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Solute carrier organic anion transporter family member 1B1 (Liver-specific organic anion transporter 1) (LST-1) (OATP-C) (Sodium-independent organic anion-transporting polypeptide 2) (OATP-2) (Solute carrier family 21 member 6)

 SO1B1_HUMAN             Reviewed;         691 AA.
Q9Y6L6; B2R7G2; Q29R64; Q9NQ37; Q9UBF3; Q9UH89;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
25-OCT-2017, entry version 162.
RecName: Full=Solute carrier organic anion transporter family member 1B1;
AltName: Full=Liver-specific organic anion transporter 1;
Short=LST-1;
AltName: Full=OATP-C;
AltName: Full=Sodium-independent organic anion-transporting polypeptide 2;
Short=OATP-2;
AltName: Full=Solute carrier family 21 member 6;
Name=SLCO1B1; Synonyms=LST1, OATP1B1, OATP2, OATPC, SLC21A6;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND VARIANTS
LYS-152 AND ASN-241.
TISSUE=Liver;
PubMed=10358072; DOI=10.1074/jbc.274.24.17159;
Abe T., Kakyo M., Tokui T., Nakagomi R., Nishio T., Nakai D.,
Nomura H., Unno M., Suzuki M., Naitoh T., Matsuno S., Yawo H.;
"Identification of a novel gene family encoding human liver-specific
organic anion transporter LST-1.";
J. Biol. Chem. 274:17159-17163(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND VARIANT
ASP-130.
TISSUE=Liver;
PubMed=10601278; DOI=10.1074/jbc.274.52.37161;
Hsiang B.H., Zhu Y., Wang Z., Wu Y., Sasseville V., Yang W.-P.,
Kirchgessner T.G.;
"A novel human hepatic organic anion transporting polypeptide (OATP2).
Identification of a liver-specific human organic anion transporting
polypeptide and identification of rat and human hydroxymethylglutaryl-
CoA reductase inhibitor transporters.";
J. Biol. Chem. 274:37161-37168(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=10644574;
Koenig J., Cui Y., Nies A.T., Keppler D.;
"A novel human organic anion transporting polypeptide localized to the
basolateral hepatocyte membrane.";
Am. J. Physiol. 278:G156-G164(2000).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
Nezu J.;
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10779507; DOI=10.1074/jbc.M001448200;
Koenig J., Cui Y., Nies A.T., Keppler D.;
"Localization and genomic organization of a new hepatocellular organic
anion transporting polypeptide.";
J. Biol. Chem. 275:23161-23168(2000).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ASP-130.
SeattleSNPs variation discovery resource;
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary gland;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASP-130 AND
THR-155.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
FUNCTION, TISSUE SPECIFICITY, AND INVOLVEMENT IN HBLRR.
PubMed=22232210; DOI=10.1172/JCI59526;
van de Steeg E., Stranecky V., Hartmannova H., Noskova L.,
Hrebicek M., Wagenaar E., van Esch A., de Waart D.R.,
Oude Elferink R.P., Kenworthy K.E., Sticova E., al-Edreesi M.,
Knisely A.S., Kmoch S., Jirsa M., Schinkel A.H.;
"Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome
by interrupting conjugated bilirubin reuptake into the liver.";
J. Clin. Invest. 122:519-528(2012).
[11]
GLYCOSYLATION AT ASN-134; ASN-503 AND ASN-516.
PubMed=23285087; DOI=10.1371/journal.pone.0052563;
Yao J., Hong W., Huang J., Zhan K., Huang H., Hong M.;
"N-Glycosylation dictates proper processing of organic anion
transporting polypeptide 1B1.";
PLoS ONE 7:E52563-E52563(2012).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293; SER-295; SER-672
AND SER-682, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[13]
VARIANTS LEU-73; ALA-82; ASP-130; LYS-152; THR-155; GLY-156; ALA-174;
ASN-241; THR-353; ASP-432; GLY-462; ALA-488; GLY-655 AND GLY-667, AND
CHARACTERIZATION.
PubMed=11477075; DOI=10.1074/jbc.M103792200;
Tirona R.G., Leake B.F., Merino G., Kim R.B.;
"Polymorphisms in OATP-C: identification of multiple allelic variants
associated with altered transport activity among European- and
African-Americans.";
J. Biol. Chem. 276:35669-35675(2001).
[14]
CHARACTERIZATION OF VARIANTS ASP-130; THR-155 AND ARG-193, FUNCTION,
AND SUBCELLULAR LOCATION.
