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Somatotropin

 I6WN98_BOVIN            Unreviewed;       216 AA.
I6WN98;
03-OCT-2012, integrated into UniProtKB/TrEMBL.
03-OCT-2012, sequence version 1.
25-APR-2018, entry version 30.
SubName: Full=Somatotropin {ECO:0000313|EMBL:AFN44376.1};
Name=Gh1 {ECO:0000313|EMBL:AFN44376.1};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|EMBL:AFN44376.1};
[1] {ECO:0000313|EMBL:AFN44376.1}
NUCLEOTIDE SEQUENCE.
Martinez R., Abuabara Y., Gallego F., Polanco N., Pedraza A.;
"New Variation in Genes Related to Growth in Colombian Creole
Cattle.";
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU003618,
ECO:0000256|SAAS:SAAS00687159}.
-!- SIMILARITY: Belongs to the somatotropin/prolactin family.
{ECO:0000256|RuleBase:RU003618, ECO:0000256|SAAS:SAAS00680088}.
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EMBL; JQ711182; AFN44376.1; -; Genomic_DNA.
UniGene; Bt.28019; -.
SMR; I6WN98; -.
eggNOG; ENOG410IFR6; Eukaryota.
eggNOG; ENOG4111HU8; LUCA.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0005131; F:growth hormone receptor binding; IMP:AgBase.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0008283; P:cell proliferation; IDA:AgBase.
GO; GO:0030073; P:insulin secretion; IDA:AgBase.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:AgBase.
GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IDA:AgBase.
GO; GO:0010629; P:negative regulation of gene expression; IDA:AgBase.
GO; GO:1901984; P:negative regulation of protein acetylation; IMP:AgBase.
GO; GO:2000844; P:negative regulation of testosterone secretion; IMP:AgBase.
GO; GO:0035811; P:negative regulation of urine volume; IDA:AgBase.
GO; GO:2000860; P:positive regulation of aldosterone secretion; IDA:AgBase.
GO; GO:0045542; P:positive regulation of cholesterol biosynthetic process; IDA:AgBase.
GO; GO:1900482; P:positive regulation of diacylglycerol biosynthetic process; IDA:AgBase.
GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IDA:AgBase.
GO; GO:2000253; P:positive regulation of feeding behavior; IDA:AgBase.
GO; GO:1903489; P:positive regulation of lactation; IDA:AgBase.
GO; GO:0050996; P:positive regulation of lipid catabolic process; IDA:AgBase.
GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IDA:AgBase.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:AgBase.
GO; GO:0071073; P:positive regulation of phospholipid biosynthetic process; IDA:AgBase.
GO; GO:2000833; P:positive regulation of steroid hormone secretion; IMP:AgBase.
GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; IDA:AgBase.
GO; GO:0009306; P:protein secretion; IDA:AgBase.
GO; GO:0070294; P:renal sodium ion absorption; IDA:AgBase.
GO; GO:0032094; P:response to food; IDA:AgBase.
GO; GO:1903576; P:response to L-arginine; IDA:AgBase.
GO; GO:0031667; P:response to nutrient levels; IDA:AgBase.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR034975; Somatotropin.
InterPro; IPR001400; Somatotropin/Prolactin.
InterPro; IPR018116; Somatotropin_CS.
PANTHER; PTHR11417; PTHR11417; 1.
PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
Pfam; PF00103; Hormone_1; 1.
PRINTS; PR00836; SOMATOTROPIN.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00266; SOMATOTROPIN_1; 1.
PROSITE; PS00338; SOMATOTROPIN_2; 1.
3: Inferred from homology;
Disulfide bond {ECO:0000256|SAAS:SAAS00887446};
Hormone {ECO:0000256|RuleBase:RU003618,
ECO:0000256|SAAS:SAAS00887457};
Secreted {ECO:0000256|SAAS:SAAS00119356};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 26 {ECO:0000256|SAM:SignalP}.
CHAIN 27 216 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003706618.
SEQUENCE 216 AA; 24429 MW; 85C1DB06ABF93734 CRC64;
MMAAGPRTSL LLAFALLCLP WTQVVGAFPA MSLSGLFANA VLRAQHLHQL AADTFKEFRT
YIPEGQRYSI QNTQVAFCFS ETIPAPTGKN EAQQKSDLEL LRISLLLIQS WLGPLQFLSR
VFTNSLVFGT SDRVYEKLKD LEEGILALMR ELEDGTPRAG QILKQTYDKF DTNMRSDDAL
LKNYGLLSCF RKDLHKTETY LRVMKCRRFG EASCAF


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