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Spleen associated tyrosine kinase

 M3WKA9_FELCA            Unreviewed;       637 AA.
M3WKA9;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
31-JAN-2018, entry version 42.
SubName: Full=Spleen associated tyrosine kinase {ECO:0000313|Ensembl:ENSFCAP00000013189};
Name=SYK {ECO:0000313|Ensembl:ENSFCAP00000013189};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000013189, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000013189, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013189,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000013189}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013189};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000013189}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000013189};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|SAAS:SAAS00897325}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|SAAS:SAAS00941529}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSFCAP00000013189}.
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EMBL; AANG02194074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AANG02194075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AANG02194076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AANG02194077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9685.ENSFCAP00000013189; -.
Ensembl; ENSFCAT00000014219; ENSFCAP00000013189; ENSFCAG00000014214.
eggNOG; ENOG410IH0T; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00760000118799; -.
InParanoid; M3WKA9; -.
OMA; KPFNRPP; -.
OrthoDB; EOG091G07KU; -.
Proteomes; UP000011712; Chromosome D4.
Bgee; ENSFCAG00000014214; -.
GO; GO:0019815; C:B cell receptor complex; IEA:Ensembl.
GO; GO:0032009; C:early phagosome; IEA:Ensembl.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0042101; C:T cell receptor complex; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0005102; F:receptor binding; IBA:GO_Central.
GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
GO; GO:0004716; F:signal transducer, downstream of receptor, with protein tyrosine kinase activity; IEA:Ensembl.
GO; GO:0035325; F:Toll-like receptor binding; IEA:Ensembl.
GO; GO:0007257; P:activation of JUN kinase activity; IEA:Ensembl.
GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
GO; GO:0050853; P:B cell receptor signaling pathway; IBA:GO_Central.
GO; GO:0043366; P:beta selection; IEA:Ensembl.
GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0016477; P:cell migration; IBA:GO_Central.
GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
GO; GO:0071226; P:cellular response to molecule of fungal origin; IEA:Ensembl.
GO; GO:0038063; P:collagen-activated tyrosine kinase receptor signaling pathway; IEA:Ensembl.
GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
GO; GO:0019370; P:leukotriene biosynthetic process; IEA:Ensembl.
GO; GO:0001945; P:lymph vessel development; IEA:Ensembl.
GO; GO:0002281; P:macrophage activation involved in immune response; IBA:GO_Central.
GO; GO:0002283; P:neutrophil activation involved in immune response; IBA:GO_Central.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central.
GO; GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IBA:GO_Central.
GO; GO:0045579; P:positive regulation of B cell differentiation; IBA:GO_Central.
GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Ensembl.
GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; IBA:GO_Central.
GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Ensembl.
GO; GO:0045425; P:positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; IEA:Ensembl.
GO; GO:0045401; P:positive regulation of interleukin-3 biosynthetic process; IEA:Ensembl.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IBA:GO_Central.
GO; GO:1900086; P:positive regulation of peptidyl-tyrosine autophosphorylation; IEA:Ensembl.
GO; GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl.
GO; GO:0032481; P:positive regulation of type I interferon production; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0090237; P:regulation of arachidonic acid secretion; IEA:Ensembl.
GO; GO:0051090; P:regulation of DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0043313; P:regulation of neutrophil degranulation; IEA:Ensembl.
GO; GO:0050764; P:regulation of phagocytosis; IEA:Ensembl.
GO; GO:0090330; P:regulation of platelet aggregation; IBA:GO_Central.
GO; GO:0032928; P:regulation of superoxide anion generation; IEA:Ensembl.
GO; GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002554; P:serotonin secretion by platelet; IEA:Ensembl.
GO; GO:0042991; P:transcription factor import into nucleus; IEA:Ensembl.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
CDD; cd09938; SH2_N-SH2_Zap70_Syk_like; 1.
Gene3D; 1.10.930.10; -; 1.
Gene3D; 3.30.505.10; -; 2.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR023420; Kinase_SYK/ZAP-70_inter-SH2_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR035838; SYK/ZAP-70_N_SH2.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR012234; Tyr_kinase_non-rcpt_SYK/ZAP70.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF00017; SH2; 2.
PIRSF; PIRSF000604; TyrPK_SYK; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00109; TYRKINASE.
SMART; SM00252; SH2; 2.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF55550; SSF55550; 2.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS50001; SH2; 2.
3: Inferred from homology;
ATP-binding {ECO:0000256|PIRSR:PIRSR000604-2,
ECO:0000256|SAAS:SAAS00897857};
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Kinase {ECO:0000256|SAAS:SAAS00897698};
Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000604-2,
ECO:0000256|SAAS:SAAS00897857};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
Transferase {ECO:0000256|SAAS:SAAS00897698};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00897698}.
DOMAIN 15 107 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 169 260 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 373 633 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
NP_BIND 379 387 ATP. {ECO:0000256|PIRSR:PIRSR000604-2}.
ACT_SITE 496 496 Proton acceptor.
{ECO:0000256|PIRSR:PIRSR000604-1}.
BINDING 404 404 ATP. {ECO:0000256|PIRSR:PIRSR000604-2}.
SEQUENCE 637 AA; 72238 MW; FFE38F691DD14813 CRC64;
MAGGVAADNA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK
AHHYTIEREL NGTYAIAGGR AHGSPAELCH YHSQECDGLV CLLKKPFHRP PGVQPKTGPF
EDLKESLIRE YVRQTWNLQQ GQALEQAIIS QKPQLEKLIA TTAHEKMPWF HGKISRVESE
QIVLIGSKTN GKFLIRDRND NGSYALCLLH EGKVLHYRID KDKTGKLSIP DGKKFDTLWQ
LVEHYSYKAD GLLRVLTVPC QKIGGQTGNI NFGARAPLPG PHPATWSAGG IISRIKSYSF
PKPGHRKAST SQGSRPESAV TFNPYEPDRG PWPTDRDAQR EALPMDTEVY ESPYADPEEI
RPKEVYLDRK LLTLEDNELG SGNFGTVKKG YYQMKKVVKT VAVKILKNEA NDPALKDELL
AEANVMQQLD NPYIVRMIGI CEAESWMLVM EMAELGPLNK YLQQNRHVKD KNIIELVHQV
SMGMKYLEES NFVHRDLAAR NVLLVTQHYA KISDFGLSKA LRADENYYKA QTHGKWPVKW
YAPECINYYK FSSKSDVWSF GVLMWEAFSY GQKPYRGMKG SEVSAMLEKG ERMGCPTGCP
REMYELMKLC WTYEVESRPG FAAVELRLRN YYYDVVN


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