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Sperm mitochondrial-associated cysteine-rich protein

 MCSP_HUMAN              Reviewed;         116 AA.
P49901; Q96A42;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
31-JAN-2002, sequence version 2.
27-SEP-2017, entry version 123.
RecName: Full=Sperm mitochondrial-associated cysteine-rich protein;
Name=SMCP; Synonyms=MCS, MCSP;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
TISSUE=Testis;
PubMed=8833144; DOI=10.1006/geno.1996.0104;
Aho H., Schwemmer M., Tessmann D., Murphy D., Mattei M.-G., Engel W.,
Adham I.M.;
"Isolation, expression, and chromosomal localization of the human
mitochondrial capsule selenoprotein gene (MCSP).";
Genomics 32:184-190(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Involved in sperm motility. Its absence is associated
with genetic background dependent male infertility. Infertility
may be due to reduced sperm motility in the female reproductive
tract and inability to penetrate the oocyte zona pellucida (By
similarity). {ECO:0000250}.
-!- INTERACTION:
Q13137:CALCOCO2; NbExp=3; IntAct=EBI-750494, EBI-739580;
A8MQ03:CYSRT1; NbExp=4; IntAct=EBI-750494, EBI-3867333;
P63167:DYNLL1; NbExp=4; IntAct=EBI-750494, EBI-349105;
Q08379:GOLGA2; NbExp=3; IntAct=EBI-750494, EBI-618309;
Q15323:KRT31; NbExp=5; IntAct=EBI-750494, EBI-948001;
P60412:KRTAP10-11; NbExp=4; IntAct=EBI-750494, EBI-10217483;
P60370:KRTAP10-5; NbExp=3; IntAct=EBI-750494, EBI-10172150;
P60409:KRTAP10-7; NbExp=3; IntAct=EBI-750494, EBI-10172290;
P60410:KRTAP10-8; NbExp=7; IntAct=EBI-750494, EBI-10171774;
P60411:KRTAP10-9; NbExp=7; IntAct=EBI-750494, EBI-10172052;
Q9BYQ6:KRTAP4-11; NbExp=5; IntAct=EBI-750494, EBI-10302392;
Q9BQ66:KRTAP4-12; NbExp=9; IntAct=EBI-750494, EBI-739863;
Q9BYR3:KRTAP4-4; NbExp=4; IntAct=EBI-750494, EBI-11958132;
Q9BYR0:KRTAP4-7; NbExp=3; IntAct=EBI-750494, EBI-10302547;
Q701N4:KRTAP5-2; NbExp=4; IntAct=EBI-750494, EBI-11958178;
Q6L8G9:KRTAP5-6; NbExp=5; IntAct=EBI-750494, EBI-10250562;
P26371:KRTAP5-9; NbExp=9; IntAct=EBI-750494, EBI-3958099;
Q9BYQ4:KRTAP9-2; NbExp=7; IntAct=EBI-750494, EBI-1044640;
Q9BYQ3:KRTAP9-3; NbExp=4; IntAct=EBI-750494, EBI-1043191;
Q9BYQ2:KRTAP9-4; NbExp=3; IntAct=EBI-750494, EBI-10185730;
Q9BYQ0:KRTAP9-8; NbExp=6; IntAct=EBI-750494, EBI-11958364;
Q5TA81:LCE2C; NbExp=4; IntAct=EBI-750494, EBI-11973993;
Q5TA78:LCE4A; NbExp=5; IntAct=EBI-750494, EBI-10246358;
Q7Z3S9:NOTCH2NL; NbExp=5; IntAct=EBI-750494, EBI-945833;
Q9UGC6:RGS17; NbExp=3; IntAct=EBI-750494, EBI-3918154;
P15884:TCF4; NbExp=3; IntAct=EBI-750494, EBI-533224;
-!- SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion membrane
{ECO:0000305}; Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Note=Becomes associated with the
spermatid mitochondrion capsule at step 16 of spermatogenesis.
{ECO:0000250}.
-!- TISSUE SPECIFICITY: Testis. Is selectively expressed in the
spermatids of seminiferous tubules. {ECO:0000269|PubMed:8833144}.
-!- DEVELOPMENTAL STAGE: Expressed in postmeiotic cells.
{ECO:0000269|PubMed:8833144}.
-!- CAUTION: Was originally thought to be a selenoprotein and was
known as sperm mitochondrial capsule selenoprotein.
{ECO:0000305|PubMed:8833144}.
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EMBL; X89960; CAA62000.1; -; mRNA.
EMBL; X89961; CAD56487.1; -; Genomic_DNA.
EMBL; BC014593; AAH14593.1; -; mRNA.
EMBL; BC016744; AAH16744.1; -; mRNA.
CCDS; CCDS1029.1; -.
RefSeq; NP_109588.2; NM_030663.2.
UniGene; Hs.111850; -.
ProteinModelPortal; P49901; -.
BioGrid; 110350; 20.
IntAct; P49901; 68.
MINT; MINT-1436940; -.
STRING; 9606.ENSP00000357754; -.
PhosphoSitePlus; P49901; -.
BioMuta; SMCP; -.
PaxDb; P49901; -.
PeptideAtlas; P49901; -.
PRIDE; P49901; -.
DNASU; 4184; -.
Ensembl; ENST00000368765; ENSP00000357754; ENSG00000163206.
GeneID; 4184; -.
KEGG; hsa:4184; -.
CTD; 4184; -.
DisGeNET; 4184; -.
EuPathDB; HostDB:ENSG00000163206.5; -.
GeneCards; SMCP; -.
HGNC; HGNC:6962; SMCP.
HPA; HPA035105; -.
MIM; 601148; gene.
neXtProt; NX_P49901; -.
OpenTargets; ENSG00000163206; -.
PharmGKB; PA30710; -.
eggNOG; ENOG410KI9M; Eukaryota.
eggNOG; ENOG4110QG7; LUCA.
GeneTree; ENSGT00440000039991; -.
HOGENOM; HOG000113504; -.
HOVERGEN; HBG057842; -.
InParanoid; P49901; -.
OMA; GNQCCPP; -.
OrthoDB; EOG091G12JZ; -.
PhylomeDB; P49901; -.
ChiTaRS; SMCP; human.
GeneWiki; SMCP; -.
GenomeRNAi; 4184; -.
PRO; PR:P49901; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000163206; -.
CleanEx; HS_SMCP; -.
ExpressionAtlas; P49901; baseline and differential.
Genevisible; P49901; HS.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
GO; GO:0007341; P:penetration of zona pellucida; ISS:UniProtKB.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Fertilization; Membrane; Mitochondrion;
Reference proteome; Repeat.
CHAIN 1 116 Sperm mitochondrial-associated cysteine-
rich protein.
/FTId=PRO_0000096307.
REPEAT 6 13 1.
REPEAT 14 21 2.
REPEAT 30 37 3.
REPEAT 38 45 4.
REPEAT 46 53 5.
REPEAT 54 61 6.
REPEAT 62 68 7.
REGION 6 68 7 X 7 (OR 8) AA approximate repeats.
CONFLICT 63 63 P -> A (in Ref. 1; CAA62000/CAD56487).
{ECO:0000305}.
SEQUENCE 116 AA; 12767 MW; 242191C60AEE03B2 CRC64;
MCDQTKHSKC CPAKGNQCCP PQQNQCCQSK GNQCCPPKQN QCCQPKGSQC CPPKHNHCCQ
PKPPCCIQAR CCGLETKPEV SPLNMESEPN SPQTQDKGCQ TQQQPHSPQN ESRPSK


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