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Sperm acrosome membrane-associated protein 3 (Cancer/testis antigen 54) (CT54) (Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17) (Lysozyme-like protein 3) (Sperm lysozyme-like protein 1) (Sperm protein reactive with antisperm antibodies) (Sperm protein reactive with ASA) [Cleaved into: Sperm acrosome membrane-associated protein 3, membrane form; Sperm acrosome membrane-associated protein 3, processed form]

 SACA3_HUMAN             Reviewed;         215 AA.
Q8IXA5; Q7Z4Y5;
31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
20-JUN-2018, entry version 122.
RecName: Full=Sperm acrosome membrane-associated protein 3;
AltName: Full=Cancer/testis antigen 54;
Short=CT54;
AltName: Full=Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17;
AltName: Full=Lysozyme-like protein 3;
AltName: Full=Sperm lysozyme-like protein 1;
AltName: Full=Sperm protein reactive with antisperm antibodies;
Short=Sperm protein reactive with ASA;
Contains:
RecName: Full=Sperm acrosome membrane-associated protein 3, membrane form;
Contains:
RecName: Full=Sperm acrosome membrane-associated protein 3, processed form;
Name=SPACA3; Synonyms=LYC3, LYZL3, SLLP1, SPRASA;
ORFNames=UNQ424/PRO862;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 88-109,
FUNCTION IN FERTILIZATION, IDENTIFICATION BY MASS SPECTROMETRY,
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
TISSUE=Testis;
PubMed=12606493; DOI=10.1095/biolreprod.102.010108;
Mandal A., Klotz K.L., Shetty J., Jayes F.L., Wolkowicz M.J.,
Bolling L.C., Coonrod S.A., Black M.B., Diekman A.B., Haystead T.A.J.,
Flickinger C.J., Herr J.C.;
"SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like
protein of human spermatozoa.";
Biol. Reprod. 68:1525-1537(2003).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
TISSUE=Testis;
PubMed=16014814; DOI=10.1095/biolreprod.105.041889;
Zhang K., Gao R., Zhang H., Cai X., Shen C., Wu C., Zhao S., Yu L.;
"Molecular cloning and characterization of three novel lysozyme-like
genes, predominantly expressed in the male reproductive system of
humans, belonging to the c-type lysozyme/alpha-lactalbumin family.";
Biol. Reprod. 73:1064-1071(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY.
TISSUE=Sperm;
PubMed=14747161; DOI=10.1093/humrep/deh050;
Chiu W.W.C., Erikson E.K., Sole C.A., Shelling A.N., Chamley L.W.;
"SPRASA, a novel sperm protein involved in immune-mediated
infertility.";
Hum. Reprod. 19:243-249(2004).
-!- FUNCTION: Sperm surface membrane protein that may be involved in
sperm-egg plasma membrane adhesion and fusion during
fertilization. It could be a potential receptor for the egg
oligosaccharide residue N-acetylglucosamine, which is present in
the extracellular matrix over the egg plasma membrane. The
processed form has no detectable bacteriolytic activity in vitro.
{ECO:0000269|PubMed:12606493}.
-!- SUBUNIT: Interacts with ASTL. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Isoform 1: Cytoplasmic vesicle, secretory
vesicle, acrosome membrane {ECO:0000305}; Single-pass type II
membrane protein {ECO:0000305}. Note=Anterior acrosome in non-
capacitated spermatozoa and retained in the equatorial segment and
in the luminal face of both the inner and outer acrosomal
membranes following capacitation and the acrosome reaction.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q8IXA5-1; Sequence=Displayed;
Name=2;
IsoId=Q8IXA5-2; Sequence=VSP_021329;
-!- TISSUE SPECIFICITY: The processed form is expressed in sperm (at
protein level). Expressed in testis, epididymis and placenta.
{ECO:0000269|PubMed:12606493, ECO:0000269|PubMed:16014814}.
-!- PTM: The processed form derives from the membrane form by
proteolytic processing.
-!- SIMILARITY: Belongs to the glycosyl hydrolase 22 family.
{ECO:0000255|PROSITE-ProRule:PRU00680}.
-!- CAUTION: Although it belongs to the glycosyl hydrolase 22 family,
Thr-122 and Asn-139 are present instead of the conserved Glu and
Asp which are active site residues. It is therefore expected that
this protein lacks hydrolase activity. {ECO:0000305}.
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EMBL; AF216311; AAK01478.1; -; mRNA.
EMBL; AF099029; AAP97222.1; -; Genomic_DNA.
EMBL; AY358653; AAQ89016.1; -; mRNA.
EMBL; BC100886; AAI00887.1; -; mRNA.
EMBL; BC100887; AAI00888.1; -; mRNA.
CCDS; CCDS11275.1; -. [Q8IXA5-1]
RefSeq; NP_001304155.1; NM_001317226.1.
RefSeq; NP_776246.1; NM_173847.4. [Q8IXA5-1]
UniGene; Hs.434112; -.
ProteinModelPortal; Q8IXA5; -.
SMR; Q8IXA5; -.
BioGrid; 125897; 6.
IntAct; Q8IXA5; 2.
STRING; 9606.ENSP00000269053; -.
CAZy; GH22; Glycoside Hydrolase Family 22.
iPTMnet; Q8IXA5; -.
PhosphoSitePlus; Q8IXA5; -.
BioMuta; SPACA3; -.
DMDM; 74723659; -.
PaxDb; Q8IXA5; -.
PeptideAtlas; Q8IXA5; -.
PRIDE; Q8IXA5; -.
ProteomicsDB; 70978; -.
ProteomicsDB; 70979; -. [Q8IXA5-2]
DNASU; 124912; -.
