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Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)

 SOAT1_RAT               Reviewed;         545 AA.
O70536;
18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
22-NOV-2017, entry version 112.
RecName: Full=Sterol O-acyltransferase 1;
EC=2.3.1.26 {ECO:0000250|UniProtKB:P35610};
AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 1;
Short=ACAT-1;
AltName: Full=Cholesterol acyltransferase 1;
Name=Soat1; Synonyms=Acact, Acat;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Wistar; TISSUE=Adrenal gland;
PubMed=9555010; DOI=10.1016/S0005-2760(98)00007-1;
Matsuda H., Hakamata H., Kawasaki T., Sakashita N., Miyazaki A.,
Takahashi K., Shichiri M., Horiuchi S.;
"Molecular cloning, functional expression and tissue distribution of
rat acyl-coenzyme A:cholesterol acyltransferase.";
Biochim. Biophys. Acta 1391:193-203(1998).
-!- FUNCTION: Catalyzes the formation of fatty acid-cholesterol
esters. Plays a role in lipoprotein assembly and dietary
cholesterol absorption.
-!- CATALYTIC ACTIVITY: Acyl-CoA + cholesterol = CoA + cholesterol
ester. {ECO:0000250|UniProtKB:P35610}.
-!- SUBUNIT: May form homo- or heterodimers. Interacts with UBIAD1.
{ECO:0000250|UniProtKB:P35610}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
membrane protein.
-!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
Sterol o-acyltransferase subfamily. {ECO:0000305}.
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EMBL; D86373; BAA25372.1; -; mRNA.
RefSeq; NP_112380.1; NM_031118.1.
UniGene; Rn.59; -.
STRING; 10116.ENSRNOP00000005677; -.
BindingDB; O70536; -.
ChEMBL; CHEMBL285; -.
PaxDb; O70536; -.
PRIDE; O70536; -.
GeneID; 81782; -.
KEGG; rno:81782; -.
UCSC; RGD:621641; rat.
CTD; 6646; -.
RGD; 621641; Soat1.
eggNOG; KOG0380; Eukaryota.
eggNOG; COG5056; LUCA.
HOGENOM; HOG000020782; -.
HOVERGEN; HBG058198; -.
InParanoid; O70536; -.
KO; K00637; -.
PhylomeDB; O70536; -.
PRO; PR:O70536; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:RGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; ISO:RGD.
GO; GO:0015485; F:cholesterol binding; ISO:RGD.
GO; GO:0034736; F:cholesterol O-acyltransferase activity; ISO:RGD.
GO; GO:0000062; F:fatty-acyl-CoA binding; ISO:RGD.
GO; GO:0004772; F:sterol O-acyltransferase activity; IDA:RGD.
GO; GO:0033344; P:cholesterol efflux; ISO:RGD.
GO; GO:0034435; P:cholesterol esterification; ISO:RGD.
GO; GO:0042632; P:cholesterol homeostasis; IEA:InterPro.
GO; GO:0008203; P:cholesterol metabolic process; ISO:RGD.
GO; GO:0010878; P:cholesterol storage; ISO:RGD.
GO; GO:0010742; P:macrophage derived foam cell differentiation; ISO:RGD.
GO; GO:0042986; P:positive regulation of amyloid precursor protein biosynthetic process; ISO:RGD.
GO; GO:0034379; P:very-low-density lipoprotein particle assembly; ISO:RGD.
InterPro; IPR004299; MBOAT_fam.
InterPro; IPR014371; Oat_ACAT_DAG_ARE.
InterPro; IPR030687; Sterol_acyltranf_meta.
PANTHER; PTHR10408; PTHR10408; 1.
Pfam; PF03062; MBOAT; 1.
PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
PIRSF; PIRSF500230; Sterol_acyltranf_ACAT; 1.
2: Evidence at transcript level;
Acetylation; Acyltransferase; Cholesterol metabolism;
Complete proteome; Disulfide bond; Endoplasmic reticulum;
Lipid metabolism; Membrane; Phosphoprotein; Reference proteome;
Steroid metabolism; Sterol metabolism; Transferase; Transmembrane;
Transmembrane helix.
CHAIN 1 545 Sterol O-acyltransferase 1.
/FTId=PRO_0000207643.
TOPO_DOM 1 135 Cytoplasmic. {ECO:0000255}.
TRANSMEM 136 154 Helical. {ECO:0000255}.
TOPO_DOM 155 176 Lumenal. {ECO:0000255}.
TRANSMEM 177 196 Helical. {ECO:0000255}.
TOPO_DOM 197 219 Cytoplasmic. {ECO:0000255}.
TRANSMEM 220 238 Helical. {ECO:0000255}.
TOPO_DOM 239 241 Lumenal. {ECO:0000255}.
TRANSMEM 242 259 Helical. {ECO:0000255}.
TOPO_DOM 260 496 Cytoplasmic. {ECO:0000255}.
TRANSMEM 497 512 Helical. {ECO:0000255}.
TOPO_DOM 513 535 Lumenal. {ECO:0000255}.
ACT_SITE 455 455 {ECO:0000250}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P35610}.
MOD_RES 7 7 Phosphoserine.
{ECO:0000250|UniProtKB:P35610}.
DISULFID 523 541 {ECO:0000250}.
SEQUENCE 545 AA; 64146 MW; 40129EF21257BEBF CRC64;
MVGEETSLRN RLSRSAENPE QDEAQKNLLD THRNGHITMK QLIAKKRQLA AEAEELKPLF
LKEVGCHFDD FVTNLIDKSA SLDNGGCALT TFSILEEMKN NHRAKDLRAP PEQGKIFISR
RSLLDELFEV DHIRTIYHMF IALLIIFILS TLVVDYIDEG RLVLEFSLLA YAFGQFPIVI
WTWWAMFLST LAIPYFLFQR WAHGYSKSSH PLIYSLIHGA FFLVFQLGIL GFIPTYVVLA
YTLPPASRFI LILEQIRLVM KAHSYVRENV PRVLSAAKEK SSTVPVPTVN QYLYFLFAPT
LIYRDSYPRT PTVRWGYVAM QFLQVFGCLF YVYYIFERLC APLFRNIKQE PFSARVLVLC
VFNSILPGVL MLFLSFFAFL HCWLNAFAEM LRFGDRMFYK DWWNSTSYSN YYRTWNVVVH
DWLYYYVYKD LLWFFSKRFR PAAMLAVFAL SAVVHEYALA VCLSYFYPVL FVLFMFFGMA
FNFIVNDSRK RPVWNIMVRA SLFLGHGVIL CFYSQEWYAR QRCPLKNPTF LDYVRPRTWT
CRYVF


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