Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Steroid hormone receptor ERR1 (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)

 ERR1_RAT                Reviewed;         422 AA.
Q5QJV7; Q3MHT1;
10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
10-JUL-2007, sequence version 2.
12-SEP-2018, entry version 113.
RecName: Full=Steroid hormone receptor ERR1;
AltName: Full=Estrogen-related receptor alpha;
Short=ERR-alpha;
AltName: Full=Nuclear receptor subfamily 3 group B member 1;
Name=Esrra; Synonyms=Nr3b1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
Lui K., Chen S., Chan F.L.;
"Molecular cloning and expression study of estrogen receptor-related
receptor alpha in rat ovary.";
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Binds to an ERR-alpha response element (ERRE) containing
a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the
medium-chain acyl coenzyme A dehydrogenase (MCAD) response element
NRRE-1 and may act as an important regulator of MCAD promoter.
Binds to the C1 region of the lactoferrin gene promoter. Requires
dimerization and the coactivator, PGC-1A, for full activity. The
ERRalpha/PGC1alpha complex is a regulator of energy metabolism.
Induces the expression of PERM1 in the skeletal muscle.
-!- SUBUNIT: Binds DNA as a monomer or a homodimer. Interacts (via the
AF2 domain) with coactivator PPARGC1A (via the L3 motif); the
interaction greatly enhances transcriptional activity of genes
involved in energy metabolism. Interacts with PIAS4; the
interaction enhances sumoylation (By similarity). Interacts with
MAPK15; promotes re-localization of ESRRA to the cytoplasm through
a XPO1-dependent mechanism then inhibits ESRRA transcriptional
activity (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:P11474}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P11474,
ECO:0000255|PROSITE-ProRule:PRU00407}. Cytoplasm
{ECO:0000250|UniProtKB:P11474}. Note=Co-localizes to the cytoplasm
only in presence of MAPK15. {ECO:0000250|UniProtKB:P11474}.
-!- PTM: Phosphorylation on Ser-19 enhances sumoylation on Lys-14
increasing repression of transcriptional activity. {ECO:0000250}.
-!- PTM: Sumoylated with SUMO2. Main site is Lys-14 which is enhanced
by phosphorylation on Ser-19, cofactor activation, and by
interaction with PIAS4. Sumoylation enhances repression of
transcriptional activity, but has no effect on subcellular
location nor on DNA binding (By similarity). {ECO:0000250}.
-!- PTM: Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129,
Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases
transcriptional activity probably by inhibiting DNA-binding
activity; deacetylation involves SIRT1 and HDAC8 and increases
DNA-binding (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAI04702.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Sequence=AAQ17212.1; Type=Frameshift; Positions=408, 413; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AY280663; AAQ17212.1; ALT_FRAME; mRNA.
EMBL; BC104701; AAI04702.1; ALT_INIT; mRNA.
RefSeq; NP_001008511.2; NM_001008511.2.
UniGene; Rn.130171; -.
ProteinModelPortal; Q5QJV7; -.
SMR; Q5QJV7; -.
STRING; 10116.ENSRNOP00000028697; -.
iPTMnet; Q5QJV7; -.
PhosphoSitePlus; Q5QJV7; -.
PaxDb; Q5QJV7; -.
Ensembl; ENSRNOT00000028697; ENSRNOP00000028697; ENSRNOG00000021139.
GeneID; 293701; -.
KEGG; rno:293701; -.
UCSC; RGD:1583866; rat.
CTD; 2101; -.
RGD; 1583866; Esrra.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00760000118887; -.
HOGENOM; HOG000233467; -.
HOVERGEN; HBG108344; -.
InParanoid; Q5QJV7; -.
KO; K08552; -.
OMA; CHPGHKE; -.
OrthoDB; EOG091G0DYP; -.
PhylomeDB; Q5QJV7; -.
TreeFam; TF323751; -.
Reactome; R-RNO-383280; Nuclear Receptor transcription pathway.
PRO; PR:Q5QJV7; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000021139; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue.
ExpressionAtlas; Q5QJV7; baseline and differential.
Genevisible; Q5QJV7; RN.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
GO; GO:0005496; F:steroid binding; IEA:InterPro.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0051216; P:cartilage development; IMP:RGD.
GO; GO:1900078; P:positive regulation of cellular response to insulin stimulus; IMP:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:RGD.
GO; GO:0042127; P:regulation of cell proliferation; IMP:RGD.
GO; GO:0030278; P:regulation of ossification; IMP:RGD.
