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Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)

 SOAT1_CRIGR             Reviewed;         546 AA.
Q60457;
18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
23-MAY-2018, entry version 83.
RecName: Full=Sterol O-acyltransferase 1;
EC=2.3.1.26 {ECO:0000250|UniProtKB:P35610};
AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 1;
Short=ACAT-1;
AltName: Full=Cholesterol acyltransferase 1;
Name=SOAT1; Synonyms=ACAT, ACAT1;
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8662991; DOI=10.1074/jbc.271.24.14642;
Cao G., Goldstein J.L., Brown M.S.;
"Complementation of mutation in acyl-CoA:cholesterol acyltransferase
(ACAT) fails to restore sterol regulation in ACAT-defective sterol-
resistant hamster cells.";
J. Biol. Chem. 271:14642-14648(1996).
-!- FUNCTION: Catalyzes the formation of fatty acid-cholesterol
esters. Plays a role in lipoprotein assembly and dietary
cholesterol absorption.
-!- CATALYTIC ACTIVITY: Acyl-CoA + cholesterol = CoA + cholesterol
ester. {ECO:0000250|UniProtKB:P35610}.
-!- SUBUNIT: May form homo- or heterodimers. Interacts with UBIAD1.
{ECO:0000250|UniProtKB:P35610}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
membrane protein.
-!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
Sterol o-acyltransferase subfamily. {ECO:0000305}.
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EMBL; U47320; AAC52670.1; -; mRNA.
RefSeq; NP_001233679.1; NM_001246750.1.
BindingDB; Q60457; -.
ChEMBL; CHEMBL1075066; -.
PRIDE; Q60457; -.
GeneID; 100689317; -.
KEGG; cge:100689317; -.
CTD; 6646; -.
HOVERGEN; HBG058198; -.
KO; K00637; -.
PRO; PR:Q60457; -.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0034736; F:cholesterol O-acyltransferase activity; IEA:UniProtKB-EC.
GO; GO:0034435; P:cholesterol esterification; IEA:InterPro.
GO; GO:0042632; P:cholesterol homeostasis; IEA:InterPro.
GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
InterPro; IPR004299; MBOAT_fam.
InterPro; IPR014371; Oat_ACAT_DAG_ARE.
InterPro; IPR030687; Sterol_acyltranf_meta.
PANTHER; PTHR10408; PTHR10408; 1.
Pfam; PF03062; MBOAT; 1.
PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
PIRSF; PIRSF500230; Sterol_acyltranf_ACAT; 1.
2: Evidence at transcript level;
Acetylation; Acyltransferase; Cholesterol metabolism; Disulfide bond;
Endoplasmic reticulum; Lipid metabolism; Membrane; Phosphoprotein;
Steroid metabolism; Sterol metabolism; Transferase; Transmembrane;
Transmembrane helix.
CHAIN 1 546 Sterol O-acyltransferase 1.
/FTId=PRO_0000207639.
TOPO_DOM 1 136 Cytoplasmic. {ECO:0000255}.
TRANSMEM 137 155 Helical. {ECO:0000255}.
TOPO_DOM 156 177 Lumenal. {ECO:0000255}.
TRANSMEM 178 197 Helical. {ECO:0000255}.
TOPO_DOM 198 220 Cytoplasmic. {ECO:0000255}.
TRANSMEM 221 239 Helical. {ECO:0000255}.
TOPO_DOM 240 242 Lumenal. {ECO:0000255}.
TRANSMEM 243 260 Helical. {ECO:0000255}.
TOPO_DOM 261 497 Cytoplasmic. {ECO:0000255}.
TRANSMEM 498 513 Helical. {ECO:0000255}.
TOPO_DOM 514 546 Lumenal. {ECO:0000255}.
ACT_SITE 456 456 {ECO:0000250}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P35610}.
MOD_RES 8 8 Phosphoserine.
{ECO:0000250|UniProtKB:P35610}.
DISULFID 524 542 {ECO:0000250}.
SEQUENCE 546 AA; 64111 MW; 4ED6C403AAC7E65B CRC64;
MVGEEKMSLR NRLSKSGENP EQDEAQRSVS DTQSNGRITM KQLIAKKRQL AAEAEELKPL
FLKEVGCHFD DFVTNLIEKS ASLDNGGCAL TTFSILEEMK NNHRAKDLRA PPEKGKIFIS
RRSLLDELFE VDHIRTIYHM FIGLLILFIL STLVVDYIDE GRLVLEFNLL GYAFGKLPTV
IWTWWAMFLS TLSIPYFLFQ RWAHGYSKTS HPLIYSLSHG FFFLVFQLGI LGFVPTYVVL
AYTLPPASRF IVILEQIRMV MKAHSFVREN VPRVLNAAKE KSSTVPVPTV NQYLYFLFAP
TLIYRDSYPR TPTVRWGYVA VQFLQVFGCL FYVYYIFERL CAPLFRNIKQ EPFSARVLVL
CVFNSILPGV LMLFLTFFAF LHCWLNAFAE MLRFGDRMFY KDWWNSTSYS NYYRTWNVVV
HDWLYYYAYK DLLWFFSKRF KSAAMLAVFA LSAVVHEYAL AVCLSYFYPV LFVLFMFFGM
AFNFIVNDSR KRPIWNIMVW ASLFLGHGVI LCFYSQEWYA RQHCPLKNPT FLDYVRPRSW
TCQYVF


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