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Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (EC 1.14.14.32) (17-alpha-hydroxyprogesterone aldolase) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17)

 CP17A_HORSE             Reviewed;         508 AA.
Q95328; Q29483;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
25-OCT-2017, entry version 118.
RecName: Full=Steroid 17-alpha-hydroxylase/17,20 lyase;
EC=1.14.14.19 {ECO:0000250|UniProtKB:P05093};
EC=1.14.14.32 {ECO:0000250|UniProtKB:P05093};
AltName: Full=17-alpha-hydroxyprogesterone aldolase;
AltName: Full=CYPXVII;
AltName: Full=Cytochrome P450 17A1;
AltName: Full=Cytochrome P450-C17;
Short=Cytochrome P450c17;
Name=CYP17A1; Synonyms=CYP17;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE.
TISSUE=Testis;
Hasegawa T., Mukoyama H., Yoshida S., Takahashi M.;
"Molecular cloning and nucleotide sequence of equine testicular
cytochrome P-450 steroid 17alpha-hydroxylase/C17,20-lyase messenger
ribonucleic acid.";
(In) Sharp D.C., Bazer F.W. (eds.);
Biology of Reproduction Monograph Series 1: Equine Reproduction,
pp.VI:615-622, The Society for the Study of Reproduction, Madison
(1995).
[2]
NUCLEOTIDE SEQUENCE.
STRAIN=Thoroughbred; TISSUE=Leukocyte;
Hasegawa T.;
"Exon/intron structure of equine P450c17.";
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Conversion of pregnenolone and progesterone to their 17-
alpha-hydroxylated products and subsequently to
dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both
the 17-alpha-hydroxylation and the 17,20-lyase reaction.
-!- CATALYTIC ACTIVITY: A C(21)-steroid + [reduced NADPH--hemoprotein
reductase] + O(2) = a 17-alpha-hydroxy-C(21)-steroid + [oxidized
NADPH--hemoprotein reductase] + H(2)O.
{ECO:0000250|UniProtKB:P05093}.
-!- CATALYTIC ACTIVITY: 17-alpha-hydroxyprogesterone + [reduced
NADPH--hemoprotein reductase] + O(2) = androstenedione + acetate +
[oxidized NADPH--hemoprotein reductase] + H(2)O.
{ECO:0000250|UniProtKB:P05093}.
-!- CATALYTIC ACTIVITY: 17-alpha-hydroxypregnenolone + [reduced
NADPH--hemoprotein reductase] + O(2) = 3-beta-hydroxyandrost-5-en-
17-one + acetate + [oxidized NADPH--hemoprotein reductase] +
H(2)O. {ECO:0000250|UniProtKB:P05093}.
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
-!- PATHWAY: Lipid metabolism; steroid biosynthesis.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}.
-!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; D30688; BAA06350.1; -; mRNA.
EMBL; D88184; BAA13551.1; -; Genomic_DNA.
RefSeq; NP_001075992.1; NM_001082523.1.
UniGene; Eca.12075; -.
ProteinModelPortal; Q95328; -.
SMR; Q95328; -.
STRING; 9796.ENSECAP00000008577; -.
PaxDb; Q95328; -.
GeneID; 100034232; -.
KEGG; ecb:100034232; -.
CTD; 1586; -.
eggNOG; KOG0156; Eukaryota.
eggNOG; COG2124; LUCA.
HOGENOM; HOG000036991; -.
HOVERGEN; HBG106944; -.
InParanoid; Q95328; -.
KO; K00512; -.
TreeFam; TF105095; -.
UniPathway; UPA00062; -.
Proteomes; UP000002281; Unplaced.
GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO; GO:0047442; F:17-alpha-hydroxyprogesterone aldolase activity; ISS:UniProtKB.
GO; GO:0020037; F:heme binding; ISS:UniProtKB.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0004508; F:steroid 17-alpha-monooxygenase activity; ISS:UniProtKB.
GO; GO:0042446; P:hormone biosynthetic process; ISS:UniProtKB.
GO; GO:0042448; P:progesterone metabolic process; ISS:UniProtKB.
GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0008202; P:steroid metabolic process; ISS:UniProtKB.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002401; Cyt_P450_E_grp-I.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00463; EP450I.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
2: Evidence at transcript level;
Complete proteome; Heme; Iron; Lyase; Membrane; Metal-binding;
Monooxygenase; Oxidoreductase; Reference proteome; Steroidogenesis.
CHAIN 1 508 Steroid 17-alpha-hydroxylase/17,20 lyase.
/FTId=PRO_0000051930.
METAL 442 442 Iron (heme axial ligand). {ECO:0000250}.
CONFLICT 388 388 D -> E (in Ref. 1; BAA06350).
{ECO:0000305}.
SEQUENCE 508 AA; 57394 MW; 71862C8B50AC4BE5 CRC64;
MWELLAFLLL AIAYFFRPKV KCPGAKYPKS LPYLPLVGSL PFLPRHGHPH VNFFKLQKKY
GPIYSLRMGT KTTVMVGHYQ LAKEVLIKKG KEFSGRPQVA TLNILSDNQK GVAFADHGAP
WQLHRKLVRA AFALFKDGNQ KLEKIICHET SLLCDLLATQ NGQTIDLSSP LFLAVTNVIC
WICFNSSYMK GDPALETMQN YHKGILETLE KDNVVDIFPA LKIFPNKSLE KMRHCVNIRN
ELLSKIFEKH KENFNSDSIT SMLDLLIQAK KNSDNNNTGP DQDSKLLSDK HILATIGDIF
GAGVETTTSV VKWIVAFLLH DPQLKKKIQE EIDQNVGFSR TPTLSDRNRL LLLEATIREV
LRIRPVAPML IPHKALVDSS IGEFAVDDGT NVIINLWALH HNEKEWHQPD RFMPERFLDP
TGSQLISPSL SYLPFGAGPR SCIGELLARQ ELFLFTAWLL QRFNLEVPDD GQLPSLEGHP
TAVFLIDSFK VKINVRQAWR EAQAEGST


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