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Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)

 SOAT2_MOUSE             Reviewed;         525 AA.
O88908; Q8R0Y9;
18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
12-SEP-2018, entry version 126.
RecName: Full=Sterol O-acyltransferase 2;
EC=2.3.1.26;
AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 2;
Short=ACAT-2;
AltName: Full=Cholesterol acyltransferase 2;
Name=Soat2; Synonyms=Acact-2, Acat2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
PubMed=9756919; DOI=10.1074/jbc.273.41.26755;
Cases S., Novak S., Zheng Y.-W., Myers H.M., Lear S.R., Sande E.,
Welch C.B., Lusis A.J., Spencer T.A., Krause B.R., Erickson S.K.,
Farese R.V. Jr.;
"ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its
cloning, expression, and characterization.";
J. Biol. Chem. 273:26755-26764(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
TOPOLOGY, AND SUBCELLULAR LOCATION.
PubMed=11071899; DOI=10.1091/mbc.11.11.3675;
Joyce C.W., Shelness G.S., Davis M.A., Lee R.G., Skinner K.,
Anderson R.A., Rudel L.L.;
"ACAT1 and ACAT2 membrane topology segregates a serine residue
essential for activity to opposite sides of the endoplasmic reticulum
membrane.";
Mol. Biol. Cell 11:3675-3687(2000).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Plays a role in lipoprotein assembly and dietary
cholesterol absorption. In addition to its acyltransferase
activity, it may act as a ligase. May provide cholesteryl esters
for lipoprotein secretion from hepatocytes and intestinal mucosa.
-!- CATALYTIC ACTIVITY: Acyl-CoA + cholesterol = CoA + cholesterol
ester.
-!- SUBUNIT: May form homo- or heterodimers. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
membrane protein {ECO:0000269|PubMed:11071899}.
-!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
Sterol o-acyltransferase subfamily. {ECO:0000305}.
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EMBL; AF078751; AAC64057.1; -; mRNA.
EMBL; CH466550; EDL04004.1; -; Genomic_DNA.
EMBL; BC025931; AAH25931.1; -; mRNA.
CCDS; CCDS27872.1; -.
RefSeq; NP_666176.1; NM_146064.1.
UniGene; Mm.358862; -.
ProteinModelPortal; O88908; -.
STRING; 10090.ENSMUSP00000023806; -.
ChEMBL; CHEMBL2653; -.
iPTMnet; O88908; -.
PhosphoSitePlus; O88908; -.
SwissPalm; O88908; -.
EPD; O88908; -.
MaxQB; O88908; -.
PaxDb; O88908; -.
PRIDE; O88908; -.
Ensembl; ENSMUST00000023806; ENSMUSP00000023806; ENSMUSG00000023045.
GeneID; 223920; -.
KEGG; mmu:223920; -.
UCSC; uc007xut.1; mouse.
CTD; 8435; -.
MGI; MGI:1332226; Soat2.
eggNOG; KOG0380; Eukaryota.
eggNOG; COG5056; LUCA.
GeneTree; ENSGT00530000063122; -.
HOGENOM; HOG000020782; -.
HOVERGEN; HBG058198; -.
InParanoid; O88908; -.
KO; K00637; -.
OMA; DRAMWEA; -.
OrthoDB; EOG091G0991; -.
TreeFam; TF315226; -.
BRENDA; 2.3.1.26; 3474.
Reactome; R-MMU-8964038; LDL clearance.
PRO; PR:O88908; -.
Proteomes; UP000000589; Chromosome 15.
Bgee; ENSMUSG00000023045; Expressed in 54 organ(s), highest expression level in jejunum.
CleanEx; MM_ACAT2; -.
CleanEx; MM_SOAT2; -.
ExpressionAtlas; O88908; baseline and differential.
Genevisible; O88908; MM.
GO; GO:0005903; C:brush border; ISO:MGI.
GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0015485; F:cholesterol binding; ISO:MGI.
GO; GO:0034736; F:cholesterol O-acyltransferase activity; ISO:MGI.
GO; GO:0000062; F:fatty-acyl-CoA binding; ISO:MGI.
GO; GO:0004772; F:sterol O-acyltransferase activity; IDA:MGI.
GO; GO:0033344; P:cholesterol efflux; ISO:MGI.
