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Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora kinase)

 IPL1_KLULA              Reviewed;         361 AA.
Q6CWQ4;
21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
16-AUG-2004, sequence version 1.
28-MAR-2018, entry version 100.
RecName: Full=Spindle assembly checkpoint kinase;
EC=2.7.11.1;
AltName: Full=Aurora kinase;
Name=IPL1; OrderedLocusNames=KLLA0B02332g;
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
NCBI_TaxID=284590;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=15229592; DOI=10.1038/nature02579;
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
-!- FUNCTION: Required for high-fidelity chromosome segregation during
the later part of each cell cycle. Acts in opposition to the
phosphatase PP1. Has a role in attaching the kinetochores to the
microtubules and ensuring that sister kinetochores connect to
opposite poles. The promotion of bi-orientation is achieved by
selectively detaching kinetochore-microtubule attachments that are
not under tension. Phosphorylates histone H3 to form H3S10ph
during mitosis and meiosis (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm,
cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere,
kinetochore {ECO:0000250}. Note=Associates with the mitotic
spindle and on elongated and disassembling spindles. Also
associated with the kinetochore (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. Aurora subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
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EMBL; CR382122; CAH02028.1; -; Genomic_DNA.
RefSeq; XP_451635.1; XM_451635.1.
ProteinModelPortal; Q6CWQ4; -.
SMR; Q6CWQ4; -.
STRING; 284590.XP_451635.1; -.
PRIDE; Q6CWQ4; -.
EnsemblFungi; CAH02028; CAH02028; KLLA0_B02332g.
GeneID; 2897422; -.
KEGG; kla:KLLA0B02332g; -.
eggNOG; KOG0580; Eukaryota.
eggNOG; ENOG410XNRB; LUCA.
HOGENOM; HOG000233016; -.
InParanoid; Q6CWQ4; -.
KO; K08850; -.
OMA; QATSVPH; -.
OrthoDB; EOG092C0QJU; -.
Proteomes; UP000000598; Chromosome B.
GO; GO:0032133; C:chromosome passenger complex; IEA:EnsemblFungi.
GO; GO:0000939; C:condensed chromosome inner kinetochore; IEA:EnsemblFungi.
GO; GO:0000778; C:condensed nuclear chromosome kinetochore; IEA:EnsemblFungi.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0005828; C:kinetochore microtubule; IEA:EnsemblFungi.
GO; GO:1990385; C:meiotic spindle midzone; IEA:EnsemblFungi.
GO; GO:1990023; C:mitotic spindle midzone; IEA:EnsemblFungi.
GO; GO:0000784; C:nuclear chromosome, telomeric region; IEA:EnsemblFungi.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0035175; F:histone kinase activity (H3-S10 specific); IEA:EnsemblFungi.
GO; GO:0051316; P:attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation; IEA:EnsemblFungi.
GO; GO:0031670; P:cellular response to nutrient; IEA:EnsemblFungi.
GO; GO:0090699; P:correction of merotelic kinetochore attachment, meiosis I; IEA:EnsemblFungi.
GO; GO:0098783; P:correction of merotelic kinetochore attachment, mitotic; IEA:EnsemblFungi.
GO; GO:0120110; P:interphase mitotic telomere clustering; IEA:EnsemblFungi.
GO; GO:0045144; P:meiotic sister chromatid segregation; IEA:EnsemblFungi.
GO; GO:0033316; P:meiotic spindle assembly checkpoint; IEA:EnsemblFungi.
GO; GO:0044774; P:mitotic DNA integrity checkpoint; IEA:EnsemblFungi.
GO; GO:0007094; P:mitotic spindle assembly checkpoint; IEA:EnsemblFungi.
GO; GO:0051228; P:mitotic spindle disassembly; IEA:EnsemblFungi.
GO; GO:1901925; P:negative regulation of protein import into nucleus during spindle assembly checkpoint; IEA:EnsemblFungi.
GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:EnsemblFungi.
GO; GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IEA:EnsemblFungi.
GO; GO:1903380; P:positive regulation of mitotic chromosome condensation; IEA:EnsemblFungi.
GO; GO:1905824; P:positive regulation of mitotic sister chromatid arm separation; IEA:EnsemblFungi.
GO; GO:0034501; P:protein localization to kinetochore; IEA:EnsemblFungi.
GO; GO:0034503; P:protein localization to nucleolar rDNA repeats; IEA:EnsemblFungi.
GO; GO:1902412; P:regulation of mitotic cytokinesis; IEA:EnsemblFungi.
GO; GO:1901673; P:regulation of mitotic spindle assembly; IEA:EnsemblFungi.
InterPro; IPR030616; Aur.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24350; PTHR24350; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding; Cell cycle; Centromere; Chromosome; Chromosome partition;
Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Kinetochore;
Nucleotide-binding; Nucleus; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 361 Spindle assembly checkpoint kinase.
/FTId=PRO_0000086010.
DOMAIN 100 351 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 106 114 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 223 223 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 129 129 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
SEQUENCE 361 AA; 41892 MW; D4400926919B6AFC CRC64;
MRPSLSRDAS DTGRRHSLLQ QSKLLSIRLS NAGKRPSLSR GHAHEKDSIT SSHHRLSTGP
VNNNPRRSLM VKKPNTAHGT RVPILNDHND KFENMTLQDF EIGKILGKGK FGKVYCVKHR
ETGLICALKA MEKKEIVQYT IQKQFRREVE IQGSFKHKNL TQLYGFFYDE KRVYLLMEYV
YYGELYKFLK NNGPLNETLA SYFVYQMANA LDYMHSKNIL HRDIKPENIL IGFNNTIKLT
DFGWSVYNED GQKRKTLCGT IDYLSPELIK SREYNNKVDV WALGVLTYEL LVGSPPFEED
TKEMTYRRIL RCDLKFPLNV SPQARDLIVR LLQFEPSKRI PLSEVKSHAW IANNRGSWTD
L


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