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Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora kinase)

 IPL1_ASHGO              Reviewed;         367 AA.
Q755C4;
21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
23-MAY-2018, entry version 104.
RecName: Full=Spindle assembly checkpoint kinase;
EC=2.7.11.1;
AltName: Full=Aurora kinase;
Name=IPL1; OrderedLocusNames=AFL101C;
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL
Y-1056) (Yeast) (Eremothecium gossypii).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium.
NCBI_TaxID=284811;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
PubMed=15001715; DOI=10.1126/science.1095781;
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient
Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
PubMed=23749448; DOI=10.1534/g3.112.002881;
Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
"Genomes of Ashbya fungi isolated from insects reveal four mating-type
loci, numerous translocations, lack of transposons, and distinct gene
duplications.";
G3 (Bethesda) 3:1225-1239(2013).
-!- FUNCTION: Required for high-fidelity chromosome segregation during
the later part of each cell cycle. Acts in opposition to the
phosphatase PP1. Has a role in attaching the kinetochores to the
microtubules and ensuring that sister kinetochores connect to
opposite poles. The promotion of bi-orientation is achieved by
selectively detaching kinetochore-microtubule attachments that are
not under tension. Phosphorylates histone H3 to form H3S10ph
during mitosis and meiosis (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm,
cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere,
kinetochore {ECO:0000250}. Note=Associates with the mitotic
spindle and on elongated and disassembling spindles. Also
associated with the kinetochore (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. Aurora subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
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EMBL; AE016819; AAS53273.1; -; Genomic_DNA.
RefSeq; NP_985449.1; NM_210803.1.
ProteinModelPortal; Q755C4; -.
SMR; Q755C4; -.
STRING; 33169.AAS53273; -.
PRIDE; Q755C4; -.
EnsemblFungi; AAS53273; AAS53273; AGOS_AFL101C.
GeneID; 4621676; -.
KEGG; ago:AGOS_AFL101C; -.
HOGENOM; HOG000233016; -.
InParanoid; Q755C4; -.
KO; K08850; -.
OMA; QATSVPH; -.
OrthoDB; EOG092C0QJU; -.
Proteomes; UP000000591; Chromosome VI.
GO; GO:0032133; C:chromosome passenger complex; IBA:GO_Central.
GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0035174; F:histone serine kinase activity; IBA:GO_Central.
GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
InterPro; IPR030616; Aur.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24350; PTHR24350; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding; Cell cycle; Centromere; Chromosome; Chromosome partition;
Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Kinetochore;
Nucleotide-binding; Nucleus; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 367 Spindle assembly checkpoint kinase.
/FTId=PRO_0000086024.
DOMAIN 109 360 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 115 123 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 232 232 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 138 138 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
SEQUENCE 367 AA; 42445 MW; 31DBA2392ACA6A2A CRC64;
MDADAILKKD QRRSSLKQRN LLLSMRLNQT TATNGAPPQA RVQPGKGYRN PGKVLSPIRN
QEMSPGKRPT LEISELKNVS PINQAHKTGK ARAGGVPLSK LQNLKLADFE IGKVLGKGKF
GRVYCVRHIE SGFVCALKAM EKKDIIQYNI EKQFRREVEI QSSLRHPNLT QLYGYFHDEK
RVYLLMEYLV NGELYKHLKG RSHFNDVVAS YYVYQMADAL DYMHERNILH RDIKPENIII
GFNNTIKLTD FGWSVITPKG SKRKTLCGTV DYLSPELIRS REYNEKVDVW ALGVLTYELL
VGSPPFEEES KELTYKRILK RNLIFPDHVD TEARHLISRL LEYDPGDRIP LKEVKKHPWI
EKNKPFW


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