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Solute carrier family 22 member 18 (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Multi-membrane-spanning polyspecific transporter) (Organic cation transporter-like protein 2) (ORCTL-2)

 S22AI_MOUSE             Reviewed;         406 AA.
Q78KK3; O35428; O54959; O88283; Q99NF4;
06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
06-DEC-2005, sequence version 2.
25-OCT-2017, entry version 112.
RecName: Full=Solute carrier family 22 member 18;
AltName: Full=Imprinted multi-membrane-spanning polyspecific transporter-related protein 1;
Short=Multi-membrane-spanning polyspecific transporter;
AltName: Full=Organic cation transporter-like protein 2;
Short=ORCTL-2;
Name=Slc22a18; Synonyms=Impt1, Itm, Orctl2, Tssc5;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=9802569; DOI=10.1093/dnares/5.4.235;
Morisaki H., Hatada I., Morisaki T., Mukai T.;
"A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in
mice.";
DNA Res. 5:235-240(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=9570947; DOI=10.1006/geno.1998.5221;
Cooper P.R., Smilinich N.J., Day C.D., Nowak N.J., Reid L.H.,
Pearsall R.S., Reece M., Prawitt D., Landers J., Housman D.E.,
Winterpacht A., Zabel B.U., Pelletier J., Weissman B.E., Shows T.B.,
Higgins M.J.;
"Divergently transcribed overlapping genes expressed in liver and
kidney and located in the 11p15.5 imprinted domain.";
Genomics 49:38-51(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
PubMed=9499412; DOI=10.1093/hmg/7.4.597;
Dao D., Frank D., Qian N., O'Keefe D., Vosatka R.J., Walsh C.P.,
Tycko B.;
"IMPT1, an imprinted gene similar to polyspecific transporter and
multi-drug resistance genes.";
Hum. Mol. Genet. 7:597-608(1998).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=11063728; DOI=10.1093/hmg/9.18.2691;
Engemann S., Stroedicke M., Paulsen M., Franck O., Reinhardt R.,
Lane N., Reik W., Walter J.;
"Sequence and functional comparison in the Beckwith-Wiedemann region:
implications for a novel imprinting centre and extended imprinting.";
Hum. Mol. Genet. 9:2691-2706(2000).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney, and Liver;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: May act as a transporter of organic cations based on a
proton efflux antiport mechanism. May play a role in the transport
of chloroquine and quinidine-related compounds in kidney (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with RNF167. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-
pass membrane protein {ECO:0000250}. Note=Localized at the apical
membrane surface of renal proximal tubules. {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed at high levels in fetal and adult
kidney and liver, and extraembryonic membranes (yolk sac).
Expressed at moderate levels in intestine, heart, lung and testis.
{ECO:0000269|PubMed:9499412, ECO:0000269|PubMed:9570947,
ECO:0000269|PubMed:9802569}.
-!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1)
superfamily. Organic cation transporter (TC 2.A.1.19) family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAC04788.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAH03734.2; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AB012084; BAA32780.1; -; mRNA.
EMBL; AF037065; AAC04788.1; ALT_INIT; mRNA.
EMBL; AF028739; AAB82728.1; -; mRNA.
EMBL; AJ276505; CAC16401.2; -; Genomic_DNA.
EMBL; BC003734; AAH03734.2; ALT_INIT; mRNA.
RefSeq; NP_001036225.1; NM_001042760.1.
RefSeq; NP_032793.2; NM_008767.2.
UniGene; Mm.271740; -.
ProteinModelPortal; Q78KK3; -.
STRING; 10090.ENSMUSP00000056082; -.
iPTMnet; Q78KK3; -.
PhosphoSitePlus; Q78KK3; -.
MaxQB; Q78KK3; -.
PaxDb; Q78KK3; -.
PRIDE; Q78KK3; -.
GeneID; 18400; -.
KEGG; mmu:18400; -.
UCSC; uc009kpg.1; mouse.
CTD; 5002; -.
MGI; MGI:1336884; Slc22a18.
eggNOG; ENOG410IIP5; Eukaryota.
eggNOG; ENOG4111F2C; LUCA.
HOGENOM; HOG000068014; -.
HOVERGEN; HBG082086; -.
InParanoid; Q78KK3; -.
KO; K08214; -.
PhylomeDB; Q78KK3; -.
TreeFam; TF352510; -.
PRO; PR:Q78KK3; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; ISS:MGI.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0005635; C:nuclear envelope; ISO:MGI.
GO; GO:0015238; F:drug transmembrane transporter activity; ISO:MGI.
GO; GO:0008514; F:organic anion transmembrane transporter activity; TAS:MGI.
GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
GO; GO:0006820; P:anion transport; TAS:MGI.
GO; GO:0015893; P:drug transport; ISO:MGI.
CDD; cd06174; MFS; 1.
InterPro; IPR011701; MFS.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
Pfam; PF07690; MFS_1; 1.
PRINTS; PR01035; TCRTETA.
SUPFAM; SSF103473; SSF103473; 1.
PROSITE; PS50850; MFS; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Ion transport; Membrane;
Reference proteome; Symport; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 406 Solute carrier family 22 member 18.
/FTId=PRO_0000220510.
TRANSMEM 8 28 Helical. {ECO:0000255}.
TRANSMEM 43 63 Helical. {ECO:0000255}.
TRANSMEM 85 105 Helical. {ECO:0000255}.
TRANSMEM 140 160 Helical. {ECO:0000255}.
TRANSMEM 168 188 Helical. {ECO:0000255}.
TRANSMEM 226 246 Helical. {ECO:0000255}.
TRANSMEM 258 278 Helical. {ECO:0000255}.
TRANSMEM 295 315 Helical. {ECO:0000255}.
TRANSMEM 316 336 Helical. {ECO:0000255}.
TRANSMEM 374 394 Helical. {ECO:0000255}.
CONFLICT 33 33 Y -> V (in Ref. 4; CAC16401).
{ECO:0000305}.
CONFLICT 66 66 F -> Y (in Ref. 4; CAC16401).
{ECO:0000305}.
CONFLICT 68 68 D -> N (in Ref. 2; AAC04788).
{ECO:0000305}.
CONFLICT 83 83 A -> G (in Ref. 3; AAB82728).
{ECO:0000305}.
CONFLICT 117 117 L -> I (in Ref. 2; AAC04788).
{ECO:0000305}.
CONFLICT 119 120 AA -> GT (in Ref. 4; CAC16401).
{ECO:0000305}.
CONFLICT 149 149 I -> M (in Ref. 2; AAC04788).
{ECO:0000305}.
CONFLICT 164 164 I -> Y (in Ref. 4; CAC16401).
{ECO:0000305}.
CONFLICT 178 178 G -> R (in Ref. 3; AAB82728).
{ECO:0000305}.
CONFLICT 205 205 A -> G (in Ref. 3; AAB82728).
{ECO:0000305}.
CONFLICT 228 231 VKVI -> SVF (in Ref. 2; AAC04788).
{ECO:0000305}.
CONFLICT 238 238 L -> V (in Ref. 4; CAC16401).
{ECO:0000305}.
CONFLICT 271 271 M -> V (in Ref. 4; CAC16401).
{ECO:0000305}.
CONFLICT 305 305 A -> V (in Ref. 4; CAC16401).
{ECO:0000305}.
CONFLICT 346 346 T -> A (in Ref. 4; CAC16401).
{ECO:0000305}.
SEQUENCE 406 AA; 43013 MW; 034D8223CEB8013C CRC64;
MAALPRQGII ILTYVLAALE LTCLFMQFSI LPYLSRTLGL DSVSFGYLQT TFGVLQLLGG
PVFGRFADQC GARAALSLSF LAASALYLLL VASCSPALPG VFLLFASRIP SALMHTLPAA
QMVITDLTAP TERPAALGRL GLCFGIGIIF GSLLGGTLNT AYGIQCPAIL AFVVTLLGAV
LSFTCVPATT KEASVQSAPQ GGTKASVFDL KAITRLLLLP RVLPVFLVKV ISGLPSGLFL
VMFSIISMDF FQLEAAQAGY LMSFFGILQM MIQGLVIGRL STHFPEEALL RSSVLVFAVV
GLGMALMSSV LHFCFLMPGL VFSLCTLNVV TDSMLTKAVS ASDTGTMLGL SASVQPLTRT
LGPTLGGLLY RSYGVPIFGH VQLMVNLLVL LVLWKKPLSQ KGEKAR


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