Ensembl; ENST00000269053; ENSP00000269053; ENSG00000141316. [Q8IXA5-1]
Ensembl; ENST00000580599; ENSP00000463386; ENSG00000141316. [Q8IXA5-2]
GeneID; 124912; -.
KEGG; hsa:124912; -.
UCSC; uc002hhs.2; human. [Q8IXA5-1]
CTD; 124912; -.
DisGeNET; 124912; -.
EuPathDB; HostDB:ENSG00000141316.12; -.
GeneCards; SPACA3; -.
H-InvDB; HIX0039076; -.
HGNC; HGNC:16260; SPACA3.
HPA; HPA023633; -.
MIM; 612749; gene.
neXtProt; NX_Q8IXA5; -.
OpenTargets; ENSG00000141316; -.
PharmGKB; PA38101; -.
eggNOG; ENOG410IG3E; Eukaryota.
eggNOG; ENOG41118PT; LUCA.
GeneTree; ENSGT00550000074398; -.
HOGENOM; HOG000037357; -.
HOVERGEN; HBG052297; -.
InParanoid; Q8IXA5; -.
OMA; KDTVICA; -.
OrthoDB; EOG091G0R9V; -.
PhylomeDB; Q8IXA5; -.
TreeFam; TF324882; -.
ChiTaRS; SPACA3; human.
GeneWiki; SPACA3; -.
GenomeRNAi; 124912; -.
PRO; PR:Q8IXA5; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000141316; -.
CleanEx; HS_SPACA3; -.
ExpressionAtlas; Q8IXA5; baseline and differential.
Genevisible; Q8IXA5; HS.
GO; GO:0043159; C:acrosomal matrix; IDA:UniProtKB.
GO; GO:0002080; C:acrosomal membrane; IDA:UniProtKB.
GO; GO:0005576; C:extracellular region; TAS:UniProtKB.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0030141; C:secretory granule; IDA:UniProtKB.
GO; GO:0016998; P:cell wall macromolecule catabolic process; TAS:UniProtKB.
GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
GO; GO:0050830; P:defense response to Gram-positive bacterium; TAS:UniProtKB.
GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IMP:UniProtKB.
GO; GO:0042117; P:monocyte activation; TAS:UniProtKB.
GO; GO:0009253; P:peptidoglycan catabolic process; TAS:UniProtKB.
GO; GO:0043032; P:positive regulation of macrophage activation; TAS:UniProtKB.
GO; GO:0050766; P:positive regulation of phagocytosis; TAS:UniProtKB.
GO; GO:0009615; P:response to virus; TAS:UniProtKB.
GO; GO:0035036; P:sperm-egg recognition; IEA:Ensembl.
CDD; cd00119; LYZ1; 1.
InterPro; IPR001916; Glyco_hydro_22.
InterPro; IPR019799; Glyco_hydro_22_CS.
InterPro; IPR000974; Glyco_hydro_22_lys.
InterPro; IPR023346; Lysozyme-like_dom_sf.
InterPro; IPR030058; LYZL3.
PANTHER; PTHR11407:SF25; PTHR11407:SF25; 1.
Pfam; PF00062; Lys; 1.
PRINTS; PR00137; LYSOZYME.
PRINTS; PR00135; LYZLACT.
SMART; SM00263; LYZ1; 1.
SUPFAM; SSF53955; SSF53955; 1.
PROSITE; PS00128; LACTALBUMIN_LYSOZYME_1; 1.
PROSITE; PS51348; LACTALBUMIN_LYSOZYME_2; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Cytoplasmic vesicle;
Direct protein sequencing; Disulfide bond; Membrane; Polymorphism;
Reference proteome; Secreted; Signal-anchor; Transmembrane;
Transmembrane helix.
CHAIN 1 215 Sperm acrosome membrane-associated
protein 3, membrane form.
/FTId=PRO_0000256219.
CHAIN 88 215 Sperm acrosome membrane-associated
protein 3, processed form.
/FTId=PRO_0000256220.
TOPO_DOM 1 63 Cytoplasmic. {ECO:0000255}.
TRANSMEM 64 84 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 85 215 Extracellular. {ECO:0000255}.
SITE 87 88 Cleavage; to produce processed form.
{ECO:0000305}.
DISULFID 93 213 {ECO:0000255|PROSITE-ProRule:PRU00680}.
DISULFID 117 201 {ECO:0000255|PROSITE-ProRule:PRU00680}.
DISULFID 151 166 {ECO:0000255|PROSITE-ProRule:PRU00680}.
DISULFID 162 180 {ECO:0000255|PROSITE-ProRule:PRU00680}.
VAR_SEQ 1 69 Missing (in isoform 2).
{ECO:0000303|PubMed:12975309}.
/FTId=VSP_021329.
VARIANT 80 80 C -> Y (in dbSNP:rs16967845).
/FTId=VAR_028885.
VARIANT 100 100 H -> R (in dbSNP:rs28963).
/FTId=VAR_028886.
VARIANT 128 128 A -> T (in dbSNP:rs35420663).
/FTId=VAR_050008.
SEQUENCE 215 AA; 23431 MW; 39988565D592BCC8 CRC64;
MVSALRGAPL IRVHSSPVSS PSVSGPRRLV SCLSSQSSAL SQSGGGSTSA AGIEARSRAL
RRRWCPAGIM LLALVCLLSC LLPSSEAKLY GRCELARVLH DFGLDGYRGY SLADWVCLAY
FTSGFNAAAL DYEADGSTNN GIFQINSRRW CSNLTPNVPN VCRMYCSDLL NPNLKDTVIC
AMKITQEPQG LGYWEAWRHH CQGKDLTEWV DGCDF


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