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Sodium-dependent dopamine transporter (DA transporter) (DAT)

 NTDO_CAEEL              Reviewed;         615 AA.
Q03614; Q9XTK0;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
11-JUL-2001, sequence version 3.
25-OCT-2017, entry version 129.
RecName: Full=Sodium-dependent dopamine transporter;
Short=DA transporter;
Short=DAT;
Name=dat-1; ORFNames=T23G5.5;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=9765501;
Jayanthi L.D., Apparsundaram S., Malone M.D., Ward E., Miller D.M.,
Eppler M., Blakely R.D.;
"The Caenorhabditis elegans gene T23G5.5 encodes an
antidepressant- and cocaine-sensitive dopamine transporter.";
Mol. Pharmacol. 54:601-609(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=7906398; DOI=10.1038/368032a0;
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M.,
Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A.,
Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A.,
Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M.,
Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N.,
Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M.,
Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R.,
Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R.,
Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K.,
Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J.,
Wohldman P.;
"2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
elegans.";
Nature 368:32-38(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
-!- FUNCTION: Dopamine transporter. Terminates the action of dopamine
by its high affinity sodium-dependent reuptake into presynaptic
terminals. {ECO:0000269|PubMed:9765501}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9765501};
Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7K4Y6}.
-!- MISCELLANEOUS: This protein is the target of psychomotor
stimulants such as amphetamines or cocaine.
-!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF)
(TC 2.A.22) family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF079899; AAC83661.1; -; mRNA.
EMBL; Z19158; CAA79575.2; -; Genomic_DNA.
EMBL; Z19156; CAA79575.2; JOINED; Genomic_DNA.
PIR; D88551; D88551.
PIR; S28306; S28306.
PIR; T43330; T43330.
RefSeq; NP_499043.1; NM_066642.5.
UniGene; Cel.19618; -.
ProteinModelPortal; Q03614; -.
SMR; Q03614; -.
DIP; DIP-46293N; -.
IntAct; Q03614; 1.
STRING; 6239.T23G5.5; -.
TCDB; 2.A.22.1.4; the neurotransmitter:sodium symporter (nss) family.
PaxDb; Q03614; -.
EnsemblMetazoa; T23G5.5; T23G5.5; WBGene00000934.
GeneID; 176304; -.
KEGG; cel:CELE_T23G5.5; -.
UCSC; T23G5.5; c. elegans.
CTD; 176304; -.
WormBase; T23G5.5; CE25124; WBGene00000934; dat-1.
eggNOG; KOG3659; Eukaryota.
eggNOG; COG0733; LUCA.
GeneTree; ENSGT00760000118857; -.
HOGENOM; HOG000116406; -.
InParanoid; Q03614; -.
KO; K05036; -.
OMA; TQGGFYF; -.
OrthoDB; EOG091G08PX; -.
PhylomeDB; Q03614; -.
Reactome; R-CEL-379401; Dopamine clearance from the synaptic cleft.
Reactome; R-CEL-442660; Na+/Cl- dependent neurotransmitter transporters.
PRO; PR:Q03614; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00000934; -.
GO; GO:0030673; C:axolemma; IDA:WormBase.
GO; GO:0032590; C:dendrite membrane; IDA:WormBase.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0032809; C:neuronal cell body membrane; IDA:WormBase.
GO; GO:0042734; C:presynaptic membrane; IDA:WormBase.
GO; GO:0005275; F:amine transmembrane transporter activity; IMP:WormBase.
GO; GO:0005254; F:chloride channel activity; IDA:WormBase.
GO; GO:0005329; F:dopamine transmembrane transporter activity; IDA:WormBase.
GO; GO:0005330; F:dopamine:sodium symporter activity; IDA:WormBase.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0015837; P:amine transport; IMP:WormBase.
GO; GO:0006821; P:chloride transport; IDA:WormBase.
GO; GO:0090494; P:dopamine uptake; IDA:WormBase.
GO; GO:0051583; P:dopamine uptake involved in synaptic transmission; IDA:WormBase.
GO; GO:1905803; P:negative regulation of cellular response to manganese ion; IGI:UniProtKB.
GO; GO:1905847; P:negative regulation of cellular response to oxidopamine; IMP:UniProtKB.
GO; GO:1901216; P:positive regulation of neuron death; IMP:UniProtKB.
InterPro; IPR000175; Na/ntran_symport.
PANTHER; PTHR11616; PTHR11616; 1.
Pfam; PF00209; SNF; 1.
PRINTS; PR00176; NANEUSMPORT.
PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Membrane; Metal-binding; Neurotransmitter transport;
Reference proteome; Sodium; Symport; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 615 Sodium-dependent dopamine transporter.
/FTId=PRO_0000214815.
TOPO_DOM 1 46 Cytoplasmic.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 47 72 Helical; Name=1.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 73 76 Extracellular.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 77 100 Helical; Name=2.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 101 120 Cytoplasmic.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 121 151 Helical; Name=3.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 152 229 Extracellular.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 230 250 Helical; Name=4.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 251 253 Cytoplasmic.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 254 278 Helical; Name=5.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 279 302 Extracellular.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 303 328 Helical; Name=6.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 329 334 Cytoplasmic.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 335 358 Helical; Name=7.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 359 398 Extracellular.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 399 424 Helical; Name=8.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 425 439 Cytoplasmic.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 440 460 Helical; Name=9.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 461 461 Extracellular.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 462 488 Helical; Name=10.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 489 518 Cytoplasmic.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 519 541 Helical; Name=11.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 542 544 Extracellular.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TRANSMEM 545 565 Helical; Name=12.
{ECO:0000250|UniProtKB:Q7K4Y6}.
TOPO_DOM 566 615 Cytoplasmic.
{ECO:0000250|UniProtKB:Q7K4Y6}.
METAL 55 55 Sodium 1; via carbonyl oxygen.
{ECO:0000250|UniProtKB:Q7K4Y6}.
METAL 57 57 Sodium 2; via carbonyl oxygen.
{ECO:0000250|UniProtKB:Q7K4Y6}.
METAL 58 58 Sodium 1; via carbonyl oxygen.
{ECO:0000250|UniProtKB:Q7K4Y6}.
METAL 62 62 Sodium 2. {ECO:0000250|UniProtKB:Q7K4Y6}.
METAL 314 314 Sodium 2. {ECO:0000250|UniProtKB:Q7K4Y6}.
METAL 346 346 Sodium 2. {ECO:0000250|UniProtKB:Q7K4Y6}.
METAL 411 411 Sodium 1; via carbonyl oxygen.
{ECO:0000250|UniProtKB:Q7K4Y6}.
METAL 414 414 Sodium 1. {ECO:0000250|UniProtKB:Q7K4Y6}.
METAL 415 415 Sodium 1. {ECO:0000250|UniProtKB:Q7K4Y6}.
CARBOHYD 162 162 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 187 187 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 161 170 {ECO:0000250|UniProtKB:Q7K4Y6}.
SEQUENCE 615 AA; 69266 MW; 0DA2876EB3AC8049 CRC64;
MQLVPTDDPD EKIGRTSNGM QNATLPIDGP VNTEPKDPAR EQWSGKLDFL LSVVGFAVDL
GNIWRFPYLC FKNGGGVFLI PYSIMVLLTG VPLFYMELCL GQYYRKGAIT TWGRICPLFK
GIGYCVILTA FYVDFFYNVI LAWGLHYLYT SFSFNLPWAS CNNSYNSPAC YEPHWSEDGT
AMCRSANQSV SAEKISAAEE YFYKGFLGLH EANAPNSHVI RSVTDLGNVR WDIALSLFVV
YLICYFSMWK GIHTSGKVVW FTALFPYVVL GILFIRGVTL PGWQNGIEYY LRPNFEMLKR
PSVWQDAATQ VFFSLGPGFG VLMAYSSYND FHNNVYVDAL FTSFINCATS FLSGFVIFSV
LGYMSCKSGK PIEAVAQEGP GLVFVVYPEA LSTMPYAPFW SVLFFLMLMT LGLDSSFGGS
EAIITGLSDE FPILKKNREV FVGCLFAFYM VIGIAMCTEG GILIMEWLII YGTTWGLLIA
VFCEAMVIAY IYGLRQFVHD VKEMMGFRPG NYWKFCWSCA APFILLSMIT SNFINYQALT
YQDYTYPTAA NVIGIIFALS GASFIPLVGI YKFVNARGNT ISEKWQRVTM PYRKRPNQTE
YIPIPTTQPH SDIML


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