PubMed=12196548; DOI=10.1074/jbc.M207735200;
Michalski C., Cui Y., Nies A.T., Nuessler A.K., Neuhaus P.,
Zanger U.M., Klein K., Eichelbaum M., Keppler D., Koenig J.;
"A naturally occurring mutation in the SLC21A6 gene causing impaired
membrane localization of the hepatocyte uptake transporter.";
J. Biol. Chem. 277:43058-43063(2002).
[15]
VARIANTS ASP-130; LYS-152; ALA-174 AND ASN-241.
PubMed=12130747; DOI=10.1124/jpet.302.2.804;
Nozawa T., Nakajima M., Tamai I., Noda K., Nezu J., Sai Y., Tsuji A.,
Yokoi T.;
"Genetic polymorphisms of human organic anion transporters OATP-C
(SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese
population and functional analysis.";
J. Pharmacol. Exp. Ther. 302:804-813(2002).
-!- FUNCTION: Mediates the Na(+)-independent uptake of organic anions
such as pravastatin, taurocholate, methotrexate,
dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol,
estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3,
leukotriene E4, thyroxine and triiodothyronine. Involved in the
clearance of bile acids and organic anions from the liver.
{ECO:0000269|PubMed:10358072, ECO:0000269|PubMed:10601278,
ECO:0000269|PubMed:12196548, ECO:0000269|PubMed:22232210}.
-!- SUBCELLULAR LOCATION: Basolateral cell membrane
{ECO:0000269|PubMed:12196548}; Multi-pass membrane protein
{ECO:0000269|PubMed:12196548}. Note=Detected in basolateral
membranes of hepatocytes.
-!- TISSUE SPECIFICITY: Highly expressed in liver, at the basolateral
membranes of centrilobular hepatocytes. Not detected in heart,
brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen,
thymus, prostate, testis, ovary, small intestine, colon and
leukocyte. {ECO:0000269|PubMed:10358072,
ECO:0000269|PubMed:10601278, ECO:0000269|PubMed:22232210}.
-!- DISEASE: Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An
autosomal recessive form of primary conjugated hyperbilirubinemia.
Affected individuals develop mild jaundice not associated with
hemolysis shortly after birth or in childhood. They have delayed
plasma clearance of the unconjugated anionic dye bromsulphthalein
and prominent urinary excretion of coproporphyrin I. Hepatic
pigmentation is normal. {ECO:0000269|PubMed:22232210}. Note=The
disease is caused by mutations affecting the gene represented in
this entry.
-!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60)
family. {ECO:0000305}.
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/slco1b1/";
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EMBL; AF060500; AAD38323.1; -; mRNA.
EMBL; AF205071; AAF20212.1; -; mRNA.
EMBL; AJ132573; CAB62577.1; -; mRNA.
EMBL; AB026257; BAA78639.1; -; mRNA.
EMBL; AJ400749; CAB97007.1; -; Genomic_DNA.
EMBL; AJ400750; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400751; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400752; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400753; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400754; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400755; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400756; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400757; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400758; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400759; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400760; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400761; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AJ400762; CAB97007.1; JOINED; Genomic_DNA.
EMBL; AY945934; AAX20114.1; -; Genomic_DNA.
EMBL; AK312970; BAG35809.1; -; mRNA.
EMBL; CH471094; EAW96420.1; -; Genomic_DNA.
EMBL; BC114376; AAI14377.1; -; mRNA.
CCDS; CCDS8685.1; -.
RefSeq; NP_006437.3; NM_006446.4.
UniGene; Hs.449738; -.
ProteinModelPortal; Q9Y6L6; -.
BioGrid; 115847; 11.
STRING; 9606.ENSP00000256958; -.
BindingDB; Q9Y6L6; -.
ChEMBL; CHEMBL1697668; -.
DrugBank; DB06151; Acetylcysteine.
DrugBank; DB06403; Ambrisentan.
DrugBank; DB00345; Aminohippuric acid.
DrugBank; DB01076; Atorvastatin.
DrugBank; DB06626; Axitinib.
DrugBank; DB01053; Benzylpenicillin.
DrugBank; DB01393; Bezafibrate.
DrugBank; DB06772; Cabazitaxel.
DrugBank; DB00520; Caspofungin.
DrugBank; DB00439; Cerivastatin.
DrugBank; DB02659; Cholic Acid.
DrugBank; DB01211; Clarithromycin.
DrugBank; DB05239; Cobimetinib.
DrugBank; DB00286; Conjugated Equine Estrogens.
DrugBank; DB00091; Cyclosporine.
DrugBank; DB08912; Dabrafenib.
DrugBank; DB09102; Daclatasvir.
DrugBank; DB05804; dehydroepiandrosterone sulfate.
DrugBank; DB00509; Dextrothyroxine.
DrugBank; DB00390; Digoxin.
DrugBank; DB00917; Dinoprostone.
DrugBank; DB04881; Elacridar.
DrugBank; DB06210; Eltrombopag.
DrugBank; DB09272; Eluxadoline.
DrugBank; DB00783; Estradiol.
DrugBank; DB00655; Estrone.
DrugBank; DB00973; Ezetimibe.
DrugBank; DB00950; Fexofenadine.
DrugBank; DB01095; Fluvastatin.
DrugBank; DB08884; Gadoxetic acid.
DrugBank; DB01241; Gemfibrozil.
DrugBank; DB11575; Grazoprevir.
DrugBank; DB01892; Hyperforin.
DrugBank; DB09054; Idelalisib.
DrugBank; DB00224; Indinavir.
DrugBank; DB00762; Irinotecan.
DrugBank; DB00583; L-Carnitine.
DrugBank; DB13153; Levomenol.
DrugBank; DB13139; Levosalbutamol.
DrugBank; DB00451; Levothyroxine.
DrugBank; DB00279; Liothyronine.
DrugBank; DB01583; Liotrix.
DrugBank; DB00227; Lovastatin.
DrugBank; DB00563; Methotrexate.
DrugBank; DB00688; Mycophenolate mofetil.
DrugBank; DB02691; N-Cholylglycine.
DrugBank; DB00220; Nelfinavir.
DrugBank; DB00275; Olmesartan.
DrugBank; DB01092; Ouabain.
DrugBank; DB00213; Pantoprazole.
DrugBank; DB13154; Parachlorophenol.
DrugBank; DB06589; Pazopanib.
DrugBank; DB00859; Penicillamine.
DrugBank; DB01132; Pioglitazone.
DrugBank; DB08860; Pitavastatin.
DrugBank; DB00175; Pravastatin.
DrugBank; DB00908; Quinidine.
DrugBank; DB00912; Repaglinide.
DrugBank; DB01045; Rifampicin.
DrugBank; DB08864; Rilpivirine.
DrugBank; DB00503; Ritonavir.
DrugBank; DB00412; Rosiglitazone.
DrugBank; DB01098; Rosuvastatin.
DrugBank; DB09292; Sacubitril.
DrugBank; DB01232; Saquinavir.
DrugBank; DB11362; Selexipag.
DrugBank; DB06290; Simeprevir.
DrugBank; DB00641; Simvastatin.
DrugBank; DB00877; Sirolimus.
DrugBank; DB00669; Sumatriptan.
DrugBank; DB04348; Taurocholic Acid.
DrugBank; DB09137; Technetium Tc 99m Mebrofenin.
DrugBank; DB00197; Troglitazone.
DrugBank; DB00177; Valsartan.
DrugBank; DB00661; Verapamil.
GuidetoPHARMACOLOGY; 1220; -.
TCDB; 2.A.60.1.5; the organo anion transporter (oat) family.
iPTMnet; Q9Y6L6; -.
PhosphoSitePlus; Q9Y6L6; -.
BioMuta; SLCO1B1; -.
DMDM; 12643959; -.
EPD; Q9Y6L6; -.
PaxDb; Q9Y6L6; -.
PeptideAtlas; Q9Y6L6; -.
PRIDE; Q9Y6L6; -.
Ensembl; ENST00000256958; ENSP00000256958; ENSG00000134538.
GeneID; 10599; -.
KEGG; hsa:10599; -.
UCSC; uc001req.5; human.
CTD; 10599; -.
DisGeNET; 10599; -.
EuPathDB; HostDB:ENSG00000134538.2; -.
GeneCards; SLCO1B1; -.
GeneReviews; SLCO1B1; -.
HGNC; HGNC:10959; SLCO1B1.
HPA; HPA050892; -.
MalaCards; SLCO1B1; -.
MIM; 237450; phenotype.
MIM; 604843; gene.
neXtProt; NX_Q9Y6L6; -.
OpenTargets; ENSG00000134538; -.
Orphanet; 3111; Rotor syndrome.
Orphanet; 413696; Statin toxicity.
PharmGKB; PA134865839; -.
eggNOG; KOG3626; Eukaryota.
eggNOG; ENOG410XRSF; LUCA.
GeneTree; ENSGT00760000119014; -.
HOGENOM; HOG000231269; -.
HOVERGEN; HBG063896; -.
InParanoid; Q9Y6L6; -.
KO; K05043; -.
OMA; IDRACMK; -.
OrthoDB; EOG091G08QD; -.
PhylomeDB; Q9Y6L6; -.
TreeFam; TF317540; -.
Reactome; R-HSA-159418; Recycling of bile acids and salts.
Reactome; R-HSA-879518; Transport of organic anions.
ChiTaRS; SLCO1B1; human.
GeneWiki; SLCO1B1; -.
GenomeRNAi; 10599; -.
PRO; PR:Q9Y6L6; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000134538; -.
CleanEx; HS_LST1; -.
CleanEx; HS_SLCO1B1; -.
ExpressionAtlas; Q9Y6L6; baseline and differential.
Genevisible; Q9Y6L6; HS.
GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0016020; C:membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0015125; F:bile acid transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; TAS:ProtInc.
GO; GO:0015349; F:thyroid hormone transmembrane transporter activity; TAS:Reactome.
GO; GO:0015721; P:bile acid and bile salt transport; TAS:Reactome.
GO; GO:0015711; P:organic anion transport; TAS:ProtInc.
GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
CDD; cd06174; MFS; 1.
InterPro; IPR002350; Kazal_dom.
InterPro; IPR036058; Kazal_dom_sf.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
InterPro; IPR004156; OA_transporter.
PANTHER; PTHR11388; PTHR11388; 1.
Pfam; PF07648; Kazal_2; 1.
Pfam; PF03137; OATP; 1.
SUPFAM; SSF100895; SSF100895; 1.
SUPFAM; SSF103473; SSF103473; 3.
TIGRFAMs; TIGR00805; oat; 1.
PROSITE; PS51465; KAZAL_2; 1.
PROSITE; PS50850; MFS; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Ion transport; Membrane; Phosphoprotein; Polymorphism;
Reference proteome; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 691 Solute carrier organic anion transporter
family member 1B1.
/FTId=PRO_0000191050.
TOPO_DOM 1 28 Cytoplasmic. {ECO:0000255}.
TRANSMEM 29 48 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 49 67 Extracellular. {ECO:0000255}.
TRANSMEM 68 88 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 89 94 Cytoplasmic. {ECO:0000255}.
TRANSMEM 95 119 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 120 168 Extracellular. {ECO:0000255}.
TRANSMEM 169 197 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 198 216 Cytoplasmic. {ECO:0000255}.
TRANSMEM 217 237 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 238 255 Extracellular. {ECO:0000255}.
TRANSMEM 256 280 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 281 331 Cytoplasmic. {ECO:0000255}.
TRANSMEM 332 353 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 354 373 Extracellular. {ECO:0000255}.
TRANSMEM 374 397 Helical; Name=8. {ECO:0000255}.
TOPO_DOM 398 401 Cytoplasmic. {ECO:0000255}.
TRANSMEM 402 425 Helical; Name=9. {ECO:0000255}.
TOPO_DOM 426 537 Extracellular. {ECO:0000255}.
TRANSMEM 538 560 Helical; Name=10. {ECO:0000255}.
TOPO_DOM 561 569 Cytoplasmic. {ECO:0000255}.
TRANSMEM 570 595 Helical; Name=11. {ECO:0000255}.
TOPO_DOM 596 629 Extracellular. {ECO:0000255}.
TRANSMEM 630 647 Helical; Name=12. {ECO:0000255}.
TOPO_DOM 648 691 Cytoplasmic. {ECO:0000255}.
DOMAIN 453 508 Kazal-like. {ECO:0000255|PROSITE-
ProRule:PRU00798}.
MOD_RES 293 293 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 295 295 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 672 672 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 682 682 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
CARBOHYD 130 130 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 134 134 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:23285087}.
CARBOHYD 432 432 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 503 503 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:23285087}.
CARBOHYD 516 516 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:23285087}.
CARBOHYD 617 617 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 459 485 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 463 474 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 465 489 {ECO:0000255|PROSITE-ProRule:PRU00798}.
VARIANT 73 73 F -> L (in dbSNP:rs56101265).
{ECO:0000269|PubMed:11477075}.
/FTId=VAR_015070.
VARIANT 82 82 V -> A (in dbSNP:rs56061388).
{ECO:0000269|PubMed:11477075}.
/FTId=VAR_015071.
VARIANT 130 130 N -> D (in dbSNP:rs2306283).
{ECO:0000269|PubMed:10601278,
ECO:0000269|PubMed:11477075,
ECO:0000269|PubMed:12130747,
ECO:0000269|PubMed:12196548,
ECO:0000269|PubMed:15489334,
ECO:0000269|Ref.6}.
/FTId=VAR_015072.
VARIANT 151 151 N -> S (in dbSNP:rs2306282).
/FTId=VAR_057724.
VARIANT 152 152 R -> K. {ECO:0000269|PubMed:10358072,
ECO:0000269|PubMed:11477075,
ECO:0000269|PubMed:12130747}.
/FTId=VAR_015073.
VARIANT 155 155 P -> T (decreased transport activity;
dbSNP:rs11045819).
{ECO:0000269|PubMed:11477075,
ECO:0000269|PubMed:12196548,
ECO:0000269|PubMed:15489334}.
/FTId=VAR_015074.
VARIANT 156 156 E -> G (decreased transport activity;
dbSNP:rs72559745).
{ECO:0000269|PubMed:11477075}.
/FTId=VAR_015075.
VARIANT 174 174 V -> A (decreased transport activity;
dbSNP:rs4149056).
{ECO:0000269|PubMed:11477075,
ECO:0000269|PubMed:12130747}.
/FTId=VAR_015076.
VARIANT 193 193 L -> R (strongly decreases expression at
the plasma membrane; abolishes transport
activity; dbSNP:rs72559746).
{ECO:0000269|PubMed:12196548}.
/FTId=VAR_015077.
VARIANT 241 241 D -> N. {ECO:0000269|PubMed:10358072,
ECO:0000269|PubMed:11477075,
ECO:0000269|PubMed:12130747}.
/FTId=VAR_015078.
VARIANT 245 245 I -> V (in dbSNP:rs11045852).
/FTId=VAR_060108.
VARIANT 353 353 I -> T (in dbSNP:rs55901008).
{ECO:0000269|PubMed:11477075}.
/FTId=VAR_015079.
VARIANT 432 432 N -> D (in dbSNP:rs56387224).
{ECO:0000269|PubMed:11477075}.
/FTId=VAR_015080.
VARIANT 462 462 D -> G (in dbSNP:rs72559748).
{ECO:0000269|PubMed:11477075}.
/FTId=VAR_015081.
VARIANT 488 488 G -> A (in dbSNP:rs59502379).
{ECO:0000269|PubMed:11477075}.
/FTId=VAR_015082.
VARIANT 643 643 L -> F (in dbSNP:rs34671512).
/FTId=VAR_057725.
VARIANT 655 655 D -> G (in dbSNP:rs56199088).
{ECO:0000269|PubMed:11477075}.
/FTId=VAR_015083.
VARIANT 667 667 E -> G (in dbSNP:rs55737008).
{ECO:0000269|PubMed:11477075}.
/FTId=VAR_015084.
SEQUENCE 691 AA; 76449 MW; D13D5130189383A3 CRC64;
MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS SIIHIERRFE
ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CFIMGIGGVL TALPHFFMGY
YRYSKETNIN SSENSTSTLS TCLINQILSL NRASPEIVGK GCLKESGSYM WIYVFMGNML
RGIGETPIVP LGLSYIDDFA KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV
DLSTIRITPT DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE
TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS SYIGAFTYVF
KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF KLNTVGIAKF SCFTAVMSLS
FYLLYFFILC ENKSVAGLTM TYDGNNPVTS HRDVPLSYCN SDCNCDESQW EPVCGNNGIT
YISPCLAGCK SSSGNKKPIV FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI
QVLNLFFSAL GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI
KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK YQEKDINASE
NGSVMDEANL ESLNKNKHFV PSAGADSETH C


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