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Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)

 ERR2_RAT                Reviewed;         433 AA.
P11475; Q5QJB1;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 1.
22-NOV-2017, entry version 157.
RecName: Full=Steroid hormone receptor ERR2 {ECO:0000305};
AltName: Full=Estrogen receptor-like 2;
AltName: Full=Estrogen-related receptor beta {ECO:0000250|UniProtKB:O95718};
Short=ERR-beta;
AltName: Full=Nuclear receptor subfamily 3 group B member 2;
Name=Esrrb {ECO:0000312|RGD:1359557}; Synonyms=Err2, Esrl2, Nr3b2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
PubMed=3267207; DOI=10.1038/331091a0;
Giguere V., Yang N., Segui P., Evans R.M.;
"Identification of a new class of steroid hormone receptors.";
Nature 331:91-94(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Lui K., Chen S., Chan F.L.;
"Molecular cloning and expression study of estrogen receptor-related
receptor beta in rat prostate.";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[3]
SHOWS THAT SEQUENCE DESCRIBED IN PUBMED:3267207 ORIGINATES FROM RAT.
PubMed=10072763; DOI=10.1016/S0378-1119(98)00619-2;
Chen F., Zhang Q., McDonald T., Davidoff M.J., Bailey W., Bai C.,
Liu Q., Caskey C.T.;
"Identification of two hERR2-related novel nuclear receptors utilizing
bioinformatics and inverse PCR.";
Gene 228:101-109(1999).
-!- FUNCTION: Transcription factor that binds a canonical ESRRB
recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter
and enhancer of targets genes regulating their expression or their
transcription activity (By similarity). Plays a role, in a LIF
independent manner, in maintainance of self-renewal and
pluripotency of embryonic and trophoblast stem cells through
different signaling pathways including FGF signaling pathway and
Wnt signaling pathways. Upon FGF signaling pathway activation,
interacts with KDM1A by directly binding to enhancer site of ELF5
and EOMES and activating their transcription leading to self-
renewal of trophoblast stem cells. Also regulates expression of
multiple rod-specific genes and is required for survival of this
cell type (By similarity). Plays a role as transcription factor
activator of GATA6, NR0B1, POU5F1 and PERM1 (By similarity). Plays
a role as transcription factor repressor of NFE2L2 transcriptional
activity and ESR1 transcriptional activity (By similarity). During
mitosis remains bound to a subset of interphase target genes,
including pluripotency regulators, through the canonical ESRRB
recognition (ERRE) sequence, leading to their transcriptional
activation in early G1 phase. Can coassemble on structured DNA
elements with other transcription factors like SOX2, POU5F1, KDM1A
and NCOA3 to trigger ESRRB-dependent gene activation. This
mechanism, in the case of SOX2 corecruitment prevents the
embryonic stem cells (ESCs) to epiblast stem cells (EpiSC)
transition through positive regulation of NR0B1 that inhibits the
EpiSC transcriptional program. Also plays a role inner ear
development by controlling expression of ion channels and
transporters and in early placentation (By similarity).
{ECO:0000250|UniProtKB:O95718, ECO:0000250|UniProtKB:Q61539}.
-!- SUBUNIT: Binds DNA as a monomer (By similarity). Interacts with
NR0B1; represses ESRRB activity at the GATA6 promoter. Interacts
with NANOG; reciprocally modulates their transcriptional
activities and activates POU5F1 expression. Interacts with NCOA3;
mediates the interaction between ESRRB and RNA polymerase II
complexes and allows NCOA3 corecruitment to ESRRB, KLF4, NANOG,
and SOX2 enhancer regions to trigger ESRRB-dependent gene
activation involved in self-renewal and pluripotency. Interacts
with KDM1A; co-occupes the core set of ESRRB targets including
ELF5 and EOMES. Interacts with the multiprotein complex
Integrator, at least composed of INTS1, INTS2, INTS3, INTS4,
INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and
INTS12; ESRRB is probably not a core component of the integrator
complex and associates to integrator via its interaction with
INTS1 and INTS9; attracts the transcriptional machinery. Interacts
with JARID2. Interacts with POU5F1; recruits ESRRB near the
POU5F1-SOX2 element in the NANOG proximal promoter leading to
activation of NANOG expression; the intercaction is DNA
independent (By similarity). {ECO:0000250|UniProtKB:O95718,
ECO:0000250|UniProtKB:Q61539}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61539}.
Cytoplasm {ECO:0000250|UniProtKB:Q61539}. Chromosome
{ECO:0000250|UniProtKB:Q61539}.
-!- PTM: Acetylated by PCAF/KAT2 (in vitro).
{ECO:0000250|UniProtKB:O95718}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
subfamily. {ECO:0000305}.
-!- CAUTION: Was originally (PubMed:3267207) thought to originate from
human but was later shown (PubMed:10072763) to be derived from
rat. {ECO:0000305|PubMed:10072763, ECO:0000305|PubMed:3267207}.
-----------------------------------------------------------------------
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EMBL; X51417; CAA35779.1; -; mRNA.
