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Spectinomycin phosphotransferase

 O06916_LEGPN            Unreviewed;       331 AA.
O06916; E1XXQ2;
01-JUL-1997, integrated into UniProtKB/TrEMBL.
01-JUL-1997, sequence version 1.
22-NOV-2017, entry version 86.
SubName: Full=Spectinomycin phosphotransferase {ECO:0000313|EMBL:AAB58447.1};
Name=aph {ECO:0000313|EMBL:AAB58447.1};
Legionella pneumophila.
Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
Legionellaceae; Legionella.
NCBI_TaxID=446 {ECO:0000313|EMBL:AAB58447.1};
[1] {ECO:0000313|EMBL:AAB58447.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Wadsworth 130b {ECO:0000313|EMBL:AAB58447.1};
PubMed=9174205;
Suter T.M., Viswanathan V.K., Cianciotto N.P.;
"Isolation of a gene encoding a novel spectinomycin phosphotransferase
from Legionella pneumophila.";
Antimicrob. Agents Chemother. 41:1385-1388(1997).
[2] {ECO:0000213|PDB:3I0O, ECO:0000213|PDB:3I0Q, ECO:0000213|PDB:3I1A}
X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH ADP AND AMP.
PubMed=20089863; DOI=10.1074/jbc.M109.038364;
Fong D.H., Lemke C.T., Hwang J., Xiong B., Berghuis A.M.;
"Structure of the antibiotic resistance factor spectinomycin
phosphotransferase from Legionella pneumophila.";
J. Biol. Chem. 285:9545-9555(2010).
[3] {ECO:0000213|PDB:3Q2M}
X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS).
PubMed=21573013; DOI=10.1371/journal.pone.0019589;
Fong D.H., Xiong B., Hwang J., Berghuis A.M.;
"Crystal structures of two aminoglycoside kinases bound with a
eukaryotic protein kinase inhibitor.";
PLoS ONE 6:e19589-e19589(2011).
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EMBL; U94857; AAB58447.1; -; Genomic_DNA.
RefSeq; WP_038839037.1; NZ_FJAB01000008.1.
PDB; 3I0O; X-ray; 2.40 A; A=1-331.
PDB; 3I0Q; X-ray; 2.80 A; A=1-331.
PDB; 3I1A; X-ray; 1.70 A; A/B=1-331.
PDB; 3Q2M; X-ray; 2.90 A; A=1-331.
PDBsum; 3I0O; -.
PDBsum; 3I0Q; -.
PDBsum; 3I1A; -.
PDBsum; 3Q2M; -.
ProteinModelPortal; O06916; -.
SMR; O06916; -.
KEGG; ag:AAB58447; -.
KO; K18844; -.
EvolutionaryTrace; O06916; -.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
InterPro; IPR002575; Aminoglycoside_PTrfase.
InterPro; IPR011009; Kinase-like_dom_sf.
Pfam; PF01636; APH; 1.
SUPFAM; SSF56112; SSF56112; 1.
1: Evidence at protein level;
3D-structure {ECO:0000213|PDB:3I0O, ECO:0000213|PDB:3I0Q,
ECO:0000213|PDB:3I1A, ECO:0000213|PDB:3Q2M};
Nucleotide-binding {ECO:0000213|PDB:3I0O, ECO:0000213|PDB:3I0Q};
Transferase {ECO:0000313|EMBL:AAB58447.1}.
DOMAIN 110 245 APH. {ECO:0000259|Pfam:PF01636}.
NP_BIND 50 52 ADP. {ECO:0000213|PDB:3I0O}.
NP_BIND 101 103 ADP. {ECO:0000213|PDB:3I0O}.
NP_BIND 101 103 AMP. {ECO:0000213|PDB:3I0Q}.
BINDING 50 50 AMP. {ECO:0000213|PDB:3I0Q}.
BINDING 217 217 ADP. {ECO:0000213|PDB:3I0O}.
BINDING 230 230 ADP. {ECO:0000213|PDB:3I0O}.
BINDING 230 230 AMP. {ECO:0000213|PDB:3I0Q}.
SEQUENCE 331 AA; 38525 MW; 8410CA444DD95E51 CRC64;
MLKQPIQAQQ LIELLKVHYG IDIHTAQFIQ GGADTNAFAY QADSESKSYF IKLKYGYHDE
INLSIIRLLH DSGIKEIIFP IHTLEAKLFQ QLKHFKIIAY PFIHAPNGFT QNLTGKQWKQ
LGKVLRQIHE TSVPISIQQQ LRKEIYSPKW REIVRSFYNQ IEFDNSDDKL TAAFKSFFNQ
NSAAIHRLVD TSEKLSKKIQ PDLDKYVLCH SDIHAGNVLV GNEESIYIID WDEPMLAPKE
RDLMFIGGGV GNVWNKPHEI QYFYEGYGEI NVDKTILSYY RHERIVEDIA VYGQDLLSRN
QNNQSRLESF KYFKEMFDPN NVVEIAFATE Q


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