GO; GO:0045667; P:regulation of osteoblast differentiation; IMP:RGD.
GO; GO:0045670; P:regulation of osteoclast differentiation; IMP:RGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR027289; Oest-rel_rcp.
InterPro; IPR024178; Oest_rcpt/oest-rel_rcp.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PIRSF; PIRSF002527; ER-like_NR; 1.
PIRSF; PIRSF500939; ERR1-2-3; 1.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 2.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; Cytoplasm; DNA-binding;
Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Receptor;
Reference proteome; Transcription; Transcription regulation;
Ubl conjugation; Zinc; Zinc-finger.
CHAIN 1 422 Steroid hormone receptor ERR1.
/FTId=PRO_0000295232.
DOMAIN 192 420 NR LBD. {ECO:0000255|PROSITE-
ProRule:PRU01189}.
DNA_BIND 76 151 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 79 99 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 115 134 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 1 76 Repressor domain. {ECO:0000250}.
REGION 402 422 AF-2 domain. {ECO:0000250}.
SITE 124 124 Required for DNA-dependent dimerization.
{ECO:0000250}.
MOD_RES 19 19 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 22 22 Phosphoserine.
{ECO:0000250|UniProtKB:P11474}.
MOD_RES 129 129 N6-acetyllysine; by PCAF/KAT2B.
{ECO:0000250|UniProtKB:P11474}.
MOD_RES 138 138 N6-acetyllysine; by PCAF/KAT2B.
{ECO:0000250|UniProtKB:P11474}.
MOD_RES 160 160 N6-acetyllysine; by PCAF/KAT2B.
{ECO:0000250|UniProtKB:P11474}.
MOD_RES 162 162 N6-acetyllysine; by PCAF/KAT2B.
{ECO:0000250|UniProtKB:P11474}.
CROSSLNK 14 14 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
CROSSLNK 189 189 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P11474}.
CROSSLNK 402 402 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO);
alternate. {ECO:0000250}.
CROSSLNK 402 402 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2);
alternate.
{ECO:0000250|UniProtKB:P11474}.
SEQUENCE 422 AA; 45464 MW; 2F54EEA1BD3B511D CRC64;
MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVTLASG PAPARCLPGH KEEEDGEGAG
SGEQGSGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE
CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGPFPAGP
LAVAGGPRKT APVNALVSHL LVVEPEKLYA MPDPASPDGH LPAVATLCDL FDREIVVTIS
WAKSIPGFSS LSLSDQMSVL QSVWMEVLVL GVAQRSLPLQ DELAFAEDLV LDEEGARAAG
LGDLGAALLQ LVRRLQALRL EREEYVLLKA LALANSDSVH IEDAEAVEQL REALHEALLE
YEAGRAGPGG GAERRRAGRL LLTLPLLRQT AGKVLAHFYG VKLEGKVPMH KLFLEMLEAM
MD


Related products :

Catalog number Product name Quantity
EIAAB13281 Err1,ERR-alpha,Esrra,Estrogen receptor-like 1,Estrogen-related receptor alpha,Estrra,Mouse,Mus musculus,Nr3b1,Nuclear receptor subfamily 3 group B member 1,Steroid hormone receptor ERR1
EIAAB13282 ERR1,ERR-alpha,ESRL1,ESRRA,Estrogen receptor-like 1,Estrogen-related receptor alpha,Homo sapiens,Human,NR3B1,Nuclear receptor subfamily 3 group B member 1,Steroid hormone receptor ERR1
EIAAB13280 ERR-alpha,Esrra,Estrogen-related receptor alpha,Nr3b1,Nuclear receptor subfamily 3 group B member 1,Rat,Rattus norvegicus,Steroid hormone receptor ERR1
EIAAB13283 Canis familiaris,Canis lupus familiaris,Dog,ERR-alpha,ESRRA,Estrogen-related receptor alpha,NR3B1,Nuclear receptor subfamily 3 group B member 1,Steroid hormone receptor ERR1