EMBL; AY383731; AAR89824.1; -; mRNA.
RefSeq; NP_001008516.2; NM_001008516.2.
UniGene; Rn.104984; -.
ProteinModelPortal; P11475; -.
SMR; P11475; -.
STRING; 10116.ENSRNOP00000013867; -.
PhosphoSitePlus; P11475; -.
PaxDb; P11475; -.
PRIDE; P11475; -.
Ensembl; ENSRNOT00000013867; ENSRNOP00000013867; ENSRNOG00000010259.
GeneID; 299210; -.
KEGG; rno:299210; -.
UCSC; RGD:1359557; rat.
CTD; 2103; -.
RGD; 1359557; Esrrb.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00760000118887; -.
HOGENOM; HOG000233467; -.
HOVERGEN; HBG108344; -.
InParanoid; P11475; -.
KO; K08553; -.
OMA; LPFNGKL; -.
OrthoDB; EOG091G0DYP; -.
PhylomeDB; P11475; -.
TreeFam; TF323751; -.
Reactome; R-RNO-383280; Nuclear Receptor transcription pathway.
PRO; PR:P11475; -.
Proteomes; UP000002494; Chromosome 6.
Bgee; ENSRNOG00000010259; -.
GO; GO:0000793; C:condensed chromosome; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0001047; F:core promoter binding; ISS:UniProtKB.
GO; GO:0035326; F:enhancer binding; ISS:UniProtKB.
GO; GO:0001158; F:enhancer sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; ISO:RGD.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0005496; F:steroid binding; IEA:InterPro.
GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
GO; GO:0003713; F:transcription coactivator activity; ISO:RGD.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; ISS:UniProtKB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0008134; F:transcription factor binding; ISO:RGD.
GO; GO:0001205; F:transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding; ISS:UniProtKB.
GO; GO:0001191; F:transcriptional repressor activity, RNA polymerase II transcription factor binding; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0043697; P:cell dedifferentiation; ISS:UniProtKB.
GO; GO:0008283; P:cell proliferation; ISS:UniProtKB.
GO; GO:0001892; P:embryonic placenta development; ISO:RGD.
GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
GO; GO:0048839; P:inner ear development; ISS:UniProtKB.
GO; GO:2000737; P:negative regulation of stem cell differentiation; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; IDA:BHF-UCL.
GO; GO:0045821; P:positive regulation of glycolytic process; IDA:BHF-UCL.
GO; GO:1902459; P:positive regulation of stem cell population maintenance; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0090282; P:positive regulation of transcription involved in G2/M transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:2000035; P:regulation of stem cell division; ISS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0017145; P:stem cell division; ISS:UniProtKB.
GO; GO:0019827; P:stem cell population maintenance; ISS:UniProtKB.
GO; GO:0001834; P:trophectodermal cell proliferation; ISO:RGD.
GO; GO:0001831; P:trophectodermal cellular morphogenesis; ISO:RGD.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR_like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR027289; Oest-rel_rcp.
InterPro; IPR024178; Oest_rcpt/oest-rel_rcp.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PIRSF; PIRSF002527; ER-like_NR; 1.
PIRSF; PIRSF500939; ERR1-2-3; 1.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
Acetylation; Chromosome; Complete proteome; Cytoplasm; DNA-binding;
Metal-binding; Nucleus; Receptor; Reference proteome; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 433 Steroid hormone receptor ERR2.
/FTId=PRO_0000053664.
DNA_BIND 100 186 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 103 123 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 139 163 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 93 211 Interaction with NANOG.
{ECO:0000250|UniProtKB:Q61539}.
REGION 203 433 Essential for ESRRB transcriptional
activity and interaction with NCOA3.
{ECO:0000250|UniProtKB:Q61539}.
SITE 185 185 Important for stabilizing DNA-binding.
{ECO:0000250}.
SEQUENCE 433 AA; 48288 MW; EE2C4C5B2F9A3E13 CRC64;
MSSEDRHLGS SCGSFIKTEP SSPSSGIDAL SHHSPSGSSD ASGGFGMALG THANGLDSPP
MFAGAGLGGN PCRKSYEDCT SGIMEDSAIK CEYMLNAIPK RLCLVCGDIA SGYHYGVASC
EACKAFFKRT IQGNIEYSCP ATNECEITKR RRKSCQACRF MKCLKVGMLK EGVRLDRVRG
GRQKYKRRLD SENSPYLSLQ ISPPAKKPLT KIVSYLLVAE PDKLYAMPPD DVPEGDIKAL
TTLCDLADRE LVFLISWAKH IPGFSNLTLG DQMSLLQSAW MEILILGIVY RSLPYDDKLA
YAEDYIMDEE HSRLVGLLEL YRAILQLVRR YKKLKVEKEE FVMLKALALA NSDSMYIENL
EAVQKLQDLL HEALQDYELS QRHEEPRRAG KLLLTLPLLR QTAAKAVQHF YSVKLQGKVP
MHKLFLEMLE AKV


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