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Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1) (Metal transporter protein 1) (MTP1)

 S40A1_MOUSE             Reviewed;         570 AA.
Q9JHI9; Q3UHZ9; Q8BME5; Q8BUM5; Q9JIM9; Q9JKP4;
07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
25-OCT-2017, entry version 127.
RecName: Full=Solute carrier family 40 member 1;
AltName: Full=Ferroportin-1;
AltName: Full=Iron-regulated transporter 1;
AltName: Full=Metal transporter protein 1;
Short=MTP1;
Name=Slc40a1; Synonyms=Fpn1, Ireg1, Slc11a3, Slc39a1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=10747949; DOI=10.1074/jbc.M000713200;
Abboud S., Haile D.J.;
"A novel mammalian iron-regulated protein involved in intracellular
iron metabolism.";
J. Biol. Chem. 275:19906-19912(2000).
[2]
NUCLEOTIDE SEQUENCE.
TISSUE=Liver;
PubMed=10693807; DOI=10.1038/35001596;
Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S.J., Moynihan J.,
Paw B.H., Drejer A., Barut B., Zapata A., Law T.C., Brugnara C.,
Lux S.E. IV, Pinkus G.S., Pinkus J.L., Kingsley P.D., Palis J.,
Fleming M.D., Andrews N.C., Zon L.I.;
"Positional cloning of zebrafish ferroportin1 identifies a conserved
vertebrate iron exporter.";
Nature 403:776-781(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10882071; DOI=10.1016/S1097-2765(00)80425-6;
McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D.,
Miret S., Bomford A., Peters T.J., Farzaneh F., Hediger M.A.,
Hentze M.W., Simpson R.J.;
"A novel duodenal iron-regulated transporter, IREG1, implicated in the
basolateral transfer of iron to the circulation.";
Mol. Cell 5:299-309(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryo, Liver, Lung, and Stomach;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: May be involved in iron export from duodenal epithelial
cell and also in transfer of iron between maternal and fetal
circulation. Mediates iron efflux in the presence of a ferroxidase
(hephaestin and/or ceruloplasmin).
-!- SUBUNIT: Identified in a complex with STOM. {ECO:0000250}.
-!- INTERACTION:
Self; NbExp=2; IntAct=EBI-2931424, EBI-2931424;
P12023:App; NbExp=2; IntAct=EBI-2931424, EBI-78814;
O60674:JAK2 (xeno); NbExp=3; IntAct=EBI-2931424, EBI-518647;
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Note=Localized to the basolateral membrane of polarized epithelial
cells.
-!- TISSUE SPECIFICITY: High expression in spleen, liver, kidney,
heart and duodenum.
-!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family.
SLC40A subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF215637; AAF80987.1; -; mRNA.
EMBL; AF216834; AAF82036.1; -; Genomic_DNA.
EMBL; AF226613; AAF36696.1; -; mRNA.
EMBL; AF231120; AAF44329.1; -; mRNA.
EMBL; AK008700; BAB25840.1; -; mRNA.
EMBL; AK032732; BAC28001.1; -; mRNA.
EMBL; AK083288; BAC38844.1; -; mRNA.
EMBL; AK144780; BAE26063.1; -; mRNA.
EMBL; AK147137; BAE27707.1; -; mRNA.
EMBL; AK159294; BAE34969.1; -; mRNA.
EMBL; AK159855; BAE35431.1; -; mRNA.
EMBL; BC003438; AAH03438.1; -; mRNA.
CCDS; CCDS14933.1; -.
RefSeq; NP_058613.2; NM_016917.2.
RefSeq; XP_006496200.1; XM_006496137.2.
RefSeq; XP_017177198.1; XM_017321709.1.
UniGene; Mm.28756; -.
ProteinModelPortal; Q9JHI9; -.
DIP; DIP-58649N; -.
IntAct; Q9JHI9; 4.
STRING; 10090.ENSMUSP00000027137; -.
TCDB; 2.A.100.1.1; the ferroportin (fpn) family.
iPTMnet; Q9JHI9; -.
PhosphoSitePlus; Q9JHI9; -.
MaxQB; Q9JHI9; -.
PaxDb; Q9JHI9; -.
PRIDE; Q9JHI9; -.
