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Somatotropin (Growth hormone)

 SOMA_CANLF              Reviewed;         216 AA.
P33711; Q9TQT6;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
23-MAY-2018, entry version 114.
RecName: Full=Somatotropin;
AltName: Full=Growth hormone;
Flags: Precursor;
Name=GH1; Synonyms=GH;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8206387; DOI=10.1016/0378-1119(94)90110-4;
Ascacio-Martinez J.A., Barrera-Saldana H.A.;
"A dog growth hormone cDNA codes for a mature protein identical to pig
growth hormone.";
Gene 143:277-280(1994).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
van Leeuwen I.S., Teske E., van Garderen E., Rutteman G.R., Mol J.A.;
"Extrapituitary growth hormone expression in the dog is initiated at
the normal pituitary transcription start site in the mammary gland and
at multiple upstream sites in lymphoid cells.";
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
PubMed=10411306; DOI=10.1016/S0303-7207(99)00010-6;
Lantinga-van Leeuwen I.S., Oudshoorn M., Mol J.A.;
"Canine mammary growth hormone gene transcription initiates at the
pituitary-specific start site in the absence of Pit-1.";
Mol. Cell. Endocrinol. 150:121-128(1999).
-!- FUNCTION: Plays an important role in growth control. Its major
role in stimulating body growth is to stimulate the liver and
other tissues to secrete IGF-1. It stimulates both the
differentiation and proliferation of myoblasts. It also stimulates
amino acid uptake and protein synthesis in muscle and other
tissues.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the somatotropin/prolactin family.
{ECO:0000305}.
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EMBL; Z23067; CAA80601.1; -; mRNA.
EMBL; U92533; AAF21502.1; -; Genomic_DNA.
EMBL; AF069071; AAD43366.1; -; mRNA.
PIR; I46145; I46145.
RefSeq; NP_001003168.1; NM_001003168.1.
RefSeq; XP_005624232.1; XM_005624175.2.
UniGene; Cfa.3656; -.
ProteinModelPortal; P33711; -.
STRING; 9615.ENSCAFP00000018659; -.
PaxDb; P33711; -.
PRIDE; P33711; -.
Ensembl; ENSCAFT00000020118; ENSCAFP00000018659; ENSCAFG00000012681.
GeneID; 403795; -.
KEGG; cfa:403795; -.
CTD; 2688; -.
eggNOG; ENOG410IFR6; Eukaryota.
eggNOG; ENOG4111HU8; LUCA.
GeneTree; ENSGT00730000111012; -.
HOGENOM; HOG000068443; -.
HOVERGEN; HBG011318; -.
InParanoid; P33711; -.
KO; K05438; -.
OMA; TYLRVMK; -.
OrthoDB; EOG091G0KPU; -.
TreeFam; TF332592; -.
Reactome; R-CFA-1170546; Prolactin receptor signaling.
Reactome; R-CFA-422085; Synthesis, secretion, and deacylation of Ghrelin.
Reactome; R-CFA-982772; Growth hormone receptor signaling.
Proteomes; UP000002254; Chromosome 9.
Bgee; ENSCAFG00000012681; -.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0030141; C:secretory granule; IEA:Ensembl.
GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
GO; GO:0005131; F:growth hormone receptor binding; IEA:Ensembl.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
GO; GO:0032094; P:response to food; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR034975; Somatotropin.
InterPro; IPR001400; Somatotropin/Prolactin.
InterPro; IPR018116; Somatotropin_CS.
PANTHER; PTHR11417; PTHR11417; 1.
PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
Pfam; PF00103; Hormone_1; 1.
PRINTS; PR00836; SOMATOTROPIN.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00266; SOMATOTROPIN_1; 1.
PROSITE; PS00338; SOMATOTROPIN_2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Hormone; Metal-binding;
Phosphoprotein; Reference proteome; Secreted; Signal; Zinc.
SIGNAL 1 26 {ECO:0000250}.
CHAIN 27 216 Somatotropin.
/FTId=PRO_0000032978.
METAL 45 45 Zinc. {ECO:0000250}.
METAL 198 198 Zinc. {ECO:0000250}.
MOD_RES 131 131 Phosphoserine.
{ECO:0000250|UniProtKB:P01241}.
DISULFID 78 189 {ECO:0000250}.
DISULFID 206 214 {ECO:0000250}.
CONFLICT 4 4 S -> G (in Ref. 1; CAA80601).
{ECO:0000305}.
CONFLICT 7 7 N -> T (in Ref. 1; CAA80601).
{ECO:0000305}.
SEQUENCE 216 AA; 24468 MW; A8AD1DD59F1DAAED CRC64;
MAASPRNSVL LAFALLCLPW PQEVGAFPAM PLSSLFANAV LRAQHLHQLA ADTYKEFERA
YIPEGQRYSI QNAQAAFCFS ETIPAPTGKD EAQQRSDVEL LRFSLLLIQS WLGPVQFLSR
VFTNSLVFGT SDRVYEKLKD LEEGIQALMR ELEDGSPRAG QILKQTYDKF DTNLRSDDAL
LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF


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