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Solute carrier family 22 member 2 (Organic cation transporter 2)

 S22A2_MOUSE             Reviewed;         553 AA.
O70577; Q8BWF6; Q8K4X8;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
25-OCT-2017, entry version 139.
RecName: Full=Solute carrier family 22 member 2;
AltName: Full=Organic cation transporter 2;
Name=Slc22a2; Synonyms=Oct2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
STRAIN=129, and BALB/cJ; TISSUE=Kidney, and Liver;
PubMed=10051314; DOI=10.1007/s003359900976;
Mooslehner K.A., Allen N.D.;
"Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from
an enhancer-trap transgene integration locus.";
Mamm. Genome 10:218-224(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=C57BL/6J; TISSUE=Kidney;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=FVB/N; TISSUE=Kidney;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 226-553.
STRAIN=129S6/SvEvTac;
Brathwaite M., Waeltz P., Qian Y., Dudekula D., Schlessinger D.,
Nagaraja R.;
"Genomic sequence analysis in the mouse T-complex region.";
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Mediates tubular uptake of organic compounds from
circulation. Mediates the influx of agmatine, dopamine,
noradrenaline (norepinephrine), serotonin, choline, famotidine,
ranitidine, histamin, creatinine, amantadine, memantine,
acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP,
amiloride, metformin, N-1-methylnicotinamide (NMN),
tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP),
cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a
nephrotoxic action. Transport of creatinine is inhibited by
fluoroquinolones such as DX-619 and LVFX. This transporter is a
major determinant of the anticancer activity of oxaliplatin and
may contribute to antitumor specificity (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O70577-1; Sequence=Displayed;
Name=2;
IsoId=O70577-2; Sequence=VSP_031775, VSP_031776;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in kidney and ureter. To a lower
extent, also expressed in brain and embryo.
{ECO:0000269|PubMed:10051314}.
-!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1)
superfamily. Organic cation transporter (TC 2.A.1.19) family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AJ006036; CAA06827.1; -; mRNA.
EMBL; AK052658; BAC35086.1; -; mRNA.
EMBL; BC015250; AAH15250.1; -; mRNA.
EMBL; BC069911; AAH69911.1; -; mRNA.
EMBL; AF481054; AAM22158.1; -; Genomic_DNA.
CCDS; CCDS28392.1; -. [O70577-1]
RefSeq; NP_038695.1; NM_013667.2. [O70577-1]
RefSeq; XP_011244498.1; XM_011246196.1. [O70577-2]
UniGene; Mm.17322; -.
ProteinModelPortal; O70577; -.
STRING; 10090.ENSMUSP00000041186; -.
BindingDB; O70577; -.
ChEMBL; CHEMBL2073662; -.
iPTMnet; O70577; -.
PhosphoSitePlus; O70577; -.
MaxQB; O70577; -.
PaxDb; O70577; -.
PRIDE; O70577; -.
Ensembl; ENSMUST00000046959; ENSMUSP00000041186; ENSMUSG00000040966. [O70577-1]
GeneID; 20518; -.
KEGG; mmu:20518; -.
UCSC; uc008akw.1; mouse. [O70577-1]
CTD; 6582; -.
MGI; MGI:1335072; Slc22a2.
eggNOG; KOG0255; Eukaryota.
eggNOG; COG0477; LUCA.
GeneTree; ENSGT00760000118852; -.
HOGENOM; HOG000234568; -.
HOVERGEN; HBG061545; -.
InParanoid; O70577; -.
KO; K08199; -.
OMA; IYLDFFY; -.
OrthoDB; EOG091G05AC; -.
PhylomeDB; O70577; -.
TreeFam; TF315847; -.
Reactome; R-MMU-112311; Neurotransmitter clearance.
Reactome; R-MMU-181430; Norepinephrine Neurotransmitter Release Cycle.
Reactome; R-MMU-2161517; Abacavir transmembrane transport.
Reactome; R-MMU-442660; Na+/Cl- dependent neurotransmitter transporters.
Reactome; R-MMU-549127; Organic cation transport.
PRO; PR:O70577; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000040966; -.
Genevisible; O70577; MM.
GO; GO:0070062; C:extracellular exosome; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
GO; GO:0005277; F:acetylcholine transmembrane transporter activity; IBA:GO_Central.
GO; GO:0005329; F:dopamine transmembrane transporter activity; IBA:GO_Central.
GO; GO:0005333; F:norepinephrine transmembrane transporter activity; IBA:GO_Central.
GO; GO:0008514; F:organic anion transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015101; F:organic cation transmembrane transporter activity; IDA:MGI.
GO; GO:0015651; F:quaternary ammonium group transmembrane transporter activity; IBA:GO_Central.
GO; GO:0008513; F:secondary active organic cation transmembrane transporter activity; IBA:GO_Central.
