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Spermatogenesis-associated protein 31 (Acrosome-expressed protein 1)

 SPT31_RAT               Reviewed;        1048 AA.
B6VQA5; Q5U2N7; Q7TSL1;
09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
16-DEC-2008, sequence version 1.
05-JUL-2017, entry version 51.
RecName: Full=Spermatogenesis-associated protein 31;
AltName: Full=Acrosome-expressed protein 1;
Name=Spata31; Synonyms=Aep1, Vad1.3;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
PubMed=15057822; DOI=10.1038/nature02426;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 20-1048, FUNCTION, SUBCELLULAR LOCATION,
INTERACTION WITH ACTB, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
STRAIN=Sprague-Dawley; TISSUE=Testis;
PubMed=16924657; DOI=10.1002/jcp.20746;
Luk J.M., Lee N.P., Shum C.K., Lam B.Y., Siu A.F., Che C.M., Tam P.C.,
Cheung A.N., Yang Z.M., Lin Y.N., Matzuk M.M., Lee K.F., Yeung W.S.;
"Acrosome-specific gene AEP1: identification, characterization and
roles in spermatogenesis.";
J. Cell. Physiol. 209:755-766(2006).
[4]
IDENTIFICATION, AND TISSUE SPECIFICITY.
PubMed=12878178; DOI=10.1016/S0006-291X(03)01250-6;
Luk J.M., Mok B.W., Shum C.K., Yeung W.S., Tam P.C., Tse J.Y.,
Chow J.F., Woo J., Kam K., Lee K.F.;
"Identification of novel genes expressed during spermatogenesis in
stage-synchronized rat testes by differential display.";
Biochem. Biophys. Res. Commun. 307:782-790(2003).
[5]
SUBCELLULAR LOCATION, AND INTERACTION WITH ACTB AND SYNTAXIN.
PubMed=20850414; DOI=10.1016/j.bbrc.2010.09.049;
Zuo Y., Gao J., Yeung W.S., Lee K.F.;
"The testis-specific VAD1.3/AEP1 interacts with ?-actin and syntaxin 1
and directs peri-nuclear/Golgi expression with bipartite nucleus
localization (BNL) sequence.";
Biochem. Biophys. Res. Commun. 401:275-280(2010).
-!- FUNCTION: May play a role in spermatogenesis.
{ECO:0000269|PubMed:16924657}.
-!- SUBUNIT: May interact with ACTB and the syntaxin STX1A and/or
STX1B.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle,
acrosome membrane {ECO:0000305}; Single-pass membrane protein
{ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome
lumen {ECO:0000269|PubMed:16924657, ECO:0000269|PubMed:20850414}.
Note=Localizes to the inner and outer membranes as well as to the
matrix of the acrosome.
-!- TISSUE SPECIFICITY: Specifically expressed in testis by haploid
germ cells. {ECO:0000269|PubMed:12878178,
ECO:0000269|PubMed:16924657}.
-!- DEVELOPMENTAL STAGE: First detected at day 25 postpartum, the
expression increases until day 35 and remains identical till
adulthood. {ECO:0000269|PubMed:16924657}.
-!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAP42847.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; BC085936; AAH85936.2; -; mRNA.
EMBL; AF511042; AAP42847.2; ALT_INIT; mRNA.
RefSeq; NP_001008360.2; NM_001008359.2.
UniGene; Rn.96432; -.
STRING; 10116.ENSRNOP00000024504; -.
iPTMnet; B6VQA5; -.
PhosphoSitePlus; B6VQA5; -.
PaxDb; B6VQA5; -.
PRIDE; B6VQA5; -.
Ensembl; ENSRNOT00000024504; ENSRNOP00000024504; ENSRNOG00000018202.
GeneID; 353306; -.
KEGG; rno:353306; -.
UCSC; RGD:727950; rat.
CTD; 727905; -.
RGD; 727950; Spata31.
eggNOG; ENOG410IF6X; Eukaryota.
eggNOG; ENOG4111EH8; LUCA.
GeneTree; ENSGT00530000063191; -.
HOGENOM; HOG000077952; -.
HOVERGEN; HBG056622; -.
InParanoid; B6VQA5; -.
OMA; STIWAMD; -.
OrthoDB; EOG091G024V; -.
TreeFam; TF338531; -.
PRO; PR:B6VQA5; -.
Proteomes; UP000002494; Chromosome 17.
Bgee; ENSRNOG00000018202; -.
Genevisible; B6VQA5; RN.
GO; GO:0043160; C:acrosomal lumen; IEA:UniProtKB-SubCell.
GO; GO:0002080; C:acrosomal membrane; IEA:UniProtKB-SubCell.
GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003779; F:actin binding; IPI:UniProtKB.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
1: Evidence at protein level;
Complete proteome; Cytoplasmic vesicle; Differentiation; Membrane;
Reference proteome; Spermatogenesis; Transmembrane;
Transmembrane helix.
CHAIN 1 1048 Spermatogenesis-associated protein 31.
/FTId=PRO_0000420573.
TRANSMEM 22 42 Helical. {ECO:0000255}.
SEQUENCE 1048 AA; 119551 MW; 6917B272715EAC8D CRC64;
MENLPSLLES IYTTWLSLSS TIWAMDMILA FVCGLGLYLL LLPFLESHLS SSPSDINFTR
KPQIQMTWQS QYMKKFRNHC RNDAKAWEEC LKKLKEKEKD ELFLEEMSPG HHLNSLGNMF
NSASAKQDST TLSPFWNLKE KSEEQMATQK LSYPKISGDH LQEKYDQLYW GLPSLHSESL
VAAAWIPQTT STLPSPFFLF NVISSVYPIH LQDKMSPVLP HTHPLSYLDL QPPPLILSPL
EFQSPALNQV HFQSPLPVLL PSSLPYSRDS GACYSQSQSK PHCPTTEIQY RERPLVTKQL
ESRLTLPLMV QKDAYSILAS NPSHDWAVPI FPDNFPISCE LRDKLEQHIQ KWFIQHQWYF
PPEIQESEEV MGLQNSVTGN YQIRDQPCTS QAHMSTGEHN KQGQKVKFQL ENESCKNLGP
ILGKGPKDPV KGLEKNVVKV QGANILEPER NLVKHFKSDS RNDSSNYIDE DLENNWKANF
GTKSGQINQG LTPLSMRQSW LAMNDSFCDT DIHMETRNLT AIKSSEKFMC SREKLAFLNP
ETRQTLEEHV VRFWVKHRWG LPLKMLKPIN LFKLKSTESL PLTLCTQPSS TNSVHRTNSA
VEVVRFLGKP CLRQIIIKDS SPPPGNLLLV SSPSCKRAAI RRPPSGVDHE PSVALPNKPQ
SAYLAETLAY NFMETPTQSG GVLKDEMETE EVLLLPRMTC APNLRAHNPQ AKVVSEYPYN
VETELTGQPQ IYTTSVLLPK HSRSMPLPVD TLTSNALGDI VMVDGGNGLV QQRPSTPKHQ
VSQKGQIKML VPTYQGEDTK RQSERKYEDM SKFSPVTERK NNFENQYYQT LPKTTQVLPE
SLFQRLLSRF LPRVHPKKTI KGQECHPQKD NPTAATAQNQ RRQVRKQPYM DDNVTEAQKL
MTTVGQMLEK KMMQHQHHAS KVNQPRVVPP GPTSWFSHGH MPVSCLKRRR PPSYPANSLC
QRRYIQGRHN RGQLPQKSVQ FSQKPQILRN PRHMYPKSAL NVVNSSQNRT TVPRTPNQHL
CCPRHCAFQR NVCRELGHPS VAFPNRKT


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