EIAAB13284 ERR beta-2,ERRB2,ERR-beta,ESRL2,ESRRB,Estrogen receptor-like 2,Estrogen-related receptor beta,Homo sapiens,Human,NR3B2,Nuclear receptor subfamily 3 group B member 2,Steroid hormone receptor ERR2
18-461-10208 Steroid hormone receptor ERR1 - Estrogen-related receptor. alpha; ERR-alpha; Estrogen receptor-like 1 Polyclonal 0.05 ml
18-461-10210 Steroid hormone receptor ERR1 - Estrogen-related receptor. alpha; ERR-alpha; Estrogen receptor-like 1 Polyclonal 0.05 ml
EIAAB13286 Err2,ERR-beta,Esrl2,Esrrb,Estrogen receptor-like 2,Estrogen-related receptor beta,Nr3b2,Nuclear receptor subfamily 3 group B member 2,Rat,Rattus norvegicus,Steroid hormone receptor ERR2
EIAAB13285 Err2,Err-2,ERR-beta,Esrrb,Estrogen receptor-like 2,Estrogen-related receptor beta,Mouse,Mus musculus,Nr3b2,Nuclear receptor subfamily 3 group B member 2,Steroid hormone receptor ERR2
EIAAB35712 Homo sapiens,Human,NR1F1,Nuclear receptor ROR-alpha,Nuclear receptor RZR-alpha,Nuclear receptor subfamily 1 group F member 1,Retinoid-related orphan receptor-alpha,RORA,RZRA
EIAAB35713 Mouse,Mus musculus,Nr1f1,Nuclear receptor ROR-alpha,Nuclear receptor RZR-alpha,Nuclear receptor subfamily 1 group F member 1,Retinoid-related orphan receptor-alpha,Rora,Rzra
E1050p ELISA kit ER,ER-alpha,ESR,ESR1,Estradiol receptor,Estrogen receptor,NR3A1,Nuclear receptor subfamily 3 group A member 1,Pig,Sus scrofa 96T
E1050p ELISA ER,ER-alpha,ESR,ESR1,Estradiol receptor,Estrogen receptor,NR3A1,Nuclear receptor subfamily 3 group A member 1,Pig,Sus scrofa 96T
U1050p CLIA ER,ER-alpha,ESR,ESR1,Estradiol receptor,Estrogen receptor,NR3A1,Nuclear receptor subfamily 3 group A member 1,Pig,Sus scrofa 96T
EIAAB13287 Errg,Esrrg,Estrogen receptor-related protein 3,Estrogen-related receptor gamma,Nr3b3,Nuclear receptor subfamily 3 group B member 3,Rat,Rattus norvegicus
EIAAB13288 Err3,Esrrg,Estrogen receptor-related protein 3,Estrogen-related receptor gamma,Kiaa0832,Mouse,Mus musculus,Nr3b3,Nuclear receptor subfamily 3 group B member 3
E1050b ELISA Bos taurus,Bovine,ER,ER-alpha,ESR,ESR1,Estradiol receptor,Estrogen receptor,NR3A1,Nuclear receptor subfamily 3 group A member 1 96T
U1050b CLIA Bos taurus,Bovine,ER,ER-alpha,ESR,ESR1,Estradiol receptor,Estrogen receptor,NR3A1,Nuclear receptor subfamily 3 group A member 1 96T
E1050b ELISA kit Bos taurus,Bovine,ER,ER-alpha,ESR,ESR1,Estradiol receptor,Estrogen receptor,NR3A1,Nuclear receptor subfamily 3 group A member 1 96T
E1050r ELISA ER,ER-alpha,Esr,Esr1,Estr,Estradiol receptor,Estrogen receptor,Nr3a1,Nuclear receptor subfamily 3 group A member 1,Rat,Rattus norvegicus 96T
U1050h CLIA ER,ER-alpha,ESR,ESR1,Estradiol receptor,Estrogen receptor,Homo sapiens,Human,NR3A1,Nuclear receptor subfamily 3 group A member 1 96T
E1050r ELISA kit ER,ER-alpha,Esr,Esr1,Estr,Estradiol receptor,Estrogen receptor,Nr3a1,Nuclear receptor subfamily 3 group A member 1,Rat,Rattus norvegicus 96T
U1050r CLIA ER,ER-alpha,Esr,Esr1,Estr,Estradiol receptor,Estrogen receptor,Nr3a1,Nuclear receptor subfamily 3 group A member 1,Rat,Rattus norvegicus 96T
E1050h ELISA kit ER,ER-alpha,ESR,ESR1,Estradiol receptor,Estrogen receptor,Homo sapiens,Human,NR3A1,Nuclear receptor subfamily 3 group A member 1 96T
E1050h ELISA ER,ER-alpha,ESR,ESR1,Estradiol receptor,Estrogen receptor,Homo sapiens,Human,NR3A1,Nuclear receptor subfamily 3 group A member 1 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur