Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Sphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Membrane lipid desaturase)

 DEGS1_HUMAN             Reviewed;         323 AA.
O15121;
04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
25-OCT-2017, entry version 145.
RecName: Full=Sphingolipid delta(4)-desaturase DES1;
EC=1.14.19.17 {ECO:0000269|PubMed:11937514};
AltName: Full=Cell migration-inducing gene 15 protein;
AltName: Full=Degenerative spermatocyte homolog 1;
AltName: Full=Membrane lipid desaturase;
Name=DEGS1; Synonyms=DES1, MLD; ORFNames=MIG15;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
TISSUE=Cervix carcinoma;
PubMed=9188692; DOI=10.1021/bi970091l;
Cadena D.L., Kurten R.C., Gill G.N.;
"The product of the MLD gene is a member of the membrane fatty acid
desaturase family: overexpression of MLD inhibits EGF receptor
biosynthesis.";
Biochemistry 36:6960-6967(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
TISSUE=Lung;
PubMed=11937514; DOI=10.1074/jbc.M202947200;
Ternes P., Franke S., Zaehringer U., Sperling P., Heinz E.;
"Identification and characterization of a sphingolipid delta 4-
desaturase family.";
J. Biol. Chem. 277:25512-25518(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kim J.W.;
"Identification of a human migration-inducing gene.";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[7]
SUBCELLULAR LOCATION, AND MYRISTOYLATION AT GLY-2.
PubMed=19647031; DOI=10.1016/j.biochi.2009.07.014;
Beauchamp E., Tekpli X., Marteil G., Lagadic-Gossmann D., Legrand P.,
Rioux V.;
"N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to
mitochondria: partial involvement in the apoptotic effect of myristic
acid.";
Biochimie 91:1411-1419(2009).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[9]
MYRISTOYLATION AT GLY-2, CLEAVAGE OF INITIATOR METHIONINE, AND
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=25255805; DOI=10.1038/ncomms5919;
Thinon E., Serwa R.A., Broncel M., Brannigan J.A., Brassat U.,
Wright M.H., Heal W.P., Wilkinson A.J., Mann D.J., Tate E.W.;
"Global profiling of co- and post-translationally N-myristoylated
proteomes in human cells.";
Nat. Commun. 5:4919-4919(2014).
-!- FUNCTION: Has sphingolipid-delta-4-desaturase activity. Converts
D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).
{ECO:0000269|PubMed:11937514}.
-!- CATALYTIC ACTIVITY: A dihydroceramide + 2 ferrocytochrome b5 +
O(2) + 2 H(+) = a (4E)-sphing-4-enine ceramide + 2 ferricytochrome
b5 + 2 H(2)O. {ECO:0000269|PubMed:11937514}.
-!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19647031}.
Endoplasmic reticulum membrane {ECO:0000269|PubMed:19647031,
ECO:0000269|PubMed:9188692}; Multi-pass membrane protein
{ECO:0000269|PubMed:19647031, ECO:0000269|PubMed:9188692}.
Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
-!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9188692}.
-!- PTM: Myristoylation can target the enzyme to the mitochondria
leading to an increase in ceramide levels.
{ECO:0000269|PubMed:19647031}.
-!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
DEGS subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF002668; AAB62238.1; -; mRNA.
EMBL; AF466375; AAM12531.1; -; mRNA.
EMBL; AY423730; AAS00493.1; -; mRNA.
EMBL; CH471098; EAW69711.1; -; Genomic_DNA.
EMBL; BC000961; AAH00961.1; -; mRNA.
CCDS; CCDS1540.1; -.
RefSeq; NP_003667.1; NM_003676.3.
UniGene; Hs.299878; -.
ProteinModelPortal; O15121; -.
BioGrid; 114130; 37.
IntAct; O15121; 3.
STRING; 9606.ENSP00000316476; -.
BindingDB; O15121; -.
ChEMBL; CHEMBL2021749; -.
GuidetoPHARMACOLOGY; 2484; -.
SwissLipids; SLP:000000166; -.
iPTMnet; O15121; -.
PhosphoSitePlus; O15121; -.
