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Somatotropin (Growth hormone)

 SOMA_TRITC              Reviewed;         204 AA.
Q98UF6;
16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
25-OCT-2017, entry version 63.
RecName: Full=Somatotropin;
AltName: Full=Growth hormone;
Flags: Precursor;
Name=gh;
Trichopodus trichopterus (Three spot gourami) (Trichogaster
trichopterus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Anabantaria; Anabantiformes; Anabantoidei; Osphronemidae;
Luciocephalinae; Trichopodus.
NCBI_TaxID=96903;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Doron G., Ofir M., Jackson K., Czosnek H., Degani G.;
"The growth hormone of the blue gourami (Trichogaster trichopterus):
cloning of its cDNA and analysis of its expression during oogenesis.";
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Growth hormone plays an important role in growth control
and is involved in the regulation of several anabolic processes.
Implicated as an osmoregulatory substance important for seawater
adaptation.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the somatotropin/prolactin family.
{ECO:0000305}.
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EMBL; AF157633; AAG60346.1; -; mRNA.
ProteinModelPortal; Q98UF6; -.
SMR; Q98UF6; -.
HOVERGEN; HBG011318; -.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0005131; F:growth hormone receptor binding; IEA:InterPro.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR034975; Somatotropin.
InterPro; IPR001400; Somatotropin/Prolactin.
InterPro; IPR018116; Somatotropin_CS.
PANTHER; PTHR11417; PTHR11417; 1.
PANTHER; PTHR11417:SF2; PTHR11417:SF2; 1.
Pfam; PF00103; Hormone_1; 1.
PRINTS; PR00836; SOMATOTROPIN.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00266; SOMATOTROPIN_1; 1.
PROSITE; PS00338; SOMATOTROPIN_2; 1.
2: Evidence at transcript level;
Disulfide bond; Hormone; Metal-binding; Pyrrolidone carboxylic acid;
Secreted; Signal; Zinc.
SIGNAL 1 17 {ECO:0000250}.
CHAIN 18 204 Somatotropin.
/FTId=PRO_0000033059.
METAL 36 36 Zinc. {ECO:0000250}.
METAL 186 186 Zinc. {ECO:0000250}.
MOD_RES 18 18 Pyrrolidone carboxylic acid.
{ECO:0000250}.
DISULFID 69 177 {ECO:0000250}.
DISULFID 194 202 {ECO:0000250}.
SEQUENCE 204 AA; 23412 MW; 2D7941646A5C9CF1 CRC64;
MDKVLFLLFV LSLGVSSQPI TDSQRLFSIA VSRVQHLHLL AQRLFTDFES SLQIEEQRQL
NKIFLQDFCN SDYIISPIDK HETQRSSVLK LLSISYRLIE SWEFPSRSLY GGSAQRYQIS
PKLSELMRGI QLLIKANQDG AEMFSDGVVP QLAPYGNYYQ SLGEDESLRR SYELLACFKK
DMHKVETYLT VAKCRLSPEA NCTL


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