11. {ECO:0000255}.
TRANSMEM 536 556 Helical; Name=12. {ECO:0000255}.
TOPO_DOM 557 600 Cytoplasmic. {ECO:0000255}.
CARBOHYD 165 165 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 273 273 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 600 AA; 67391 MW; 0B7CF7000FC1FAB9 CRC64;
MGTSEHVPLP TDEAKAKELE QSQHSEEPDR GQWTGKFDFL MSMVAYAVGL GNVWRFPYLC
YKNGGGSFLV VYMIFFCLAA VPIFLMEVTV GQYLQKGAME MWLMCPLFRG VGIGNVVIAF
MCIAYFCVIV AWAMFYMISS IAWVFPWETC NNYWNDATCV TGKENFTELA RIKALVASAG
GHTQTSVEQF WEKRVLHDTG DISEFGGIQW ELFFIMAAAW LIVYFALWKG ITQARKFVYF
CALFPYVLIF ILLIRGLTLE GAGTGIYFYL KPNATRLLDT AVWKDAGTQV FYSYGVGFGA
LIALGSHNKF NHNCFKDAIT MCFINGCTSI TAGFAVFSIL GYMSHVAQKD ISEIVKPGVG
LAFLAYPEVA SNLPMKQVFA VLFFLMITIL GLDSQVCMME GLFTALEDAF PILRKYKKQS
LGIFCLFFFC IGIPMVTHSG SHWLTLFDAY GASGYALLFV VFFEVVGLAY GFGAHNIRKA
LHEMIGVTLP KGIEYVWKFC APATSLVLFV FCVVYYHPVK YPDGKDFPFW ANAFGWFLSS
CSMVVIPGYA IYYLFFTNKH LTLKERVRKG LNLDGSFESP AKKNLVNNAE ELKFIESSSQ


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