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Sodium-dependent phosphate transport protein 2C (Sodium-phosphate transport protein 2C) (Na( )-dependent phosphate cotransporter 2C) (Sodium/phosphate cotransporter 2C) (Na( )/Pi cotransporter 2C) (NaPi-2c) (Solute carrier family 34 member 3)

 NPT2C_MOUSE             Reviewed;         601 AA.
Q80SU6; Q05AC3;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
20-JUN-2018, entry version 103.
RecName: Full=Sodium-dependent phosphate transport protein 2C;
Short=Sodium-phosphate transport protein 2C;
AltName: Full=Na(+)-dependent phosphate cotransporter 2C;
AltName: Full=Sodium/phosphate cotransporter 2C;
Short=Na(+)/Pi cotransporter 2C;
Short=NaPi-2c;
AltName: Full=Solute carrier family 34 member 3;
Name=Slc34a3; Synonyms=Npt2c;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], CHARACTERIZATION, AND
INDUCTION.
PubMed=12690469; DOI=10.1007/s00424-003-1010-6;
Ohkido I., Segawa H., Yanagida R., Nakamura M., Miyamoto K.;
"Cloning, gene structure and dietary regulation of the type-IIc Na/Pi
cotransporter in the mouse kidney.";
Pflugers Arch. 446:106-115(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
MUTAGENESIS OF GLY-195 AND 189-SER--SER-191.
PubMed=16113079; DOI=10.1073/pnas.0505882102;
Bacconi A., Virkki L.V., Biber J., Murer H., Forster I.C.;
"Renouncing electroneutrality is not free of charge: switching on
electrogenicity in a Na+-coupled phosphate cotransporter.";
Proc. Natl. Acad. Sci. U.S.A. 102:12606-12611(2005).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: May be involved in actively transporting phosphate into
cells via Na(+) cotransport in the renal brush border membrane.
Probably mediates 20-30% of the apical influx.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Observed only in kidney.
-!- MISCELLANEOUS: The cotransport has a Na(+):Pi stoichiometry of 2:1
and is electroneutral.
-!- SIMILARITY: Belongs to the SLC34A transporter family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB054999; BAB83241.1; -; mRNA.
EMBL; AB080134; BAC55069.1; -; Genomic_DNA.
EMBL; AL732309; CAM14672.1; -; Genomic_DNA.
EMBL; CH466542; EDL08215.1; -; Genomic_DNA.
EMBL; CH466542; EDL08216.1; -; Genomic_DNA.
EMBL; BC125326; AAI25327.1; -; mRNA.
EMBL; BC131997; AAI31998.1; -; mRNA.
CCDS; CCDS15754.1; -.
RefSeq; NP_543130.2; NM_080854.3.
RefSeq; XP_006497740.1; XM_006497677.1.
RefSeq; XP_006497741.1; XM_006497678.1.
UniGene; Mm.346652; -.
UniGene; Mm.490356; -.
STRING; 10090.ENSMUSP00000006638; -.
iPTMnet; Q80SU6; -.
PhosphoSitePlus; Q80SU6; -.
PaxDb; Q80SU6; -.
PRIDE; Q80SU6; -.
Ensembl; ENSMUST00000006638; ENSMUSP00000006638; ENSMUSG00000006469.
GeneID; 142681; -.
KEGG; mmu:142681; -.
UCSC; uc008iqt.3; mouse.
CTD; 142680; -.
MGI; MGI:2159410; Slc34a3.
eggNOG; ENOG410IE8P; Eukaryota.
eggNOG; COG1283; LUCA.
GeneTree; ENSGT00390000005032; -.
HOGENOM; HOG000006550; -.
HOVERGEN; HBG006527; -.
InParanoid; Q80SU6; -.
KO; K14683; -.
OMA; WAWLPLW; -.
OrthoDB; EOG091G0DR5; -.
TreeFam; TF313981; -.
Reactome; R-MMU-427589; Type II Na+/Pi cotransporters.
PRO; PR:Q80SU6; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000006469; -.
Genevisible; Q80SU6; MM.
GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
GO; GO:0005903; C:brush border; IDA:MGI.
GO; GO:0031526; C:brush border membrane; ISO:MGI.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031982; C:vesicle; IBA:GO_Central.
GO; GO:0015321; F:sodium-dependent phosphate transmembrane transporter activity; IDA:MGI.
GO; GO:0005436; F:sodium:phosphate symporter activity; ISO:MGI.
GO; GO:0030643; P:cellular phosphate ion homeostasis; ISO:MGI.
GO; GO:0006817; P:phosphate ion transport; IDA:MGI.