Ensembl; ENSMUST00000027137; ENSMUSP00000027137; ENSMUSG00000025993.
GeneID; 53945; -.
KEGG; mmu:53945; -.
UCSC; uc007awu.1; mouse.
CTD; 30061; -.
MGI; MGI:1315204; Slc40a1.
eggNOG; KOG2601; Eukaryota.
eggNOG; ENOG410XS3F; LUCA.
GeneTree; ENSGT00390000015143; -.
HOGENOM; HOG000234273; -.
HOVERGEN; HBG055582; -.
InParanoid; Q9JHI9; -.
KO; K14685; -.
OMA; AQMRRID; -.
OrthoDB; EOG091G06RI; -.
PhylomeDB; Q9JHI9; -.
TreeFam; TF313463; -.
Reactome; R-MMU-425410; Metal ion SLC transporters.
Reactome; R-MMU-917937; Iron uptake and transport.
PRO; PR:Q9JHI9; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000025993; -.
ExpressionAtlas; Q9JHI9; baseline and differential.
Genevisible; Q9JHI9; MM.
GO; GO:0016323; C:basolateral plasma membrane; IGI:BHF-UCL.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; ISO:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0008021; C:synaptic vesicle; IDA:MGI.
GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IDA:BHF-UCL.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0097689; F:iron channel activity; IDA:BHF-UCL.
GO; GO:0005381; F:iron ion transmembrane transporter activity; IDA:MGI.
GO; GO:0017046; F:peptide hormone binding; IPI:BHF-UCL.
GO; GO:0004872; F:receptor activity; IDA:BHF-UCL.
GO; GO:0006879; P:cellular iron ion homeostasis; ISO:MGI.
GO; GO:0003158; P:endothelium development; IMP:MGI.
GO; GO:1903988; P:ferrous iron export across plasma membrane; IDA:BHF-UCL.
GO; GO:0055072; P:iron ion homeostasis; IMP:MGI.
GO; GO:0034755; P:iron ion transmembrane transport; IGI:MGI.
GO; GO:0006826; P:iron ion transport; IDA:MGI.
GO; GO:0002260; P:lymphocyte homeostasis; IMP:MGI.
GO; GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:BHF-UCL.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
GO; GO:0034395; P:regulation of transcription from RNA polymerase II promoter in response to iron; IDA:MGI.
GO; GO:0048536; P:spleen development; IMP:MGI.
GO; GO:0060345; P:spleen trabecula formation; IMP:MGI.
InterPro; IPR009716; Ferroportin-1.
InterPro; IPR036259; MFS_trans_sf.
Pfam; PF06963; FPN1; 1.
SUPFAM; SSF103473; SSF103473; 3.
1: Evidence at protein level;
Cell membrane; Complete proteome; Glycoprotein; Ion transport; Iron;
Iron transport; Membrane; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 570 Solute carrier family 40 member 1.
/FTId=PRO_0000191311.
TRANSMEM 12 34 Helical. {ECO:0000255}.
TRANSMEM 58 80 Helical. {ECO:0000255}.
TRANSMEM 93 115 Helical. {ECO:0000255}.
TRANSMEM 125 147 Helical. {ECO:0000255}.
TRANSMEM 302 324 Helical. {ECO:0000255}.
TRANSMEM 339 361 Helical. {ECO:0000255}.
TRANSMEM 373 395 Helical. {ECO:0000255}.
TRANSMEM 449 471 Helical. {ECO:0000255}.
TRANSMEM 491 513 Helical. {ECO:0000255}.
TRANSMEM 518 540 Helical. {ECO:0000255}.
CARBOHYD 166 166 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 174 174 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 437 437 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 566 566 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 570 AA; 62702 MW; 7125CC6171394A0A CRC64;
MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL
TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKNEL
LTMYHGWVLT VCYILIITIA NIANLASTAT AITIQRDWIV VVAGENRSRL ADMNATIRRI
DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK
VEESELKQLT SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF
TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFVNVEPVSP
TTKIPETVFT TEMHMSNMSN VHEMSTKPIP IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ
ENVIESERGI INGVQNSMNY LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF
AQKTLGNQIF VCGPDEKEVT DENQPNTSVV


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