SwissPalm; O15121; -.
BioMuta; DEGS1; -.
EPD; O15121; -.
MaxQB; O15121; -.
PaxDb; O15121; -.
PeptideAtlas; O15121; -.
PRIDE; O15121; -.
DNASU; 8560; -.
Ensembl; ENST00000323699; ENSP00000316476; ENSG00000143753.
Ensembl; ENST00000391877; ENSP00000375749; ENSG00000143753.
GeneID; 8560; -.
KEGG; hsa:8560; -.
UCSC; uc001hoj.4; human.
CTD; 8560; -.
DisGeNET; 8560; -.
EuPathDB; HostDB:ENSG00000143753.12; -.
GeneCards; DEGS1; -.
HGNC; HGNC:13709; DEGS1.
HPA; HPA076422; -.
MIM; 615843; gene.
neXtProt; NX_O15121; -.
OpenTargets; ENSG00000143753; -.
PharmGKB; PA27250; -.
eggNOG; KOG2987; Eukaryota.
eggNOG; ENOG410XQVT; LUCA.
GeneTree; ENSGT00390000013448; -.
HOGENOM; HOG000188299; -.
HOVERGEN; HBG052775; -.
InParanoid; O15121; -.
KO; K04712; -.
OMA; QIFFYAL; -.
OrthoDB; EOG091G09NW; -.
PhylomeDB; O15121; -.
TreeFam; TF313582; -.
BioCyc; MetaCyc:ENSG00000143753-MONOMER; -.
Reactome; R-HSA-1660661; Sphingolipid de novo biosynthesis.
Reactome; R-HSA-6798695; Neutrophil degranulation.
ChiTaRS; DEGS1; human.
GenomeRNAi; 8560; -.
PRO; PR:O15121; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000143753; -.
CleanEx; HS_DEGS1; -.
ExpressionAtlas; O15121; baseline and differential.
Genevisible; O15121; HS.
GO; GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0016020; C:membrane; TAS:ProtInc.
GO; GO:0005739; C:mitochondrion; IDA:HPA.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0035579; C:specific granule membrane; TAS:Reactome.
GO; GO:0009055; F:electron carrier activity; TAS:UniProtKB.
GO; GO:0042284; F:sphingolipid delta-4 desaturase activity; IBA:GO_Central.
GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central.
GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome.
GO; GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome.
GO; GO:0006636; P:unsaturated fatty acid biosynthetic process; TAS:ProtInc.
CDD; cd03508; Delta4-sphingolipid-FADS-like; 1.
InterPro; IPR011388; DES1/DES2.
InterPro; IPR005804; FA_desaturase_dom.
InterPro; IPR013866; Sphingolipid_d4-desaturase_N.
Pfam; PF00487; FA_desaturase; 1.
Pfam; PF08557; Lipid_DES; 1.
PIRSF; PIRSF017228; Sphnglp_dlt4_des; 1.
SMART; SM01269; Lipid_DES; 1.
1: Evidence at protein level;
Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis;
Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism;
Lipoprotein; Membrane; Mitochondrion; Myristate; Oxidoreductase;
Phosphoprotein; Reference proteome; Transmembrane;
Transmembrane helix.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:25255805}.
CHAIN 2 323 Sphingolipid delta(4)-desaturase DES1.
/FTId=PRO_0000312727.
TRANSMEM 41 61 Helical. {ECO:0000255}.
TRANSMEM 68 88 Helical. {ECO:0000255}.
TRANSMEM 102 122 Helical. {ECO:0000255}.
TRANSMEM 152 172 Helical. {ECO:0000255}.
TRANSMEM 184 204 Helical. {ECO:0000255}.
TRANSMEM 209 229 Helical. {ECO:0000255}.
MOTIF 89 93 Histidine box-1. {ECO:0000305}.
MOTIF 128 132 Histidine box-2. {ECO:0000305}.
MOTIF 259 263 Histidine box-3. {ECO:0000305}.
MOD_RES 307 307 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
LIPID 2 2 N-myristoyl glycine.
{ECO:0000269|PubMed:19647031,
ECO:0000269|PubMed:25255805}.
