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Sperm-associated antigen 6 (Axoneme central apparatus protein) (Protein PF16 homolog)

 SPAG6_MOUSE             Reviewed;         507 AA.
Q9JLI7; Q8K461;
26-APR-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
12-SEP-2018, entry version 118.
RecName: Full=Sperm-associated antigen 6;
AltName: Full=Axoneme central apparatus protein;
AltName: Full=Protein PF16 homolog;
Name=Spag6; Synonyms=Pf16;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
SUBCELLULAR LOCATION.
TISSUE=Sperm;
PubMed=10684790; DOI=10.1095/biolreprod62.3.511;
Sapiro R., Tarantino L.M., Velazquez F., Kiriakidou M., Hecht N.B.,
Bucan M., Strauss J.F. III;
"Sperm antigen 6 is the murine homologue of the Chlamydomonas
reinhardtii central apparatus protein encoded by the PF16 locus.";
Biol. Reprod. 62:511-518(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Testis;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-96, FUNCTION, AND DISEASE.
STRAIN=C57BL/6J; TISSUE=Testis;
PubMed=12167721; DOI=10.1128/MCB.22.17.6298-6305.2002;
Sapiro R., Kostetskii I., Olds-Clarke P., Gerton G.L., Radice G.L.,
Strauss J.F. III;
"Male infertility, impaired sperm motility, and hydrocephalus in mice
deficient in sperm-associated antigen 6.";
Mol. Cell. Biol. 22:6298-6305(2002).
[4]
INTERACTION WITH SPAG16, AND TISSUE SPECIFICITY.
TISSUE=Sperm;
PubMed=12391165; DOI=10.1128/MCB.22.22.7993-8004.2002;
Zhang Z., Sapiro R., Kapfhamer D., Bucan M., Bray J.,
Chennathukuzhi V., McNamara P., Curtis A., Zhang M.,
Blanchette-Mackie E.J., Strauss J.F. III;
"A sperm-associated WD repeat protein orthologous to Chlamydomonas
PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas
PF16.";
Mol. Cell. Biol. 22:7993-8004(2002).
[5]
INTERACTION WITH SPAG17, AND DISRUPTION PHENOTYPE.
STRAIN=C57BL/6J;
PubMed=15827353; DOI=10.1074/mcp.M400177-MCP200;
Zhang Z., Jones B.H., Tang W., Moss S.B., Wei Z., Ho C., Pollack M.,
Horowitz E., Bennett J., Baker M.E., Strauss J.F. III;
"Dissecting the axoneme interactome: the mammalian orthologue of
Chlamydomonas PF6 interacts with sperm-associated antigen 6, the
mammalian orthologue of Chlamydomonas PF16.";
Mol. Cell. Proteomics 4:914-923(2005).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Important for structural integrity of the central
apparatus in the sperm tail and for flagellar motility.
{ECO:0000269|PubMed:10684790, ECO:0000269|PubMed:12167721}.
-!- SUBUNIT: Interacts with SPAG16 AND SPAG17.
{ECO:0000269|PubMed:12391165, ECO:0000269|PubMed:15827353}.
-!- INTERACTION:
Q5S003:Spag17; NbExp=3; IntAct=EBI-1783654, EBI-1783665;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
{ECO:0000269|PubMed:10684790}. Cell projection, cilium, flagellum
{ECO:0000269|PubMed:10684790}. Note=Associated with microtubules.
Detected on the sperm flagellum.
-!- TISSUE SPECIFICITY: Highly expressed in testis. Not detected in
prostate, ovary, spleen, thymus, small intestine, colon and
peripheral blood leukocytes. {ECO:0000269|PubMed:10684790,
ECO:0000269|PubMed:12391165}.
-!- DISEASE: Note=Defects in Spag6 are a cause of hydrocephalus and of
male infertility. {ECO:0000269|PubMed:12167721}.
-!- DISRUPTION PHENOTYPE: In null embryos the central apparatus is
unstable leading to a loss, and presumably degradation of proteins
to which SPAG6 normally binds, including SPAG16 AND SPAG17.
{ECO:0000269|PubMed:15827353}.
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EMBL; AF173866; AAF35831.1; -; mRNA.
EMBL; AK005732; BAB24211.1; -; mRNA.
EMBL; AF486266; AAM64149.1; -; Genomic_DNA.
CCDS; CCDS27988.1; -.
RefSeq; NP_056588.1; NM_015773.2.
UniGene; Mm.31701; -.
ProteinModelPortal; Q9JLI7; -.
BioGrid; 206052; 1.
IntAct; Q9JLI7; 1.
STRING; 10090.ENSMUSP00000023468; -.
PhosphoSitePlus; Q9JLI7; -.
MaxQB; Q9JLI7; -.
PaxDb; Q9JLI7; -.
PRIDE; Q9JLI7; -.
Ensembl; ENSMUST00000023468; ENSMUSP00000023468; ENSMUSG00000022783.
GeneID; 50525; -.
KEGG; mmu:50525; -.
UCSC; uc007yjb.2; mouse.
CTD; 50525; -.
MGI; MGI:1354388; Spag6.
eggNOG; KOG0166; Eukaryota.
eggNOG; COG5064; LUCA.
GeneTree; ENSGT00900000141099; -.
HOGENOM; HOG000257051; -.
HOVERGEN; HBG055326; -.
InParanoid; Q9JLI7; -.
OMA; RVENYQP; -.
OrthoDB; EOG091G07CA; -.
PhylomeDB; Q9JLI7; -.
TreeFam; TF328894; -.
PRO; PR:Q9JLI7; -.
Proteomes; UP000000589; Chromosome 16.
Bgee; ENSMUSG00000022783; Expressed in 72 organ(s), highest expression level in testis.
CleanEx; MM_SPAG6; -.
ExpressionAtlas; Q9JLI7; baseline and differential.
Genevisible; Q9JLI7; MM.
GO; GO:1990716; C:axonemal central apparatus; IGI:MGI.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0015630; C:microtubule cytoskeleton; ISO:MGI.
GO; GO:0097228; C:sperm principal piece; IDA:MGI.
GO; GO:0030317; P:flagellated sperm motility; IMP:MGI.
GO; GO:0007288; P:sperm axoneme assembly; IMP:MGI.
GO; GO:0021591; P:ventricular system development; IMP:MGI.
Gene3D; 1.25.10.10; -; 2.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR000225; Armadillo.
InterPro; IPR000357; HEAT.
Pfam; PF00514; Arm; 4.
Pfam; PF02985; HEAT; 1.
SMART; SM00185; ARM; 7.
SUPFAM; SSF48371; SSF48371; 1.
1: Evidence at protein level;
Cell projection; Cilium; Cilium biogenesis/degradation;
Complete proteome; Cytoplasm; Cytoskeleton; Flagellum; Microtubule;
Reference proteome; Repeat.
CHAIN 1 507 Sperm-associated antigen 6.
/FTId=PRO_0000072096.
REPEAT 31 70 ARM 1.
REPEAT 73 112 ARM 2.
REPEAT 115 154 ARM 3.
REPEAT 157 196 ARM 4.
REPEAT 199 238 ARM 5.
REPEAT 241 280 ARM 6.
REPEAT 325 365 ARM 7.
REPEAT 402 441 ARM 8.
SEQUENCE 507 AA; 55269 MW; EFFAE719EC111285 CRC64;
MSQRQVLQVF EQYQKARTQF VQMVAELATR PQNIETLQNA GVMSLLRPLL LDVVPTIQQT
AALALGRLAN YNDDLAEAVV KGDILPQLVY SLAEQNRFYK KAAAFVLRAV GKHSPQLAQA
IVDCGALDTL VICLEDFDPG VKEAAAWALG YIARHNTELS QAVVDAGAIP LLVLCIQEPE
IALKRIAASA LSDISKHSPE LAQTVVDAGA IAHLAQMILN PDAKLKRQVL SALSQIAKHS
VDLAEMVVEA EIFPVVLTCL KDKDEYVKKN ACTLIREIAK HTPELSQLIV NAGGVAAVID
CIGSCKGNIR LPGIMMLGYV AAHSENLAMA VIISKGVPQL SICLSEEPED HIKAAAAWAL
GQLGRHTPEH ARAVAVTNTL PVLLSLYMSP ESSEDLQLKS KKAIKNILQK CTYLPALEPF
LYDAPPNILK HVVGQFSKVL PHDSKARRLF VTSGGLKKVQ EIKAEPGSLL QEYINSINNC
YPEEIVRYYS PGYSDTLLQR VDSYQPL


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