GO; GO:0006812; P:cation transport; IDA:MGI.
GO; GO:0015872; P:dopamine transport; IBA:GO_Central.
GO; GO:0006836; P:neurotransmitter transport; IBA:GO_Central.
GO; GO:0015874; P:norepinephrine transport; IBA:GO_Central.
GO; GO:0015695; P:organic cation transport; ISO:MGI.
CDD; cd06174; MFS; 1.
InterPro; IPR020846; MFS_dom.
InterPro; IPR005828; MFS_sugar_transport-like.
InterPro; IPR036259; MFS_trans_sf.
InterPro; IPR004749; Orgcat_transp/SVOP.
InterPro; IPR005829; Sugar_transporter_CS.
Pfam; PF00083; Sugar_tr; 1.
SUPFAM; SSF103473; SSF103473; 1.
TIGRFAMs; TIGR00898; 2A0119; 1.
PROSITE; PS50850; MFS; 1.
PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Glycoprotein; Ion transport;
Membrane; Reference proteome; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 553 Solute carrier family 22 member 2.
/FTId=PRO_0000320958.
TOPO_DOM 1 21 Cytoplasmic. {ECO:0000255}.
TRANSMEM 22 42 Helical. {ECO:0000255}.
TOPO_DOM 43 150 Extracellular. {ECO:0000255}.
TRANSMEM 151 171 Helical. {ECO:0000255}.
TOPO_DOM 172 177 Cytoplasmic. {ECO:0000255}.
TRANSMEM 178 198 Helical. {ECO:0000255}.
TOPO_DOM 199 210 Extracellular. {ECO:0000255}.
TRANSMEM 211 231 Helical. {ECO:0000255}.
TOPO_DOM 232 238 Cytoplasmic. {ECO:0000255}.
TRANSMEM 239 259 Helical. {ECO:0000255}.
TOPO_DOM 260 263 Extracellular. {ECO:0000255}.
TRANSMEM 264 284 Helical. {ECO:0000255}.
TOPO_DOM 285 348 Cytoplasmic. {ECO:0000255}.
TRANSMEM 349 369 Helical. {ECO:0000255}.
TOPO_DOM 370 375 Extracellular. {ECO:0000255}.
TRANSMEM 376 396 Helical. {ECO:0000255}.
TOPO_DOM 397 404 Cytoplasmic. {ECO:0000255}.
TRANSMEM 405 425 Helical. {ECO:0000255}.
TOPO_DOM 426 432 Extracellular. {ECO:0000255}.
TRANSMEM 433 453 Helical. {ECO:0000255}.
TOPO_DOM 454 464 Cytoplasmic. {ECO:0000255}.
TRANSMEM 465 485 Helical. {ECO:0000255}.
TOPO_DOM 486 494 Extracellular. {ECO:0000255}.
TRANSMEM 495 515 Helical. {ECO:0000255}.
TOPO_DOM 516 553 Cytoplasmic. {ECO:0000255}.
SITE 451 451 Involved in recognition of organic
cations and participates in structural
changes that occur during translocation
of organic cations. {ECO:0000250}.
CARBOHYD 71 71 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 534 544 RPRKKKEKRIY -> SLGRLVQTVCH (in isoform
2). {ECO:0000303|PubMed:16141072}.
/FTId=VSP_031775.
VAR_SEQ 545 553 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_031776.
SEQUENCE 553 AA; 61831 MW; 1E9744F0D5415483 CRC64;
MPTVDDILEH IGEFHLFQKQ TFFLLALLSG AFTPIYVGIV FLGFTPNHHC RSPGVAELSQ
RCGWSPAEEL NYTVPGLGSA GEVSFLSQCM RYEVDWNQST LDCVDPLSSL AANRSHLPLS
PCEHGWVYDT PGSSIVTEFN LVCAHSWMLD LFQSLVNVGF FIGAVGIGYL ADRFGRKFCL
LVTILINAIS GVLMAISPNY AWMLVFRFLQ GLVSKAGWLI GYILITEFVG LGYRRTVGIC
YQIAFTVGLL ILAGVAYALP NWRWLQFAVT LPNFCFLLYF WCIPESPRWL ISQNKNAKAM
KIIKHIAKKN GKSVPVSLQS LTADEDTGMK LNPSFLDLVR TPQIRKHTLI LMYNWFTSSV
LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFIIILTIDR IGRRYPWAVS NMVAGAACLA
SVFIPDDLQW LKITVACLGR MGITIAYEMV CLVNAELYPT YIRNLAVLVC SSMCDIGGIV
TPFLVYRLTD IWLEFPLVVF AVVGLVAGGL VLLLPETKGK ALPETIEDAE KMQRPRKKKE
KRIYLQVKKA ELS


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