GO; GO:0006814; P:sodium ion transport; ISO:MGI.
InterPro; IPR003841; Na/Pi_transpt.
InterPro; IPR029850; Na/Pi_transpt_2C.
PANTHER; PTHR10010; PTHR10010; 1.
PANTHER; PTHR10010:SF35; PTHR10010:SF35; 1.
Pfam; PF02690; Na_Pi_cotrans; 2.
TIGRFAMs; TIGR01013; 2a58; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Ion transport;
Membrane; Phosphoprotein; Reference proteome; Sodium;
Sodium transport; Symport; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 601 Sodium-dependent phosphate transport
protein 2C.
/FTId=PRO_0000068618.
TOPO_DOM 1 75 Cytoplasmic. {ECO:0000255}.
TRANSMEM 76 96 Helical; Name=M1. {ECO:0000255}.
TOPO_DOM 97 110 Extracellular. {ECO:0000255}.
TRANSMEM 111 131 Helical; Name=M2. {ECO:0000255}.
TOPO_DOM 132 187 Cytoplasmic. {ECO:0000255}.
TRANSMEM 188 208 Helical; Name=M3. {ECO:0000255}.
TOPO_DOM 209 324 Extracellular. {ECO:0000255}.
TRANSMEM 325 345 Helical; Name=M4. {ECO:0000255}.
TOPO_DOM 346 369 Cytoplasmic. {ECO:0000255}.
TRANSMEM 370 390 Helical; Name=M5. {ECO:0000255}.
TOPO_DOM 391 441 Extracellular. {ECO:0000255}.
TRANSMEM 442 462 Helical; Name=M6. {ECO:0000255}.
TOPO_DOM 463 487 Cytoplasmic. {ECO:0000255}.
TRANSMEM 488 508 Helical; Name=M7. {ECO:0000255}.
TOPO_DOM 509 512 Extracellular. {ECO:0000255}.
TRANSMEM 513 533 Helical; Name=M8. {ECO:0000255}.
TOPO_DOM 534 601 Cytoplasmic. {ECO:0000255}.
COMPBIAS 426 429 Poly-Thr.
MOD_RES 4 4 Phosphoserine.
{ECO:0000250|UniProtKB:Q8K4R8}.
CARBOHYD 264 264 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 267 267 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 299 299 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 275 311 {ECO:0000250}.
MUTAGEN 189 191 SGS->AGA: Change of cotransport Na(+):Pi
stoichiometry to 3:1; when associated
with D-195.
{ECO:0000269|PubMed:16113079}.
MUTAGEN 195 195 G->D: Change of cotransport Na(+):Pi
stoichiometry to 3:1; when associated
with 189-AGA-191.
{ECO:0000269|PubMed:16113079}.
CONFLICT 353 353 K -> R (in Ref. 1; BAB83241/BAC55069).
{ECO:0000305}.
CONFLICT 361 361 K -> R (in Ref. 1; BAB83241/BAC55069).
{ECO:0000305}.
SEQUENCE 601 AA; 63939 MW; 4B7FE1FBC5877AB6 CRC64;
MPNSLAGGQV PNPTLDAFDL VDRSLRNAGI SGSIPGLEEG GTDPWTFSPL KNADQLKEVG
MASRLRRVVS SFLKACGLLG SLYFFICSLD ILSSAFQLLG SKMAGDIFKD NVVLSNPVAG
LVIGVLVTVL VQSSSTSSSI VVSMVASKLL TVQVSVPIIM GVNVGTSITS TLVSMAQSGD
RDEFQRAFSG SAVHGIFNWL TVLVLLPLES ATAALERLSE LALGAASLQP GQQAPDILKA
LTRPFTHLII QLDSSVITSG ITSNTTNSSL IKHWCGFRGE TPQGSSEGCG LFSSCTERNS
SASPEEDRLL CHHLFAGSKL TDLAVGFILL AGSLLVLCVC LVLIVKLLNS VLKGRIAQAV
KTVINADFPF PFGWLSGYLA ILVGAGLTFL LQSSSVFTAA IVPLMGVGVI DLERAYPLFL
GSNIGTTTTA LLAALASPAD MLIFAVQVAL IHFFFNLAGI LLWYLVPVLR LPIPLAKRFG
NLTAQYRWVA IVYLLLTFLL LPLAAFGLSL AGGTVLAAVG GPLVGLVLLI ILVNVLQQHR
PSWLPRCLQS WAWLPLWLHS LEPWDRLVTA CCPCRACSNS PMTSKVAHCY ENPQVIASQQ
L


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