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Solute carrier organic anion transporter family member 1C1 (BBB-specific anion transporter type 1) (Blood-brain barrier-specific anion transporter 1) (Solute carrier family 21 member 14) (Thyroxine transporter)

 SO1C1_RAT               Reviewed;         716 AA.
Q9EPZ7;
10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
25-OCT-2017, entry version 112.
RecName: Full=Solute carrier organic anion transporter family member 1C1;
AltName: Full=BBB-specific anion transporter type 1;
AltName: Full=Blood-brain barrier-specific anion transporter 1;
AltName: Full=Solute carrier family 21 member 14;
AltName: Full=Thyroxine transporter;
Name=Slco1c1; Synonyms=Bsat1, Oatp1c1, Oatpf, Slc21a14;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Brain capillary;
PubMed=11149669; DOI=10.1097/00004647-200101000-00008;
Li J.Y., Boado R.J., Pardridge W.M.;
"Blood-brain barrier genomics.";
J. Cereb. Blood Flow Metab. 21:61-68(2001).
[2]
TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=18687783; DOI=10.1210/en.2008-0378;
Roberts L.M., Woodford K., Zhou M., Black D.S., Haggerty J.E.,
Tate E.H., Grindstaff K.K., Mengesha W., Raman C., Zerangue N.;
"Expression of the thyroid hormone transporters monocarboxylate
transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at
the blood-brain barrier.";
Endocrinology 149:6251-6261(2008).
-!- FUNCTION: Mediates the Na(+)-independent high affinity transport
of organic anions such as the thyroid hormones thyroxine (T4) and
rT3. Other potential substrates, such as triiodothyronine (T3),
17-beta-glucuronosyl estradiol, estrone-3-sulfate and
sulfobromophthalein (BSP) are transported with much lower
efficiency (By similarity). May play a signifiant role in
regulating T4 flux into and out of the brain. {ECO:0000250,
ECO:0000269|PubMed:18687783}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18687783};
Multi-pass membrane protein {ECO:0000269|PubMed:18687783}.
Note=Expressed in both luminal and abluminal membranes of brain
capillary endothelial cells. Localized to the apical membrane and
basal surfaces of choroid plexus.
-!- TISSUE SPECIFICITY: Highly expressed in cerebral microvessels (at
protein level). Brain-specific. Not detected in glioma cells,
kidney, heart, lung or liver. Highly expressed in cerebral
microvessels throughout the brain and in tanycytes of the third
ventricle. {ECO:0000269|PubMed:18687783}.
-!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60)
family. {ECO:0000305}.
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EMBL; AF306546; AAG37066.1; -; mRNA.
RefSeq; NP_445893.1; NM_053441.1.
UniGene; Rn.45744; -.
ProteinModelPortal; Q9EPZ7; -.
BioGrid; 250000; 1.
STRING; 10116.ENSRNOP00000013230; -.
TCDB; 2.A.60.1.10; the organo anion transporter (oat) family.
PhosphoSitePlus; Q9EPZ7; -.
UniCarbKB; Q9EPZ7; -.
PaxDb; Q9EPZ7; -.
PRIDE; Q9EPZ7; -.
GeneID; 84511; -.
KEGG; rno:84511; -.
UCSC; RGD:628660; rat.
CTD; 53919; -.
RGD; 628660; Slco1c1.
eggNOG; KOG3626; Eukaryota.
eggNOG; ENOG410XRSF; LUCA.
HOGENOM; HOG000231269; -.
HOVERGEN; HBG063896; -.
InParanoid; Q9EPZ7; -.
KO; K08747; -.
PhylomeDB; Q9EPZ7; -.
PRO; PR:Q9EPZ7; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0015125; F:bile acid transmembrane transporter activity; IDA:RGD.
GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015349; F:thyroid hormone transmembrane transporter activity; IEA:InterPro.
GO; GO:0015721; P:bile acid and bile salt transport; IDA:RGD.
GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
CDD; cd06174; MFS; 1.
InterPro; IPR002350; Kazal_dom.
InterPro; IPR036058; Kazal_dom_sf.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
InterPro; IPR004156; OA_transporter.
InterPro; IPR030764; OATP1C1.
PANTHER; PTHR11388; PTHR11388; 1.
PANTHER; PTHR11388:SF99; PTHR11388:SF99; 1.
Pfam; PF07648; Kazal_2; 1.
Pfam; PF03137; OATP; 1.
SUPFAM; SSF100895; SSF100895; 1.
SUPFAM; SSF103473; SSF103473; 5.
TIGRFAMs; TIGR00805; oat; 1.
PROSITE; PS51465; KAZAL_2; 1.
PROSITE; PS50850; MFS; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Ion transport; Membrane; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 716 Solute carrier organic anion transporter
family member 1C1.
/FTId=PRO_0000191057.
TOPO_DOM 1 43 Cytoplasmic. {ECO:0000255}.
TRANSMEM 44 63 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 64 82 Extracellular. {ECO:0000255}.
TRANSMEM 83 103 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 104 109 Cytoplasmic. {ECO:0000255}.
TRANSMEM 110 134 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 135 187 Extracellular. {ECO:0000255}.
TRANSMEM 188 216 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 217 235 Cytoplasmic. {ECO:0000255}.
TRANSMEM 236 256 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 257 274 Extracellular. {ECO:0000255}.
TRANSMEM 275 299 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 300 352 Cytoplasmic. {ECO:0000255}.
TRANSMEM 353 374 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 375 394 Extracellular. {ECO:0000255}.
TRANSMEM 395 418 Helical; Name=8. {ECO:0000255}.
TOPO_DOM 419 422 Cytoplasmic. {ECO:0000255}.
TRANSMEM 423 446 Helical; Name=9. {ECO:0000255}.
TOPO_DOM 447 558 Extracellular. {ECO:0000255}.
TRANSMEM 559 581 Helical; Name=10. {ECO:0000255}.
TOPO_DOM 582 590 Cytoplasmic. {ECO:0000255}.
TRANSMEM 591 616 Helical; Name=11. {ECO:0000255}.
TOPO_DOM 617 650 Extracellular. {ECO:0000255}.
TRANSMEM 651 668 Helical; Name=12. {ECO:0000255}.
TOPO_DOM 669 716 Cytoplasmic. {ECO:0000255}.
DOMAIN 474 529 Kazal-like. {ECO:0000255|PROSITE-
ProRule:PRU00798}.
CARBOHYD 453 453 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 524 524 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 537 537 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 480 506 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 484 495 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 486 510 {ECO:0000255|PROSITE-ProRule:PRU00798}.
SEQUENCE 716 AA; 78627 MW; 487734B82A50A6EA CRC64;
MDTSSKENAH LFHKNSAQPA GGPSFKAGYP STEEARPCCG KLKVFLGALS FVYFAKALTE
GYLKSTITQI ERRFDIPSSL VGIIDGSFEI GNLLVITFVS YFGAKLHRPK IIGAGCLVMG
FGTMLIAVPQ FFMEKYSYEK YERYSPSSNL TPNISPCYLE SSSPSPRSIV GKSQNKINDE
CEVDTSSSMW VYVFLGNLLR GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI
FGFLLGSLCA KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK
TLPRSQSRED SGSSSEKSKF ITDDPVNYQM APREESMKIM EMARDFLPSL KSLFRNPVYI
LYLCASTVQF NSLFGMVTYK PKYIEQQYGQ SSSKANFVIG LINIPAVALG IFSGGIVMKK
FRLGICEATK LYLGSSVFGY LLFLSLFALG CENSSVAGLT VSYQGTKPVS YHERALFSDC
NSRCKCSDSK WEPMCGDNGI TYASACLAGC QSSSRSGKNI IFSNCTCVGF AAPKSGNWSG
MMGRCQKDNG CSQMFLYFLV ISVITSYTLS LGGIPGYILL LRCIQPQLKS FALGIYTLAV
RVLAGIPAPV YFGVLIDTSC LKWGFKKCGS RGSCRLYDSH AFRHIYLGLT TLLGTVSVFL
STAVLLVLKK KYVSKRSSFI TAREKIVMSS SVKKETCAAR DHGLQPKYWP GKETRL


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