GO; GO:0034435; P:cholesterol esterification; ISO:MGI.
GO; GO:0042632; P:cholesterol homeostasis; IEA:InterPro.
GO; GO:0008203; P:cholesterol metabolic process; IDA:MGI.
GO; GO:0034379; P:very-low-density lipoprotein particle assembly; ISO:MGI.
InterPro; IPR004299; MBOAT_fam.
InterPro; IPR014371; Oat_ACAT_DAG_ARE.
InterPro; IPR030687; Sterol_acyltranf_meta.
PANTHER; PTHR10408; PTHR10408; 1.
Pfam; PF03062; MBOAT; 1.
PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
PIRSF; PIRSF500230; Sterol_acyltranf_ACAT; 1.
1: Evidence at protein level;
Acyltransferase; Cholesterol metabolism; Complete proteome;
Endoplasmic reticulum; Lipid metabolism; Membrane; Reference proteome;
Steroid metabolism; Sterol metabolism; Transferase; Transmembrane;
Transmembrane helix.
CHAIN 1 525 Sterol O-acyltransferase 2.
/FTId=PRO_0000207646.
TOPO_DOM 1 122 Cytoplasmic. {ECO:0000255}.
TRANSMEM 123 141 Helical. {ECO:0000255}.
TOPO_DOM 142 160 Lumenal. {ECO:0000255}.
TRANSMEM 161 179 Helical. {ECO:0000255}.
TOPO_DOM 180 203 Cytoplasmic. {ECO:0000255}.
TRANSMEM 204 222 Helical. {ECO:0000255}.
TOPO_DOM 223 343 Lumenal. {ECO:0000255}.
TRANSMEM 344 366 Helical. {ECO:0000255}.
TOPO_DOM 367 478 Cytoplasmic. {ECO:0000255}.
TRANSMEM 479 497 Helical. {ECO:0000255}.
TOPO_DOM 498 525 Lumenal. {ECO:0000255}.
ACT_SITE 437 437 {ECO:0000255}.
CONFLICT 93 93 Q -> P (in Ref. 1; AAC64057).
{ECO:0000305}.
CONFLICT 96 96 H -> R (in Ref. 1; AAC64057).
{ECO:0000305}.
CONFLICT 104 105 IT -> VA (in Ref. 1; AAC64057).
{ECO:0000305}.
CONFLICT 131 132 CV -> WF (in Ref. 1; AAC64057).
{ECO:0000305}.
CONFLICT 175 175 S -> Y (in Ref. 1; AAC64057).
{ECO:0000305}.
CONFLICT 262 262 G -> R (in Ref. 1; AAC64057).
{ECO:0000305}.
CONFLICT 519 519 R -> Q (in Ref. 1; AAC64057).
{ECO:0000305}.
CONFLICT 525 525 P -> T (in Ref. 1; AAC64057).
{ECO:0000305}.
SEQUENCE 525 AA; 60597 MW; F1C2DFEB5AB6CCA8 CRC64;
MQPKVPQLRR REGLGEEQEK GARGGEGNAR THGTPDLVQW TRHMEAVKTQ FLEQAQRELA
ELLDRALWEA MQAYPKQDRP LPSAAPDSTS KTQELHPGKR KVFITRKSLI DELMEVQHFR
TIYHMFIAGL CVLIISTLAI DFIDEGRLML EFDLLLFSFG QLPLALMTWV PMFLSTLLVP
YQTLWLWARP RAGGAWMLGA SLGCVLLAAH AVVLCVLPVH VSVRHELPPA SRCVLVFEQV
RLLMKSYSFL RETVPGIFCV RGGKGISPPS FSSYLYFLFC PTLIYRETYP RTPSIRWNYV
AKNFAQVLGC LLYACFILGR LCVPVFANMS REPFSTRALL LSILHATGPG IFMLLLIFFA
FLHCWLNAFA EMLRFGDRMF YRDWWNSTSF SNYYRTWNVV VHDWLYSYVY QDGLWLLGRR
ARGVAMLGVF LVSAVVHEYI FCFVLGFFYP VMLMLFLVFG GLLNFTMNDR HTGPAWNILM
WTFLFMGQGI QVSLYCQEWY ARRHCPLPQT TFWGMVTPRS WSCHP


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