SEQUENCE 323 AA; 37866 MW; 9FF2E4A0B87EA71C CRC64;
MGSRVSREDF EWVYTDQPHA DRRREILAKY PEIKSLMKPD PNLIWIIIMM VLTQLGAFYI
VKDLDWKWVI FGAYAFGSCI NHSMTLAIHE IAHNAAFGNC KAMWNRWFGM FANLPIGIPY
SISFKRYHMD HHRYLGADGV DVDIPTDFEG WFFCTAFRKF IWVILQPLFY AFRPLFINPK
PITYLEVINT VAQVTFDILI YYFLGIKSLV YMLAASLLGL GLHPISGHFI AEHYMFLKGH
ETYSYYGPLN LLTFNVGYHN EHHDFPNIPG KSLPLVRKIA AEYYDNLPHY NSWIKVLYDF
VMDDTISPYS RMKRHQKGEM VLE


Related products :

Catalog number Product name Quantity
EIAAB10883 Cell migration-inducing gene 15 protein,Degenerative spermatocyte homolog 1,DEGS1,DES1,Homo sapiens,Human,Membrane lipid desaturase,MIG15,MLD,Sphingolipid delta(4)-desaturase DES1
EIAAB10884 Degenerative spermatocyte homolog 1,Degenerative spermatocyte-like protein RDES,Degs,Degs1,Des1,Rat,Rattus norvegicus,Sphingolipid delta(4)-desaturase DES1
EIAAB10886 Bos taurus,Bovine,Degenerative spermatocyte homolog 1,DEGS1,DES1,Sphingolipid delta(4)-desaturase DES1
EIAAB10887 Degenerative spermatocyte homolog 1,Degs,Degs1,Des1,Mdes,Mouse,Mus musculus,Sphingolipid delta(4)-desaturase DES1
EIAAB10885 Chicken,Degenerative spermatocyte homolog 1,DEGS1,DES1,Gallus gallus,RCJMB04_22e12,Sphingolipid delta(4)-desaturase DES1
DEK DEGS1 Gene degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)
DEL11P15P14 DEGS2 Gene degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)
SL100729 Ad-DEGS1 Degenerative Spermatocyte Homolog 1, Lipid Desaturase 0.2 ML
ARP45501_P050 DEGS1(degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)) 50 µg
SL100729 Viruses: Degenerative Spermatocyte Homolog 1, Lipid Desaturase , Ad-DEGS1 1E+10~1E+11 (PFU/ml)
DEGS1_RAT ELISA Kit FOR Sphingolipid delta(4)-desaturase DES1; organism: Rat; gene name: Degs1 96T
DEGS1_MOUSE ELISA Kit FOR Sphingolipid delta(4)-desaturase DES1; organism: Mouse; gene name: Degs1 96T
CSB-EL006708RA Rat degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) (DEGS1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
CSB-EL006709RA Rat degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) (DEGS2) ELISA kit, Species Rat, Sample Type serum, plasma 96T
DEGS1_HUMAN Human ELISA Kit FOR Sphingolipid delta(4)-desaturase DES1 96T
DEGS1_BOVIN Bovine ELISA Kit FOR Sphingolipid delta(4)-desaturase DES1 96T
E0980m Mouse ELISA Kit FOR Sphingolipid delta(4)-desaturase DES1 96T
CSB-EL006708CH Chicken degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) (DEGS1) ELISA kit, Species Chicken, Sample Type serum, plasma 96T
CSB-EL006708BO Bovine degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) (DEGS1) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
CSB-EL006708HU Human degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) (DEGS1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL006709HU Human degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) (DEGS2) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL006709BO Bovine degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) (DEGS2) ELISA kit, Species Bovine, Sample Type serum, plasma 96T
CSB-EL006709MO Mouse degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) (DEGS2) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL006708MO Mouse degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) (DEGS1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
18-003-42290 Acyl-CoA desaturase - EC 1.14.19.1; Stearoyl-CoA desaturase; Fatty acid desaturase; Delta(9)-desaturase Polyclonal 0.1 mg Protein A


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur