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Sonic hedgehog

 U3JWP0_FICAL            Unreviewed;       231 AA.
13-NOV-2013, integrated into UniProtKB/TrEMBL.
13-NOV-2013, sequence version 1.
16-JAN-2019, entry version 36.
SubName: Full=Sonic hedgehog {ECO:0000313|Ensembl:ENSFALP00000007194};
Name=SHH {ECO:0000313|Ensembl:ENSFALP00000007194};
Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000007194, ECO:0000313|Proteomes:UP000016665};
[1] {ECO:0000313|Ensembl:ENSFALP00000007194}
Submitted (SEP-2013) to UniProtKB.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AGTO01000105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSFALT00000007226; ENSFALP00000007194; ENSFALG00000006895.
GeneTree; ENSGT00940000159119; -.
Proteomes; UP000016665; Unplaced.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
GO; GO:0043237; F:laminin-1 binding; IEA:Ensembl.
GO; GO:0005113; F:patched binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
GO; GO:0008209; P:androgen metabolic process; IEA:Ensembl.
GO; GO:0048645; P:animal organ formation; IEA:Ensembl.
GO; GO:0097190; P:apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0060840; P:artery development; IEA:Ensembl.
GO; GO:0007411; P:axon guidance; IEA:Ensembl.
GO; GO:0060020; P:Bergmann glial cell differentiation; IEA:Ensembl.
GO; GO:0007596; P:blood coagulation; IEA:Ensembl.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0060447; P:bud outgrowth involved in lung branching; IEA:Ensembl.
GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0043369; P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; IEA:Ensembl.
GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
GO; GO:0071285; P:cellular response to lithium ion; IEA:Ensembl.
GO; GO:0021930; P:cerebellar granule cell precursor proliferation; IEA:Ensembl.
GO; GO:0003140; P:determination of left/right asymmetry in lateral mesoderm; IEA:Ensembl.
GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0007398; P:ectoderm development; IEA:Ensembl.
GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0048617; P:embryonic foregut morphogenesis; IEA:Ensembl.
GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
GO; GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Ensembl.
GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
GO; GO:0006897; P:endocytosis; IEA:Ensembl.
GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IEA:Ensembl.
GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
GO; GO:0048859; P:formation of anatomical boundary; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0007442; P:hindgut morphogenesis; IEA:Ensembl.
GO; GO:0048839; P:inner ear development; IEA:Ensembl.
GO; GO:0045109; P:intermediate filament organization; IEA:Ensembl.
GO; GO:0060459; P:left lung development; IEA:Ensembl.
GO; GO:0060174; P:limb bud formation; IEA:Ensembl.
GO; GO:0060428; P:lung epithelium development; IEA:Ensembl.
GO; GO:0060463; P:lung lobe morphogenesis; IEA:Ensembl.
GO; GO:0060484; P:lung-associated mesenchyme development; IEA:Ensembl.
GO; GO:0002320; P:lymphoid progenitor cell differentiation; IEA:Ensembl.
GO; GO:0030539; P:male genitalia development; IEA:Ensembl.
GO; GO:0060916; P:mesenchymal cell proliferation involved in lung development; IEA:Ensembl.
GO; GO:0060783; P:mesenchymal smoothened signaling pathway involved in prostate gland development; IEA:Ensembl.
GO; GO:0072136; P:metanephric mesenchymal cell proliferation involved in metanephros development; IEA:Ensembl.
GO; GO:0030901; P:midbrain development; IEA:Ensembl.
GO; GO:0045445; P:myoblast differentiation; IEA:Ensembl.
GO; GO:0014902; P:myotube differentiation; IEA:Ensembl.
GO; GO:0046639; P:negative regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0090370; P:negative regulation of cholesterol efflux; IEA:Ensembl.
GO; GO:1904339; P:negative regulation of dopaminergic neuron differentiation; IEA:Ensembl.
GO; GO:2000357; P:negative regulation of kidney smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:2001054; P:negative regulation of mesenchymal cell apoptotic process; IEA:Ensembl.
GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0042130; P:negative regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:2000062; P:negative regulation of ureter smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
GO; GO:0031016; P:pancreas development; IEA:Ensembl.
GO; GO:0009949; P:polarity specification of anterior/posterior axis; IEA:Ensembl.
GO; GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0051781; P:positive regulation of cell division; IEA:Ensembl.
GO; GO:0060769; P:positive regulation of epithelial cell proliferation involved in prostate gland development; IEA:Ensembl.
GO; GO:0007228; P:positive regulation of hh target transcription factor activity; IEA:Ensembl.
GO; GO:0033092; P:positive regulation of immature T cell proliferation in thymus; IEA:Ensembl.
GO; GO:2000358; P:positive regulation of kidney smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:2000729; P:positive regulation of mesenchymal cell proliferation involved in ureter development; IEA:Ensembl.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0061189; P:positive regulation of sclerotome development; IEA:Ensembl.
GO; GO:0014858; P:positive regulation of skeletal muscle cell proliferation; IEA:Ensembl.
GO; GO:0048643; P:positive regulation of skeletal muscle tissue development; IEA:Ensembl.
GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0051155; P:positive regulation of striated muscle cell differentiation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:2000063; P:positive regulation of ureter smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
GO; GO:0045059; P:positive thymic T cell selection; IEA:Ensembl.
GO; GO:0060516; P:primary prostatic bud elongation; IEA:Ensembl.
GO; GO:0060523; P:prostate epithelial cord elongation; IEA:Ensembl.
GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
GO; GO:0060782; P:regulation of mesenchymal cell proliferation involved in prostate gland development; IEA:Ensembl.
GO; GO:0042481; P:regulation of odontogenesis; IEA:Ensembl.
GO; GO:0060685; P:regulation of prostatic bud formation; IEA:Ensembl.
GO; GO:0060458; P:right lung development; IEA:Ensembl.
GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
GO; GO:0060662; P:salivary gland cavitation; IEA:Ensembl.
GO; GO:0043588; P:skin development; IEA:Ensembl.
GO; GO:0021938; P:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; IEA:Ensembl.
GO; GO:0061053; P:somite development; IEA:Ensembl.
GO; GO:0021513; P:spinal cord dorsal/ventral patterning; IEA:Ensembl.
GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
GO; GO:0014706; P:striated muscle tissue development; IEA:Ensembl.
GO; GO:0021978; P:telencephalon regionalization; IEA:Ensembl.
GO; GO:0021794; P:thalamus development; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
GO; GO:0060439; P:trachea morphogenesis; IEA:Ensembl.
GO; GO:1905327; P:tracheoesophageal septum formation; IEA:Ensembl.
GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
Gene3D; 3.30.1380.10; -; 1.
InterPro; IPR001657; Hedgehog.
InterPro; IPR009045; Hedgehog_sig/DD-Pept_Zn-bd_sf.
InterPro; IPR000320; Hedgehog_signalling_dom.
Pfam; PF01085; HH_signal; 1.
SUPFAM; SSF55166; SSF55166; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000016665};
Reference proteome {ECO:0000313|Proteomes:UP000016665};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 26 {ECO:0000256|SAM:SignalP}.
CHAIN 27 231 {ECO:0000256|SAM:SignalP}.
DOMAIN 27 187 HH_signal. {ECO:0000259|Pfam:PF01085}.
SEQUENCE 231 AA; 25648 MW; ACB1F7C4508395A7 CRC64;

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