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Sodium- and chloride-dependent creatine transporter 1 (CHOT1) (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8)

 SC6A8_RAT               Reviewed;         635 AA.
P28570;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
01-DEC-1992, sequence version 1.
22-NOV-2017, entry version 128.
RecName: Full=Sodium- and chloride-dependent creatine transporter 1;
Short=CHOT1;
Short=CT1;
Short=Creatine transporter 1;
AltName: Full=Solute carrier family 6 member 8;
Name=Slc6a8;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Brain;
PubMed=1633856; DOI=10.1016/0014-5793(92)80649-2;
Mayser W., Schloss P., Betz H.;
"Primary structure and functional expression of a choline transporter
expressed in the rat nervous system.";
FEBS Lett. 305:31-36(1992).
-!- FUNCTION: Required for the uptake of creatine. Plays an important
role in supplying creatine to the brain via the blood-brain
barrier (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in brain, cerebellum, spinal cord,
to a lesser extent, heart, but only very low expression in lung,
kidney, and muscle.
-!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF)
(TC 2.A.22) family. SLC6A8 subfamily. {ECO:0000305}.
-!- CAUTION: Was originally thought to be a choline transporter.
{ECO:0000305|PubMed:1633856}.
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EMBL; X66494; CAA47119.1; -; mRNA.
PIR; S23431; S23431.
RefSeq; NP_059044.1; NM_017348.2.
UniGene; Rn.10336; -.
ProteinModelPortal; P28570; -.
STRING; 10116.ENSRNOP00000025702; -.
BindingDB; P28570; -.
ChEMBL; CHEMBL3814; -.
TCDB; 2.A.22.3.5; the neurotransmitter:sodium symporter (nss) family.
iPTMnet; P28570; -.
PhosphoSitePlus; P28570; -.
PaxDb; P28570; -.
Ensembl; ENSRNOT00000092123; ENSRNOP00000074536; ENSRNOG00000057620.
GeneID; 50690; -.
KEGG; rno:50690; -.
CTD; 6535; -.
RGD; 619711; Slc6a8.
eggNOG; KOG3659; Eukaryota.
eggNOG; COG0733; LUCA.
GeneTree; ENSGT00760000118857; -.
HOGENOM; HOG000116406; -.
HOVERGEN; HBG071421; -.
InParanoid; P28570; -.
KO; K05039; -.
OMA; VPPRETW; -.
OrthoDB; EOG091G08PX; -.
PhylomeDB; P28570; -.
Reactome; R-RNO-71288; Creatine metabolism.
PRO; PR:P28570; -.
Proteomes; UP000002494; Chromosome X.
Bgee; ENSRNOG00000057620; -.
ExpressionAtlas; P28570; differential.
Genevisible; P28570; RN.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:RGD.
GO; GO:0015220; F:choline transmembrane transporter activity; IDA:RGD.
GO; GO:0005308; F:creatine transmembrane transporter activity; IDA:RGD.
GO; GO:0005309; F:creatine:sodium symporter activity; IDA:RGD.
GO; GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
GO; GO:0015881; P:creatine transport; IDA:RGD.
GO; GO:1990403; P:embryonic brain development; IEP:RGD.
InterPro; IPR000175; Na/ntran_symport.
InterPro; IPR002984; Na/ntran_symport_creatine.
InterPro; IPR037272; SNS_sf.
PANTHER; PTHR11616; PTHR11616; 1.
Pfam; PF00209; SNF; 1.
PRINTS; PR01199; CRTTRANSPORT.
PRINTS; PR00176; NANEUSMPORT.
SUPFAM; SSF161070; SSF161070; 2.
PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
2: Evidence at transcript level;
Complete proteome; Glycoprotein; Ion transport; Membrane;
Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport;
Transmembrane; Transmembrane helix; Transport.
CHAIN 1 635 Sodium- and chloride-dependent creatine
transporter 1.
/FTId=PRO_0000214777.
TOPO_DOM 1 60 Cytoplasmic. {ECO:0000255}.
TRANSMEM 61 81 Helical. {ECO:0000255}.
TOPO_DOM 82 87 Extracellular. {ECO:0000255}.
TRANSMEM 88 108 Helical. {ECO:0000255}.
TOPO_DOM 109 138 Cytoplasmic. {ECO:0000255}.
TRANSMEM 139 159 Helical. {ECO:0000255}.
TOPO_DOM 160 230 Extracellular. {ECO:0000255}.
TRANSMEM 231 251 Helical. {ECO:0000255}.
TOPO_DOM 252 269 Cytoplasmic. {ECO:0000255}.
TRANSMEM 270 290 Helical. {ECO:0000255}.
TOPO_DOM 291 304 Extracellular. {ECO:0000255}.
TRANSMEM 305 325 Helical. {ECO:0000255}.
TOPO_DOM 326 341 Cytoplasmic. {ECO:0000255}.
TRANSMEM 342 362 Helical. {ECO:0000255}.
TOPO_DOM 363 394 Extracellular. {ECO:0000255}.
TRANSMEM 395 415 Helical. {ECO:0000255}.
TOPO_DOM 416 444 Cytoplasmic. {ECO:0000255}.
TRANSMEM 445 465 Helical. {ECO:0000255}.
TOPO_DOM 466 479 Extracellular. {ECO:0000255}.
TRANSMEM 480 500 Helical. {ECO:0000255}.
TOPO_DOM 501 520 Cytoplasmic. {ECO:0000255}.
TRANSMEM 521 541 Helical. {ECO:0000255}.
TOPO_DOM 542 560 Extracellular. {ECO:0000255}.
TRANSMEM 561 581 Helical. {ECO:0000255}.
TOPO_DOM 582 635 Cytoplasmic. {ECO:0000255}.
MOD_RES 617 617 Phosphothreonine.
{ECO:0000250|UniProtKB:P48029}.
MOD_RES 620 620 Phosphothreonine.
{ECO:0000250|UniProtKB:P48029}.
MOD_RES 623 623 Phosphoserine.
{ECO:0000250|UniProtKB:Q8VBW1}.
CARBOHYD 192 192 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 197 197 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 548 548 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 635 AA; 70632 MW; 5D6A944035103787 CRC64;
MAKKSAENGI YSVSGDEKKG PLIVSGPDGA PSKGDGPAGL GAPSSRLAVP PRETWTRQMD
FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS
INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD
CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSTGLEVPGA LNWEVTLCLL
ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL
GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF
SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV
GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG
TTLLWQAFWE CVVVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNVV
YYKPLVYNNT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG
LHHLEYRAQD ADVRGLTTLT PVSESSKVVV VESVM


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